{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:43:08Z","timestamp":1785253388869,"version":"3.55.0"},"reference-count":27,"publisher":"Medknow","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["smedj"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>INTRODUCTION Umbilical venous catheters (UVCs), commonly inserted in neonates for vascular access, are not without complications. METHODS A single-centre retrospective cohort study that reviewed complications related to UVC insertion in neonates was conducted in a tertiary neonatal unit in Singapore from January 2016 to July 2017. Ideal UVC position was defined as catheter tip within 0.5 cm above or below the diaphragm. Catheter-related sepsis was defined as clinical or biochemical abnormalities suggesting any new-onset or worsening sepsis 72 hours before or after removal of UVCs, with or without positive culture. Catheter-associated bloodstream infection (CABSI) was defined as positive microbiological growth in one or more blood cultures obtained from a symptomatic infant up to two days after UVC placement or within 48 hours of catheter removal. RESULTS 108 patients had UVC insertions. Mean gestational age and birth weight were 30.4 \u00b1 4.0 weeks and 1,536.2 g \u00b1 788.9 g, respectively. Mean UVC duration was 6.6 days. The UVC was in an ideal position in 27 (25.0%), deep in 13 (12.0%) and short in 35 (32.4%) neonates. One-third of the UVCs (n = 33) were malpositioned. Catheter-related sepsis was observed in 16 (14.8%) neonates, with 5 (4.6%) having CABSI. The most common organism was coagulase-negative Staphylococcus. Other complications include peritoneal extravasation in 3 (2.8%) patients, with two requiring surgical intervention. Venous thrombosis occurred in 2 (1.9%) neonates and was managed conservatively. CONCLUSION Although complication rates were in line with international norms, UVCs were associated with serious complications and should be judiciously used.<\/jats:p>","DOI":"10.11622\/smedj.2019140","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T06:58:28Z","timestamp":1572850708000},"page":"29-33","source":"Crossref","is-referenced-by-count":33,"title":["A review of umbilical venous catheter-related complications at a tertiary neonatal unit in Singapore"],"prefix":"10.4103","volume":"62","author":[{"given":"SSM","family":"Goh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SY","family":"Kan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Bharadwaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WB","family":"Poon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2581","published-online":{"date-parts":[[2021,1]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1097\/00129804-200611000-00005","article-title":"Umbilical catheters, placement, and complication management","volume":"29","author":"Nash","year":"2006","unstructured":"1. Nash P. Umbilical catheters, placement, and complication management. J Infus Nurs 2006; 29:346-52.","journal-title":"J Infus Nurs"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"301","DOI":"10.2307\/30145489","article-title":"Intravascular catheter colonization and related bloodstream infection in critically ill neonates","volume":"11","author":"Cronin","year":"1990","unstructured":"2. Cronin WA, Germanson TP, Donowitz LG. Intravascular catheter colonization and related bloodstream infection in critically ill neonates. Infect Control Hosp Epidemiol 1990; 11:301-8.","journal-title":"Infect Control Hosp Epidemiol"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3. Gordon A, Greenhalgh M, McGuire W. Early planned removal of umbilical venous catheters to prevent infection in newborn infants. Cochrane Database Syst Rev 2017; 10:CD012142.","DOI":"10.1002\/14651858.CD012142.pub2"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1097\/MBC.0b013e328364f9b0","article-title":"Neonatal central venous catheter thrombosis: diagnosis, management and outcome","volume":"25","author":"CK","year":"2014","unstructured":"4. Park CK, Paes BA, Nagel K, Chan AK, Murthy P; Thrombosis and Hemostasis in Newborns (THiN) Group. Neonatal central venous catheter thrombosis: diagnosis, management and outcome. Blood Coagul Fibrinolysis 2014; 25:97-106.","journal-title":"Blood Coagul Fibrinolysis"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1055\/s-0034-1370346","article-title":"Severe liver injury while using umbilical venous catheter: case series and literature review","volume":"31","author":"Grizelj","year":"2014","unstructured":"5. Grizelj R, Vukovic J, Bojanic K, et al. Severe liver injury while using umbilical venous catheter: case series and literature review. Am J Perinatol 2014; 31:965-74.","journal-title":"Am J Perinatol"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"6. Abiramalatha T, Kumar M, Shabeer MP, Thomas N. Advantages of being diligent: lessons learnt from umbilical venous catheterisation in neonates. BMJ Case Rep 2016; pii:bcr2015214073.","DOI":"10.1136\/bcr-2015-214073"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"67","DOI":"10.3233\/NPM-16915060","article-title":"Incorrect umbilical vein catheterization is associated with severe periventricular hemorrhages and mortality in extremely premature newborns","volume":"9","author":"Kurtom","year":"2016","unstructured":"7. Kurtom W, Quast D, Worley L, Oelberg DG. Incorrect umbilical vein catheterization is associated with severe periventricular hemorrhages and mortality in extremely premature newborns. J Neonatal Perinatal Med 2016; 9:67-72.","journal-title":"J Neonatal Perinatal Med"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8. Hollingsworth C, Clarke P, Sharma A, Upton M. National survey of umbilical venous catheterisation practices in the wake of two deaths. Arch Dis Child Fetal Neonatal Ed 2015; 100:F371-2.","DOI":"10.1136\/archdischild-2015-308327"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1542\/peds.2015-2710","article-title":"Risk of infection using peripherally inserted central and umbilical catheters in preterm neonates","volume":"136","author":"Shalabi","year":"2015","unstructured":"9. Shalabi M, Adel M, Yoon E, et al; Canadian Neonatal Network. Risk of infection using peripherally inserted central and umbilical catheters in preterm neonates. Pediatrics 2015; 136:1073-9.","journal-title":"Pediatrics"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1093\/cid\/cir523","article-title":"Defining bloodstream infections related to central venous catheters in patients with cancer: a systematic review","volume":"53","author":"Tomlinson","year":"2011","unstructured":"10. Tomlinson D, Mermel LA, Ethier MC, et al. Defining bloodstream infections related to central venous catheters in patients with cancer: a systematic review. Clin Infect Dis 2011; 53:697-710.","journal-title":"Clin Infect Dis"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1097\/00006454-200206000-00006","article-title":"Variations in central venous catheter-related infection risks among Canadian neonatal intensive care units","volume":"21","author":"LY","year":"2002","unstructured":"11. Chien LY, Macnab Y, Aziz K, et al; Canadian Neonatal Network. Variations in central venous catheter-related infection risks among Canadian neonatal intensive care units. Pediatr Infect Dis J 2002; 21:505-11.","journal-title":"Pediatr Infect Dis J"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1055\/s-0031-1295650","article-title":"Catheter-related infection and pathogens of umbilical venous catheterization in a neonatal intensive care unit in China","volume":"29","author":"Hei","year":"2012","unstructured":"12. Hei MY, Zhang XC, Gao XY, et al. Catheter-related infection and pathogens of umbilical venous catheterization in a neonatal intensive care unit in China. Am J Perinatol 2012; 29:107-14.","journal-title":"Am J Perinatol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1016\/S0022-3468(98)90013-6","article-title":"Central venous catheter bloodstream infections in the neonatal intensive care unit","volume":"33","author":"Fallat","year":"1998","unstructured":"13. Fallat ME, Gallinaro RN, Stover BH, Wilkerson S, Goldsmith LJ. Central venous catheter bloodstream infections in the neonatal intensive care unit. J Pediatr Surg 1998; 33:1383-7.","journal-title":"J Pediatr Surg"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1097\/00006454-200201000-00005","article-title":"Central venous catheter removal versus in situ treatment in neonates with coagulase-negative staphylococcal bacteremia","volume":"21","author":"Karlowicz","year":"2002","unstructured":"14. Karlowicz MG, Furigay PJ, Croitoru DP, Buescher ES. Central venous catheter removal versus in situ treatment in neonates with coagulase-negative staphylococcal bacteremia. Pediatr Infect Dis J 2002; 21:22-7.","journal-title":"Pediatr Infect Dis J"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1111\/1552-6909.12278","article-title":"Comparison of complication rates between umbilical and peripherally inserted central venous catheters in newborns","volume":"43","author":"Arnts","year":"2014","unstructured":"15. Arnts IJ, Bullens LM, Groenewoud JM, Liem KD. Comparison of complication rates between umbilical and peripherally inserted central venous catheters in newborns. J Obstet Gynecol Neonatal Nurs 2014; 43:205-15.","journal-title":"J Obstet Gynecol Neonatal Nurs"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"16. Mutlu M, Aslan Y, Kul S, Y\u0131lmaz G. Umbilical venous catheter complications in newborns: a 6-year single-center experience. J Matern Fetal Neonatal Med 2016; 29:2817-22.","DOI":"10.3109\/14767058.2015.1105952"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1093\/tropej\/fmw099","article-title":"Umbilical venous catheter versus peripherally inserted central catheter in neonates: a randomized controlled trial","volume":"63","author":"Dongara","year":"2017","unstructured":"17. Dongara AR, Patel DV, Nimbalkar SM, Potana N, Nimbalkar AS. Umbilical venous catheter versus peripherally inserted central catheter in neonates: a randomized controlled trial. J Trop Pediatr 2017; 63:374-9.","journal-title":"J Trop Pediatr"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"18. Butler-O'Hara M, Buzzard CJ, Reubens L, et al. A randomized trial comparing long-term and short-term use of umbilical venous catheters in premature infants with birth weights of less than 1251 grams. Pediatrics 2006; 118:e25-35.","DOI":"10.1542\/peds.2005-1880"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"19. Butler-O'Hara M, D'Angio CT, Hoey H, Stevens TP. An evidence-based catheter bundle alters central venous catheter strategy in newborn infants. J Pediatr 2012; 972-7.e2.","DOI":"10.1016\/j.jpeds.2011.12.004"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.jped.2016.05.004","article-title":"Accuracy of chest radiography for positioning of the umbilical venous catheter","volume":"93","author":"Guimar\u00e3es","year":"2017","unstructured":"20. Guimar\u00e3es AF, Souza AA, Bouzada MC, Meira ZM. Accuracy of chest radiography for positioning of the umbilical venous catheter. J Pediatr (Rio J) 2017; 93:172-8.","journal-title":"J Pediatr (Rio J)"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1097\/PCC.0b013e31829f5efa","article-title":"Determination of umbilical venous catheter tip position with radiograph","volume":"15","author":"Hoellering","year":"2014","unstructured":"21. Hoellering AB, Koorts PJ, Cartwright DW, Davies MW. Determination of umbilical venous catheter tip position with radiograph. Pediatr Crit Care Med 2014; 15:56-61.","journal-title":"Pediatr Crit Care Med"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"22. Saboo A, Shama A, Edelman J, Salter C. PC.112: Umbilical venous catheter extravasation: a retrospective study and quality improvement programme. Poster presentation. Arch Dis Child Fetal Neonatal Ed 2014; 99:A75.","DOI":"10.1136\/archdischild-2014-306576.213"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1002\/pbc.21714","article-title":"Risk factors for umbilical venous catheter-associated thrombosis in very low birth weight infants","volume":"52","author":"Narang","year":"2009","unstructured":"23. Narang S, Roy J, Stevens TP, et al. Risk factors for umbilical venous catheter-associated thrombosis in very low birth weight infants. Pediatr Blood Cancer 2009; 52:75-9.","journal-title":"Pediatr Blood Cancer"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1159\/000451022","article-title":"Umbilical venous catheter malposition is associated with necrotizing enterocolitis in premature infants","volume":"111","author":"Sulemanji","year":"2017","unstructured":"24. Sulemanji M, Vakili K, Zurakowski D, et al. Umbilical venous catheter malposition is associated with necrotizing enterocolitis in premature infants. Neonatology 2017; 111:337-43.","journal-title":"Neonatology"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"25. Marshall AS, Jayapal SS, Whitburn JA, Akinbiyi BA, Willetts IE. Recognising serious umbilical cord anomalies. BMJ Case Rep 2013; pii:bcr2013201663.","DOI":"10.1136\/bcr-2013-201663"},{"key":"ref25","unstructured":"26. British Association of Perinatal Medicine. Use of central venous catheters in neonates: a framework for practice. Available at: https:\/\/hubble-live-assets.s3.amazonaws.com\/bapm\/attachment\/file\/17\/BAPM_CVC_final_Jan16__addition_Aug_2018_.pdf. Accessed January 11, 2021."},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"27. Shahid S, Dutta S, Symington A, Shivananda S; McMaster University NICU. Standardizing umbilical catheter usage in preterm infants. Pediatrics 2014; 133:e1742-52.","DOI":"10.1542\/peds.2013-1373"}],"container-title":["Singapore Medical Journal"],"original-title":[],"link":[{"URL":"http:\/\/www.smj.org.sg\/article\/review-umbilical-venous-catheter-related-complications-tertiary-neonatal-unit-singapore","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T05:44:54Z","timestamp":1721972694000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.smj.org.sg\/article\/review-umbilical-venous-catheter-related-complications-tertiary-neonatal-unit-singapore"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1]]},"published-print":{"date-parts":[[2021,1]]}},"URL":"https:\/\/doi.org\/10.11622\/smedj.2019140","relation":{},"ISSN":["0037-5675"],"issn-type":[{"value":"0037-5675","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}