{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:53:39Z","timestamp":1792043619887,"version":"4.4.0"},"reference-count":136,"publisher":"MIT Press","license":[{"start":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T00:00:00Z","timestamp":1698969600000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["direct.mit.edu"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,11,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The thalamus is primarily known as a relay for sensory information; however, it also critically contributes to higher-order cortical processing and coordination. Thalamocortical hyperconnectivity is associated with hallucinatory phenomena that occur in various psychopathologies (e.g., psychosis, migraine aura) and altered states of consciousness (ASC; e.g., induced by psychedelic drugs). However, the exact functional contribution of thalamocortical hyperconnectivity in forming hallucinatory experiences is unclear. Flicker light stimulation (FLS) can be used as an experimental tool to induce transient visual hallucinatory phenomena in healthy participants. Here, we use FLS in combination with fMRI to test how FLS modulates thalamocortical connectivity between specific thalamic nuclei and visual areas. We show that FLS induces thalamocortical hyperconnectivity between lateral geniculate nucleus (LGN), early visual areas, and proximal upstream areas of the ventral visual stream (e.g., hV4, VO1). Further, an exploratory analysis indicates specific higher-order thalamic nuclei, such as anterior and mediodorsal nuclei, to be strongly affected by FLS. Here, the connectivity changes to upstream cortical visual areas directly reflect a frequency-dependent increase in experienced visual phenomena. Together, these findings contribute to the identification of specific thalamocortical interactions in the emergence of visual hallucinations.<\/jats:p>","DOI":"10.1162\/imag_a_00033","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T06:41:27Z","timestamp":1698993687000},"update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":9,"title":["Flicker light stimulation induces thalamocortical hyperconnectivity with LGN and higher-order thalamic nuclei"],"prefix":"10.1162","volume":"1","author":[{"given":"Ioanna A.","family":"Amaya","sequence":"first","affiliation":[{"name":"Neurocomputation and Neuroimaging Unit, Department of Education and Psychology, Freie Universit\u00e4t Berlin, Berlin, Germany"},{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Einstein Center for Neurosciences Berlin, Berlin, Germany"},{"name":"Berlin School of Mind and Brain, Humboldt-Universita\u0308t zu Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna E.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Neurocomputation and Neuroimaging Unit, Department of Education and Psychology, Freie Universit\u00e4t Berlin, Berlin, Germany"},{"name":"Max Planck School of Cognition, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie T.","family":"Bartossek","sequence":"additional","affiliation":[{"name":"Neurocomputation and Neuroimaging Unit, Department of Education and Psychology, Freie Universit\u00e4t Berlin, Berlin, Germany"},{"name":"Faculty of Psychology, TUD Dresden University of Technology, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Kemmerer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Vivantes Hospital Am Urban und Vivantes Hospital im Friedrichshain, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeniya","family":"Kirilina","sequence":"additional","affiliation":[{"name":"Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Till","family":"Nierhaus","sequence":"additional","affiliation":[{"name":"Neurocomputation and Neuroimaging Unit, Department of Education and Psychology, Freie Universit\u00e4t Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo T.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Neurocomputation and Neuroimaging Unit, Department of Education and Psychology, Freie Universit\u00e4t Berlin, Berlin, 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