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Advancements in perfusion-weighted imaging (PWI) with an algorithm designed for diseases with anticipated contrast agent extravasation offer insight into microvascular impairment and flow heterogeneity. Our study aimed to assess these factors in MS patients and their association with clinically relevant white matter injury and disease course. We evaluated 60 adults with white matter lesions (WML), including 50 diagnosed with MS or MS syndromes and 10 non-diseased symptomatic controls (SC) with unspecific WML. MRI included conventional three-dimensional (3D) T2-weighted fluid-attenuated inversion recovery (T2-FLAIR), 3D magnetization-prepared two rapid acquisition gradient-echo (MP2RAGE), post-contrast 3D T1-weighted (T1) images, and Dynamic Susceptibility Contrast (DSC) PWI at 3T. WML masks of \u201cunspecific T2-FLAIR lesions\u201d, \u201cMS T2-FLAIR lesions\u201d, and \u201cMS T1-lesions\u201d were manually outlined and validated by a neuroradiologist. DSC-derived parameters were analyzed in WML masks and healthy-appearing tissue. MS T2-FLAIR lesions showed increased flow heterogeneity and vasodilation compared to unspecific T2-FLAIR lesions in SC, as well as compared to unspecific T2-FLAIR lesions within the MS group. MS T1-lesions exhibited more homogenized flow. Our findings suggest that DSC-PWI, combined with lesion delineation, can provide clinically relevant differentiation of MS lesions from unspecific WML, highlighting potential microvascular pathology previously overlooked in MS.<\/jats:p>","DOI":"10.1162\/imag_a_00357","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T16:00:49Z","timestamp":1729526449000},"update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":4,"title":["Differentiation of MS lesions through analysis of microvascular distribution"],"prefix":"10.1162","volume":"2","author":[{"given":"Linda","family":"Sundvall","sequence":"first","affiliation":[{"name":"Department of Neurology, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene Kl\u00e6rke","family":"Mikkelsen","sequence":"additional","affiliation":[{"name":"Center of Functionally Integrative 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