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The mean-field model is capable of correctly predicting the average spontaneous activity levels in asynchronous irregular regimes similar to in vivo activity. It also captures the transient temporal response of the network to complex external inputs. Finally, the mean-field model is also able to quantitatively describe regimes where high- and low-activity states alternate (up-down state dynamics), leading to slow oscillations. We conclude that such mean-field models are biologically realistic in the sense that they can capture both spontaneous and evoked activity, and they naturally appear as candidates to build very large-scale models involving multiple brain areas.<\/jats:p>","DOI":"10.1162\/neco_a_01173","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T21:01:44Z","timestamp":1550178104000},"page":"653-680","source":"Crossref","is-referenced-by-count":113,"title":["Biologically Realistic Mean-Field Models of Conductance-Based Networks of Spiking Neurons with Adaptation"],"prefix":"10.1162","volume":"31","author":[{"given":"Matteo","family":"di Volo","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Neuroscience, Information et Complexit\u00e9, CNRS FRE 3693, 91198 Gif sur Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Romagnoni","sequence":"additional","affiliation":[{"name":"Centre de Recherche sur 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