{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:28:32Z","timestamp":1787758112536,"version":"build-2784847793"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>\n                      Microinvasion (Mi) is often thought to be an interim stage between ductal carcinoma\n                      <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                      (DCIS) and invasive ductal carcinoma. This study aimed to investigate the potential influence of Mi on survival and assess its correlations with clinicopathological parameters, prognosis and molecular markers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The number of Mi foci in a cohort of 66 DCIS-Mi cases was assessed from haematoxylin and eosin\u2013stained sections. Disease-free survival, clinicopathological parameters and biomarker expression were correlated with the number of Mi foci.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Higher numbers of Mi foci were found in larger tumours (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.031).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Greater extent of DCIS is associated with multifocal Mi.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.11622\/smedj.2022089","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T05:07:12Z","timestamp":1658120832000},"page":"493-496","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["More microinvasive foci in larger tumours of breast ductal carcinoma in situ"],"prefix":"10.4103","volume":"64","author":[{"given":"Xiao-Yang","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Pathology, Singapore General Hospital, Singapore"},{"name":"Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aye Aye","family":"Thike","sequence":"additional","affiliation":[{"name":"Duke-NUS Medical School, Singapore"},{"name":"Department of Anatomical Pathology, Singapore General Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnathan Xiande","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Pathology, Singapore General Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boon Huat","family":"Bay","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puay Hoon","family":"Tan","sequence":"additional","affiliation":[{"name":"Division of Pathology, Singapore General Hospital, Singapore"},{"name":"Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"},{"name":"Duke-NUS Medical School, Singapore"},{"name":"Department of Anatomical Pathology, Singapore General Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,7,18]]},"reference":[{"key":"R1-20240829","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s10549-015-3472-6","article-title":"Characteristics and behaviour of screen-detected ductal carcinoma in situ of the breast:Comparison with symptomatic patients","volume":"152","author":"Koh","year":"2015","journal-title":"Breast Cancer Res Treat"},{"key":"R3-20240829","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10549-019-05272-2","article-title":"Prognostic role of immune infiltrates in breast ductal carcinoma in situ","volume":"177","author":"Chen","year":"2019","journal-title":"Breast Cancer Res Treat"},{"key":"R4-20240829","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.molonc.2013.07.005","article-title":"Progression from ductal carcinoma in situ to invasive breast cancer:Revisited","volume":"7","author":"Cowell","year":"2013","journal-title":"Mol Oncol"},{"key":"R6-20240829","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0002-9610(03)00166-1","article-title":"Ductal carcinoma in situ with microinvasion","volume":"186","author":"Adamovich","year":"2003","journal-title":"Am J Surg"},{"key":"R7-20240829","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1016\/j.humpath.2013.07.010","article-title":"Microinvasive breast carcinoma carries an excellent prognosis regardless of the tumor characteristics","volume":"44","author":"Shatat","year":"2013","journal-title":"Hum Pathol"},{"key":"R8-20240829","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1002\/cncr.10451","article-title":"Breast ductal carcinoma in situ with microinvasion:A definition supported by a long-term study of 1248 serially sectioned ductal carcinomas","volume":"94","author":"de Mascarel","year":"2002","journal-title":"Cancer"},{"key":"R9-20240829","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ejrad.2008.09.037","article-title":"Microinvasive ductal carcinoma in situ:Clinical presentation, imaging features, pathologic findings, and outcome","volume":"73","author":"Vieira","year":"2010","journal-title":"Eur J Radiol"},{"key":"R10-20240829","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.prp.2006.01.001","article-title":"Ductal carcinoma in situ with microinvasion:Clinicopathologic study and biopathologic profile","volume":"202","author":"Cavaliere","year":"2006","journal-title":"Pathol Res Pract"},{"key":"R11-20240829","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1245\/s10434-012-2640-8","article-title":"Microinvasive breast cancer:ER, PR, and HER-2\/neu status and clinical outcomes after breast-conserving therapy or mastectomy","volume":"20","author":"Margalit","year":"2013","journal-title":"Ann Surg Oncol"},{"key":"R12-20240829","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ijrobp.2010.08.027","article-title":"Ductal carcinoma in situ with microinvasion:Prognostic implications, long-term outcomes, and role of axillary evaluation","volume":"82","author":"Parikh","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R13-20240829","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s00428-020-02959-6","article-title":"Breast ductal carcinoma in situ associated with microinvasion induces immunological response and predicts ipsilateral invasive recurrence","volume":"478","author":"Chen","year":"2021","journal-title":"Virchows Arch"},{"key":"R14-20240829","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1200\/JCO.19.02309","article-title":"Estrogen and progesterone receptor testing in breast cancer:ASCO\/CAP guideline update","volume":"38","author":"Allison","year":"2020","journal-title":"J Clin Oncol"},{"key":"R15-20240829","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1200\/JCO.2018.77.8738","article-title":"Human epidermal growth factor receptor 2 testing in breast cancer:American Society of Clinical Oncology\/College of American Pathologists clinical practice guideline focused update","volume":"36","author":"Wolff","year":"2018","journal-title":"J Clin Oncol"},{"key":"R16-20240829","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/sj.bjc.6605718","article-title":"A new pathological system for grading DCIS with improved prediction of local recurrence:Results from the UKCCCR\/ANZ DCIS trial","volume":"103","author":"Pinder","year":"2010","journal-title":"Br J Cancer"},{"key":"R17-20240829","doi-asserted-by":"crossref","first-page":"e13055","DOI":"10.1097\/MD.0000000000013055","article-title":"Expression of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, and Ki-67 in ductal carcinoma in situ (DCIS) and DCIS with microinvasion","volume":"97","author":"Wan","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"R18-20240829","doi-asserted-by":"crossref","first-page":"197","DOI":"10.4048\/jbc.2018.21.2.197","article-title":"Microinvasive carcinoma versus ductal carcinoma in situ:A comparison of clinicopathological features and clinical outcomes","volume":"21","author":"Kim","year":"2018","journal-title":"J Breast Cancer"},{"key":"R19-20240829","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/bjc.1984.112","article-title":"Breast cancer:Relationship between the size of the primary tumour and the probability of metastatic dissemination","volume":"49","author":"Koscielny","year":"1984","journal-title":"Br J Cancer"},{"key":"R20-20240829","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1080\/028418699431357","article-title":"The rationale for early diagnosis of cancer--the example of breast cancer","volume":"38","author":"Tubiana","year":"1999","journal-title":"Acta Oncol"}],"container-title":["Singapore Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.11622\/smedj.2022089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:04:52Z","timestamp":1787756692000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.11622\/smedj.2022089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,18]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.11622\/smedj.2022089","relation":{},"ISSN":["0037-5675","2737-5935"],"issn-type":[{"value":"0037-5675","type":"print"},{"value":"2737-5935","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,18]]},"assertion":[{"value":"2020-10-22","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-09","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}