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While laminar fMRI studies have extensively explored the evoked cortical response in multiple subsystems, the investigation of the laminar component of functional networks throughout the entire brain has been hindered due to constraints in high-resolution layer-fMRI imaging methodologies. Our study addresses this gap by introducing an innovative layer-specific 3D VAPER (integrated VASO and Perfusion contrast) technique in humans at 7 T, for achieving fMRI at high resolution (800 \u00b5m isotropic), high specificity (not biased toward unspecific vein signals as BOLD), high sensitivity (robust measurement at submillimeter resolution), high spatial accuracy (analysis in native fMRI space), near-whole-brain coverage (cerebellum not included), and eventually extending layer fMRI to more flexible connectivity-based experiment designs. To demonstrate its effectiveness, we collected 0.8-mm isotropic fMRI data during both resting-state and movie-watching scenarios, established a layer-specific functional connectivity analysis pipeline from individual to group levels, and explored the role of different cortical layers in maintaining functional networks. Our results revealed distinct layer-specific connectivity patterns within the default mode, somatomotor, and visual networks, as well as at the global hubness level. The cutting-edge technique and insights derived from our exploration into near-whole-brain layer-specific connectivity provide unparalleled understanding of the organization principles and underlying mechanisms governing communication between different brain regions.<\/jats:p>","DOI":"10.1162\/imag_a_00140","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T11:12:12Z","timestamp":1712315532000},"update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":13,"title":["Unlocking near-whole-brain, layer-specific functional connectivity with 3D VAPER fMRI"],"prefix":"10.1162","volume":"2","author":[{"given":"Yuhui","family":"Chai","sequence":"first","affiliation":[{"name":"Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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