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Recent studies have shown that CSF effective motility can be interrogated using low b-value diffusion magnetic resonance imaging (low-b dMRI). Nevertheless, the spatial organization of intracranial CSF flow dynamics remains largely elusive. Here, we developed a whole-brain voxel-based analysis framework, termed CSF pseudo-diffusion spatial statistics (C\u03a8SS), to examine CSF mean pseudo-diffusivity (M\u03a8), a measure of CSF flow magnitude derived from low-b dMRI. We showed that intracranial CSF M\u03a8 demonstrates characteristic covariance patterns by employing seed-based correlation analysis. Next, we applied non-negative matrix factorization analysis to further elucidate the covariance patterns of CSF M\u03a8 in a hypothesis-free, data-driven way. We identified 10 distinct CSF compartments with high reproducibility and reliability, reflected by a high mean adjusted Rand index with a low standard deviation (0.82 [SD: 0.018]) in split-half analyses of the discovery multimodal aging dataset (n = 187). The identified patterns displayed similar M\u03a8 across three replication datasets. In discovery and replication multimodal aging cohorts (unique n = 264), our study revealed that age, sex, brain atrophy, ventricular anatomy, and cerebral perfusion differentially influence M\u03a8 across these CSF spaces. Notably, of the 35 individuals exhibiting anomalous CSF flow patterns, five displayed clinically consequential incidental findings on multimodal neuroradiological examinations, which were not observed in other participants (p = 3.04 \u00d7 10-5). Our work sets forth a new paradigm to study CSF flow, with potential applications in clinical settings.<\/jats:p>","DOI":"10.1162\/imag_a_00473","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T15:01:27Z","timestamp":1738249287000},"update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":6,"title":["Characterizing the spatial patterns and determinants of cerebrospinal fluid pseudorandom flow in the human brain with low b-value diffusion MRI"],"prefix":"10.1162","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6983-0641","authenticated-orcid":false,"given":"Arash","family":"Nazeri","sequence":"first","affiliation":[{"name":"Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, United 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