{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T01:35:12Z","timestamp":1789263312180,"version":"build-2803163510"},"reference-count":45,"publisher":"MIT Press","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":260,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Dutch Science Foundation Open Technology","award":["18981"],"award-info":[{"award-number":["18981"]}]},{"DOI":"10.13039\/100000865","name":"Gates Foundation","doi-asserted-by":"publisher","award":["INV-04788"],"award-info":[{"award-number":["INV-04788"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre","award":["NIHR203318"],"award-info":[{"award-number":["NIHR203318"]}]}],"content-domain":{"domain":["direct.mit.edu"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Very-low-field MRI (&amp;lt;100 mT) holds promise for Point-of-Care brain imaging applications, including stroke and multiple sclerosis, with T1 mapping emerging as a key biomarker for brain development and pathology. However, current low-field T1 mapping protocols suffer from long acquisition times and limited multi-site repeatability. This study aimed to improve T1 mapping at 64 mT using a clinically feasible 10-minute protocol and assess repeatability and reproducibility across sites. We present an analysis of the repeatability and reproducibility of rapid T1 measurements in a commercially available phantom and in 60 volunteers, scanned with a portable 64 mT MRI systems at six sites. T1 mapping was performed using an undersampled 3D inversion-recovery turbo spin-echo sequence with a 10.8-minute scan time, and reconstructed with a locally low-rank approach. Our results in phantom demonstrated high reproducibility in T1 measurements (below 3% differences from the average), with non-significant differences between sites. Longitudinal measurements demonstrated high repeatability over time both in vivo and in phantom settings in one site, with minimal variability (average Coefficient of Variation of 0.6%). Average in vivo T1 values for white matter and cortex were 290 \u00b1 6 ms and 332 \u00b1 8 ms, respectively and the values demonstrated high reproducibility, with differences of less than 4% from the average across sites. Our results demonstrate the feasibility of multi-site in vivo T1 mapping at 64 mT, providing normative T1 values at this field strength and supporting its use as a quantitative biomarker in clinical applications.<\/jats:p>","DOI":"10.1162\/imag.a.916","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T20:01:39Z","timestamp":1758225699000},"update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":1,"title":["Repeatability and reproducibility of rapid T1 mapping of brain tissues at 64 mT: A multicentre study"],"prefix":"10.1162","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9283-5918","authenticated-orcid":false,"given":"Beatrice","family":"Lena","sequence":"first","affiliation":[{"name":"C.J. 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Gorter MRI Center, Leiden University Medical Center, Leiden, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Hollander","sequence":"additional","affiliation":[{"name":"CaliberMRI, Boulder, CO, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9833-9915","authenticated-orcid":false,"given":"Todor","family":"Karaulanov","sequence":"additional","affiliation":[{"name":"CaliberMRI, Boulder, CO, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0633-6328","authenticated-orcid":false,"given":"Sean C.L.","family":"Deoni","sequence":"additional","affiliation":[{"name":"MNCH D&T, Bill & Melinda Gates Foundation, Seattle, WA, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4299-1941","authenticated-orcid":false,"given":"Steven C.R.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9237-1236","authenticated-orcid":false,"given":"Pia C.","family":"Sundgren","sequence":"additional","affiliation":[{"name":"Institution of Clinical Sciences\/Radiology, Lund University, Lund, Sweden"},{"name":"Lund Bioimaging Centre, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4045-9732","authenticated-orcid":false,"given":"Andrew G.","family":"Webb","sequence":"additional","affiliation":[{"name":"C.J. 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