{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T11:36:51Z","timestamp":1769168211402,"version":"3.49.0"},"reference-count":55,"publisher":"MIT Press","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Health","award":["RF1AG077578"],"award-info":[{"award-number":["RF1AG077578"]}]},{"name":"National Institute of Health","award":["RF1AG064584"],"award-info":[{"award-number":["RF1AG064584"]}]},{"name":"National Institute of Health","award":["R01EB022744"],"award-info":[{"award-number":["R01EB022744"]}]},{"name":"National Institute of Health","award":["R01AG062007"],"award-info":[{"award-number":["R01AG062007"]}]},{"name":"National Institute of Health","award":["U19AG078109"],"award-info":[{"award-number":["U19AG078109"]}]},{"name":"National Institute of Health","award":["P30AG066530"],"award-info":[{"award-number":["P30AG066530"]}]},{"name":"National Institute of Health","award":["S10OD032285"],"award-info":[{"award-number":["S10OD032285"]}]},{"name":"National Institute of Health","award":["U01AG051218"],"award-info":[{"award-number":["U01AG051218"]}]}],"content-domain":{"domain":["direct.mit.edu"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hyperphosphorylated tau tangles are essential hallmarks of Alzheimer\u2019s disease (AD) and their propagation across brain regions was often considered to follow the classic Braak stages. Recent post-mortem and in vivo tau positron emission tomography (PET) studies, however, revealed the frequent presence of tau pathology heterogeneity. Clustering or event-based methods were proposed previously for the subtyping to tau pathology in AD, but they often lack robustness to varying distributions of disease severity across cohorts. To robustly discover and model tau pathology subtypes in AD, we propose in this work a novel graphical modeling framework that can disentangle the phenotypical differences of tau PET imaging due to disease heterogeneity from the spatiotemporal variations of disease stages. First, we propose a novel Reeb graph representation at the individual level to characterize the topographic patterns of salient tau pathology on cortical surfaces. Next, we use only cross-sectional tau PET data to develop a graphical model at the population level to encode the inter-subject spatiotemporal relationships, which enables us to robustly derive subtypes based on the topographic patterns of tau pathology and hence achieve increased generalization power to new samples with distinct tau pathology severity from the training data. Using synthetic and large-scale tau PET imaging data from the Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI) and Anti-Amyloid Treatment in Asymptomatic Alzheimer\u2019s (A4) studies, we compare with the state-of-the-art SuStaIn method and demonstrate the improved generalization performance of the proposed method. In addition, we validate both methods on a cohort of autosomal dominant Alzheimer\u2019s disease (ADAD) patients with known tau pathology patterns to show that our method has more robust performance in testing data with large deviations from training data. Furthermore, for preclinical patients of the A4 cohort, we demonstrate more significant differences in clinical cognitive measures can be observed across subtypes discovered by our method.<\/jats:p>","DOI":"10.1162\/imag.a.1110","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T20:01:14Z","timestamp":1767729674000},"update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":0,"title":["Graphical modeling of cortical tau pathology topography for its subtyping in Alzheimer\u2019s disease"],"prefix":"10.1162","volume":"4","author":[{"given":"Jiaxin","family":"Yue","sequence":"first","affiliation":[{"name":"USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States"},{"name":"Ming Hsieh Department of Electrical and Computer Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinkai","family":"Wang","sequence":"additional","affiliation":[{"name":"USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States"},{"name":"Ming Hsieh Department of Electrical and Computer Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Ringman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonggang","family":"Shi","sequence":"additional","affiliation":[{"name":"USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States"},{"name":"Ming Hsieh Department of Electrical and Computer Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, United States"},{"name":"Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States"},{"name":"Alfred E. Mann Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"281","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"issue":"12","key":"2026012214560670700_IMAG.a.1110-b1","doi-asserted-by":"crossref","first-page":"4935","DOI":"10.1093\/brain\/awad232","article-title":"A data-driven study of Alzheimer\u2019s disease related amyloid and tau pathology progression","volume":"146","author":"Aksman","year":"2023","journal-title":"Brain"},{"issue":"10","key":"2026012214560670700_IMAG.a.1110-b2","doi-asserted-by":"crossref","first-page":"P10008","DOI":"10.1088\/1742-5468\/2008\/10\/P10008","article-title":"Fast unfolding of communities in large networks","volume":"2008","author":"Blondel","year":"2008","journal-title":"Journal of Statistical Mechanics: Theory and Experiment"},{"issue":"4","key":"2026012214560670700_IMAG.a.1110-b3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Aeuropathologica"},{"issue":"1","key":"2026012214560670700_IMAG.a.1110-b4","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2967\/jnumed.117.195248","article-title":"Off-target 18f-AV-1451 binding in the basal ganglia correlates with age-related iron accumulation","volume":"59","author":"Choi","year":"2018","journal-title":"Journal of Nuclear Medicine"},{"issue":"2","key":"2026012214560670700_IMAG.a.1110-b5","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S1474-4422(11)70289-7","article-title":"Posterior cortical atrophy","volume":"11","author":"Crutch","year":"2012","journal-title":"The Lancet Neurology"},{"issue":"1","key":"2026012214560670700_IMAG.a.1110-b6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/cercor\/bhg087","article-title":"Automatically parcellating the human cerebral cortex","volume":"14","author":"Fischl","year":"2004","journal-title":"Cerebral Cortex"},{"issue":"11","key":"2026012214560670700_IMAG.a.1110-b7","first-page":"1129","article-title":"Graph drawing by force-directed placement","volume":"21","author":"Fruchterman","year":"1991","journal-title":"Software: Practice and Experience"},{"issue":"10","key":"2026012214560670700_IMAG.a.1110-b8","doi-asserted-by":"crossref","first-page":"e0164492","DOI":"10.1371\/journal.pone.0164492","article-title":"Practice effects on story memory and list learning tests in the neuropsychological assessment of older adults","volume":"11","author":"Gavett","year":"2016","journal-title":"PLoS One"},{"issue":"4","key":"2026012214560670700_IMAG.a.1110-b9","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1093\/brain\/awz019","article-title":"Tau PET in autosomal dominant Alzheimer\u2019s disease: Relationship with cognition, dementia and other biomarkers","volume":"142","author":"Gordon","year":"2019","journal-title":"Brain"},{"key":"2026012214560670700_IMAG.a.1110-b10","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.neuroimage.2013.12.021","article-title":"Cortical surface-based analysis reduces bias and variance in kinetic modeling of brain PET data","volume":"92","author":"Greve","year":"2014","journal-title":"NeuroImage"},{"issue":"9","key":"2026012214560670700_IMAG.a.1110-b11","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1162\/jocn_a_00405","article-title":"A surface-based analysis of language lateralization and cortical asymmetry","volume":"25","author":"Greve","year":"2013","journal-title":"Journal of Cognitive Neuroscience"},{"issue":"9","key":"2026012214560670700_IMAG.a.1110-b12","first-page":"2755","article-title":"Molecular properties underlying regional vulnerability to Alzheimer\u2019s disease pathology","volume":"141","author":"Grothe","year":"2018","journal-title":"Brain"},{"issue":"1","key":"2026012214560670700_IMAG.a.1110-b13","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.biopsych.2020.01.016","article-title":"Disentangling heterogeneity in Alzheimer\u2019s disease and related dementias using data-driven methods","volume":"88","author":"Habes","year":"2020","journal-title":"Biological Psychiatry"},{"issue":"4","key":"2026012214560670700_IMAG.a.1110-b14","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1111\/j.1471-4159.2009.06181.x","article-title":"The amyloid hypothesis for Alzheimer\u2019s disease: A critical reappraisal","volume":"110","author":"Hardy","year":"2009","journal-title":"Journal of Neurochemistry"},{"issue":"41","key":"2026012214560670700_IMAG.a.1110-b15","first-page":"E4376","article-title":"Proteopathic tau seeding predicts tauopathy in vivo","volume":"111","author":"Holmes","year":"2014","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"2026012214560670700_IMAG.a.1110-b16","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/BF01908075","article-title":"Comparing partitions","volume":"2","author":"Hubert","year":"1985","journal-title":"Journal of Classification"},{"issue":"2","key":"2026012214560670700_IMAG.a.1110-b17","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/ana.24706","article-title":"[F-18] AV-1451 PET retention in choroid plexus: More than \u201coff-target\u201d binding","volume":"80","author":"Ikonomovic","year":"2016","journal-title":"Annals of Neurology"},{"issue":"4","key":"2026012214560670700_IMAG.a.1110-b18","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA research framework: Toward a biological definition of Alzheimer\u2019s disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimer\u2019s & Dementia"},{"issue":"5","key":"2026012214560670700_IMAG.a.1110-b19","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1212\/WNL.0000000000002923","article-title":"A\/T\/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers","volume":"87","author":"Jack","year":"2016","journal-title":"Neurology"},{"issue":"1","key":"2026012214560670700_IMAG.a.1110-b20","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1474-4422(09)70299-6","article-title":"Hypothetical model of dynamic biomarkers of the Alzheimer\u2019s pathological cascade","volume":"9","author":"Jack","year":"2010","journal-title":"The Lancet Neurology"},{"issue":"3","key":"2026012214560670700_IMAG.a.1110-b21","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jalz.2016.08.005","article-title":"Defining imaging biomarker cut points for brain aging and Alzheimer\u2019s disease","volume":"13","author":"Jack","year":"2017","journal-title":"Alzheimer\u2019s & Dementia"},{"issue":"5","key":"2026012214560670700_IMAG.a.1110-b22","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/JCP.0000000000000941","article-title":"Digit symbol substitution test: The case for sensitivity over specificity in neuropsychological testing","volume":"38","author":"Jaeger","year":"2018","journal-title":"Journal of Clinical Psychopharmacology"},{"key":"2026012214560670700_IMAG.a.1110-b23","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3389\/fnagi.2019.00211","article-title":"Topographical heterogeneity of Alzheimer\u2019s disease based on MR imaging, tau PET, and amyloid PET","volume":"11","author":"Jeon","year":"2019","journal-title":"Frontiers in Aging Neuroscience"},{"issue":"3","key":"2026012214560670700_IMAG.a.1110-b24","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","article-title":"Neuroinflammation and microglial activation in Alzheimer disease: Where do we go from here?","volume":"17","author":"Leng","year":"2021","journal-title":"Nature Reviews Neurology"},{"issue":"1","key":"2026012214560670700_IMAG.a.1110-b25","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/brain\/awx320","article-title":"Widespread brain tau and its association with ageing, Braak stage and Alzheimer\u2019s dementia","volume":"141","author":"Lowe","year":"2018","journal-title":"Brain"},{"issue":"1","key":"2026012214560670700_IMAG.a.1110-b26","doi-asserted-by":"crossref","first-page":"5133","DOI":"10.1038\/s41467-024-49402-x","article-title":"Disease progression modelling reveals heterogeneity in trajectories of Lewy-type \u03b1-synuclein pathology","volume":"15","author":"Mastenbroek","year":"2024","journal-title":"Nature Communications"},{"issue":"1","key":"2026012214560670700_IMAG.a.1110-b27","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13024-022-00543-x","article-title":"Imaging tau pathology in Alzheimer\u2019s disease with positron emission tomography: Lessons learned from imaging-neuropathology validation studies","volume":"17","author":"Moscoso","year":"2022","journal-title":"Molecular Neurodegeneration"},{"issue":"4","key":"2026012214560670700_IMAG.a.1110-b28","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.nic.2005.09.008","article-title":"The Alzheimer\u2019s disease neuroimaging initiative","volume":"15","author":"Mueller","year":"2005","journal-title":"Neuroimaging Clinics of North America"},{"issue":"9","key":"2026012214560670700_IMAG.a.1110-b29","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S1474-4422(11)70156-9","article-title":"Neuropathologically defined subtypes of Alzheimer\u2019s disease with distinct clinical characteristics: A retrospective study","volume":"10","author":"Murray","year":"2011","journal-title":"The Lancet Neurology"},{"key":"2026012214560670700_IMAG.a.1110-b30","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s10048-006-0053-1","article-title":"The A431E mutation in PSEN1 causing familial Alzheimer\u2019s disease originating in Jalisco State, Mexico: An additional fifteen families","volume":"7","author":"Murrell","year":"2006","journal-title":"Neurogenetics"},{"issue":"5","key":"2026012214560670700_IMAG.a.1110-b31","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/NEN.0b013e31825018f7","article-title":"Correlation of Alzheimer disease neuropathologic changes with cognitive status: A review of the literature","volume":"71","author":"Nelson","year":"2012","journal-title":"Journal of Neuropathology & Experimental Neurology"},{"issue":"2","key":"2026012214560670700_IMAG.a.1110-b32","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jalz.2019.08.201","article-title":"Distinct tau PET patterns in atrophy-defined subtypes of Alzheimer\u2019s disease","volume":"16","author":"Ossenkoppele","year":"2020","journal-title":"Alzheimer\u2019s & Dementia"},{"issue":"9","key":"2026012214560670700_IMAG.a.1110-b33","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1093\/brain\/awv191","article-title":"The behavioural\/dysexecutive variant of Alzheimer\u2019s disease: Clinical, neuroimaging and pathological features","volume":"138","author":"Ossenkoppele","year":"2015","journal-title":"Brain"},{"issue":"5","key":"2026012214560670700_IMAG.a.1110-b34","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1093\/brain\/aww027","article-title":"Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer\u2019s disease","volume":"139","author":"Ossenkoppele","year":"2016","journal-title":"Brain"},{"issue":"4","key":"2026012214560670700_IMAG.a.1110-b35","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s00401-019-02036-6","article-title":"Alzheimer\u2019s disease clinical variants show distinct regional patterns of neurofibrillary tangle accumulation","volume":"138","author":"Petersen","year":"2019","journal-title":"Acta Neuropathologica"},{"issue":"6","key":"2026012214560670700_IMAG.a.1110-b36","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.neuron.2011.12.040","article-title":"A network diffusion model of disease progression in dementia","volume":"73","author":"Raj","year":"2012","journal-title":"Neuron"},{"key":"2026012214560670700_IMAG.a.1110-b37","unstructured":"Reeb, G.\n           (1946). Sur les points singuliers d\u2019une forme de pfaff completement integrable ou d\u2019une fonction numerique [on the singular points of a completely integrable pfaff form or of a numerical function]. Comptes Rendus Acad. Sciences Paris, 222, 847\u2013849. https:\/\/cir.nii.ac.jp\/crid\/1571417125676878592"},{"issue":"2","key":"2026012214560670700_IMAG.a.1110-b38","doi-asserted-by":"crossref","first-page":"fcad030","DOI":"10.1093\/braincomms\/fcad030","article-title":"Characterization of spastic paraplegia in a family with a novel PSEN1 mutation","volume":"5","author":"Ringman","year":"2023","journal-title":"Brain Communications"},{"issue":"5","key":"2026012214560670700_IMAG.a.1110-b39","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.neuron.2016.01.028","article-title":"PET imaging of tau deposition in the aging human brain","volume":"89","author":"Sch\u00f6ll","year":"2016","journal-title":"Neuron"},{"issue":"3","key":"2026012214560670700_IMAG.a.1110-b40","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1109\/TMI.2012.2224879","article-title":"Cortical surface reconstruction via unified Reeb analysis of geometric and topological outliers in magnetic resonance images","volume":"32","author":"Shi","year":"2012","journal-title":"IEEE Transactions on Medical Imaging"},{"key":"2026012214560670700_IMAG.a.1110-b41","first-page":"306","article-title":"Persistent Reeb graph matching for fast brain search","volume-title":"International Workshop on Machine Learning in Medical Imaging","author":"Shi","year":"2014"},{"issue":"228","key":"2026012214560670700_IMAG.a.1110-b42","doi-asserted-by":"crossref","first-page":"228fs13","DOI":"10.1126\/scitranslmed.3007941","article-title":"The A4 study: Stopping AD before symptoms begin?","volume":"6","author":"Sperling","year":"2014","journal-title":"Science Translational Medicine"},{"issue":"12","key":"2026012214560670700_IMAG.a.1110-b43","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1177\/0271678X19879226","article-title":"Test\u2013retest repeatability of [18f] Flortaucipir PET in Alzheimer\u2019s disease and cognitively normal individuals","volume":"40","author":"Timmers","year":"2020","journal-title":"Journal of Cerebral Blood Flow & Metabolism"},{"issue":"1","key":"2026012214560670700_IMAG.a.1110-b44","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s42003-025-07575-1","article-title":"Searching for the cellular underpinnings of the selective vulnerability to tauopathic insults in Alzheimer\u2019s disease","volume":"8","author":"Torok","year":"2025","journal-title":"Communications Biology"},{"issue":"1","key":"2026012214560670700_IMAG.a.1110-b45","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1038\/s41467-020-15701-2","article-title":"Spread of pathological tau proteins through communicating neurons in human Alzheimer\u2019s disease","volume":"11","author":"Vogel","year":"2020","journal-title":"Nature Communications"},{"issue":"5","key":"2026012214560670700_IMAG.a.1110-b46","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/s41591-021-01309-6","article-title":"Four distinct trajectories of tau deposition identified in Alzheimer\u2019s disease","volume":"27","author":"Vogel","year":"2021","journal-title":"Nature Medicine"},{"issue":"1","key":"2026012214560670700_IMAG.a.1110-b47","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13195-022-00986-w","article-title":"What\u2019s the cut-point?: A systematic investigation of tau PET thresholding methods","volume":"14","author":"Weigand","year":"2022","journal-title":"Alzheimer\u2019s Research & Therapy"},{"issue":"10","key":"2026012214560670700_IMAG.a.1110-b48","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/S1474-4422(12)70200-4","article-title":"Neuroimaging correlates of pathologically defined subtypes of Alzheimer\u2019s disease: A case-control study","volume":"11","author":"Whitwell","year":"2012","journal-title":"The Lancet Neurology"},{"issue":"2","key":"2026012214560670700_IMAG.a.1110-b49","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/ana.25142","article-title":"[18F] AV-1451 clustering of entorhinal and cortical uptake in Alzheimer\u2019s disease","volume":"83","author":"Whitwell","year":"2018","journal-title":"Annals of Neurology"},{"issue":"2","key":"2026012214560670700_IMAG.a.1110-b50","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s41870-022-00873-5","article-title":"Assessing the impact of the density and sparsity of the network on community detection using a Gaussian mixture random partition graph generator","volume":"14","author":"Wickramasinghe","year":"2022","journal-title":"International Journal of Information Technology"},{"issue":"4","key":"2026012214560670700_IMAG.a.1110-b51","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1001\/jamaneurol.2016.5755","article-title":"Association of in vivo [18F]AV-1451 tau PET imaging results with cortical atrophy and symptoms in typical and atypical Alzheimer disease","volume":"74","author":"Xia","year":"2017","journal-title":"JAMA Neurology"},{"issue":"1","key":"2026012214560670700_IMAG.a.1110-b52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-018-05892-0","article-title":"Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference","volume":"9","author":"Young","year":"2018","journal-title":"Nature Communications"},{"issue":"7","key":"2026012214560670700_IMAG.a.1110-b53","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1093\/brain\/awad145","article-title":"Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies","volume":"146","author":"Young","year":"2023","journal-title":"Brain"},{"key":"2026012214560670700_IMAG.a.1110-b54","first-page":"262","article-title":"Uncovering heterogeneity in Alzheimer\u2019s disease from graphical modeling of the tau spatiotemporal topography","volume-title":"International Conference on Medical Image Computing and Computer-Assisted Intervention","author":"Yue","year":"2023"},{"key":"2026012214560670700_IMAG.a.1110-b55","first-page":"1","article-title":"Tau PET harmonization via surface-based diffusion model","volume-title":"2025 IEEE 22nd International Symposium on Biomedical Imaging (ISBI)","author":"Yue","year":"2025"}],"container-title":["Imaging Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/direct.mit.edu\/imag\/article-pdf\/doi\/10.1162\/IMAG.a.1110\/2573830\/imag.a.1110.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/direct.mit.edu\/imag\/article-pdf\/doi\/10.1162\/IMAG.a.1110\/2573830\/imag.a.1110.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T19:56:20Z","timestamp":1769111780000},"score":1,"resource":{"primary":{"URL":"https:\/\/direct.mit.edu\/imag\/article\/doi\/10.1162\/IMAG.a.1110\/134777\/Graphical-modeling-of-cortical-tau-pathology"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":55,"URL":"https:\/\/doi.org\/10.1162\/imag.a.1110","relation":{},"ISSN":["2837-6056"],"issn-type":[{"value":"2837-6056","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"IMAG.a.1110"}}