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Animal models provide a helpful approach to this research, since they allow for controlled follow-up during the disease evolution. In this work, transgenic TgF344-AD rats were longitudinally evaluated starting at 6 months of age. Every 3 months, cognitive abilities were assessed by a memory-related task and magnetic resonance imaging (MRI) was acquired. Structural and functional brain networks were estimated and characterized by graph metrics to identify differences between the groups in connectivity, its evolution with age, and its influence on cognition. Structural networks of transgenic animals were altered since the earliest stage. Likewise, aging significantly affected network metrics in TgF344-AD, but not in the control group. In addition, while the structural brain network influenced cognitive outcome in transgenic animals, functional network impacted how control subjects performed. TgF344-AD brain network alterations were present from very early stages, difficult to identify in clinical research. Likewise, the characterization of aging in these animals, involving structural network reorganization and its effects on cognition, opens a window to evaluate new treatments for the disease.<\/jats:p>","DOI":"10.1162\/netn_a_00126","type":"journal-article","created":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T17:34:58Z","timestamp":1579109698000},"page":"397-415","update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":19,"title":["Brain connectivity during Alzheimer\u2019s disease progression and its\n          cognitive impact in a transgenic rat model"],"prefix":"10.1162","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2104-7265","authenticated-orcid":false,"given":"Emma","family":"Mu\u00f1oz-Moreno","sequence":"first","affiliation":[{"name":"Experimental 7T MRI Unit, Institut d\u2019Investigacions Bimediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain"},{"name":"Magnetic Resonance Image Core Facility, Institut d\u2019Investigacions Biomdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra\u00fal","family":"Tudela","sequence":"additional","affiliation":[{"name":"Experimental 7T MRI Unit, Institut d\u2019Investigacions Bimediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain"},{"name":"Experimental 7T MRI Unit, Institut d\u2019Investigacions Bimediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"L\u00f3pez-Gil","sequence":"additional","affiliation":[{"name":"Experimental 7T MRI Unit, Institut d\u2019Investigacions Bimediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guadalupe","family":"Soria","sequence":"additional","affiliation":[{"name":"Experimental 7T MRI Unit, Institut d\u2019Investigacions Bimediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain"},{"name":"Consorcio Centro de Investigacin Biomdica en Red (CIBER) de Bioingeniera, Biomateriales y Nanomedicina (CIBER-BBN), Group of Biomedical Imaging, University of Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"281","published-online":{"date-parts":[[2020,4,1]]},"reference":[{"key":"2021101915394925000_bib1","doi-asserted-by":"crossref","unstructured":"Anckaerts,\n              C., Blockx,\n                I., Summer,\n                P.,\n              Michael, J.,\n                Hamaide,\n            J., Kreutzer,\n                C., \u2026 Van der\n                Linden, A.\n            (2019). 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The\n            clinical use of structural MRI in Alzheimer disease. Nature\n            Reviews Neurology, 6(2),\n            67\u201377.","DOI":"10.1038\/nrneurol.2009.215"},{"key":"2021101915394925000_bib20","doi-asserted-by":"crossref","unstructured":"Galeano,\n              P., Martino\n                Adami, P. V.,\n                Do Carmo,\n              S., Blanco,\n                E.,\n                Rotondaro,\n              C., Capani,\n                F., \u2026\n                Morelli,\n            L. (2014).\n            Longitudinal analysis of the behavioral phenotype in a novel transgenic\n            rat model of early stages of Alzheimer\u2019s disease.\n            Frontiers in Behavioral Neuroscience, 8,\n            321.","DOI":"10.3389\/fnbeh.2014.00321"},{"key":"2021101915394925000_bib21","doi-asserted-by":"crossref","unstructured":"Garyfallidis,\n              E., Brett,\n                M.,\n                Amirbekian,\n              B., Rokem,\n                A., van der\n                Walt, S.,\n                Descoteaux,\n              M., &\n                Nimmo-Smith,\n              I. (2014).\n            Dipy, a library for the analysis of diffusion MRI data.\n            Frontiers in Neuroinformatics, 8,\n          8.","DOI":"10.3389\/fninf.2014.00008"},{"key":"2021101915394925000_bib22","doi-asserted-by":"crossref","unstructured":"Gomez-Ramirez,\n              J., & Wu,\n                J. 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