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In this study, we consider a model of astrocyte-regulated synapses to investigate this hypothesis at the level of layered networks of interacting neurons and astrocytes. Our simulations hint that gliotransmission sustains the transfer function across layers, although it decorrelates the neuronal activity from the signal pattern. Overall, our results make clear how astrocytes could transform neuronal activity by inducing a lowfrequency modulation of postsynaptic activity.<\/jats:p>","DOI":"10.1162\/neco_a_01399","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T21:38:13Z","timestamp":1623101893000},"page":"1970-1992","update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":16,"title":["A Computational Study on Synaptic Plasticity Regulation and Information Processing in Neuron-Astrocyte Networks"],"prefix":"10.1162","volume":"33","author":[{"given":"Roman","family":"Vuillaume","sequence":"first","affiliation":[{"name":"Laboratory ImViA EA 7535, Universit\u00e9 Bourgogne, Franche-Comt\u00e9, 21078 Dijon, France roman.vuillaume@u-bourgogne.fr"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhunlyn","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"Laboratory ImViA EA 7535, Universit\u00e9 Bourgogne, Franche-Comt\u00e9, 21078 Dijon, France Jhunlyn.Lorenzo@u-bourgogne.fr"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Binczak","sequence":"additional","affiliation":[{"name":"Laboratory ImViA EA 7535, Universit\u00e9 Bourgogne, Franche-Comt\u00e9, 21078 Dijon, France stbinc@u-bourgogne.fr"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabir","family":"Jacquir","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, CNRS, Institut des Neurosciences Paris-Saclay, 91190 Gif-sur-Yvette, France sabir.jacquir@u-psud.fr"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"281","published-online":{"date-parts":[[2021,6,11]]},"reference":[{"key":"2021061420583605200_B1","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/81453","article-title":"Synaptic plasticity: Taming the beast","volume":"3","author":"Abbott","year":"2000","journal-title":"Nature 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