{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:37:32Z","timestamp":1785213452453,"version":"3.55.0"},"reference-count":60,"publisher":"Medknow","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["smedj"],"published-print":{"date-parts":[[2021,8,31]]},"abstract":"<jats:p>A well-functioning chain of survival is critical for good outcomes following out-of-hospital cardiac arrest, a major public health concern in Singapore. While the percentage of survivors to hospital admission has increased over the years, the percentage of survivors to hospital discharge and the number of patients with good neurological recovery can be greatly improved. This underscores the urgent need to focus on \u2018post-cardiac arrest care\u2019, the fifth link in the chain of survival, to improve the outcomes of patients who are admitted to the intensive care unit (ICU) after return of spontaneous circulation. This review builds on earlier recommendations of the Singapore National Targeted Temperature Management Workgroup in 2017 to provide a focused update on post-cardiac arrest management and a practical guide for physicians managing resuscitated patients with cardiac arrest in the ICU.<\/jats:p>","DOI":"10.11622\/smedj.2021115","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T06:51:40Z","timestamp":1632466300000},"page":"444-451","source":"Crossref","is-referenced-by-count":7,"title":["Beyond return of spontaneous circulation: update on post-cardiac arrest management in the intensive care unit"],"prefix":"10.4103","volume":"62","author":[{"name":"Singapore National Targeted Temperature Management Workgroup","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4635-3333","authenticated-orcid":false,"given":"YW","family":"Chia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1151-2357","authenticated-orcid":false,"given":"SL","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7996-6646","authenticated-orcid":false,"given":"JK","family":"Loh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1403-8993","authenticated-orcid":false,"given":"BSH","family":"Leong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7874-7612","authenticated-orcid":false,"given":"MEH","family":"Ong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2581","reference":[{"key":"ref0","unstructured":"1. Balitsky K, Vorontsova A, Lisnyak I (1991) Tumor Metastasis: Pathogenic Aspects. Kiev: Naukova Dumka."},{"key":"ref1","unstructured":"2. Gershanovich M (1982) Complications during Chemotherapy and Hormone Therapy of Malignant Tumors. Moskow: Medicine."},{"key":"ref2","unstructured":"3. Andreenko G (1979) Fibrinolysis. Moscow: State University Publishing House."},{"key":"ref3","unstructured":"4. Zubairov DM (1978) Biochemistry of Blood Coagulation. Moscow: Medicine."},{"key":"ref4","unstructured":"5. Chazov EI, Lakin KM (1977) Anticoagulants and Fibrinolytic Agents. Moscow: Medicine."},{"key":"ref5","unstructured":"6. Gaffney PJ, Balkuv-Ulyutina S (Eds.) (1982) Fibrinolysis: Modern Fundamental and Clinical Concepts. Moscow: Medicine"},{"key":"ref6","unstructured":"7. Gavrilov OK (Eds.) (1981) Problems and Hypotheses in the Studies of Blood Coagulation. Moscow: Medicine."},{"key":"ref7","unstructured":"8. Wolf M, Ransberger K (1976) Enzyme Therapy. Moscow: Mir."},{"key":"ref8","unstructured":"9. Nadiradze ISh (2000) Machabeli Syndrome in Oncology. Tbilisi: Chronograph."},{"key":"ref9","unstructured":"10. Nadiradze IS (1982) Intravascular Blood Coagulation in Patients with Malignant Neoplasms. Surgery 131-134."},{"key":"ref10","unstructured":"11. Potapov VM (1976) Stereochemistry. Moscow: Chemistry."},{"key":"ref11","unstructured":"12. Pomogailo AD, Uflyand IE (1991) Macromolecular Metal Chelates. Moscow: Chemistry."},{"key":"ref12","unstructured":"13. Mokrushin VS, Vavilov GA (2018) Fundamentals of Chemistry and Technology of Bioorganic and Synthetic Drugs. St. Petersburg, Science Avenue."},{"key":"ref13","unstructured":"14. Tyukavkina NA, Baukov YuI (1991) Bioorganic Chemistry. Moscow: Medicine."},{"key":"ref14","unstructured":"15. Albert A (1989) Selective Toxicity. The Physico-Chemical Bases of Therapy (Vols.1-2). Moscow: Medicine."},{"key":"ref15","unstructured":"16. Vardanyan RS (2004) Synthesis of Essential Drugs. Moscow: Medical Information Agency."},{"key":"ref16","unstructured":"17. Shelley K, Eckhardt Sh, Nemeth L (1975) Medicinal Treatment of Tumor Diseases. Budapest: Publishing House of the Hungarian Academy of Sciences."},{"key":"ref17","unstructured":"18. Nikolaev AYa (1989) Biological Chemistry. Moscow: Higher School."},{"key":"ref18","unstructured":"19. Ovchinnikov YuA (1987) Bioorganic Chemistry. Moscow: Education."},{"key":"ref19","unstructured":"20. Mashkovsky MD (2005) Drugs. (15 ed.) Moscow: New Wave."},{"key":"ref20","unstructured":"21. McAuliffe C (Eds.) (1978) Techniques and Topics in Bioinorganic Chemistry. Moscow: Mir."},{"key":"ref21","unstructured":"22. Yatsimirsky KB (Eds.) (1979) Biological Aspects of Coordination Chemistry. Kiev: Naukova Dumka."},{"key":"ref22","unstructured":"23. Hughes M (1983) The Inorganic Chemistry of Biological Processes. Moscow: Mir."},{"key":"ref23","unstructured":"24. Boldyrev AA (1986) Biological Membranes and Ion Transport. Moscow: Science"},{"key":"ref24","unstructured":"25. Basolo F, Johnson R (1996) Coordination Chemistry. Moscow: Mir."},{"key":"ref25","unstructured":"26. Dyatlova NM, Temkina VYa, Popov KI (1988) Complexones and Complexonates of Metals. Moscow: Chemistry."},{"key":"ref26","unstructured":"27. Corbridge D (1982) Phosphorus: Chemistry, Biochemistry and Technology. Moscow: Mir. Griffith, E., Biton, A., Spenser, J., & Mitchell, D.(Eds). (1977) Fosfor v okruzhayushchei srede (Phosphorus in Environment). Moscow: Mir."},{"key":"ref27","unstructured":"28. Los K (1963) Synthetic Poisons. Moscow: Foreign Languages Publishing House."},{"key":"ref28","unstructured":"29. Granik VG (2001) Fundamentals of Medicinal Chemistry. Moscow: University Book."},{"key":"ref29","unstructured":"30. Spitsyna VI, Martynenko LI (Eds.) (1979) Coordination Chemistry of Rare Earth Elements. Moscow: Moscow State University."},{"key":"ref30","unstructured":"31. Ryles A, Smith K, Ward R (1983) Essential Organic Chemistry. Moscow: Mir."},{"key":"ref31","unstructured":"32. Tsivtsivadze T, Machkhoshvili R, Chigogidze N, Kldiashvili R, Skhiladze R, et al. (2012) Synthesis, Structure and Properties of Anti-Cancer Biocompatible Compounds with Plant Alkaloids. Proceedings of the Academy of Sciences of Georgia. Chemical series. 38: 317-324."},{"key":"ref32","unstructured":"33. Chigogidze N, Japaridze R (2015) Synthesis of New, Promising Compounds for Chemotherapy of Oncological Diseases. International Scientific-Practical Conference, Innovative Technologies for the Production of Functional Use Food Products. Kutaisi."},{"key":"ref33","unstructured":"34. Chigogidze NSh, Tsivtsivadze TI, Nadiradze ISh, Kldiashvili RSh, Petriashvili ZhD, et al. (2016) Antitumor Activity of Copper Complexes with Clotrimazole as a Result of the Formation of a Specific pentacoordinated structure. Georgian Engineering News. 77."},{"key":"ref34","unstructured":"35. Chigogidze NSh, Tsivtsivadze TI, Nadiradze ISh, Petriashvili ZhD, Japaridze RJ (2016) Influence of Specific Conformational Structure on Enhancing the Cytotoxic Activity of Clotrimazole Biocomplexes. Georgian Engineering News 78: 112-119."},{"key":"ref35","unstructured":"36. Tsivtsivadze T, Petriashvili Zh, Japaridze R, Chigogidze N, Kldiashvili R (2017) Complexes of Some Biometals with the Antifungal Medication Clotrimazole. Tbilisi: GTU."},{"key":"ref36","unstructured":"37. Chigogidze NSh, Petriashvili JD, Japaridze RJ (2015) Searching and synthesis of new chelating derivatives of the thiourea as antitumor remedies. 3Rd International conference on Pharmaceutical sciences. Looking towards the future, honoring the past. Tbilisi, Georgia."},{"key":"ref37","unstructured":"38. Nadiradze I, Chigogidze N (2019) Georgia Patent No. P2019 7005B."},{"key":"ref38","unstructured":"39. Nadiradze I, Chigogidze N (2019) Negative Multi-charged Long-chain Organic Ions as Inhibitors of Metastasis in Cancer Therapy. Certificate of Deposit 6811."},{"key":"ref39","unstructured":"40. Nadiradze Ish, Chigogidze NSh (2019) Amphicezin - in principle new inhibitor of malignant tumors metastasis. International Clinical Conference, Modern Approaches of diagnostics and Treatment. Batumi, Georgia."},{"key":"ref40","unstructured":"41. Nadiradze I, Chigogidze N (2016) Development of a New Class of Metastasis Inhibitors for Chemotherapy of Oncological Patients. Karozi 30-32."},{"key":"ref41","unstructured":"42. Nadiradze I, Chigogidze N (2015) Real Prospects for Cancer Defeat. Karozi 26-28."},{"key":"ref42","unstructured":"43. Chigogidze N (2019) Properties of Tumor Cells and a New Approach to Chemotherapy of Tumors. Ojakhis Mkurnali 32-35."},{"key":"ref43","unstructured":"44. Nadiradze I, Chigogidze N (2019) An Essentially New Inhibitor of Postoperative Malignancy of Malignant Tumors. Ojakhis Mkurnali. 8-12."},{"key":"ref44","unstructured":"45. Siegel HM (Eds) (1982) Metal Ions in Biological Systems. Moscow: Mir."},{"key":"ref45","unstructured":"46. Williams D (1975) The Metals of Life. Moscow: Mir."},{"key":"ref46","unstructured":"47. Ripan R, Chetyanu I (1971) Inorganic Chemistry. Moscow: Mir 1."},{"key":"ref47","unstructured":"48. Adamson AW (1979) Physical Chemistry of Surfaces. Moscow: Mir."},{"key":"ref48","unstructured":"49. Friedrichsberg DA (1984) Course of Colloid Chemistry course. Leningrad: Chemistry."},{"key":"ref49","unstructured":"50. Goodman M, Morehouse F (1977) Organic Molecules in Action. Moscow: Mir."},{"key":"ref50","unstructured":"51. Hauptmann S, Grefe Yu, Remane X (1979) Organic Chemistry. Moscow: Chemistry."},{"key":"ref51","unstructured":"52. Nesmeyanov AN, Nesmeyanov NA (1969) Beginnings of Organic Chemistry. Moscow: Chemistry 1."},{"key":"ref52","unstructured":"53. Nesmeyanov AN, Nesmeyanov NA (1970) Beginnings of Organic Chemistry. Moscow: Chemistry 2."},{"key":"ref53","unstructured":"54. Charlot G (1969) Methods of Analytical Chemistry. Part Two. Quantitative Analysis of Inorganic Compounds. Moscow: Chemistry."},{"key":"ref54","unstructured":"55. Poludek-Fabini R, Beirich T (1981) Organic Analysis. Leningrad: Chemistry."},{"key":"ref55","unstructured":"56. Gorelov IP (Eds.) (1984) Chemistry of Surfactants and Chelators. Kalinin: KSU."},{"key":"ref56","unstructured":"57. Fayngold S, Kuusk A, Kiik H (1984) Chemistry of Anionic and Amphoteric Nitrogen-containing Surfactants. Tallinn: Valgus."},{"key":"ref57","unstructured":"58. Abramzon AA (1981) Surfactants. Leningrad: Chemistry."},{"key":"ref58","unstructured":"59. Abramzon AA, Zaychenko LP, Fayngold SI (1988) Surfactants. Leningrad: Chemistry."},{"key":"ref59","unstructured":"60. Abramzon AA, Shchukin ED (Eds.) (1984) Surface Phenomena and Surfactants. Book of Reference. Leningrad: Chemistry."}],"container-title":["Singapore Medical Journal"],"original-title":[],"link":[{"URL":"http:\/\/www.smj.org.sg\/article\/beyond-return-spontaneous-circulation-update-post-cardiac-arrest-management-intensive-care","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T10:52:58Z","timestamp":1660042378000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.smj.org.sg\/article\/beyond-return-spontaneous-circulation-update-post-cardiac-arrest-management-intensive-care"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,31]]},"references-count":60,"journal-issue":{"issue":"08","published-print":{"date-parts":[[2021,8,31]]}},"URL":"https:\/\/doi.org\/10.11622\/smedj.2021115","relation":{},"ISSN":["0037-5675","2737-5935"],"issn-type":[{"value":"0037-5675","type":"print"},{"value":"2737-5935","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,31]]}}}