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Subsequent dynamical analysis confirmed this observation, in addition to revealing network dynamics that cannot be readily predicted through analysis of the wiring diagram alone. Activation thresholds depended on the stimulated layer. Low stimulation produced transient activation, while stronger activation produced sustained oscillations where the threshold for sustained responses varied by layer: 13% in layer 2\/3, 54% in layer 5A, 25% in layer 5B, and 17% in layer 6. The frequency and phase of the resulting oscillation also depended on stimulation layer. By demonstrating the effectiveness of combined static and dynamic analysis, our results show how static brain maps can be related to the results of brain activity mapping. <\/jats:p>","DOI":"10.1162\/neco_a_00602","type":"journal-article","created":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T00:15:53Z","timestamp":1396916153000},"page":"1239-1262","source":"Crossref","is-referenced-by-count":18,"title":["Motor Cortex Microcircuit Simulation Based on Brain Activity Mapping"],"prefix":"10.1162","volume":"26","author":[{"given":"George L.","family":"Chadderdon","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology, SUNY Downstate, Brooklyn, NY 11203"}]},{"given":"Ashutosh","family":"Mohan","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, SUNY Downstate, Brooklyn, NY 11203"}]},{"given":"Benjamin A.","family":"Suter","sequence":"additional","affiliation":[{"name":"Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, U.S.A."}]},{"given":"Samuel A.","family":"Neymotin","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, SUNY Downstate, Brooklyn, NY 11203, U.S.A., and Department of Neurobiology, Yale University, New Haven, CT 06510, U.S.A."}]},{"given":"Cliff C.","family":"Kerr","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, SUNY Downstate, Brooklyn, NY 11203, U.S.A., and Department of Physics, University of Sydney, Sydney, Australia"}]},{"given":"Joseph T.","family":"Francis","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, SUNY Downstate, and Program in Biomedical Engineering, SUNY Downstate\/NYU Polytechnic, Brooklyn, NY 11203, U.S.A."}]},{"given":"Gordon M. 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