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However, its mechanisms of action remain poorly understood. Using young AppNL-F\/MAPT double knock-in (dKI) mice, a model of early AD, we examined brain dynamics alterations before amyloid plaque onset. High-density EEG recordings and metrics from fields outside neuroscience were used to assess brain dynamics fluidity\u2014a measure of the brain\u2019s ability to transition between activity states. We revealed that dKI mice exhibit early, awake state-specific reductions in brain dynamics fluidity associated with cognitive deficits in complex memory tasks. Daily vGENUS sessions over 2 weeks restored brain dynamics fluidity and rescued memory deficits in dKI mice. Importantly, these effects built up during the stimulation protocol and persisted after stimulation ended, suggesting long-term modulation of brain function. Based on these results, we propose a \u201cbrain dynamics repair\u201d mechanism for vGENUS that goes beyond current amyloid-centric hypotheses. This dual insight\u2014that brain dynamics are both a target for repair and a potential diagnostic tool\u2014provides new perspectives on early Alzheimer\u2019s disease pathophysiology.<\/jats:p>","DOI":"10.1162\/imag.a.70","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T15:59:51Z","timestamp":1750867191000},"update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":1,"title":["40 Hz light stimulation restores early brain dynamics alterations and associative memory in Alzheimer\u2019s disease model mice"],"prefix":"10.1162","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4494-5244","authenticated-orcid":false,"given":"Matthieu","family":"Aguilera","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Strasbourg, CNRS, Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA), UMR 7364, Strasbourg, 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