{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:41:23Z","timestamp":1787647283744,"version":"build-2736575974"},"reference-count":47,"publisher":"MIT Press","license":[{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"vor","delay-in-days":337,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["direct.mit.edu"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Multiple neuroimaging datasets from Huntington\u2019s disease (HD) studies are publicly available, but these datasets are in various formats, omit imaging metadata, and sometimes contain corrupt scans. We have created a platform to curate, harmonize, and distribute neuroimaging datasets from eight different studies: TRACK-HD, TRACKOn-HD, PREDICT-HD, IMAGE-HD, HD-YAS, SHIELD-HD, PEARL-HD, and LONGPDE10. The platform is organized into three conceptual levels to serve the research community with both raw and processed data. Raw data are converted into Brain Imaging Data Structure (BIDS) format, while processed data are obtained from pipelines such as Freesurfer and fmriprep. Studies that had followed the same participants were combined. After combining studies, the final six BIDS datasets include a total of 2,216 participants and 7,073 sessions. We outline tools, principles, and recommendations for future data management in HD research.<\/jats:p>","DOI":"10.1162\/imag_a_00395","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T16:06:01Z","timestamp":1733241961000},"update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":2,"title":["Bridging Huntington\u2019s disease research with big data science: Harmonized neuroimaging datasets from multiple studies"],"prefix":"10.1162","volume":"2","author":[{"given":"Dorian","family":"Pustina","sequence":"first","affiliation":[{"name":"CHDI Management, Inc. (the company that manages the scientific activities of CHDI Foundation, Inc.), Princeton, NJ, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandhitsu","family":"Das","sequence":"additional","affiliation":[{"name":"Paid Consultant, Rancho BioSciences, Rancho Santa Fe, CA, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Rozelle","sequence":"additional","affiliation":[{"name":"Rancho BioSciences, Rancho Santa Fe, CA, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans J.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Iowa, Iowa City, IA, United States"},{"name":"Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IA, United States"},{"name":"Department of Psychiatry, University of Iowa, Iowa City, IA, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael I.","family":"Scahill","sequence":"additional","affiliation":[{"name":"HD Research Centre, University College London Queen Square Institute of Neurology, UCL, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Tabrizi","sequence":"additional","affiliation":[{"name":"HD Research Centre, University College London Queen Square Institute of Neurology, UCL, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nellie","family":"Georgiou-Karistianis","sequence":"additional","affiliation":[{"name":"School of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Sampaio","sequence":"additional","affiliation":[{"name":"CHDI Management, Inc. (the company that manages the scientific activities of CHDI Foundation, Inc.), Princeton, NJ, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Wood","sequence":"additional","affiliation":[{"name":"CHDI Management, Inc. 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