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To date, almost all of the work linking transcriptomics to human brain function and structure has been restricted to the cerebral cortex. The culmination of this work has identified transcriptomics as an important shared principle that can tie together function, structure, and gene expression. However, largely missing from this work is the subcortex\u2014namely the cerebellum. Here, we investigate whether transcriptomics offer a link between function and structure in the human cerebellum, using gene expression data from post-mortem cerebella and multi-modal brain atlases. We find that transcriptomic gradients from a sparse subset of genes align with a macroanatomical, rather than a functional - parcellation of the cerebellum, and the transition of the main gradient occurs at the horizontal fissure for the group, as well as individual cerebella. Conversely, when filtering for cortex-specific genes, there is an alignment with continuous functional gradients of the cerebellum, but not discrete parcellated areas.<\/jats:p>","DOI":"10.1162\/imag_a_00494","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T13:31:52Z","timestamp":1739885512000},"update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":5,"title":["Transcriptomic gradients of the human cerebellum"],"prefix":"10.1162","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6338-3614","authenticated-orcid":false,"given":"Leana","family":"King","sequence":"first","affiliation":[{"name":"Department of Neuroscience, University of California, Berkeley, CA, United States"},{"name":"Helen Wills Neuroscience Institute, University of California, Berkeley, CA, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maedbh","family":"King","sequence":"additional","affiliation":[{"name":"McGovern Institute, Massachusetts Institute of Technology, Cambridge, MA, United States"},{"name":"Department of Psychology, University of California, Berkeley, CA, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zonglei","family":"Zhen","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Applied Experimental Psychology, Beijing Normal University, Beijing, China"},{"name":"Faculty of Psychology, Beijing Normal University, Department of Neuroscience, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Ivry","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of California, Berkeley, CA, United States"},{"name":"Helen Wills Neuroscience Institute, University of California, Berkeley, CA, United States"},{"name":"Department of Psychology, University of California, Berkeley, CA, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin S.","family":"Weiner","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of California, Berkeley, CA, United States"},{"name":"Helen Wills Neuroscience Institute, University of California, Berkeley, CA, United States"},{"name":"Department of Psychology, University of California, Berkeley, CA, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"281","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"issue":"8","key":"2025022619560412200_imag_a_00494-b1","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/s41593-021-00872-y","article-title":"Spatial and cell type transcriptional landscape of human cerebellar development","volume":"24","author":"Aldinger","year":"2021","journal-title":"Nature Neuroscience"},{"issue":"1","key":"2025022619560412200_imag_a_00494-b2","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/cne.902310105","article-title":"Embryonic development of the rat cerebellum. 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