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One of the most influential models of human visual information processing posits two segregated streams and postulates that conscious object recognition relies exclusively on the ventral visual stream. However, recent evidence suggests that the dorsal stream is involved in encoding crucial attributes of visual object recognition, such as global shape. The specific role of the dorsal stream is controversial in this context. Through an individualized multimodal approach, we investigated the contribution of the dorsal pathway to object recognition. Combining MRI-based diffusion-weighted imaging tractography with cortico-cortical paired associative stimulation protocol (ccPAS), we causally manipulated V1-to-IPS dorsal stream connectivity by strengthening synaptic efficacy between targeted regions through Hebbian-like plasticity mechanisms. Thirty-two healthy participants underwent three tractography-guided ccPAS sessions targeting right V1-to-IPS connectivity with different interstimulus intervals (9 ms, 0 ms, 30 ms). Before and after each session, participants performed a two-alternative forced-choice task requiring discrimination of either global shape or local features. Results showed that the critical 9 ms V1-to-IPS ccPAS protocol improved global shape discrimination, as indexed by accuracy and d\u2032, relative to the 0 ms control condition, with no effect on reaction times or response bias. Although task specificity was not fully supported, exploratory analyses revealed no changes in local feature discrimination. These findings provide causal evidence that strengthening dorsal V1-to-IPS connectivity enhances global shape processing, supporting a direct contribution of the dorsal stream to object recognition and potentially guiding the development of targeted rehabilitative interventions after visual system damage.<\/jats:p>","DOI":"10.1162\/imag.a.1345","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T20:01:41Z","timestamp":1786046501000},"update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":1,"title":["Causal evidence for dorsal stream involvement in object shape recognition: A tractography-guided ccPAS Registered Report study"],"prefix":"10.1162","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3267-2229","authenticated-orcid":false,"given":"Elena","family":"Bertacco","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7082-314X","authenticated-orcid":false,"given":"Francesca","family":"Saviola","sequence":"additional","affiliation":[{"name":"Neuro-X Institute, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Geneva, Switzerland"},{"name":"Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Universit\u00e0 di Brescia, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7944-2081","authenticated-orcid":false,"given":"Edoardo","family":"Paolini","sequence":"additional","affiliation":[{"name":"Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6285-0989","authenticated-orcid":false,"given":"Francesca Benedetta","family":"Pizzini","sequence":"additional","affiliation":[{"name":"Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7856-3442","authenticated-orcid":false,"given":"Nicol\u00f2","family":"Cardobi","sequence":"additional","affiliation":[{"name":"Department of Diagnostics and Public Health, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9972-4348","authenticated-orcid":false,"given":"Agnese","family":"Tamanti","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8605-803X","authenticated-orcid":false,"given":"Silvia Francesca","family":"Storti","sequence":"additional","affiliation":[{"name":"Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0848-5164","authenticated-orcid":false,"given":"Debora","family":"Brignani","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences, Universit\u00e0 di Brescia, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5333-9046","authenticated-orcid":false,"given":"Silvia","family":"Savazzi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5078-6636","authenticated-orcid":false,"given":"Daniele","family":"Corbo","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Universit\u00e0 di Brescia, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4966-9341","authenticated-orcid":false,"given":"Chiara","family":"Mazzi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9193-3345","authenticated-orcid":false,"given":"Chiara","family":"Bagattini","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"281","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"2026090815555337500_IMAG.a.1345-b1","doi-asserted-by":"crossref","unstructured":"Amorosino, G., Peruzzo, D., Astolfi, P., Redaelli, D., Avesani, P., Arrigoni, F., & Olivetti, E. 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