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These sequences can be divided into two important categories: those that are abstract, in which the steps unfold according to a rule at super-second to minute time scale, and those that are motor, defined solely by individual movements and their order that unfold at the subsecond to second timescale. For example, the sequence of making spaghetti consists of abstract tasks (preparing the sauce and cooking the noodles) and nested motor actions (stir pasta water). Previous work shows neural activity increases (ramps) in the rostrolateral prefrontal cortex (RLPFC) during abstract sequence execution. During motor sequence production, activity occurs in regions of PFC. However, it remains unknown if ramping is a signature of motor sequence production as well or solely an attribute of abstract sequence monitoring and execution. We tested the hypothesis that significant ramping activity occurs during motor sequence production in the RLPFC. Contrary to our hypothesis, we did not observe significant ramping activity in the RLPFC during motor sequence production, but we found significant ramping activity in bilateral inferior parietal cortex, in regions distinct from those observed during an abstract sequence task. Our results suggest different prefrontal\u2013parietal circuitry may underlie abstract versus motor sequence execution.<\/jats:p>","DOI":"10.1162\/jocn_a_02349","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T13:36:46Z","timestamp":1747057006000},"page":"1929-1941","update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":2,"title":["Motor and Cognitive Sequence Tasks Exhibit Different Ramping Patterns in Parietal and Prefrontal Cortices"],"prefix":"10.1162","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6301-2883","authenticated-orcid":true,"given":"Hannah","family":"Doyle","sequence":"first","affiliation":[{"name":"Brown University, Providence, RI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhys","family":"Yewbrey","sequence":"additional","affiliation":[{"name":"University of Birmingham, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1562-7880","authenticated-orcid":true,"given":"Katja","family":"Kornysheva","sequence":"additional","affiliation":[{"name":"University of Birmingham, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7223-0556","authenticated-orcid":true,"given":"Theresa M.","family":"Desrochers","sequence":"additional","affiliation":[{"name":"Brown University, Providence, RI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"281","published-online":{"date-parts":[[2025,11,1]]},"reference":[{"key":"2025100913072809600_bib1","doi-asserted-by":"publisher","first-page":"e69517","DOI":"10.7554\/eLife.69517","article-title":"Motor planning brings human primary somatosensory cortex into action-specific preparatory states","volume":"11","author":"Ariani","year":"2022","journal-title":"eLife"},{"key":"2025100913072809600_bib2","doi-asserted-by":"publisher","first-page":"13172","DOI":"10.1073\/pnas.162485599","article-title":"Parallel processing of serial movements in prefrontal cortex","volume":"99","author":"Averbeck","year":"2002","journal-title":"Proceedings of the National Academy of Sciences, U.S.A."},{"key":"2025100913072809600_bib3","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.1162\/jocn.2007.19.12.2082","article-title":"Functional magnetic resonance imaging evidence for a hierarchical organization of the prefrontal cortex","volume":"19","author":"Badre","year":"2007","journal-title":"Journal of Cognitive Neuroscience"},{"key":"2025100913072809600_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/0471725153","volume-title":"Regression diagnostics: Identifying influential data and sources of collinearity","author":"Belsley","year":"1980","edition":"1st ed."},{"key":"2025100913072809600_bib5","doi-asserted-by":"publisher","first-page":"7649","DOI":"10.1523\/JNEUROSCI.0863-21.2021","article-title":"Combining repetition suppression and pattern analysis provides new insights into the role of M1 and parietal areas in skilled sequential actions","volume":"41","author":"Berlot","year":"2021","journal-title":"Journal of Neuroscience"},{"key":"2025100913072809600_bib6","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1162\/0898929054985400","article-title":"Who comes first? 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