{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T23:00:05Z","timestamp":1770332405938,"version":"3.49.0"},"reference-count":101,"publisher":"MIT Press","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Computation"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>This letter examines the results of input-output (nonparametric) modeling based on the analysis of data generated by a mechanism-based (parametric) model of CA3-CA1 neuronal connections in the hippocampus. The motivation is to obtain biological insight into the interpretation of such input-output (Volterra-equivalent) models estimated from synthetic data. The insights obtained may be subsequently used to interpretat input-output models extracted from actual experimental data. Specifically, we found that a simplified parametric model may serve as a useful tool to study the signal transformations in the hippocampal CA3-CA1 regions. Input-output modeling of model-based synthetic data show that GABAergic interneurons are responsible for regulating neuronal excitation, controlling the precision of spike timing, and maintaining network oscillations, in a manner consistent with previous studies. The input-output model obtained from real data exhibits intriguing similarities with its synthetic-data counterpart, demonstrating the importance of a dynamic resonance in the system\/model response around 2 Hz to 3 Hz. Using the input-output model from real data as a guide, we may be able to amend the parametric model by incorporating more mechanisms in order to yield better-matching input-output model. The approach we present can also be applied to the study of other neural systems and pathways.<\/jats:p>","DOI":"10.1162\/neco_a_01031","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T20:30:22Z","timestamp":1508877022000},"page":"149-183","source":"Crossref","is-referenced-by-count":13,"title":["Mechanism-Based and Input-Output Modeling of the Key Neuronal Connections and Signal Transformations in the CA3-CA1 Regions of the Hippocampus"],"prefix":"10.1162","volume":"30","author":[{"given":"Kunling","family":"Geng","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering and the Biomedical Simulations Resource Center at the University of Southern California, Los Angeles, CA, 90089, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae C.","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and the Biomedical Simulations Resource Center at the University of Southern California, Los Angeles, CA, 90089, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and the Biomedical Simulations Resource Center at the University of Southern California, Los Angeles, CA, 90089, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert E.","family":"Hampson","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, 27157, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel A.","family":"Deadwyler","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, 27157, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore 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