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Commenting on van den Bosch and Cools (2025), we evaluate the first attempt to validate Receptor-Enriched Analysis of functional Connectivity by Targets (REACT) against individual-level PET data. They found that the effects of methylphenidate on dopamine-enriched networks, but not noradrenaline-enriched networks, tracked individual differences in striatal dopamine synthesis capacity and reward prediction error signaling. While establishing the validity of molecular-enriched networks for this specific use case, the study also exposes critical methodological boundary conditions. We discuss the constraints imposed by spatial collinearity between molecular targets, the influence of state-dependent effects in task-based paradigms, and the necessity of pharmacological blocking studies for establishing causal selectivity. Finally, we look to the future of molecular-informed functional imaging.<\/jats:p>","DOI":"10.1162\/imag.a.1175","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T20:01:58Z","timestamp":1772481718000},"update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":2,"title":["Towards molecular selectivity in pharmacoimaging: Comment on van den Bosch and Cools"],"prefix":"10.1162","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1643-5987","authenticated-orcid":false,"given":"Timothy","family":"Lawn","sequence":"first","affiliation":[{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States"},{"name":"Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1152-5323","authenticated-orcid":false,"given":"Mitul A.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"281","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"issue":"1","key":"2026031815554500700_IMAG.a.1175-b1","first-page":"120","article-title":"A high-resolution in vivo atlas of the human brain\u2019s serotonin 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