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In particular, it is known that the two types of dopaminergic receptors (D1 and D2) present in the BG give rise to mechanistically different responses. The overall effect will be a difference in sensitivity to dopamine, which may have ramifications for action selection. However, which receptor type leads to a stronger response is unclear due to the complexity of the intracellular mechanisms involved. In this study, we use an existing, high-level computational model of the BG, which assumes that dopamine contributes to action selection by enabling a switch between different selection regimes, to predict which of D1 or D2 has the greater sensitivity. Thus, we ask, Assuming dopamine enables a switch between action selection regimes in the BG, what functional sensitivity values would result in improved action selection computation? To do this, we quantitatively assessed the model's capacity to perform action selection as we parametrically manipulated the sensitivity weights of D1 and D2. We show that differential (rather than equal) D1 and D2 sensitivity to dopaminergic input improves the switch between selection regimes during the action selection computation in our model. Specifically, greater D2 sensitivity compared to D1 led to these improvements.<\/jats:p>","DOI":"10.1162\/neco_a_01517","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T20:37:55Z","timestamp":1654634275000},"page":"1588-1615","update-policy":"http:\/\/dx.doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":2,"title":["Differential Dopamine Receptor-Dependent Sensitivity Improves the Switch Between Hard and Soft Selection in a Model of the Basal Ganglia"],"prefix":"10.1162","volume":"34","author":[{"given":"Olivier","family":"Codol","sequence":"first","affiliation":[{"name":"Department of Psychology and Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 3K7, Canada codol.olivier@gmail.com"}]},{"given":"Paul L.","family":"Gribble","sequence":"additional","affiliation":[{"name":"Department of Psychology and Department of 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