{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T06:40:09Z","timestamp":1789886409732,"version":"4.0.1"},"reference-count":105,"publisher":"MIT Press","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":151,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["215728"],"award-info":[{"award-number":["215728"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024021","name":"Facult\u00e9 de Biologie et de M\u00e9decine, Universit\u00e9 de Lausanne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024021","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Adrian & Simone Frutiger Foundation"},{"name":"Adrian & Simone Frutiger Foundation"},{"DOI":"10.13039\/501100006387","name":"Fondation Leenaards","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006387","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["direct.mit.edu"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,6,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Advances in three-dimensional magnetic resonance spectroscopic imaging (3D-MRSI) allow for the high-resolution mapping of multiple neurometabolites throughout the entire brain in vivo and within clinically compatible time frames. Leveraging this capability, we created a voxel-based pipeline that corrects and spatially normalizes whole-brain maps of total N-acetylaspartate (tNAA), myo-inositol (Ins), choline compounds (Cho), glutamate + glutamine (Glx) and creatine + phosphocreatine (tCr). We examined 2 different 3D-MRSI dataset: first, a clinical sample of adolescents and young adults at risk for psychosis (n = 21) meeting DSM-5 criteria for Attenuated Psychosis Syndrome (APS) or Schizotypal Personality Disorder (SCZT), and age-\/sex-matched healthy controls (n = 13); and second, a non-clinical sample of adolescents (n = 61) scanned on a different site. The objective of the study was threefold: first, to assess the reproducibility of 3D-MRSI measures across datasets and scanning sites; second, to validate the feasibility of whole-brain, voxel-based analyses on 3D-MRSI data; and third, to test the sensitivity of this approach. Metabolite distributions showed reproducible regional variation in standard space between the two independent samples and scanning sites (r ranging from 0.82 to 0.99). Relative to controls, at-risk participants exhibited higher tNAA levels in frontal grey matter; the SCZT subgroup additionally displayed widespread cortical and subcortical elevations of Ins levels compared with both APS and controls. Voxel-based analyses of structural (i.e., gray and white matter volumes or densities) and diffusion (i.e., generalized fractional anisotropy) parameters yielded no significant differences between patients and controls. These preliminary findings suggest that high-resolution 3D-MRSI may be sensitive enough to detect subtle neurometabolic alterations at the group level in the early stages of psychotic disorders when structural or diffusion measures show no difference. High-resolution whole-brain metabolic mapping may have the potential to help with early identification of young people at risk for psychosis or other mental disorders.<\/jats:p>","DOI":"10.1162\/imag.a.1276","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T20:01:55Z","timestamp":1780344115000},"update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":3,"title":["High-resolution whole-brain magnetic resonance spectroscopic imaging in youth at risk for psychosis"],"prefix":"10.1162","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6817-4092","authenticated-orcid":false,"given":"Edgar","family":"C\u00e9l\u00e9reau","sequence":"first","affiliation":[{"name":"Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9778-8460","authenticated-orcid":false,"given":"Federico","family":"Lucchetti","sequence":"additional","affiliation":[{"name":"Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6067-8639","authenticated-orcid":false,"given":"Yasser","family":"Alem\u00e1n-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Service of Diagnostic and Interventional Radiology, Department of Medical Radiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4931-9007","authenticated-orcid":false,"given":"Daniella","family":"Dwir","sequence":"additional","affiliation":[{"name":"Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Cleusix","sequence":"additional","affiliation":[{"name":"Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Baptiste","family":"Ledoux","sequence":"additional","affiliation":[{"name":"Service of Diagnostic and Interventional Radiology, Department of Medical Radiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland"},{"name":"CIBM Center for BioMedical Imaging, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6479-5381","authenticated-orcid":false,"given":"Raoul","family":"Jenni","sequence":"additional","affiliation":[{"name":"Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Conchon","sequence":"additional","affiliation":[{"name":"Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2730-4285","authenticated-orcid":false,"given":"Meritxell","family":"Bach Cuadra","sequence":"additional","affiliation":[{"name":"Service of Diagnostic and Interventional Radiology, Department of Medical Radiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland"},{"name":"CIBM Center for BioMedical Imaging, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2327-869X","authenticated-orcid":false,"given":"Zo\u00e9","family":"Schilliger","sequence":"additional","affiliation":[{"name":"Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"},{"name":"Division of child and adolescent psychiatry, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Solida","sequence":"additional","affiliation":[{"name":"Centre Neuchatelois de Psychiatrie, Neuchatel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7074-7212","authenticated-orcid":false,"given":"Marco","family":"Armando","sequence":"additional","affiliation":[{"name":"Division of child and adolescent psychiatry, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5233-6145","authenticated-orcid":false,"given":"Kerstin Jessica","family":"Plessen","sequence":"additional","affiliation":[{"name":"Division of child and adolescent psychiatry, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2854-6561","authenticated-orcid":false,"given":"Patric","family":"Hagmann","sequence":"additional","affiliation":[{"name":"Service of Diagnostic and Interventional Radiology, Department of Medical Radiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5832-1910","authenticated-orcid":false,"given":"Philippe","family":"Conus","sequence":"additional","affiliation":[{"name":"Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3019-9914","authenticated-orcid":false,"given":"Antoine","family":"Klauser","sequence":"additional","affiliation":[{"name":"Swiss Innovation Hub, Siemens Healthineers International AG, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0284-4947","authenticated-orcid":false,"given":"Paul","family":"Klauser","sequence":"additional","affiliation":[{"name":"Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"},{"name":"Division of child and adolescent psychiatry, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"281","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"issue":"1","key":"2026061715551955200_IMAG.a.1276-b1","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1093\/schbul\/sbac113","article-title":"Multimodal magnetic resonance imaging depicts widespread and subregion specific anomalies in the thalamus of early-psychosis and chronic schizophrenia patients","volume":"49","author":"Alem\u00e1n-G\u00f3mez","year":"2023","journal-title":"Schizophrenia Bulletin"},{"key":"2026061715551955200_IMAG.a.1276-b2","volume-title":"Diagnostic and statistical manual of mental disorders: DSM-IV; includes ICD-9-CM codes effective 1. Oct. 96","author":"American Psychiatric Association","year":"1998","edition":"4"},{"key":"2026061715551955200_IMAG.a.1276-b3","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and statistical manual of mental disorders: DSM-5","author":"American Psychiatric Association","year":"2013","edition":"5th"},{"issue":"3","key":"2026061715551955200_IMAG.a.1276-b4","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.biopsych.2009.08.040","article-title":"Antipsychotic dose equivalents and dose-years: A standardized method for comparing exposure to different drugs","volume":"67","author":"Andreasen","year":"2010","journal-title":"Biological Psychiatry"},{"key":"2026061715551955200_IMAG.a.1276-b5","doi-asserted-by":"crossref","first-page":"1163600","DOI":"10.3389\/fnins.2023.1163600","article-title":"The thalamus in psychosis spectrum disorder","volume":"17","author":"Anticevic","year":"2023","journal-title":"Frontiers in Neuroscience"},{"issue":"6","key":"2026061715551955200_IMAG.a.1276-b6","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1006\/nimg.2000.0582","article-title":"Voxel-based morphometry\u2014The methods","volume":"11","author":"Ashburner","year":"2000","journal-title":"NeuroImage"},{"issue":"1","key":"2026061715551955200_IMAG.a.1276-b7","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.media.2007.06.004","article-title":"Symmetric diffeomorphic image registration with cross-correlation: Evaluating automated labeling of elderly and neurodegenerative brain","volume":"12","author":"Avants","year":"2008","journal-title":"Medical Image Analysis"},{"key":"2026061715551955200_IMAG.a.1276-b8","doi-asserted-by":"crossref","first-page":"706017","DOI":"10.3389\/fpsyt.2021.706017","article-title":"Bridging the gap? Altered thalamocortical connectivity in psychotic and psychedelic states","volume":"12","author":"Avram","year":"2021","journal-title":"Frontiers in Psychiatry"},{"issue":"7","key":"2026061715551955200_IMAG.a.1276-b9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0219679","article-title":"Effects of the antidepressant medication duloxetine on brain metabolites in persistent depressive disorder: A randomized, controlled trial","volume":"14","author":"Bansal","year":"2019","journal-title":"PLoS One"},{"issue":"3","key":"2026061715551955200_IMAG.a.1276-b10","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/eip.12037","article-title":"Treatment and Early Intervention in Psychosis Program (TIPP-Lausanne): Implementation of an early intervention programme for psychosis in Switzerland","volume":"7","author":"Baumann","year":"2013","journal-title":"Early Intervention in Psychiatry"},{"key":"2026061715551955200_IMAG.a.1276-b11","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.freeradbiomed.2016.06.027","article-title":"Adaptive regulation of the brain\u2019s antioxidant defences by neurons and astrocytes","volume":"100","author":"Baxter","year":"2016","journal-title":"Free Radical Biology and Medicine"},{"issue":"5","key":"2026061715551955200_IMAG.a.1276-b12","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.4314","article-title":"Accelerated MR spectroscopic imaging\u2014A review of current and emerging techniques","volume":"34","author":"Bogner","year":"2021","journal-title":"NMR in Biomedicine"},{"key":"2026061715551955200_IMAG.a.1276-b13","doi-asserted-by":"crossref","first-page":"660850","DOI":"10.3389\/fpsyt.2021.660850","article-title":"Increased glutamate plus glutamine in the right middle cingulate in early schizophrenia but not in bipolar psychosis: A whole brain 1H-MRS study","volume":"12","author":"Bustillo","year":"2021","journal-title":"Frontiers in Psychiatry"},{"issue":"8","key":"2026061715551955200_IMAG.a.1276-b14","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1001\/jamapsychiatry.2021.1290","article-title":"Neurocognitive functioning in individuals at clinical high risk for psychosis: A systematic review and meta-analysis","volume":"78","author":"Catalan","year":"2021","journal-title":"JAMA Psychiatry"},{"issue":"9","key":"2026061715551955200_IMAG.a.1276-b15","doi-asserted-by":"crossref","first-page":"e897","DOI":"10.1038\/tp.2016.170","article-title":"Prediction of transition from ultra-high risk to first-episode psychosis using a probabilistic model combining history, clinical assessment and fatty-acid biomarkers","volume":"6","author":"Clark","year":"2016","journal-title":"Translational Psychiatry"},{"key":"2026061715551955200_IMAG.a.1276-b16","unstructured":"Claus, O. W.\n           (2024). ggridges: Ridgeline Plots in \u201cggplot2\u201d [Computer software]. https:\/\/wilkelab.org\/ggridges\/"},{"key":"2026061715551955200_IMAG.a.1276-b17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/3950312","article-title":"On surface completion and image inpainting by biharmonic functions: Numerical aspects","volume":"2018","author":"Damelin","year":"2018","journal-title":"International Journal of Mathematics and Mathematical Sciences"},{"key":"2026061715551955200_IMAG.a.1276-b18","doi-asserted-by":"crossref","first-page":"438","DOI":"10.3389\/fpsyt.2018.00438","article-title":"Putative astroglial dysfunction in schizophrenia: A meta-analysis of 1H-MRS studies of medial prefrontal myo-inositol","volume":"9","author":"Das","year":"2018","journal-title":"Frontiers in Psychiatry"},{"issue":"3","key":"2026061715551955200_IMAG.a.1276-b19","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","article-title":"An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest","volume":"31","author":"Desikan","year":"2006","journal-title":"NeuroImage"},{"issue":"7","key":"2026061715551955200_IMAG.a.1276-b20","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1001\/jamapsychiatry.2021.0638","article-title":"Association of structural magnetic resonance imaging measures with psychosis onset in individuals at clinical high risk for developing psychosis: An ENIGMA working group mega-analysis","volume":"78","author":"ENIGMA Clinical High Risk for Psychosis Working Group","year":"2021","journal-title":"JAMA Psychiatry"},{"issue":"4","key":"2026061715551955200_IMAG.a.1276-b21","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1002\/jmri.27437","article-title":"Whole-slab 3D MR spectroscopic imaging of the human brain with spiral-out-in sampling at 7T","volume":"53","author":"Esmaeili","year":"2021","journal-title":"Journal of Magnetic Resonance Imaging"},{"issue":"1","key":"2026061715551955200_IMAG.a.1276-b22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1042\/BJ20111943","article-title":"Antioxidant and bioenergetic coupling between neurons and astrocytes","volume":"443","author":"Fernandez-Fernandez","year":"2012","journal-title":"Biochemical Journal"},{"key":"2026061715551955200_IMAG.a.1276-b23","doi-asserted-by":"crossref","DOI":"10.1016\/S1053-8119(09)70884-5","article-title":"Unbiased nonlinear average age-appropriate brain templates from birth to adulthood","author":"Fonov","year":"2009","journal-title":"NeuroImage"},{"issue":"4","key":"2026061715551955200_IMAG.a.1276-b24","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/mp.2015.63","article-title":"Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium","volume":"21","author":"for the ENIGMA Schizophrenia Working Group","year":"2016","journal-title":"Molecular Psychiatry"},{"issue":"1","key":"2026061715551955200_IMAG.a.1276-b25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1001\/jamapsychiatry.2013.269","article-title":"The psychosis high-risk state: A comprehensive state-of-the-art review","volume":"70","author":"Fusar-Poli","year":"2013","journal-title":"JAMA Psychiatry"},{"issue":"6","key":"2026061715551955200_IMAG.a.1276-b26","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1176\/appi.ajp.2009.09060802","article-title":"International consensus study of antipsychotic dosing","volume":"167","author":"Gardner","year":"2010","journal-title":"American Journal of Psychiatry"},{"key":"2026061715551955200_IMAG.a.1276-b27","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giae049","article-title":"CAT: A computational anatomy toolbox for the analysis of structural MRI data","volume":"13","author":"Gaser","year":"2024","journal-title":"GigaScience"},{"issue":"1","key":"2026061715551955200_IMAG.a.1276-b28","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/archpsyc.57.1.65","article-title":"Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia","volume":"57","author":"Glantz","year":"2000","journal-title":"Archives of General Psychiatry"},{"issue":"8","key":"2026061715551955200_IMAG.a.1276-b29","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1002\/nbm.3575","article-title":"Regional distributions of brain glutamate and glutamine in normal subjects: Whole-brain Glutamate and Glutamine Estimation","volume":"29","author":"Goryawala","year":"2016","journal-title":"NMR in Biomedicine"},{"issue":"5","key":"2026061715551955200_IMAG.a.1276-b30","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1037\/0022-006X.72.5.767","article-title":"Two-year stability and change of schizotypal, borderline, avoidant, and obsessive-compulsive personality disorders","volume":"72","author":"Grilo","year":"2004","journal-title":"Journal of Consulting and Clinical Psychology"},{"issue":"12","key":"2026061715551955200_IMAG.a.1276-b31","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.4596","article-title":"Inter-subject stability and regional concentration estimates of 3D-FID-MRSI in the human brain at 7 T","volume":"34","author":"Hangel","year":"2021","journal-title":"NMR in Biomedicine"},{"issue":"3","key":"2026061715551955200_IMAG.a.1276-b32","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1177\/0269881108089818","article-title":"Review: The group II metabotropic glutamate receptor 3 (mGluR3, mGlu3, GRM3): Expression, function and involvement in schizophrenia","volume":"22","author":"Harrison","year":"2008","journal-title":"Journal of Psychopharmacology"},{"issue":"6","key":"2026061715551955200_IMAG.a.1276-b33","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/nbm.793","article-title":"Increased choline levels coincide with enhanced proliferative activity of human neuroepithelial brain tumors","volume":"15","author":"Herminghaus","year":"2002","journal-title":"NMR in Biomedicine"},{"issue":"6","key":"2026061715551955200_IMAG.a.1276-b34","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1002\/mrm.26987","article-title":"Density-weighted concentric circle trajectories for high resolution brain magnetic resonance spectroscopic imaging at 7T","volume":"79","author":"Hingerl","year":"2018","journal-title":"Magnetic Resonance in Medicine"},{"key":"2026061715551955200_IMAG.a.1276-b35","doi-asserted-by":"crossref","first-page":"111249","DOI":"10.1016\/j.pscychresns.2021.111249","article-title":"Thalamic, Amygdalar, and hippocampal nuclei morphology and their trajectories in first episode psychosis: A preliminary longitudinal study","volume":"309","author":"Hoang","year":"2021","journal-title":"Psychiatry Research: Neuroimaging"},{"issue":"9","key":"2026061715551955200_IMAG.a.1276-b36","doi-asserted-by":"crossref","first-page":"6407","DOI":"10.1002\/alz.14137","article-title":"Neurometabolic topography and associations with cognition in Alzheimer\u2019s disease: A whole-brain high-resolution 3D MRSI study","volume":"20","author":"Hu","year":"2024","journal-title":"Alzheimer\u2019s & Dementia"},{"issue":"1","key":"2026061715551955200_IMAG.a.1276-b37","doi-asserted-by":"crossref","first-page":"11204","DOI":"10.1038\/s41598-022-15489-9","article-title":"Resting-state functional connectivity of salience network in schizophrenia and depression","volume":"12","author":"Huang","year":"2022","journal-title":"Scientific Reports"},{"issue":"4","key":"2026061715551955200_IMAG.a.1276-b38","doi-asserted-by":"crossref","first-page":"e70176","DOI":"10.1002\/hbm.70176","article-title":"Rosette spectroscopic imaging for whole-brain slab metabolite mapping at 7T: Acceleration potential and reproducibility","volume":"46","author":"Huang","year":"2025","journal-title":"Human Brain Mapping"},{"key":"2026061715551955200_IMAG.a.1276-b39","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.pnpbp.2018.03.016","article-title":"Neurometabolite levels in antipsychotic-na\u00efve\/free patients with schizophrenia: A systematic review and meta-analysis of 1H-MRS studies","volume":"86","author":"Iwata","year":"2018","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"issue":"5","key":"2026061715551955200_IMAG.a.1276-b40","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1212\/WNL.57.5.930","article-title":"Decrease of N-acetylaspartate in the MTL correlates with cognitive decline of AD patients","volume":"57","author":"Jessen","year":"2001","journal-title":"Neurology"},{"issue":"8","key":"2026061715551955200_IMAG.a.1276-b41","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1038\/s41380-025-02924-2","article-title":"Multimodal evidence of mediodorsal thalamus-prefrontal circuit dysfunctions in clinical high-risk for psychosis: Findings from a combined 7T fMRI, MRSI and sleep Hd-EEG study","volume":"30","author":"Keihani","year":"2025","journal-title":"Molecular Psychiatry"},{"issue":"5","key":"2026061715551955200_IMAG.a.1276-b42","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/mp.2017.170","article-title":"Widespread white matter microstructural differences in schizophrenia across 4322 individuals: Results from the ENIGMA Schizophrenia DTI Working Group","volume":"23","author":"Kelly","year":"2018","journal-title":"Molecular Psychiatry"},{"issue":"6","key":"2026061715551955200_IMAG.a.1276-b43","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1212\/WNL.0000000000000105","article-title":"Myoinositol and glutamate complex neurometabolite abnormality after mild traumatic brain injury","volume":"82","author":"Kierans","year":"2014","journal-title":"Neurology"},{"issue":"5","key":"2026061715551955200_IMAG.a.1276-b44","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/hup.693","article-title":"A review of the possible relevance of inositol and the phosphatidylinositol second messenger system (PI-cycle) to psychiatric disorders\u2014Focus on magnetic resonance spectroscopy (MRS) studies","volume":"20","author":"Kim","year":"2005","journal-title":"Human Psychopharmacology: Clinical and Experimental"},{"issue":"1","key":"2026061715551955200_IMAG.a.1276-b45","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41537-018-0062-8","article-title":"Diagnosis and treatment of schizotypal personality disorder: Evidence from a systematic review","volume":"4","author":"Kirchner","year":"2018","journal-title":"Npj Schizophrenia"},{"issue":"2","key":"2026061715551955200_IMAG.a.1276-b46","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/s41380-021-01359-9","article-title":"Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study","volume":"27","author":"Kirschner","year":"2022","journal-title":"Molecular Psychiatry"},{"issue":"5","key":"2026061715551955200_IMAG.a.1276-b47","doi-asserted-by":"crossref","DOI":"10.1002\/mrm.27623","article-title":"Fast high-resolution brain metabolite mapping on a clinical 3T MRI by accelerated H-FID-MRSI and low-rank constrained reconstruction","volume":"81","author":"Klauser","year":"2019","journal-title":"Magnetic Resonance in Medicine"},{"issue":"1","key":"2026061715551955200_IMAG.a.1276-b48","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.4615","article-title":"Whole-brain high-resolution metabolite mapping with 3D compressed-sensing SENSE low-rank 1H FID-MRSI","volume":"35","author":"Klauser","year":"2022","journal-title":"NMR in Biomedicine"},{"key":"2026061715551955200_IMAG.a.1276-b49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1162\/imag_a_00313","article-title":"ECCENTRIC: A fast and unrestrained approach for high-resolution in vivo metabolic imaging at ultra-high field MR","volume":"2","author":"Klauser","year":"2024","journal-title":"Imaging Neuroscience"},{"issue":"2","key":"2026061715551955200_IMAG.a.1276-b50","first-page":"425","article-title":"White matter disruptions in schizophrenia are spatially widespread and topologically converge on brain network hubs","volume":"43","author":"Klauser","year":"2016","journal-title":"Schizophrenia Bulletin"},{"issue":"4","key":"2026061715551955200_IMAG.a.1276-b51","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1002\/mrm.26019","article-title":"High-resolution 1H-MRSI of the brain using SPICE: Data acquisition and image reconstruction","volume":"76","author":"Lam","year":"2016","journal-title":"Magnetic Resonance in Medicine"},{"issue":"5","key":"2026061715551955200_IMAG.a.1276-b52","doi-asserted-by":"crossref","first-page":"e4484","DOI":"10.1002\/nbm.4484","article-title":"Minimum Reporting Standards for in vivo Magnetic Resonance Spectroscopy (MRSinMRS): Experts\u2019 consensus recommendations","volume":"34","author":"Lin","year":"2021","journal-title":"NMR in Biomedicine"},{"issue":"1","key":"2026061715551955200_IMAG.a.1276-b53","doi-asserted-by":"crossref","first-page":"11344","DOI":"10.1038\/s41467-025-66124-w","article-title":"Constructing the human brain metabolic connectome with MR spectroscopic imaging reveals cerebral biochemical organization","volume":"16","author":"Lucchetti","year":"2025","journal-title":"Nature Communications"},{"issue":"2\u20133","key":"2026061715551955200_IMAG.a.1276-b54","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.schres.2005.11.020","article-title":"Decreased volume of left and total anterior insular lobule in schizophrenia","volume":"83","author":"Makris","year":"2006","journal-title":"Schizophrenia Research"},{"issue":"5","key":"2026061715551955200_IMAG.a.1276-b55","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.4309","article-title":"Advanced magnetic resonance spectroscopic neuroimaging: Experts\u2019 consensus recommendations","volume":"34","author":"Maudsley","year":"2021","journal-title":"NMR in Biomedicine"},{"issue":"3","key":"2026061715551955200_IMAG.a.1276-b56","doi-asserted-by":"crossref","DOI":"10.1002\/mrm.21875","article-title":"Mapping of brain metabolite distributions by volumetric proton MR spectroscopic imaging (MRSI)","volume":"61","author":"Maudsley","year":"2009","journal-title":"Magnetic Resonance in Medicine"},{"issue":"24","key":"2026061715551955200_IMAG.a.1276-b57","doi-asserted-by":"crossref","first-page":"15846","DOI":"10.3390\/ijms232415846","article-title":"Dorsolateral Prefrontal Cortex Glutamate\/Gamma-Aminobutyric Acid (GABA) alterations in clinical high risk and first-episode schizophrenia: A preliminary 7-T magnetic resonance spectroscopy imaging study","volume":"23","author":"Mayeli","year":"2022","journal-title":"International Journal of Molecular Sciences"},{"issue":"3","key":"2026061715551955200_IMAG.a.1276-b58","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.tins.2018.12.004","article-title":"Schizophrenia, dopamine and the striatum: From biology to symptoms","volume":"42","author":"McCutcheon","year":"2019","journal-title":"Trends in Neurosciences"},{"key":"2026061715551955200_IMAG.a.1276-b59","volume-title":"The psychosis-risk syndrome: Handbook for diagnosis and follow-up","author":"McGlashan","year":"2010"},{"issue":"7","key":"2026061715551955200_IMAG.a.1276-b60","doi-asserted-by":"crossref","first-page":"e4896","DOI":"10.1002\/nbm.4896","article-title":"MRS in neurodegenerative dementias, prodromal syndromes and at-risk states: A systematic review of the literature","volume":"36","author":"McKiernan","year":"2023","journal-title":"NMR in Biomedicine"},{"issue":"2","key":"2026061715551955200_IMAG.a.1276-b61","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2174\/1573405054038726","article-title":"Voxel-based morphometry of the human brain: methods and applications","volume":"1","author":"Mechelli","year":"2005","journal-title":"Current Medical Imaging Reviews"},{"issue":"1","key":"2026061715551955200_IMAG.a.1276-b62","doi-asserted-by":"crossref","DOI":"10.1038\/s41537-024-00451-7","article-title":"Reduction of N-acetyl aspartate (NAA) in association with relapse in early-stage psychosis: A 7-Tesla MRS study","volume":"10","author":"Mihaljevic","year":"2024","journal-title":"Schizophrenia"},{"issue":"4","key":"2026061715551955200_IMAG.a.1276-b63","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/oxfordjournals.schbul.a007040","article-title":"Prodromal assessment with the structured interview for prodromal syndromes and the scale of prodromal symptoms: Predictive validity, interrater reliability, and training to reliability","volume":"29","author":"Miller","year":"2003","journal-title":"Schizophrenia Bulletin"},{"issue":"5","key":"2026061715551955200_IMAG.a.1276-b64","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1176\/appi.ajp.159.5.863","article-title":"Prospective diagnosis of the initial prodrome for schizophrenia based on the structured interview for prodromal syndromes: Preliminary evidence of interrater reliability and predictive validity","volume":"159","author":"Miller","year":"2002","journal-title":"American Journal of Psychiatry"},{"issue":"3","key":"2026061715551955200_IMAG.a.1276-b65","doi-asserted-by":"crossref","first-page":"154","DOI":"10.4103\/0971-6203.62128","article-title":"Quantitation of normal metabolite concentrations in six brain regions by in-vivo 1H-MR spectroscopy","volume":"35","author":"Minati","year":"2010","journal-title":"Journal of Medical Physics"},{"issue":"6","key":"2026061715551955200_IMAG.a.1276-b66","doi-asserted-by":"crossref","DOI":"10.1002\/mrm.28076","article-title":"Intra-session and inter-subject variability of 3D-FID-MRSI using single-echo volumetric EPI navigators at 3T","volume":"83","author":"Moser","year":"2020","journal-title":"Magnetic Resonance in Medicine"},{"key":"2026061715551955200_IMAG.a.1276-b67","unstructured":"Nilearn contributors, Chamma, A., Frau-Pascual, A., Rothberg, A., Abadie, A., Abraham, A., Gramfort, A., Savio, A., Cionca, A., Sayal, A., Thual, A., Kodibagkar, A., Kanaan, A., Pinho, A. L., Joshi, A., Idrobo, A. H., Kieslinger, A.-S., Kumari, A., Rokem, A., \u2026 N\u00e1jera, \u00d3. (2025). Nilearn (Version TestRelease) [Computer software]. Zenodo. https:\/\/doi.org\/10.5281\/ZENODO.8397156"},{"issue":"1","key":"2026061715551955200_IMAG.a.1276-b68","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/schbul\/sbz039","article-title":"What causes the onset of psychosis in individuals at clinical high risk? A meta-analysis of risk and protective factors","volume":"46","author":"Oliver","year":"2020","journal-title":"Schizophrenia Bulletin"},{"key":"2026061715551955200_IMAG.a.1276-b69","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/978-0-8176-8379-5_19","article-title":"Simple harmonic oscillator based reconstruction and estimation for one-dimensional q-space magnetic resonance (1D-SHORE)","volume-title":"Excursions in harmonic analysis","author":"\u00d6zarslan","year":"2013"},{"issue":"10","key":"2026061715551955200_IMAG.a.1276-b70","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/j.euroneuro.2014.06.004","article-title":"N-acetyl-aspartate (NAA) as a correlate of pharmacological treatment in psychiatric disorders: A systematic review","volume":"24","author":"Paslakis","year":"2014","journal-title":"European Neuropsychopharmacology"},{"issue":"61","key":"2026061715551955200_IMAG.a.1276-b71","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.21105\/joss.03167","article-title":"Visualizations with statistical details: The \u201cggstatsplot\u201d approach","volume":"6","author":"Patil","year":"2021","journal-title":"Journal of Open Source Software"},{"issue":"8","key":"2026061715551955200_IMAG.a.1276-b72","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/eip.13235","article-title":"Randomized controlled trial of a mindfulness-based intervention in adolescents from the general population: The Mindfulteen neuroimaging study protocol","volume":"16","author":"Piguet","year":"2022","journal-title":"Early Intervention in Psychiatry"},{"key":"2026061715551955200_IMAG.a.1276-b73","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.schres.2019.06.011","article-title":"Using proton magnetic resonance spectroscopic imaging to study glutamatergic alterations in patients with schizophrenia: A systematic review","volume":"210","author":"Plitman","year":"2019","journal-title":"Schizophrenia Research"},{"issue":"2\u20133","key":"2026061715551955200_IMAG.a.1276-b74","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.schres.2013.12.013","article-title":"Glutamatergic abnormalities in schizophrenia: A review of proton MRS findings","volume":"152","author":"Poels","year":"2014","journal-title":"Schizophrenia Research"},{"issue":"4","key":"2026061715551955200_IMAG.a.1276-b75","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/nbm.698","article-title":"Automatic quantitation of localized in vivo1H spectra with LCModel","volume":"14","author":"Provencher","year":"2001","journal-title":"NMR in Biomedicine"},{"issue":"12","key":"2026061715551955200_IMAG.a.1276-b76","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1002\/nbm.3045","article-title":"Glutamate and glutamine: A review of in vivo MRS in the human brain","volume":"26","author":"Ramadan","year":"2013","journal-title":"NMR in Biomedicine"},{"key":"2026061715551955200_IMAG.a.1276-b77","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jpsychires.2020.03.006","article-title":"Magnetic resonance spectroscopy studies in subjects with high risk for psychosis: A meta-analysis and review","volume":"125","author":"Romeo","year":"2020","journal-title":"Journal of Psychiatric Research"},{"issue":"2","key":"2026061715551955200_IMAG.a.1276-b78","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.pnpbp.2006.09.013","article-title":"Glial cell activation in a subgroup of patients with schizophrenia indicated by increased S100B serum concentrations and elevated myo-inositol","volume":"31","author":"Rothermundt","year":"2007","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"issue":"8","key":"2026061715551955200_IMAG.a.1276-b79","doi-asserted-by":"crossref","first-page":"e1196","DOI":"10.1038\/tp.2017.172","article-title":"Meta-analysis supports GWAS-implicated link between GRM3 and schizophrenia risk","volume":"7","author":"Saini","year":"2017","journal-title":"Translational Psychiatry"},{"issue":"3","key":"2026061715551955200_IMAG.a.1276-b80","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1001\/jamapsychiatry.2019.3561","article-title":"Clinical validity of DSM-5 attenuated psychosis syndrome: Advances in diagnosis, prognosis, and treatment","volume":"77","author":"Salazar De Pablo","year":"2020","journal-title":"JAMA Psychiatry"},{"issue":"9","key":"2026061715551955200_IMAG.a.1276-b81","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1001\/jamapsychiatry.2021.0830","article-title":"Probability of transition to psychosis in individuals at clinical high risk: An updated meta-analysis","volume":"78","author":"Salazar De Pablo","year":"2021","journal-title":"JAMA Psychiatry"},{"issue":"5","key":"2026061715551955200_IMAG.a.1276-b82","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/mrm.1119","article-title":"Region and tissue differences of metabolites in normally aged brain using multislice 1H magnetic resonance spectroscopic imaging","volume":"45","author":"Schuff","year":"2001","journal-title":"Magnetic Resonance in Medicine"},{"issue":"7589","key":"2026061715551955200_IMAG.a.1276-b83","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature16549","article-title":"Schizophrenia risk from complex variation of complement component 4","volume":"530","author":"Sekar","year":"2016","journal-title":"Nature"},{"key":"2026061715551955200_IMAG.a.1276-b84","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.schres.2020.03.068","article-title":"Insula functional connectivity in schizophrenia","volume":"220","author":"Sheffield","year":"2020","journal-title":"Schizophrenia Research"},{"issue":"3","key":"2026061715551955200_IMAG.a.1276-b85","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/hbm.10062","article-title":"Fast robust automated brain extraction","volume":"17","author":"Smith","year":"2002","journal-title":"Human Brain Mapping"},{"issue":"1","key":"2026061715551955200_IMAG.a.1276-b86","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neuroimage.2008.03.061","article-title":"Threshold-free cluster enhancement: Addressing problems of smoothing, threshold dependence and localisation in cluster inference","volume":"44","author":"Smith","year":"2009","journal-title":"NeuroImage"},{"key":"2026061715551955200_IMAG.a.1276-b87","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.schres.2022.08.008","article-title":"A longitudinal investigation of GABA, glutamate, and glutamine across the insula during antipsychotic treatment of first-episode schizophrenia","volume":"248","author":"Sonnenschein","year":"2022","journal-title":"Schizophrenia Research"},{"issue":"8","key":"2026061715551955200_IMAG.a.1276-b88","doi-asserted-by":"crossref","first-page":"e877","DOI":"10.1038\/tp.2016.140","article-title":"Whole-brain patterns of 1H-magnetic resonance spectroscopy imaging in Alzheimer\u2019s disease and dementia with Lewy bodies","volume":"6","author":"Su","year":"2016","journal-title":"Translational Psychiatry"},{"key":"2026061715551955200_IMAG.a.1276-b89","doi-asserted-by":"crossref","first-page":"100921","DOI":"10.1016\/j.jbior.2022.100921","article-title":"Regulations of myo-inositol homeostasis: Mechanisms, implications, and perspectives","volume":"87","author":"Su","year":"2023","journal-title":"Advances in Biological Regulation"},{"issue":"1\u20133","key":"2026061715551955200_IMAG.a.1276-b90","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.schres.2008.01.022","article-title":"Schizophrenia, \u201cJust the Facts\u201d: What we know in 2008","volume":"100","author":"Tandon","year":"2008","journal-title":"Schizophrenia Research"},{"issue":"22","key":"2026061715551955200_IMAG.a.1276-b91","doi-asserted-by":"crossref","first-page":"7975","DOI":"10.1088\/0031-9155\/61\/22\/7975","article-title":"PETPVC: A toolbox for performing partial volume correction techniques in positron emission tomography","volume":"61","author":"Thomas","year":"2016","journal-title":"Physics in Medicine and Biology"},{"issue":"5","key":"2026061715551955200_IMAG.a.1276-b92","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1203\/00006450-198911000-00024","article-title":"myo-Inositol: A newly identified nonnitrogenous osmoregulatory molecule in mammalian brain","volume":"26","author":"Thurston","year":"1989","journal-title":"Pediatric Research"},{"issue":"5","key":"2026061715551955200_IMAG.a.1276-b93","doi-asserted-by":"crossref","first-page":"e4459","DOI":"10.1002\/nbm.4459","article-title":"Water and lipid suppression techniques for advanced 1H MRS and MRSI of the human brain: Experts\u2019 consensus recommendations","volume":"34","author":"Tk\u00e1\u010d","year":"2021","journal-title":"NMR in Biomedicine"},{"issue":"4","key":"2026061715551955200_IMAG.a.1276-b94","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00249-009-0517-y","article-title":"In vivo magnetic resonance spectroscopy: Basic methodology and clinical applications","volume":"39","author":"Van Der Graaf","year":"2010","journal-title":"European Biophysics Journal"},{"issue":"9","key":"2026061715551955200_IMAG.a.1276-b95","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.biopsych.2018.04.023","article-title":"Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium","volume":"84","author":"Van Erp","year":"2018","journal-title":"Biological Psychiatry"},{"issue":"19","key":"2026061715551955200_IMAG.a.1276-b96","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1212\/WNL.0000000000002672","article-title":"Myo-inositol changes precede amyloid pathology and relate to APOE genotype in Alzheimer disease","volume":"86","author":"Voevodskaya","year":"2016","journal-title":"Neurology"},{"key":"2026061715551955200_IMAG.a.1276-b97","doi-asserted-by":"crossref","first-page":"102220","DOI":"10.1016\/j.ajp.2020.102220","article-title":"Metabolite abnormalities in psychosis risk: A meta-analysis of proton magnetic resonance spectroscopy studies","volume":"54","author":"Wang","year":"2020","journal-title":"Asian Journal of Psychiatry"},{"issue":"4","key":"2026061715551955200_IMAG.a.1276-b98","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.3233\/JAD-170450","article-title":"Decreased N-acetyl aspartate\/myo-inositol ratio in the posterior cingulate cortex shown by magnetic resonance spectroscopy may be one of the risk markers of preclinical Alzheimer\u2019s disease: A 7-year follow-up study","volume":"60","author":"Waragai","year":"2017","journal-title":"Journal of Alzheimer\u2019s Disease"},{"key":"2026061715551955200_IMAG.a.1276-b99","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-24277-4","volume-title":"ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2016"},{"key":"2026061715551955200_IMAG.a.1276-b100","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.neuroimage.2014.01.060","article-title":"Permutation inference for the general linear model","volume":"92","author":"Winkler","year":"2014","journal-title":"NeuroImage"},{"issue":"9","key":"2026061715551955200_IMAG.a.1276-b101","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1001\/archpsyc.63.9.969","article-title":"Prediction of functional outcome 18 months after a first psychotic episode: A proton magnetic resonance spectroscopy study","volume":"63","author":"Wood","year":"2006","journal-title":"Archives of General Psychiatry"},{"issue":"5","key":"2026061715551955200_IMAG.a.1276-b102","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1093\/schbul\/sbt161","article-title":"Aberrant coupling within and across the default mode, task-positive, and salience network in subjects at risk for psychosis","volume":"40","author":"Wotruba","year":"2014","journal-title":"Schizophrenia Bulletin"},{"issue":"2\u20133","key":"2026061715551955200_IMAG.a.1276-b103","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.schres.2010.08.027","article-title":"The role of the insula in schizophrenia","volume":"123","author":"Wylie","year":"2010","journal-title":"Schizophrenia Research"},{"key":"2026061715551955200_IMAG.a.1276-b104","doi-asserted-by":"crossref","first-page":"103461","DOI":"10.1016\/j.nicl.2023.103461","article-title":"Meta-analytic evidence of elevated choline, reduced N-acetylaspartate, and normal creatine in schizophrenia and their moderation by measurement quality, echo time, and medication status","volume":"39","author":"Yang","year":"2023","journal-title":"NeuroImage: Clinical"},{"key":"2026061715551955200_IMAG.a.1276-b105","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/978-1-61737-992-5_9","article-title":"MR spectroscopy and spectroscopic imaging of the brain","volume-title":"Magnetic Resonance Neuroimaging","author":"Zhu","year":"2011"}],"container-title":["Imaging Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/direct.mit.edu\/imag\/article-pdf\/doi\/10.1162\/IMAG.a.1276\/2603824\/imag.a.1276.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/direct.mit.edu\/imag\/article-pdf\/doi\/10.1162\/IMAG.a.1276\/2603824\/imag.a.1276.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T19:55:41Z","timestamp":1781726141000},"score":1,"resource":{"primary":{"URL":"https:\/\/direct.mit.edu\/imag\/article\/doi\/10.1162\/IMAG.a.1276\/136970\/High-resolution-whole-brain-magnetic-resonance"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":105,"URL":"https:\/\/doi.org\/10.1162\/imag.a.1276","relation":{},"ISSN":["2837-6056"],"issn-type":[{"value":"2837-6056","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"IMAG.a.1276"}}