{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:02:41Z","timestamp":1791511361989,"version":"4.3.4"},"reference-count":138,"publisher":"MIT Press","issue":"2","license":[{"start":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T00:00:00Z","timestamp":1644278400000},"content-version":"vor","delay-in-days":38,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fonds de la Recherche du Qu\u00e9bec \u2013 Sant\u00e9","award":["FRQ-S 291486"],"award-info":[{"award-number":["FRQ-S 291486"]}]},{"name":"Canadian Institute of Health Research, CIHR Fellowship"},{"name":"National Science and Engineering Research Council of Canada","award":["NSERC Discovery-1304413"],"award-info":[{"award-number":["NSERC Discovery-1304413"]}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institute of Health Research","doi-asserted-by":"crossref","award":["FDN-154298"],"award-info":[{"award-number":["FDN-154298"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institute of Health Research","doi-asserted-by":"crossref","award":["PJT-174995"],"award-info":[{"award-number":["PJT-174995"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"name":"SickKids Foundation","award":["NI17-039"],"award-info":[{"award-number":["NI17-039"]}]},{"name":"Azrieli Center for Autism Research (ACAR-TACC), New Investigator Research Grant"},{"name":"BrainCanada, Future Leaders Research Grant"},{"name":"Helmholtz International Bigbrain Analytics and Learning Laboratory"},{"name":"FRQ-S"},{"name":"Tier-2 Canada Research Chairs Program, Tier-2"},{"name":"Canadian Institute of Health Research, CIHR Doctoral Award"},{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"crossref","award":["R01-NS099348"],"award-info":[{"award-number":["R01-NS099348"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000870","name":"John D. and Catherine T. MacArthur Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000870","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000879","name":"Alfred P. Sloan Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000879","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000952","name":"Paul Allen Family Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000952","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100019430","name":"ISI Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100019430","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["direct.mit.edu"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Epilepsy is one of the most common chronic neurological conditions, traditionally defined as a disorder of recurrent seizures. Cognitive and affective dysfunction are increasingly recognized as core disease dimensions and can affect patient well-being, sometimes more than the seizures themselves. Connectome-based approaches hold immense promise for revealing mechanisms that contribute to dysfunction and to identify biomarkers. Our review discusses emerging multimodal neuroimaging and connectomics studies that highlight network substrates of cognitive\/affective dysfunction in the common epilepsies. We first discuss work in drug-resistant epilepsy syndromes, that is, temporal lobe epilepsy, related to mesiotemporal sclerosis (TLE), and extratemporal epilepsy (ETE), related to malformations of cortical development. While these are traditionally conceptualized as \u2018focal\u2019 epilepsies, many patients present with broad structural and functional anomalies. Moreover, the extent of distributed changes contributes to difficulties in multiple cognitive domains as well as affective-behavioral challenges. We also review work in idiopathic generalized epilepsy (IGE), a subset of generalized epilepsy syndromes that involve subcortico-cortical circuits. Overall, neuroimaging and network neuroscience studies point to both shared and syndrome-specific connectome signatures of dysfunction across TLE, ETE, and IGE. Lastly, we point to current gaps in the literature and formulate recommendations for future research.<\/jats:p>","DOI":"10.1162\/netn_a_00237","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T09:56:39Z","timestamp":1644314199000},"page":"320-338","update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":27,"title":["Multimodal connectome biomarkers of cognitive and affective dysfunction in the common epilepsies"],"prefix":"10.1162","volume":"6","author":[{"given":"Raul","family":"Rodriguez-Cruces","sequence":"first","affiliation":[{"name":"McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Royer","sequence":"additional","affiliation":[{"name":"McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Larivi\u00e8re","sequence":"additional","affiliation":[{"name":"McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dani S.","family":"Bassett","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA"},{"name":"Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, USA"},{"name":"Department of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, PA, USA"},{"name":"Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA"},{"name":"Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA"},{"name":"Santa Fe Institute, Santa Fe, NM, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Caciagli","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA"},{"name":"Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9256-6041","authenticated-orcid":true,"given":"Boris C.","family":"Bernhardt","sequence":"additional","affiliation":[{"name":"McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"281","published-online":{"date-parts":[[2022,6,1]]},"reference":[{"issue":"3","key":"2022060119282412200_bib1","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1111\/epi.14017","article-title":"Topographic principles of cortical fluid-attenuated inversion recovery signal in temporal lobe epilepsy","volume":"59","author":"Adler","year":"2018","journal-title":"Epilepsia"},{"issue":"1","key":"2022060119282412200_bib2","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1002\/hbm.21432","article-title":"Brain plasticity for verbal and visual memories in patients with mesial temporal lobe epilepsy and hippocampal sclerosis: An fMRI study","volume":"34","author":"Alessio","year":"2013","journal-title":"Human Brain Mapping"},{"issue":"3","key":"2022060119282412200_bib3","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1046\/j.1528-1157.2001.36400.x","article-title":"Idiopathic generalized epilepsy with generalized and other seizures in adolescence","volume":"42","author":"Andermann","year":"2001","journal-title":"Epilepsia"},{"issue":"11","key":"2022060119282412200_bib4","doi-asserted-by":"publisher","first-page":"4404","DOI":"10.1002\/hbm.24281","article-title":"Language network measures at rest indicate individual differences in naming decline after anterior temporal lobe resection","volume":"39","author":"Audrain","year":"2018","journal-title":"Human Brain Mapping"},{"issue":"23","key":"2022060119282412200_bib5","doi-asserted-by":"publisher","first-page":"e2424","DOI":"10.1212\/wnl.0000000000009457","article-title":"Clinical utility of structural connectomics in predicting memory in temporal lobe epilepsy","volume":"94","author":"Balachandra","year":"2020","journal-title":"Neurology"},{"issue":"3","key":"2022060119282412200_bib6","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/nrneurol.2011.3","article-title":"The neurobiology of cognitive disorders in temporal lobe epilepsy","volume":"7","author":"Bell","year":"2011","journal-title":"Nature Reviews Neurology"},{"issue":"8","key":"2022060119282412200_bib7","doi-asserted-by":"publisher","first-page":"4239","DOI":"10.1002\/hbm.23661","article-title":"Presurgical language fMRI: Mapping of six critical regions","volume":"38","author":"Benjamin","year":"2017","journal-title":"Human Brain Mapping"},{"key":"2022060119282412200_bib8","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24015","article-title":"Characterization of atypical language activation patterns in focal epilepsy","author":"Berl","year":"2013","journal-title":"Annals of Neurology"},{"issue":"6","key":"2022060119282412200_bib9","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1002\/ana.1013","article-title":"Texture analysis and morphological processing of magnetic resonance imaging assist detection of focal cortical dysplasia in extra-temporal partial epilepsy","volume":"49","author":"Bernasconi","year":"2001","journal-title":"Annals of Neurology"},{"key":"2022060119282412200_bib10","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1111\/j.1528-1167.2011.03146.x","article-title":"Unveiling epileptogenic lesions: The contribution of image processing","volume":"52 Suppl 4","author":"Bernasconi","year":"2011","journal-title":"Epilepsia"},{"issue":"2","key":"2022060119282412200_bib11","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nrneurol.2010.199","article-title":"Advances in MRI for \u2018cryptogenic\u2019 epilepsies","volume":"7","author":"Bernasconi","year":"2011","journal-title":"Nature Reviews Neurology"},{"issue":"3","key":"2022060119282412200_bib12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nrneurol.2009.82-c1","article-title":"Temporal lobe epilepsy is a progressive disorder","volume":"6","author":"Bernasconi","year":"2010","journal-title":"Nature Reviews Neurology"},{"issue":"1","key":"2022060119282412200_bib13","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1002\/ana.24691","article-title":"The spectrum of structural and functional imaging abnormalities in temporal lobe epilepsy","volume":"80","author":"Bernhardt","year":"2016","journal-title":"Annals of Neurology"},{"issue":"2","key":"2022060119282412200_bib14","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1212\/wnl.0b013e31823efd0d","article-title":"Mapping thalamocortical network pathology in temporal lobe epilepsy","volume":"78","author":"Bernhardt","year":"2012","journal-title":"Neurology"},{"key":"2022060119282412200_bib15","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.neuroimage.2017.06.002","article-title":"Preferential susceptibility of limbic cortices to microstructural damage in temporal lobe epilepsy: A quantitative T1 mapping study","volume":"182","author":"Bernhardt","year":"2018","journal-title":"NeuroImage"},{"key":"2022060119282412200_bib16","doi-asserted-by":"publisher","first-page":"624","DOI":"10.3389\/fnhum.2013.00624","article-title":"Imaging structural and functional brain networks in temporal lobe epilepsy","volume":"7","author":"Bernhardt","year":"2013","journal-title":"Frontiers in Human Neuroscience"},{"issue":"3","key":"2022060119282412200_bib17","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1002\/ana.24341","article-title":"Magnetic resonance imaging pattern learning in temporal lobe epilepsy: Classification and prognostics","volume":"77","author":"Bernhardt","year":"2015","journal-title":"Annals of Neurology"},{"issue":"21","key":"2022060119282412200_bib18","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.1212\/01.wnl.0000436069.20513.92","article-title":"Patterns of subregional mesiotemporal disease progression in temporal lobe epilepsy","volume":"81","author":"Bernhardt","year":"2013","journal-title":"Neurology"},{"issue":"2","key":"2022060119282412200_bib19","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.neuroimage.2009.01.055","article-title":"Thalamo-cortical network pathology in idiopathic generalized epilepsy: Insights from MRI-based morphometric correlation analysis","volume":"46","author":"Bernhardt","year":"2009","journal-title":"NeuroImage"},{"issue":"2","key":"2022060119282412200_bib20","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.neuroimage.2008.04.261","article-title":"Mapping limbic network organization in temporal lobe epilepsy using morphometric correlations: Insights on the relation between mesiotemporal connectivity and cortical atrophy","volume":"42","author":"Bernhardt","year":"2008","journal-title":"NeuroImage"},{"issue":"20","key":"2022060119282412200_bib21","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1212\/01.wnl.0000345969.57574.f5","article-title":"Longitudinal and cross-sectional analysis of atrophy in pharmacoresistant temporal lobe epilepsy","volume":"72","author":"Bernhardt","year":"2009","journal-title":"Neurology"},{"issue":"1","key":"2022060119282412200_bib22","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.yebeh.2012.10.017","article-title":"The effects of temporal lobe epilepsy on scene encoding","volume":"26","author":"Bigras","year":"2013","journal-title":"Epilepsy & Behavior"},{"issue":"1","key":"2022060119282412200_bib23","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1111\/j.1528-1167.2010.02773.x","article-title":"Investigation of widespread neocortical pathology associated with hippocampal sclerosis in epilepsy: A postmortem study","volume":"52","author":"Blanc","year":"2011","journal-title":"Epilepsia"},{"issue":"7","key":"2022060119282412200_bib24","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1111\/epi.12220","article-title":"International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: A Task Force report from the ILAE Commission on Diagnostic Methods","volume":"54","author":"Blumcke","year":"2013","journal-title":"Epilepsia"},{"key":"2022060119282412200_bib25","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1046\/j.1528-1157.44.s.2.2.x","article-title":"From molecules to networks: Cortical\/subcortical interactions in the pathophysiology of idiopathic generalized epilepsy","volume":"44 Suppl 2","author":"Blumenfeld","year":"2003","journal-title":"Epilepsia"},{"issue":"5","key":"2022060119282412200_bib26","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1111\/j.1528-1167.2011.03057.x","article-title":"Cognitive and behavioral complications of frontal lobe epilepsy in children: a review of the literature","volume":"52","author":"Braakman","year":"2011","journal-title":"Epilepsia"},{"issue":"3","key":"2022060119282412200_bib27","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1111\/epi.12044","article-title":"Frontal lobe connectivity and cognitive impairment in pediatric frontal lobe epilepsy","volume":"54","author":"Braakman","year":"2013","journal-title":"Epilepsia"},{"key":"2022060119282412200_bib28","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.yebeh.2014.05.026","article-title":"Genetics of cognition in epilepsy","volume":"41","author":"Busch","year":"2014","journal-title":"Epilepsy & Behavior"},{"issue":"5","key":"2022060119282412200_bib29","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1212\/WNL.0000000000004176","article-title":"Time is brain? A meta-analysis on progressive atrophy in intractable temporal lobe epilepsy","volume":"89","author":"Caciagli","year":"2017","journal-title":"Neurology"},{"key":"2022060119282412200_bib30","doi-asserted-by":"publisher","first-page":"411","DOI":"10.3389\/fnins.2014.00411","article-title":"Functional network alterations and their structural substrate in drug-resistant epilepsy","volume":"8","author":"Caciagli","year":"2014","journal-title":"Frontiers in Neuroscience"},{"key":"2022060119282412200_bib31","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac150","article-title":"Disorganization of language and working memory systems in frontal versus temporal lobe epilepsy","author":"Caciagli","year":"2022","journal-title":"Brain"},{"issue":"7","key":"2022060119282412200_bib32","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1111\/epi.16575","article-title":"Motor hyperactivation during cognitive tasks: An endophenotype of juvenile myoclonic epilepsy","volume":"61","author":"Caciagli","year":"2020","journal-title":"Epilepsia"},{"issue":"9","key":"2022060119282412200_bib33","doi-asserted-by":"publisher","first-page":"2670","DOI":"10.1093\/brain\/awz215","article-title":"Abnormal hippocampal structure and function in juvenile myoclonic epilepsy and unaffected siblings","volume":"142","author":"Caciagli","year":"2019","journal-title":"Brain"},{"key":"2022060119282412200_bib34","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.nicl.2014.11.018","article-title":"Hyperconnectivity in juvenile myoclonic epilepsy: A network analysis","volume":"7","author":"Caeyenberghs","year":"2015","journal-title":"NeuroImage Clinical"},{"issue":"1","key":"2022060119282412200_bib35","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.neuroimage.2011.11.092","article-title":"Resting-state fMRI study of treatment-naive temporal lobe epilepsy patients with depressive symptoms","volume":"60","author":"Chen","year":"2012","journal-title":"Neuroimage"},{"issue":"11","key":"2022060119282412200_bib36","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1212\/WNL.0b013e3181b783dd","article-title":"Seizure frequency and lateralization affect progression of atrophy in temporal lobe epilepsy","volume":"73","author":"Coan","year":"2009","journal-title":"Neurology"},{"issue":"1","key":"2022060119282412200_bib37","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1111\/j.1528-1167.2006.00379.x","article-title":"In vivo profiling of focal cortical dysplasia on high-resolution MRI using computational models","volume":"47","author":"Colliot","year":"2005","journal-title":"Epilepsia"},{"issue":"3","key":"2022060119282412200_bib38","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1136\/jnnp.2007.139287","article-title":"White-matter diffusion abnormalities in temporal-lobe epilepsy with and without mesial temporal sclerosis","volume":"80","author":"Concha","year":"2009","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"issue":"2","key":"2022060119282412200_bib39","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1002\/ana.20334","article-title":"Bilateral limbic diffusion abnormalities in unilateral temporal lobe epilepsy","volume":"57","author":"Concha","year":"2005","journal-title":"Annals of Neurology"},{"issue":"5","key":"2022060119282412200_bib40","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1212\/WNL.0b013e31826170b6","article-title":"Spatial patterns of water diffusion along white matter tracts in temporal lobe epilepsy","volume":"79","author":"Concha","year":"2012","journal-title":"Neurology"},{"issue":"4","key":"2022060119282412200_bib41","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.yebeh.2009.05.012","article-title":"Neuroanatomical correlates of cognitive phenotypes in temporal lobe epilepsy","volume":"15","author":"Dabbs","year":"2009","journal-title":"Epilepsy & Behavior"},{"issue":"1","key":"2022060119282412200_bib42","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1093\/neuros\/nyy099","article-title":"Surgical treatment of extratemporal epilepsy: Results and prognostic factors","volume":"84","author":"Delev","year":"2019","journal-title":"Neurosurgery"},{"issue":"2","key":"2022060119282412200_bib43","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.bandc.2013.08.001","article-title":"Functional connectivity abnormalities vary by amygdala subdivision and are associated with psychiatric symptoms in unilateral temporal epilepsy","volume":"83","author":"Doucet","year":"2013","journal-title":"Brain and Cognition"},{"key":"2022060119282412200_bib44","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.nicl.2018.09.023","article-title":"Structural covariance networks relate to the severity of epilepsy with focal-onset seizures","volume":"20","author":"Drenthen","year":"2018","journal-title":"NeuroImage Clinical"},{"issue":"8","key":"2022060119282412200_bib45","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1038\/s41593-020-0658-y","article-title":"The extent and drivers of gender imbalance in neuroscience reference lists","volume":"23","author":"Dworkin","year":"2020","journal-title":"Nature Neuroscience"},{"issue":"11","key":"2022060119282412200_bib46","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1136\/jnnp-2017-315732","article-title":"Functional connectivity disturbances of the ascending reticular activating system in temporal lobe epilepsy","volume":"88","author":"Englot","year":"2017","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"issue":"1","key":"2022060119282412200_bib47","doi-asserted-by":"publisher","first-page":"e67","DOI":"10.1212\/WNL.0000000000005733","article-title":"Relating structural and functional brainstem connectivity to disease measures in epilepsy","volume":"91","author":"Englot","year":"2018","journal-title":"Neurology"},{"issue":"1","key":"2022060119282412200_bib48","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1053\/seiz.2001.0572","article-title":"Neuropsychological performance in frontal lobe epilepsy","volume":"11","author":"Exner","year":"2002","journal-title":"Seizure"},{"key":"2022060119282412200_bib49","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17032","article-title":"Atypical functional connectome hierarchy impacts cognition in temporal lobe epilepsy","author":"Fadaie","year":"2021","journal-title":"Epilepsia"},{"issue":"2","key":"2022060119282412200_bib50","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.neuroimage.2007.12.031","article-title":"Voxel-based diffusion tensor imaging in patients with mesial temporal lobe epilepsy and hippocampal sclerosis","volume":"40","author":"Focke","year":"2008","journal-title":"Neuroimage"},{"issue":"6","key":"2022060119282412200_bib51","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1001\/jamaneurol.2019.0204","article-title":"Association of piriform cortex resection with surgical outcomes in patients with temporal lobe epilepsy","volume":"76","author":"Galovic","year":"2019","journal-title":"JAMA Neurology"},{"issue":"5","key":"2022060119282412200_bib52","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/s1474-4422(18)30499-X","article-title":"Global, regional, and national burden of neurological disorders, 1990\u20132016: A systematic analysis for the Global Burden of Disease Study 2016","volume":"18","author":"GBD 2016 Neurology Collaborators","year":"2019","journal-title":"Lancet Neurology"},{"issue":"4","key":"2022060119282412200_bib53","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1111\/epi.16864","article-title":"Altered communication dynamics reflect cognitive deficits in temporal lobe epilepsy","volume":"62","author":"Girardi-Schappo","year":"2021","journal-title":"Epilepsia"},{"issue":"5","key":"2022060119282412200_bib54","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1002\/ana.25888","article-title":"Temporal lobe epilepsy surgical outcomes can be inferred based on structural connectome hubs: A machine learning study","volume":"88","author":"Gleichgerrcht","year":"2020","journal-title":"Annals of Neurology"},{"issue":"11","key":"2022060119282412200_bib55","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1111\/epi.13133","article-title":"Connectomics and graph theory analyses: Novel insights into network abnormalities in epilepsy","volume":"56","author":"Gleichgerrcht","year":"2015","journal-title":"Epilepsia"},{"issue":"42","key":"2022060119282412200_bib56","doi-asserted-by":"publisher","first-page":"15236","DOI":"10.1073\/pnas.0504935102","article-title":"Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain","volume":"102","author":"Gotman","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"Pt B","key":"2022060119282412200_bib57","doi-asserted-by":"publisher","first-page":"106118","DOI":"10.1016\/j.yebeh.2019.01.003","article-title":"Social cognition in idiopathic generalized epilepsies and potential neuroanatomical correlates","volume":"100","author":"Guida","year":"2019","journal-title":"Epilepsy & Behavior"},{"issue":"5","key":"2022060119282412200_bib58","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1006\/ebeh.2001.0259","article-title":"Behavioral aspects of frontal lobe epilepsy","volume":"2","author":"Helmstaedter","year":"2001","journal-title":"Epilepsy & Behavior"},{"issue":"5","key":"2022060119282412200_bib59","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/0028-3932(95)00121-2","article-title":"Neuropsychological aspects of frontal lobe epilepsy","volume":"34","author":"Helmstaedter","year":"1996","journal-title":"Neuropsychologia"},{"key":"2022060119282412200_bib60","doi-asserted-by":"publisher","first-page":"102341","DOI":"10.1016\/j.nicl.2020.102341","article-title":"Network, clinical and sociodemographic features of cognitive phenotypes in temporal lobe epilepsy","volume":"27","author":"Hermann","year":"2020","journal-title":"NeuroImage Clinical"},{"issue":"4","key":"2022060119282412200_bib61","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/j.ncl.2009.08.001","article-title":"The emerging architecture of neuropsychological impairment in epilepsy","volume":"27","author":"Hermann","year":"2009","journal-title":"Neurologic Clinics"},{"key":"2022060119282412200_bib62","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-66182-7_45","article-title":"Connectome-based pattern learning predicts histology and surgical outcome of epileptogenic malformations of cortical development","volume-title":"Medical image computing and computer assisted intervention \u2212 MICCAI 2017. MICCAI 2017. Lecture notes in computer science, Vol. 10433","author":"Hong","year":"2017"},{"issue":"8","key":"2022060119282412200_bib63","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1093\/brain\/awx145","article-title":"The spectrum of structural and functional network alterations in malformations of cortical development","volume":"140","author":"Hong","year":"2017","journal-title":"Brain"},{"key":"2022060119282412200_bib64","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1007\/978-3-319-24571-3_60","article-title":"MRI-based lesion profiling of epileptogenic cortical malformations","volume-title":"Medical image computing and computer-assisted intervention \u2013 MICCAI, 9350","author":"Hong","year":"2015"},{"issue":"7","key":"2022060119282412200_bib65","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1212\/WNL.0000000000002374","article-title":"Whole-brain MRI phenotying of dysplasia-related frontal lobe epilepsy","volume":"86","author":"Hong","year":"2016","journal-title":"Neurology"},{"issue":"1","key":"2022060119282412200_bib66","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1212\/WNL.0000000000000543","article-title":"Automated detection of cortical dysplasia type II in MRI-negative epilepsy","volume":"83","author":"Hong","year":"2014","journal-title":"Neurology"},{"key":"2022060119282412200_bib67","doi-asserted-by":"publisher","first-page":"102183","DOI":"10.1016\/j.nicl.2020.102183","article-title":"Brain aging in temporal lobe epilepsy: Chronological, structural, and functional","volume":"25","author":"Hwang","year":"2020","journal-title":"NeuroImage Clinical"},{"key":"2022060119282412200_bib68","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1111\/j.1528-1157.1989.tb05316.x","article-title":"Commission on Classification and Terminology of the International League Against Epilepsy: Proposal for classification of epilepsies and epileptic syndromes","volume":"30","author":"International League Against Epilepsy","year":"1989","journal-title":"Epilepsia"},{"issue":"10","key":"2022060119282412200_bib69","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1212\/WNL.57.10.1786","article-title":"Memory fMRI lateralizes temporal lobe epilepsy","volume":"57","author":"Jokeit","year":"2001","journal-title":"Neurology"},{"key":"2022060119282412200_bib70","doi-asserted-by":"publisher","first-page":"102125","DOI":"10.1016\/j.nicl.2019.102125","article-title":"The white matter connectome as an individualized biomarker of language impairment in temporal lobe epilepsy","volume":"25","author":"Kaestner","year":"2020","journal-title":"NeuroImage Clinical"},{"issue":"2","key":"2022060119282412200_bib71","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.yebeh.2012.01.007","article-title":"Depression and epilepsy: Epidemiologic and neurobiologic perspectives that may explain their high comorbid occurrence","volume":"24","author":"Kanner","year":"2012","journal-title":"Epilepsy & Behavior"},{"issue":"3","key":"2022060119282412200_bib72","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.yebeh.2013.09.039","article-title":"Alterations in functional connectivity between the hippocampus and prefrontal cortex as a correlate of depressive symptoms in temporal lobe epilepsy","volume":"29","author":"Kemmotsu","year":"2013","journal-title":"Epilepsy & Behavior"},{"issue":"4","key":"2022060119282412200_bib73","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1016\/j.neuroimage.2011.03.036","article-title":"Impaired attention and network connectivity in childhood absence epilepsy","volume":"56","author":"Killory","year":"2011","journal-title":"NeuroImage"},{"issue":"10","key":"2022060119282412200_bib74","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1056\/NEJMra1004418","article-title":"Drug-resistant epilepsy","volume":"365","author":"Kwan","year":"2011","journal-title":"New England Journal of Medicine"},{"issue":"1","key":"2022060119282412200_bib75","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/epi.16753","article-title":"Connectome biomarkers of drug-resistant epilepsy","volume":"62","author":"Larivi\u00e8re","year":"2021","journal-title":"Epilepsia"},{"issue":"47","key":"2022060119282412200_bib76","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc6457","article-title":"Network-based atrophy modeling in the common epilepsies: A worldwide ENIGMA study","volume":"6","author":"Larivi\u00e8re","year":"2020","journal-title":"Science Advances"},{"key":"2022060119282412200_bib77","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2018.0587","article-title":"Microstructure-informed connectomics: enriching large-scale descriptions of healthy and diseased brains","author":"Larivi\u00e8re","year":"2018","journal-title":"Brain Connectivity"},{"key":"2022060119282412200_bib78","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16540","article-title":"Functional connectome contractions in temporal lobe epilepsy: Microstructural underpinnings and predictors of surgical outcome","author":"Larivi\u00e8re","year":"2020","journal-title":"Epilepsia"},{"issue":"6","key":"2022060119282412200_bib79","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.seizure.2008.01.007","article-title":"Frontal lobe epilepsy: Clinical characteristics, surgical outcomes and diagnostic modalities","volume":"17","author":"Lee","year":"2008","journal-title":"Seizure"},{"key":"2022060119282412200_bib80","doi-asserted-by":"publisher","DOI":"10.1101\/2020.06.22.165290","article-title":"Atypical neural topographies underpin dysfunctional pattern separation in temporal lobe epilepsy","author":"Li","year":"2021","journal-title":"bioRxiv"},{"issue":"9848","key":"2022060119282412200_bib81","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1016\/S0140-6736(12)61455-X","article-title":"Uncovering the neurobehavioural comorbidities of epilepsy over the lifespan","volume":"380","author":"Lin","year":"2012","journal-title":"Lancet"},{"issue":"9","key":"2022060119282412200_bib82","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1093\/cercor\/bhl109","article-title":"Reduced neocortical thickness and complexity mapped in mesial temporal lobe epilepsy with hippocampal sclerosis","volume":"17","author":"Lin","year":"2007","journal-title":"Cerebral Cortex"},{"issue":"Pt 9","key":"2022060119282412200_bib83","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1093\/brain\/aww167","article-title":"The superficial white matter in temporal lobe epilepsy: A key link between structural and functional network disruptions","volume":"139","author":"Liu","year":"2016","journal-title":"Brain"},{"issue":"4","key":"2022060119282412200_bib84","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1111\/epi.14694","article-title":"Hippocampal atrophy disrupts the language network but not hemispheric language lateralization","volume":"60","author":"Lopes","year":"2019","journal-title":"Epilepsia"},{"issue":"6","key":"2022060119282412200_bib85","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1016\/j.yebeh.2004.08.019","article-title":"Determinants of quality of life in epilepsy","volume":"5","author":"Loring","year":"2004","journal-title":"Epilepsy & Behavior"},{"key":"2022060119282412200_bib86","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.neubiorev.2014.02.012","article-title":"Cognitive functioning in idiopathic generalised epilepsies: A systematic review and meta-analysis","volume":"43","author":"Loughman","year":"2014","journal-title":"Neuroscience & Biobehavioral Reviews"},{"issue":"4","key":"2022060119282412200_bib87","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.yebeh.2005.08.015","article-title":"EpiTrack: Tracking cognitive side effects of medication on attention and executive functions in patients with epilepsy","volume":"7","author":"Lutz","year":"2005","journal-title":"Epilepsy & Behavior"},{"issue":"3","key":"2022060119282412200_bib88","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1093\/brain\/89.3.499","article-title":"Epilepsy and the temporal lobes. A clinical, electroencephalographic and neuropathological study of the brain in epilepsy, with particular reference to the temporal lobes","volume":"89","author":"Margerison","year":"1966","journal-title":"Brain"},{"key":"2022060119282412200_bib89","doi-asserted-by":"publisher","first-page":"925238","DOI":"10.1155\/2012\/925238","article-title":"Neuropsychology in temporal lobe epilepsy: Influences from cognitive neuroscience and functional neuroimaging","volume":"2012","author":"McAndrews","year":"2012","journal-title":"Epilepsy Research and Treatment"},{"issue":"5","key":"2022060119282412200_bib90","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1111\/j.1528-1167.2008.01539.x","article-title":"Regional neocortical thinning in mesial temporal lobe epilepsy","volume":"49","author":"McDonald","year":"2008","journal-title":"Epilepsia"},{"issue":"1","key":"2022060119282412200_bib91","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.yebeh.2006.04.007","article-title":"The relationship of regional frontal hypometabolism to executive function: A resting fluorodeoxyglucose PET study of patients with epilepsy and healthy controls","volume":"9","author":"McDonald","year":"2006","journal-title":"Epilepsy & Behavior"},{"key":"2022060119282412200_bib92","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1111\/j.1528-1167.2005.00313.x","article-title":"Idiopathic generalized epilepsies recognized by the International League Against Epilepsy","volume":"46 Suppl 9","author":"Nordli","year":"2005","journal-title":"Epilepsia"},{"issue":"1","key":"2022060119282412200_bib93","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1212\/WNL.0b013e318203e93d","article-title":"Focal structural changes and cognitive dysfunction in juvenile myoclonic epilepsy","volume":"76","author":"O\u2019Muircheartaigh","year":"2011","journal-title":"Neurology"},{"issue":"Pt 12","key":"2022060119282412200_bib94","doi-asserted-by":"publisher","first-page":"3635","DOI":"10.1093\/brain\/aws296","article-title":"Abnormal thalamocortical structural and functional connectivity in juvenile myoclonic epilepsy","volume":"135","author":"O\u2019Muircheartaigh","year":"2012","journal-title":"Brain"},{"issue":"6","key":"2022060119282412200_bib95","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1007\/s00701-016-2786-4","article-title":"Preoperative neuropsychological presentation of patients with refractory frontal lobe epilepsy","volume":"158","author":"Patrikelis","year":"2016","journal-title":"Acta Neurochirurgica"},{"key":"2022060119282412200_bib96","doi-asserted-by":"publisher","first-page":"144","DOI":"10.3389\/fneur.2020.00144","article-title":"Cognitive function in genetic generalized epilepsies: Insights from neuropsychology and neuroimaging","volume":"11","author":"Ratcliffe","year":"2020","journal-title":"Frontiers in Neurology"},{"key":"2022060119282412200_bib97","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.neuropsychologia.2018.02.009","article-title":"Impaired spatial pattern separation performance in temporal lobe epilepsy is associated with visuospatial memory deficits and hippocampal volume loss","volume":"111","author":"Reyes","year":"2018","journal-title":"Neuropsychologia"},{"issue":"17","key":"2022060119282412200_bib98","doi-asserted-by":"publisher","first-page":"e1957","DOI":"10.1212\/WNL.0000000000007370","article-title":"Cognitive phenotypes in temporal lobe epilepsy are associated with distinct patterns of white matter network abnormalities","volume":"92","author":"Reyes","year":"2019","journal-title":"Neurology"},{"key":"2022060119282412200_bib99","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1111\/j.1528-1167.2006.00699.x","article-title":"Cognitive outcomes in patients with frontal lobe epilepsy","volume":"47 Suppl 2","author":"Risse","year":"2006","journal-title":"Epilepsia"},{"issue":"Pt A","key":"2022060119282412200_bib100","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.yebeh.2019.07.025","article-title":"Neuroanatomical correlates of personality traits in temporal lobe epilepsy: Findings from the Epilepsy Connectome Project","volume":"98","author":"Rivera Bonet","year":"2019","journal-title":"Epilepsy & Behavior"},{"key":"2022060119282412200_bib101","doi-asserted-by":"publisher","first-page":"107172","DOI":"10.1016\/j.yebeh.2020.107172","article-title":"Neuroticism in temporal lobe epilepsy is associated with altered limbic-frontal lobe resting-state functional connectivity","volume":"110","author":"Rivera Bonet","year":"2020","journal-title":"Epilepsy & Behavior"},{"key":"2022060119282412200_bib102","doi-asserted-by":"publisher","first-page":"116706","DOI":"10.1016\/j.neuroimage.2020.116706","article-title":"Multidimensional associations between cognition and connectome organization in temporal lobe epilepsy","volume":"213","author":"Rodriguez-Cruces","year":"2019","journal-title":"NeuroImage"},{"key":"2022060119282412200_bib103","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.yebeh.2017.11.040","article-title":"Association of white matter diffusion characteristics and cognitive deficits in temporal lobe epilepsy","volume":"79","author":"Rodriguez-Cruces","year":"2018","journal-title":"Epilepsy & Behavior"},{"issue":"3","key":"2022060119282412200_bib104","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1002\/hbm.24839","article-title":"Hubs disruption in mesial temporal lobe epilepsy. A resting-state fMRI study on a language-and-memory network","volume":"41","author":"Roger","year":"2020","journal-title":"Human Brain Mapping"},{"issue":"Pt 3","key":"2022060119282412200_bib105","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1093\/brain\/awp012","article-title":"Verbal memory in mesial temporal lobe epilepsy: Beyond material specificity","volume":"132","author":"Saling","year":"2009","journal-title":"Brain"},{"issue":"2","key":"2022060119282412200_bib106","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.eplepsyres.2013.12.002","article-title":"Epilepsy beyond seizure: A population-based study of comorbidities","volume":"108","author":"Selassie","year":"2014","journal-title":"Epilepsy Research"},{"issue":"Pt 6","key":"2022060119282412200_bib107","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.1093\/brain\/awt099","article-title":"A functional magnetic resonance imaging study mapping the episodic memory encoding network in temporal lobe epilepsy","volume":"136","author":"Sidhu","year":"2013","journal-title":"Brain"},{"key":"2022060119282412200_bib108","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25037","article-title":"The ENIGMA-Epilepsy working group: Mapping disease from large data sets","author":"Sisodiya","year":"2020","journal-title":"Human Brain Mapping"},{"key":"2022060119282412200_bib109","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.1805.02109","article-title":"Predicting race and ethnicity from the sequence of characters in a name","author":"Sood","year":"2018","journal-title":"arXiv preprint 1805.02109"},{"issue":"1","key":"2022060119282412200_bib110","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.bandc.2008.05.005","article-title":"Contributions of volumetrics of the hippocampus and thalamus to verbal memory in temporal lobe epilepsy patients","volume":"69","author":"Stewart","year":"2009","journal-title":"Brain and Cognition"},{"key":"2022060119282412200_bib111","doi-asserted-by":"publisher","first-page":"107841","DOI":"10.1016\/j.yebeh.2021.107841","article-title":"Regional and global resting-state functional MR connectivity in temporal lobe epilepsy: Results from the Epilepsy Connectome Project","volume":"117","author":"Struck","year":"2021","journal-title":"Epilepsy & Behavior"},{"issue":"6","key":"2022060119282412200_bib112","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.seizure.2012.04.012","article-title":"Anxiety symptoms in patients with frontal lobe epilepsy versus generalized epilepsy","volume":"21","author":"Tang","year":"2012","journal-title":"Seizure"},{"issue":"4","key":"2022060119282412200_bib113","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1111\/epi.14688","article-title":"Neuroimaging and connectomics of drug-resistant epilepsy at multiple scales: From focal lesions to macroscale networks","volume":"60","author":"Tavakol","year":"2019","journal-title":"Epilepsia"},{"issue":"12","key":"2022060119282412200_bib114","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.1111\/j.1528-1167.2007.01222.x","article-title":"Psychiatric comorbidity in epilepsy: A population-based analysis","volume":"48","author":"Tellez-Zenteno","year":"2007","journal-title":"Epilepsia"},{"issue":"5","key":"2022060119282412200_bib115","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1111\/nan.12150","article-title":"Review: Hippocampal sclerosis in epilepsy: A neuropathology review","volume":"40","author":"Thom","year":"2014","journal-title":"Neuropathology and Applied Neurobiology"},{"issue":"8","key":"2022060119282412200_bib116","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1097\/NEN.0b013e3181b05d67","article-title":"Temporal lobe sclerosis associated with hippocampal sclerosis in temporal lobe epilepsy: Neuropathological features","volume":"68","author":"Thom","year":"2009","journal-title":"Journal of Neuropathology & Experimental Neurology"},{"issue":"4","key":"2022060119282412200_bib117","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1002\/hbm.21045","article-title":"Effects of childhood absence epilepsy on associations between regional cortical morphometry and aging and cognitive abilities","volume":"32","author":"Tosun","year":"2011","journal-title":"Human Brain Mapping"},{"issue":"2","key":"2022060119282412200_bib118","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/0920-1211(95)00096-8","article-title":"General neuropsychological characteristics of frontal lobe epilepsy","volume":"23","author":"Upton","year":"1996","journal-title":"Epilepsy Research"},{"issue":"6","key":"2022060119282412200_bib119","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/s1059-1311(97)80018-0","article-title":"Neuropsychological test performance in frontal-lobe epilepsy: The influence of aetiology, seizure type, seizure frequency and duration of disorder","volume":"6","author":"Upton","year":"1997","journal-title":"Seizure"},{"issue":"8","key":"2022060119282412200_bib120","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1093\/cercor\/bhs186","article-title":"Abnormal modular organization of functional networks in cognitively impaired children with frontal lobe epilepsy","volume":"23","author":"Vaessen","year":"2013","journal-title":"Cerebral Cortex"},{"issue":"3","key":"2022060119282412200_bib121","doi-asserted-by":"publisher","first-page":"e90068","DOI":"10.1371\/journal.pone.0090068","article-title":"Functional and structural network impairment in childhood frontal lobe epilepsy","volume":"9","author":"Vaessen","year":"2014","journal-title":"PLoS One"},{"issue":"9","key":"2022060119282412200_bib122","doi-asserted-by":"publisher","first-page":"2139","DOI":"10.1093\/cercor\/bhr298","article-title":"White matter network abnormalities are associated with cognitive decline in chronic epilepsy","volume":"22","author":"Vaessen","year":"2012","journal-title":"Cerebral Cortex"},{"key":"2022060119282412200_bib123","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.yebeh.2018.08.008","article-title":"Neuropsychology of frontal lobe epilepsy in children and adults: Systematic review and meta-analysis","volume":"88","author":"Verche","year":"2018","journal-title":"Epilepsy & Behavior"},{"issue":"1\u20132","key":"2022060119282412200_bib124","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.jns.2015.10.035","article-title":"Neuropsychological impairment in childhood absence epilepsy: Review of the literature","volume":"359","author":"Verrotti","year":"2015","journal-title":"Journal of the Neurological Sciences"},{"issue":"8","key":"2022060119282412200_bib125","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1111\/j.1528-1167.2011.03108.x","article-title":"Memory processes and prefrontal network dysfunction in cryptogenic epilepsy","volume":"52","author":"Vlooswijk","year":"2011","journal-title":"Epilepsia"},{"issue":"5","key":"2022060119282412200_bib126","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1212\/WNL.0b013e3181ebdd3e","article-title":"Functional connectivity and language impairment in cryptogenic localization-related epilepsy","volume":"75","author":"Vlooswijk","year":"2010","journal-title":"Neurology"},{"issue":"10","key":"2022060119282412200_bib127","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1212\/WNL.0b013e31822cfc2f","article-title":"Loss of network efficiency associated with cognitive decline in chronic epilepsy","volume":"77","author":"Vlooswijk","year":"2011","journal-title":"Neurology"},{"issue":"Pt 6","key":"2022060119282412200_bib128","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1093\/brain\/awr098","article-title":"Motor system hyperconnectivity in juvenile myoclonic epilepsy: A cognitive functional magnetic resonance imaging study","volume":"134","author":"Vollmar","year":"2011","journal-title":"Brain"},{"issue":"Pt 9","key":"2022060119282412200_bib129","doi-asserted-by":"publisher","first-page":"2469","DOI":"10.1093\/brain\/awu175","article-title":"Motor co-activation in siblings of patients with juvenile myoclonic epilepsy: An imaging endophenotype?","volume":"137","author":"Wandschneider","year":"2014","journal-title":"Brain"},{"issue":"13","key":"2022060119282412200_bib130","doi-asserted-by":"publisher","first-page":"e1272","DOI":"10.1212\/WNL.0000000000008173","article-title":"Developmental MRI markers cosegregate juvenile patients with myoclonic epilepsy and their healthy siblings","volume":"93","author":"Wandschneider","year":"2019","journal-title":"Neurology"},{"issue":"11","key":"2022060119282412200_bib131","doi-asserted-by":"publisher","first-page":"e1112","DOI":"10.1212\/WNL.0000000000008096","article-title":"Community-informed connectomics of the thalamo-cortical system in generalized epilepsy","volume":"93","author":"Wang","year":"2019","journal-title":"Neurology"},{"key":"2022060119282412200_bib132","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.brainres.2010.12.034","article-title":"Altered resting state networks in epileptic patients with generalized tonic-clonic seizures","volume":"1374","author":"Wang","year":"2011","journal-title":"Brain Research"},{"issue":"7","key":"2022060119282412200_bib133","doi-asserted-by":"publisher","first-page":"e39701","DOI":"10.1371\/journal.pone.0039701","article-title":"Impairments of thalamic nuclei in idiopathic generalized epilepsy revealed by a study combining morphological and functional connectivity MRI","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"2022060119282412200_bib134","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1002\/ana.24407","article-title":"Voxel-based morphometric magnetic resonance imaging (MRI) postprocessing in MRI-negative epilepsies","volume":"77","author":"Wang","year":"2015","journal-title":"Annals of Neurology"},{"issue":"1","key":"2022060119282412200_bib135","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1038\/s42003-020-0958-5","article-title":"Macroscale and microcircuit dissociation of focal and generalized human epilepsies","volume":"3","author":"Weng","year":"2020","journal-title":"Communications Biology"},{"issue":"2","key":"2022060119282412200_bib136","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1093\/brain\/awx341","article-title":"Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study","volume":"141","author":"Whelan","year":"2018","journal-title":"Brain"},{"issue":"38","key":"2022060119282412200_bib137","doi-asserted-by":"publisher","first-page":"7343","DOI":"10.1523\/JNEUROSCI.1370-20.2020","article-title":"Thalamic stimulation improves postictal cortical arousal and behavior","volume":"40","author":"Xu","year":"2020","journal-title":"Journal of Neuroscience"},{"issue":"Pt A","key":"2022060119282412200_bib138","doi-asserted-by":"publisher","first-page":"106848","DOI":"10.1016\/j.yebeh.2019.106848","article-title":"Genetic and molecular basis of epilepsy-related cognitive dysfunction","volume":"104","author":"Zhu","year":"2020","journal-title":"Epilepsy & Behavior"}],"container-title":["Network Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/direct.mit.edu\/netn\/article-pdf\/6\/2\/320\/2028100\/netn_a_00237.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/direct.mit.edu\/netn\/article-pdf\/6\/2\/320\/2028100\/netn_a_00237.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T15:29:01Z","timestamp":1654097341000},"score":1,"resource":{"primary":{"URL":"https:\/\/direct.mit.edu\/netn\/article\/6\/2\/320\/109444\/Multimodal-connectome-biomarkers-of-cognitive-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":138,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,6,1]]}},"URL":"https:\/\/doi.org\/10.1162\/netn_a_00237","relation":{},"ISSN":["2472-1751"],"issn-type":[{"value":"2472-1751","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022]]},"published":{"date-parts":[[2022]]}}}