{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T10:56:06Z","timestamp":1758970566262},"reference-count":82,"publisher":"MIT Press - Journals","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Computation"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p> Neurostimulation is a promising therapy for abating epileptic seizures. However, it is extremely difficult to identify optimal stimulation patterns experimentally. In this study, human recordings are used to develop a functional 24 neuron network statistical model of hippocampal connectivity and dynamics. Spontaneous seizure-like activity is induced in silico in this reconstructed neuronal network. The network is then used as a testbed to design and validate a wide range of neurostimulation patterns. Commonly used periodic trains were not able to permanently abate seizures at any frequency. A simulated annealing global optimization algorithm was then used to identify an optimal stimulation pattern, which successfully abated 92% of seizures. Finally, in a fully responsive, or closed-loop, neurostimulation paradigm, the optimal stimulation successfully prevented the network from entering the seizure state. We propose that the framework presented here for algorithmically identifying patient-specific neurostimulation patterns can greatly increase the efficacy of neurostimulation devices for seizures. <\/jats:p>","DOI":"10.1162\/neco_a_01075","type":"journal-article","created":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T21:42:04Z","timestamp":1521754924000},"page":"1180-1208","source":"Crossref","is-referenced-by-count":14,"title":["Designing Patient-Specific Optimal Neurostimulation Patterns for Seizure Suppression"],"prefix":"10.1162","volume":"30","author":[{"given":"Roman A.","family":"Sandler","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunling","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert E.","family":"Hampson","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Wake Forest University, Winston-Salem, NC 27109, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark R.","family":"Witcher","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Wake Forest University, Winston-Salem, NC 27109, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam A.","family":"Deadwyler","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Wake Forest University, Winston-Salem, NC 27109, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore W.","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasilis Z.","family":"Marmarelis","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"281","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2013.10.051"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(02)00077-1"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb00166.x"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1109\/TNSRE.2012.2189133"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001280"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03417.x"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s11222-013-9424-2"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aah3532"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2012.09.008"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199601183340308"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1142\/S0129065714300058"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2575"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1401752111"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780195301069.001.0001"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1142\/S0129065707000993"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s10878-008-9182-9"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-008-9625-6"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.86.021920"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1159\/000099878"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70075-9"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2013.08.014"},{"key":"B22","volume":"7","author":"Desai S. A.","year":"2014","journal-title":"Frontiers in Neuroengineering"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.27702"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1109\/5.939821"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00058"},{"issue":"4","key":"B26","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1212\/01.WNL.0000055086.35806.2D","volume":"60","author":"Engel J.","year":"2003","journal-title":"Neurology"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2013.0521"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.0791s.x"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3265"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1142\/S0129065709001951"},{"key":"B31","volume-title":"Simulation-based optimization: Parametric optimization techniques and reinforcement learning","author":"Gosavi A.","year":"2014"},{"key":"B32","author":"Grill W. M.","year":"2014","journal-title":"Non-regular electrical stimulation patterns designed with a cost function for treating neurological disorders"},{"key":"B33","author":"Grill W. M.","year":"2014","journal-title":"Devices, systems and methods for deep brain stimulation parameters"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1162\/NECO_a_00015"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12534"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1007\/0-306-48056-5_10"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.07.016"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1007\/s10827-014-0523-7"},{"key":"B39","author":"Jassemidis L. D.","year":"2012","journal-title":"Pacemaker for treating physiological system dysfunction."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1142\/S0129065714500208"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1001110"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1162\/NECO_a_00654"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1126\/science.220.4598.671"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/752428"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1007\/s10827-012-0422-8"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1002\/9780471679370"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3389\/fncom.2013.00094"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl241"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2015.08.012"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0000000000000139"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2011.06.011"},{"key":"B52","volume-title":"RNS system user manual.","author":"NeuroPace","year":"2015"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/aa52d1"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/nature07140"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1162\/NECO_a_00463"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1162\/NECO_a_00883"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/11\/1\/016009"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2014.11.013"},{"key":"B59","first-page":"1","volume":"38","author":"Sandler R. A.","year":"2014","journal-title":"Journal of Computational Neuroscience"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/12\/5\/056017"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4514-06.2007"},{"key":"B62","volume-title":"Neural control engineering: The emerging intersection between control theory and neuroscience","author":"Schiff S. J.","year":"2012"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2007.891948"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.neunet.2009.05.004"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1007\/s10827-008-0097-3"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1109\/TNSRE.2016.2604423"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1007\/s10827-013-0455-7"},{"key":"B68","first-page":"133","volume-title":"The hippocampus book","author":"Spruston N.","year":"2007"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2007.10.069"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00202"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4567-13.2014"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00697.2004"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1007\/s10559-006-0087-2"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1142\/S0218127406015866"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2014.11.016"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00368.2010"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/2\/4\/010"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg144"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02750.x"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1109\/TNSRE.2008.926716"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1214\/09-AOS729"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087636"}],"container-title":["Neural Computation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mitpressjournals.org\/doi\/pdf\/10.1162\/neco_a_01075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T21:42:26Z","timestamp":1615585346000},"score":1,"resource":{"primary":{"URL":"https:\/\/direct.mit.edu\/neco\/article\/30\/5\/1180-1208\/8349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":82,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1162\/neco_a_01075"],"URL":"https:\/\/doi.org\/10.1162\/neco_a_01075","relation":{},"ISSN":["0899-7667","1530-888X"],"issn-type":[{"value":"0899-7667","type":"print"},{"value":"1530-888X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5]]}}}