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These include sustained attention, with deficits associated with various neuropsychological disorders. Neural models of attention deficits have focused on interrupted dynamics between the salience network (SAL) with the frontoparietal network, which has been associated with task-switching and processing of external stimuli, respectively. Conflicting findings for these regions suggest the possibility of upstream signaling leading to attention dysfunction, and recent research suggests LC involvement. In this study, resting-state functional connectivity and behavioral performance on an attention task was examined within 584 individuals. Analysis revealed significant clusters connected to LC activity in the SAL. Given previous findings that attention deficits may be caused by SAL network switching dysfunctions, findings here further suggest that dysfunction in LC\u2013SAL connectivity may impair attention.<\/jats:p>","DOI":"10.1162\/jocn_a_02036","type":"journal-article","created":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T10:06:30Z","timestamp":1692180390000},"page":"1557-1569","update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":16,"title":["Association of Intrinsic Functional Connectivity between the Locus Coeruleus and Salience Network with Attentional Ability"],"prefix":"10.1162","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0376-3057","authenticated-orcid":true,"given":"Joshua","family":"Neal","sequence":"first","affiliation":[{"name":"Virginia Tech, Blacksburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inuk","family":"Song","sequence":"additional","affiliation":[{"name":"Virginia Tech, Blacksburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Katz","sequence":"additional","affiliation":[{"name":"Virginia Tech, Blacksburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6458-0620","authenticated-orcid":true,"given":"Tae-Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Virginia Tech, Blacksburg"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"281","published-online":{"date-parts":[[2023,10,1]]},"reference":[{"key":"2023090619080098300_bib1","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1152\/jn.1989.61.5.900","article-title":"Dynamics of neuronal firing correlation: Modulation of \u201ceffective connectivity\u201d","volume":"61","author":"Aertsen","year":"1989","journal-title":"Journal of Neurophysiology"},{"key":"2023090619080098300_bib2","doi-asserted-by":"publisher","first-page":"2471","DOI":"10.1111\/ejn.13717","article-title":"Effects of spatial smoothing on functional brain networks","volume":"46","author":"Alak\u00f6rkk\u00f6","year":"2017","journal-title":"European Journal of Neuroscience"},{"key":"2023090619080098300_bib3","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1146\/annurev.neuro.28.061604.135709","article-title":"An integrative theory of locus coeruleus-norepinephrine function: Adaptive gain and optimal performance","volume":"28","author":"Aston-Jones","year":"2005","journal-title":"Annual Review of Neuroscience"},{"key":"2023090619080098300_bib4","doi-asserted-by":"publisher","first-page":"44","DOI":"10.3389\/fninf.2014.00044","article-title":"The insight ToolKit image registration framework","volume":"8","author":"Avants","year":"2014","journal-title":"Frontiers in Neuroinformatics"},{"key":"2023090619080098300_bib5","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.jneumeth.2013.10.018","article-title":"The MVGC multivariate Granger causality toolbox: A new approach to Granger-causal inference","volume":"223","author":"Barnett","year":"2014","journal-title":"Journal of Neuroscience Methods"},{"key":"2023090619080098300_bib6","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: A practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"Journal of the Royal Statistical Society: Series B (Methodological)"},{"key":"2023090619080098300_bib7","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1016\/j.biopsych.2004.10.020","article-title":"Attention-deficit\/hyperactivity disorder: A selective overview","volume":"57","author":"Biederman","year":"2005","journal-title":"Biological Psychiatry"},{"key":"2023090619080098300_bib8","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1002\/mrm.1910340409","article-title":"Functional connectivity in the motor cortex of resting human brain using echo-planar MRI","volume":"34","author":"Biswal","year":"1995","journal-title":"Magnetic Resonance in Medicine"},{"key":"2023090619080098300_bib9","doi-asserted-by":"publisher","first-page":"4690","DOI":"10.1073\/pnas.1113455109","article-title":"Salience network integrity predicts default mode network function after traumatic brain injury","volume":"109","author":"Bonnelle","year":"2012","journal-title":"Proceedings of the National Academy of Sciences, U.S.A."},{"key":"2023090619080098300_bib10","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1016\/j.neuroimage.2007.01.010","article-title":"Unrest at rest: Default activity and spontaneous network correlations","volume":"37","author":"Buckner","year":"2007","journal-title":"Neuroimage"},{"key":"2023090619080098300_bib11","doi-asserted-by":"publisher","first-page":"S234","DOI":"10.1016\/j.biopsych.2019.03.593","article-title":"F56. 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