{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T12:09:53Z","timestamp":1781784593628,"version":"3.54.5"},"reference-count":80,"publisher":"MIT Press","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":189,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["direct.mit.edu"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This work aims at exploiting the unique myelin specificity of the inhomogeneous magnetization transfer (ihMT) technique to characterize the recovery dynamics of active multiple sclerosis (MS) lesions. IhMT and three other myelin-sensitive techniques, conventional MT, T1-weighted, and diffusion tensor imaging, were applied in a 12-month longitudinal study performed on relapsing-remitting MS patients. An exponential recovery model was used to fit the variations over time of the metrics derived from each MR technique within new active lesions. A principal component analysis was performed on the model parameters obtained for all MR myelin-sensitive techniques across all active lesions of all patients to identify specific recovery profiles. The results show that the recovery profiles of myelin-sensitive MR metrics in active MS lesions vary according to the localization and size of lesions. The distance of lesions from the ventricles is positively associated with the recovery rates of ihMTR and T1w-MPRAGE: the further the lesion is from the ventricles, the higher the recovery rate of these metrics. Lesion size is positively associated with initial loss and negatively associated with final recovery of ihMTR and other MR metrics: small lesions have lower initial loss and greater final recovery of MR metrics than large lesions. Thanks to the specificity of the ihMT technique for myelin, these features can be interpreted in terms of remyelination. This study thus provides longitudinal in vivo support for the pathological observations of higher remyelination in small lesions compared with large ones and faster remyelination in lesions away from the ventricles. These results support the use of ihMT and other measures for quantifying remyelination rates in clinical studies of remyelination therapies.<\/jats:p>","DOI":"10.1162\/imag_a_00235","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T16:10:56Z","timestamp":1720455056000},"update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":6,"title":["Inhomogeneous magnetization transfer (ihMT) imaging reveals variable recovery profiles of active MS lesions according to size and localization"],"prefix":"10.1162","volume":"2","author":[{"given":"Lucas","family":"Soustelle","sequence":"first","affiliation":[{"name":"Aix Marseille Univ, CNRS, CRMBM, Marseille, France"},{"name":"APHM, H\u00f4pital Universitaire Timone, CEMEREM, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira","family":"Mchinda","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, CNRS, CRMBM, Marseille, France"},{"name":"APHM, H\u00f4pital Universitaire Timone, CEMEREM, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea","family":"Hertanu","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, CNRS, CRMBM, Marseille, France"},{"name":"APHM, H\u00f4pital Universitaire Timone, CEMEREM, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya","family":"Gherib","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, CNRS, CRMBM, Marseille, France"},{"name":"APHM, H\u00f4pital Universitaire Timone, CEMEREM, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauriane","family":"Pini","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, CNRS, CRMBM, Marseille, France"},{"name":"APHM, H\u00f4pital Universitaire Timone, CEMEREM, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Guye","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, CNRS, CRMBM, Marseille, France"},{"name":"APHM, H\u00f4pital Universitaire Timone, CEMEREM, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Ranjeva","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, CNRS, CRMBM, Marseille, France"},{"name":"APHM, H\u00f4pital Universitaire Timone, CEMEREM, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopal","family":"Varma","sequence":"additional","affiliation":[{"name":"Division of MR Research, Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Alsop","sequence":"additional","affiliation":[{"name":"Division of MR Research, Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Pelletier","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, CNRS, CRMBM, Marseille, France"},{"name":"APHM, H\u00f4pital Universitaire Timone, CEMEREM, Marseille, France"},{"name":"APHM, H\u00f4pital Universitaire Timone, Service de neurologie, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier M.","family":"Girard","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, CNRS, CRMBM, Marseille, France"},{"name":"APHM, H\u00f4pital Universitaire Timone, CEMEREM, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Duhamel","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, CNRS, CRMBM, Marseille, France"},{"name":"APHM, H\u00f4pital Universitaire Timone, CEMEREM, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"281","published-online":{"date-parts":[[2024,7,24]]},"reference":[{"key":"2025081117582153800_b1","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.neuroimage.2018.07.066","article-title":"Evaluation of the accuracy and precision of the diffusion parameter EStImation with Gibbs and NoisE removal pipeline","volume":"183","author":"Ades-Aron","year":"2018","journal-title":"NeuroImage"},{"key":"2025081117582153800_b2","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.neuroimage.2016.06.058","article-title":"Incorporating outlier detection and replacement into a non-parametric framework for movement and distortion correction of diffusion MR images","volume":"141","author":"Andersson","year":"2016","journal-title":"NeuroImage"},{"issue":"2","key":"2025081117582153800_b3","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/S1053-8119(03)00336-7","article-title":"How to correct susceptibility distortions in spin-echo echo-planar images: Application to diffusion tensor imaging","volume":"20","author":"Andersson","year":"2003","journal-title":"NeuroImage"},{"key":"2025081117582153800_b4","article-title":"Evaluation of open-access, automated brain extraction methods on multi-site multi-disorder data","author":"Avants","year":"2010","journal-title":"16th Annual Meeting for the Organization of Human Brain Mapping"},{"key":"2025081117582153800_b5","doi-asserted-by":"crossref","DOI":"10.54294\/uvnhin","article-title":"Advanced normalization tools: V1.0","author":"Avants","year":"2009","journal-title":"The Insight Journal"},{"issue":"3","key":"2025081117582153800_b6","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1016\/j.neuroimage.2010.09.025","article-title":"A reproducible evaluation of ANTs similarity metric performance in brain image registration","volume":"54","author":"Avants","year":"2011","journal-title":"NeuroImage"},{"issue":"4","key":"2025081117582153800_b7","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s12021-011-9109-y","article-title":"An open source multivariate framework for n-tissue segmentation with evaluation on public data","volume":"9","author":"Avants","year":"2011","journal-title":"Neuroinformatics"},{"issue":"9","key":"2025081117582153800_b8","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1002\/hbm.21344","article-title":"Evaluating and reducing the impact of white matter lesions on brain volume measurements","volume":"33","author":"Battaglini","year":"2012","journal-title":"Human Brain Mapping"},{"issue":"5","key":"2025081117582153800_b9","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1002\/ana.24620","article-title":"Dynamic imaging of individual remyelination profiles in multiple sclerosis: Imaging remyelination in multiple sclerosis","volume":"79","author":"Bodini","year":"2016","journal-title":"Annals of Neurology"},{"issue":"2","key":"2025081117582153800_b10","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/brain\/aww296","article-title":"An abnormal periventricular magnetization transfer ratio gradient occurs early in multiple sclerosis","volume":"140","author":"Brown","year":"2017","journal-title":"Brain"},{"key":"2025081117582153800_b11","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.neuroimage.2012.10.059","article-title":"Segmentation of magnetization transfer ratio lesions for longitudinal analysis of demyelination and remyelination in multiple sclerosis","volume":"66","author":"Brown","year":"2013","journal-title":"NeuroImage"},{"key":"2025081117582153800_b12","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.nicl.2014.06.009","article-title":"Imaging of repeated episodes of demyelination and remyelination in multiple sclerosis","volume":"6","author":"Brown","year":"2014","journal-title":"NeuroImage: Clinical"},{"issue":"2","key":"2025081117582153800_b13","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/ana.21302","article-title":"Magnetization transfer ratio evolution with demyelination and remyelination in multiple sclerosis lesions","volume":"63","author":"Chen","year":"2008","journal-title":"Annals of Neurology"},{"issue":"4","key":"2025081117582153800_b14","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1212\/01.WNL.0000046587.83503.1E","article-title":"MRI contrast uptake in new lesions in relapsing-remitting MS followed at weekly intervals","volume":"60","author":"Cotton","year":"2003","journal-title":"Neurology"},{"issue":"2","key":"2025081117582153800_b15","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/nimg.1998.0395","article-title":"Cortical surface-based analysis","volume":"9","author":"Dale","year":"1999","journal-title":"NeuroImage"},{"issue":"1","key":"2025081117582153800_b16","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0022-510X(00)00331-2","article-title":"In vivo evaluation of remyelination in rat brain by magnetization transfer imaging","volume":"178","author":"Deloire-Grassin","year":"2000","journal-title":"Journal of the Neurological Sciences"},{"issue":"4","key":"2025081117582153800_b17","doi-asserted-by":"crossref","first-page":"e0121945","DOI":"10.1371\/journal.pone.0121945","article-title":"cocor: A comprehensive solution for the statistical comparison of correlations","volume":"10","author":"Diedenhofen","year":"2015","journal-title":"PLOS ONE"},{"issue":"2","key":"2025081117582153800_b18","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1148\/radiology.182.2.1732968","article-title":"Experimental allergic encephalomyelitis and multiple sclerosis: Lesion characterization with magnetization transfer imaging","volume":"182","author":"Dousset","year":"1992","journal-title":"Radiology"},{"key":"2025081117582153800_b19","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.neuroimage.2019.05.061","article-title":"Validating the sensitivity of inhomogeneous magnetization transfer (ihMT) MRI to myelin with fluorescence microscopy","volume":"199","author":"Duhamel","year":"2019","journal-title":"NeuroImage"},{"issue":"12","key":"2025081117582153800_b20","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1093\/brain\/awh654","article-title":"Magnetization transfer histograms in clinically isolated syndromes suggestive of multiple sclerosis","volume":"128","author":"Fernando","year":"2005","journal-title":"Brain"},{"key":"2025081117582153800_b21","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1212\/WNL.56.3.304","article-title":"Diffusion tensor magnetic resonance imaging in multiple sclerosis","volume":"56","author":"Filippi","year":"2001","journal-title":"Neurology"},{"issue":"7","key":"2025081117582153800_b22","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1093\/brain\/awz144","article-title":"Assessment of lesions on magnetic resonance imaging in multiple sclerosis: Practical guidelines","volume":"142","author":"Filippi","year":"2019","journal-title":"Brain"},{"issue":"3","key":"2025081117582153800_b23","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S1474-4422(15)00393-2","article-title":"MRI criteria for the diagnosis of multiple sclerosis: MAGNIMS consensus guidelines","volume":"15","author":"Filippi","year":"2016","journal-title":"The Lancet Neurology"},{"key":"2025081117582153800_b24","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1212\/WNL.50.5.1289","article-title":"Magnetization transfer ratios in multiple sclerosis lesions enhancing after different doses of gadolinium","volume":"50","author":"Filippi","year":"1998","journal-title":"Neurology"},{"issue":"7","key":"2025081117582153800_b25","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0730-725X(99)00049-1","article-title":"Short-term evolution of individual enhancing MS lesions studied with magnetization transfer imaging","volume":"17","author":"Filippi","year":"1999","journal-title":"Magnetic Resonance Imaging"},{"issue":"2","key":"2025081117582153800_b26","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1177\/135245859700300205","article-title":"To what extent is oligodendrocyte progenitor migration a limiting factor in the remyelination of multiple sclerosis lesions","volume":"3","author":"Franklin","year":"1997","journal-title":"Multiple Sclerosis Journal"},{"issue":"11","key":"2025081117582153800_b27","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nrn2480","article-title":"Remyelination in the CNS: From biology to therapy","volume":"9","author":"Franklin","year":"2008","journal-title":"Nature Reviews Neuroscience"},{"issue":"11","key":"2025081117582153800_b28","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/nrneurol.2012.200","article-title":"Neuroprotection and repair in multiple sclerosis","volume":"8","author":"Franklin","year":"2012","journal-title":"Nature Reviews Neurology"},{"issue":"6","key":"2025081117582153800_b29","doi-asserted-by":"crossref","first-page":"e13136","DOI":"10.1111\/bpa.13136","article-title":"Postmortem quantitative MRI disentangles histological lesion types in multiple sclerosis","volume":"33","author":"Galbusera","year":"2022","journal-title":"Brain Pathology"},{"issue":"3","key":"2025081117582153800_b30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1001\/archneurol.2008.578","article-title":"Measuring demyelination and remyelination in acute multiple sclerosis lesion voxels","volume":"66","author":"Giacomini","year":"2009","journal-title":"Archives of Neurology"},{"key":"2025081117582153800_b31","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1212\/WNL.0b013e3181a8260a","article-title":"Remyelination capacity of the MS brain decreases with disease chronicity","volume":"72","author":"Goldschmidt","year":"2009","journal-title":"Neurology"},{"issue":"6","key":"2025081117582153800_b32","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1212\/WNL.51.6.1689","article-title":"A serial study of new MS lesions and the white matter from which they arise","volume":"51","author":"Goodkin","year":"1998","journal-title":"Neurology"},{"key":"2025081117582153800_b33","doi-asserted-by":"crossref","first-page":"116884","DOI":"10.1016\/j.neuroimage.2020.116884","article-title":"Multi-parametric quantitative in vivo spinal cord MRI with unified signal readout and image denoising","volume":"217","author":"Grussu","year":"2020","journal-title":"NeuroImage"},{"issue":"3","key":"2025081117582153800_b34","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1007\/s00330-018-5710-x","article-title":"Repeatability and reproducibility of FreeSurfer, FSL-SIENAX and SPM brain volumetric measurements and the effect of lesion filling in multiple sclerosis","volume":"29","author":"Guo","year":"2019","journal-title":"European Radiology"},{"issue":"5","key":"2025081117582153800_b35","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1002\/mrm.29140","article-title":"T 1D -weighted ihMT imaging\u2014 Part II. Investigating the long- and short-T1D components correlation with myelin content. Comparison with R1 and the macromolecular proton fraction","volume":"87","author":"Hertanu","year":"2022","journal-title":"Magnetic Resonance in Medicine"},{"issue":"1","key":"2025081117582153800_b36","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v070.i01","article-title":"missMDA: A package for handling missing values in multivariate data analysis","volume":"70","author":"Josse","year":"2016","journal-title":"Journal of Statistical Software"},{"issue":"5","key":"2025081117582153800_b37","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/ana.410340507","article-title":"Correlation between magnetic resonance imaging findings and lesion development in chronic, active multiple sclerosis","volume":"34","author":"Katz","year":"1993","journal-title":"Annals of Neurology"},{"issue":"5","key":"2025081117582153800_b38","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1002\/mrm.26054","article-title":"Gibbs-ringing artifact removal based on local subvoxel-shifts","volume":"76","author":"Kellner","year":"2016","journal-title":"Magnetic Resonance in Medicine"},{"issue":"7","key":"2025081117582153800_b39","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1111\/ene.13321","article-title":"Diffusion tensor imaging of normal-appearing white matter in patients with neuromyelitis optica spectrum disorder and multiple sclerosis","volume":"24","author":"Kim","year":"2017","journal-title":"European Journal of Neurology"},{"key":"2025081117582153800_b40","doi-asserted-by":"crossref","first-page":"103192","DOI":"10.1016\/j.nicl.2022.103192","article-title":"Exploring in vivo lesion myelination dynamics: Longitudinal myelin water imaging in early multiple sclerosis","volume":"36","author":"Kitzler","year":"2022","journal-title":"NeuroImage: Clinical"},{"issue":"4","key":"2025081117582153800_b41","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/ana.26194","article-title":"7T MRI differentiates remyelinated from demyelinated multiple sclerosis lesions","volume":"90","author":"Kolb","year":"2021","journal-title":"Annals of Neurology"},{"issue":"Pt 11","key":"2025081117582153800_b42","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1093\/brain\/awh641","article-title":"Cortical demyelination and diffuse white matter injury in multiple sclerosis","volume":"128","author":"Kutzelnigg","year":"2005","journal-title":"Brain: A Journal of Neurology"},{"issue":"5","key":"2025081117582153800_b43","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s004150050092","article-title":"Serial magnetisation transfer ratios in gadolinium-enhancing lesions in multiple sclerosis","volume":"244","author":"Lai","year":"1997","journal-title":"Journal of Neurology"},{"key":"2025081117582153800_b44","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1177\/135245859700300213","article-title":"Remyelination in multiple sclerosis","volume":"3","author":"Lassmann","year":"1997","journal-title":"Multiple Sclerosis"},{"issue":"8","key":"2025081117582153800_b45","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1007\/s00415-003-1115-z","article-title":"Evolution of focal and diffusemagnetisation transfer abnormalitiesin multiple sclerosis","volume":"250","author":"Laule","year":"2003","journal-title":"Journal of Neurology"},{"issue":"5","key":"2025081117582153800_b46","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1093\/brain\/awv065","article-title":"Magnetization transfer ratio measures in normal-appearing white matter show periventricular gradient abnormalities in multiple sclerosis","volume":"138","author":"Liu","year":"2015","journal-title":"Brain"},{"issue":"5","key":"2025081117582153800_b47","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1002\/mrm.26907","article-title":"Whole brain inhomogeneous magnetization transfer (ihMT) imaging: Sensitivity enhancement within a steady-state gradient echo sequence","volume":"79","author":"Mchinda","year":"2018","journal-title":"Magnetic Resonance in Medicine"},{"issue":"2","key":"2025081117582153800_b48","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.neuroimage.2006.04.181","article-title":"MRI time series modeling of MS lesion development","volume":"32","author":"Meier","year":"2006","journal-title":"NeuroImage"},{"issue":"3","key":"2025081117582153800_b49","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.nurt.2007.05.008","article-title":"Time-series modeling of multiple sclerosis disease activity: A promising window on disease progression and repair potential","volume":"4","author":"Meier","year":"2007","journal-title":"Neurotherapeutics"},{"issue":"5","key":"2025081117582153800_b50","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/ana.22521","article-title":"Multiple sclerosis normal-appearing white matter: Pathology-imaging correlations","volume":"70","author":"Moll","year":"2011","journal-title":"Annals of Neurology"},{"key":"2025081117582153800_b51","doi-asserted-by":"crossref","first-page":"117442","DOI":"10.1016\/j.neuroimage.2020.117442","article-title":"Characterization of the cortical myeloarchitecture with inhomogeneous magnetization transfer imaging (ihMT)","volume":"225","author":"Munsch","year":"2021","journal-title":"NeuroImage"},{"issue":"11","key":"2025081117582153800_b52","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1212\/WNL.0000000000007099","article-title":"Imaging outcome measures of neuroprotection and repair in MS: A consensus statement from NAIMS","volume":"92","author":"Oh","year":"2019","journal-title":"Neurology"},{"issue":"Pt 12","key":"2025081117582153800_b53","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1093\/brain\/awl217","article-title":"Remyelination is extensive in a subset of multiple sclerosis patients","volume":"129","author":"Patrikios","year":"2006","journal-title":"Brain: A Journal of Neurology"},{"key":"2025081117582153800_b54","doi-asserted-by":"crossref","first-page":"103012","DOI":"10.1016\/j.nicl.2022.103012","article-title":"Periventricular magnetisation transfer abnormalities in early multiple sclerosis","volume":"34","author":"Pirpamer","year":"2022","journal-title":"NeuroImage: Clinical"},{"issue":"14","key":"2025081117582153800_b55","doi-asserted-by":"crossref","first-page":"e1865","DOI":"10.1212\/WNL.0000000000011700","article-title":"Structural and clinical correlates of a periventricular gradient of neuroinflammation in multiple sclerosis","volume":"96","author":"Poirion","year":"2021","journal-title":"Neurology"},{"issue":"2","key":"2025081117582153800_b56","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/ana.410330203","article-title":"Multiple sclerosis: Remyelination of nascent lesions","volume":"33","author":"Prineas","year":"1993","journal-title":"Annals of Neurology"},{"key":"2025081117582153800_b57","unstructured":"R Core Team. (2022). R: A language and environment for statistical computing [Logiciel]. R Foundation for Statistical Computing. https:\/\/www.R-project.org\/"},{"issue":"5","key":"2025081117582153800_b58","doi-asserted-by":"crossref","first-page":"929","DOI":"10.3174\/ajnr.A6554","article-title":"Sensitivity of the inhomogeneous magnetization transfer imaging technique to spinal cord damage in multiple sclerosis","volume":"41","author":"Rasoanandrianina","year":"2020","journal-title":"American Journal of Neuroradiology"},{"issue":"5","key":"2025081117582153800_b59","first-page":"821","article-title":"Long-term changes of magnetization transfer\u2013derived measures from patients with relapsing-remitting and secondary progressive multiple sclerosis","volume":"20","author":"Rocca","year":"1999","journal-title":"American Journal of Neuroradiology"},{"key":"2025081117582153800_b60","first-page":"1939","article-title":"Evolution of multiple sclerosis lesions on serial contrast-enhanced T1-weighted and magnetization-transfer MR images","volume":"20","author":"Rovira","year":"1999","journal-title":"American Journal of Neuroradiology"},{"issue":"3","key":"2025081117582153800_b61","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/ana.20202","article-title":"Magnetization transfer ratio and myelin in postmortem multiple sclerosis brain","volume":"56","author":"Schmierer","year":"2004","journal-title":"Annals of Neurology"},{"issue":"3","key":"2025081117582153800_b62","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1212\/WNL.51.3.758","article-title":"Serial magnetization transfer imaging to characterize the early evolution of new MS lesions","volume":"51","author":"Silver","year":"1998","journal-title":"Neurology"},{"issue":"1","key":"2025081117582153800_b63","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.neuroimage.2005.01.028","article-title":"Demyelination increases radial diffusivity in corpus callosum of mouse brain","volume":"26","author":"Song","year":"2005","journal-title":"NeuroImage"},{"key":"2025081117582153800_b64","article-title":"A motion correction strategy for multi-contrast based 3D parametric imaging: Application to inhomogeneous magnetization transfer (ihMT) [Preprint]","author":"Soustelle","year":"2020","journal-title":"Biorxiv"},{"issue":"3","key":"2025081117582153800_b65","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1002\/mrm.29055","article-title":"A strategy to reduce the sensitivity of inhomogeneous magnetization transfer (ihMT) imaging to radiofrequency transmit field variations at 3 T","volume":"87","author":"Soustelle","year":"2022","journal-title":"Magnetic Resonance in Medicine"},{"issue":"2","key":"2025081117582153800_b66","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1037\/0033-2909.87.2.245","article-title":"Tests for comparing elements of a correlation matrix","volume":"87","author":"Steiger","year":"1980","journal-title":"Psychological Bulletin"},{"issue":"12","key":"2025081117582153800_b67","doi-asserted-by":"crossref","first-page":"e0144693","DOI":"10.1371\/journal.pone.0144693","article-title":"T1- thresholds in black holes increase clinical-radiological correlation in multiple sclerosis patients","volume":"10","author":"Thaler","year":"2015","journal-title":"PLOS ONE"},{"key":"2025081117582153800_b68","doi-asserted-by":"crossref","first-page":"116137","DOI":"10.1016\/j.neuroimage.2019.116137","article-title":"MRtrix3: A fast, flexible and open software framework for medical image processing and visualisation","volume":"202","author":"Tournier","year":"2019","journal-title":"NeuroImage"},{"issue":"6","key":"2025081117582153800_b69","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1109\/TMI.2010.2046908","article-title":"N4ITK: Improved N3 bias correction","volume":"29","author":"Tustison","year":"2010","journal-title":"IEEE Transactions on Medical Imaging"},{"issue":"4","key":"2025081117582153800_b70","doi-asserted-by":"crossref","first-page":"634","DOI":"10.3174\/ajnr.A5563","article-title":"Evaluation of the sensitivity of inhomogeneous magnetization transfer (ihMT) MRI for multiple sclerosis","volume":"39","author":"Van Obberghen","year":"2018","journal-title":"AJNR. American Journal of Neuroradiology"},{"key":"2025081117582153800_b71","first-page":"675","article-title":"Patterns of lesion development in multiple sclerosis: Longitudinal observations with T1-weighted spin-echo and magnetization transfer MR","volume":"19","author":"van Waesberghe","year":"1998","journal-title":"AJNR American Journal of Neuroradiology"},{"key":"2025081117582153800_b72","doi-asserted-by":"crossref","first-page":"103009","DOI":"10.1016\/j.nicl.2022.103009","article-title":"Periventricular gradient of T1 tissue alterations in multiple sclerosis","volume":"34","author":"Vaneckova","year":"2022","journal-title":"NeuroImage: Clinical"},{"issue":"2","key":"2025081117582153800_b73","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1002\/mrm.25174","article-title":"Magnetization transfer from inhomogeneously broadened lines: A potential marker for myelin","volume":"73","author":"Varma","year":"2015","journal-title":"Magnetic Resonance in Medicine"},{"key":"2025081117582153800_b74","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jmr.2015.08.024","article-title":"Interpretation of magnetization transfer from inhomogeneously broadened lines (ihMT) in tissues as a dipolar order effect within motion restricted molecules","volume":"260","author":"Varma","year":"2015","journal-title":"Journal of Magnetic Resonance"},{"issue":"5","key":"2025081117582153800_b75","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1002\/mrm.26059","article-title":"Diffusion MRI noise mapping using random matrix theory","volume":"76","author":"Veraart","year":"2016","journal-title":"Magnetic Resonance in Medicine"},{"key":"2025081117582153800_b76","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.neuroimage.2016.08.016","article-title":"Denoising of diffusion MRI using random matrix theory","volume":"142","author":"Veraart","year":"2016","journal-title":"NeuroImage"},{"issue":"3","key":"2025081117582153800_b77","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1097\/WCO.0000000000000698","article-title":"Imaging the multiple sclerosis lesion: Insights into pathogenesis, progression and repair","volume":"32","author":"Wang","year":"2019","journal-title":"Current Opinion in Neurology"},{"issue":"2","key":"2025081117582153800_b78","doi-asserted-by":"crossref","first-page":"fcac088","DOI":"10.1093\/braincomms\/fcac088","article-title":"Quantitative magnetization transfer imaging in relapsing-remitting multiple sclerosis: A systematic review and meta-analysis","volume":"4","author":"York","year":"2022","journal-title":"Brain Communications"},{"issue":"3","key":"2025081117582153800_b79","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.neuroimage.2006.01.015","article-title":"User-guided 3D active contour segmentation of anatomical structures: Significantly improved efficiency and reliability","volume":"31","author":"Yushkevich","year":"2006","journal-title":"NeuroImage"},{"key":"2025081117582153800_b80","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.mri.2020.03.010","article-title":"A comparison study of inhomogeneous magnetization transfer (ihMT) and magnetization transfer (MT) in multiple sclerosis based on whole brain acquisition at 3.0 T","volume":"70","author":"Zhang","year":"2020","journal-title":"Magnetic Resonance Imaging"}],"container-title":["Imaging Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/direct.mit.edu\/imag\/article-pdf\/doi\/10.1162\/imag_a_00235\/2462675\/imag_a_00235.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/direct.mit.edu\/imag\/article-pdf\/doi\/10.1162\/imag_a_00235\/2462675\/imag_a_00235.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T21:58:33Z","timestamp":1754949513000},"score":1,"resource":{"primary":{"URL":"https:\/\/direct.mit.edu\/imag\/article\/doi\/10.1162\/imag_a_00235\/123371\/Inhomogeneous-magnetization-transfer-ihMT-imaging"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":80,"URL":"https:\/\/doi.org\/10.1162\/imag_a_00235","relation":{},"ISSN":["2837-6056"],"issn-type":[{"value":"2837-6056","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024]]},"published":{"date-parts":[[2024]]},"article-number":"imag-2-00235"}}