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Recently interest has grown in its therapeutic efficacy in deep brain stimulation in movement disorders. This efficacy might be due to the ZI\u2019s functional projections to the other brain regions. Notwithstanding some evidence of anatomical connections between the ZI and the inferior olive (IO) and the pontine nuclei (PN), how the ZI modulates the neuronal activity in these regions remains to be determined. We first tested this by monitoring responses of single neurons in the PN and IO to optogenetic activation of channelrhodopsin-expressing ZI axons in wild-type mice, using an in vivo awake preparation. Stimulation of short, single pulses and trains of stimuli at 20 Hz elicited rapid responses in the majority of recorded cells in the PN and IO. Furthermore, the excitatory response of PN neurons scaled with the strength of ZI activation. Next, we used in vitro electrophysiology to study synaptic transmission at ZI-IO synapses. Optogenetic activation of ZI axons evoked a strong excitatory postsynaptic response in IO neurons, which remained robust with repeated stimulation at 20 Hz. Overall, our results demonstrate a functional connection within ZI-PN and ZI-IO pathways.<\/jats:p>","DOI":"10.1162\/netn_a_00350","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T15:36:29Z","timestamp":1700148989000},"page":"260-274","update-policy":"https:\/\/doi.org\/10.1162\/mitpressjournals.corrections.policy","source":"Crossref","is-referenced-by-count":6,"title":["Zona incerta modulation of the inferior olive and the pontine nuclei"],"prefix":"10.1162","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3677-4553","authenticated-orcid":true,"given":"Ramakrishnan","family":"Bhuvanasundaram","sequence":"first","affiliation":[{"name":"Dominick P. 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