{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T15:24:42Z","timestamp":1776785082136,"version":"3.51.2"},"reference-count":35,"publisher":"Medknow","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["smedj"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>INTRODUCTION Congenital heart disease (CHD) is a leading cause of infant mortality. The aim of this study was to evaluate the efficacy of a neonatal screening programme for CHD before the introduction of pulse oximetry. METHODS This was a retrospective review of live births in the period 2003\u20132012. Cases of CHD were detected through prenatal ultrasonography and\/or postnatal examination, and confirmed using two-dimensional echocardiography. Data was rigorously checked against multiple sources. The antenatal detection rate, sensitivity, specificity, predictive values and likelihood ratios of the screening programme were analysed for all cases of CHD and critical CHD. RESULTS The incidence of CHD was 9.7 per 1,000 live births. The commonest CHD was ventricular septal defect (54.8%). The antenatal detection rate was three times higher in the critical CHD group (64.0%) compared to the group as a whole (21.1%). The sensitivity and specificity of screening was 64.5% and 99.7% for all CHD, and 92.9% and 99.1% for the critical CHD group, respectively. The positive likelihood ratio was 215 and 103, while the negative likelihood ratio was 0.36 and 0.07 for all CHD and critical CHD, respectively. CONCLUSION The CHD screening programme had excellent specificity but limited sensitivity. The high positive likelihood ratios indicate that where sufficient risk factors for CHD are present, a positive result effectively confirms the presence of CHD. The low negative likelihood ratio for critical CHD indicates that, where prior suspicion for critical CHD is low, a negative result is reassuring.<\/jats:p>","DOI":"10.11622\/smedj.2019167","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T04:36:47Z","timestamp":1575952607000},"page":"341-346","source":"Crossref","is-referenced-by-count":5,"title":["Screening for congenital heart disease in a Singapore neonatal unit"],"prefix":"10.4103","author":[{"given":"AJH","family":"Ngeow","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MG","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JTL","family":"Choo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TH","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WC","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DKL","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2581","published-online":{"date-parts":[[2021,7]]},"reference":[{"key":"ref0","unstructured":"1. 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Pediatrics 2011; 128:e1259-67.","DOI":"10.1542\/peds.2011-1317"}],"container-title":["Singapore Medical Journal"],"original-title":[],"link":[{"URL":"http:\/\/www.smj.org.sg\/article\/screening-congenital-heart-disease-singapore-neonatal-unit","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T01:31:46Z","timestamp":1665192706000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.smj.org.sg\/article\/screening-congenital-heart-disease-singapore-neonatal-unit"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":35,"URL":"https:\/\/doi.org\/10.11622\/smedj.2019167","relation":{},"ISSN":["0037-5675"],"issn-type":[{"value":"0037-5675","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]}}}