{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:30:46Z","timestamp":1790865046292,"version":"4.1.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1-3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2005,8]]},"DOI":"10.1163\/156856005774423890","type":"journal-article","created":{"date-parts":[[2005,10,7]],"date-time":"2005-10-07T22:33:54Z","timestamp":1128724434000},"page":"91-101","source":"Crossref","is-referenced-by-count":31,"title":["Polyamines regulate expression of E-cadherin and play an important role in control of intestinal epithelial barrier function"],"prefix":"10.1007","volume":"13","author":[{"given":"Jian-Ying","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"77442389_CR1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/(SICI)1097-4644(20000701)78:1<85::AID-JCB8>3.0.CO;2-F","volume":"78","author":"M. S. Balda","year":"2000","unstructured":"Balda, M. S., Flores-Maldonado, C., Cereijido, M., et al. (2000). Multiple domains of occludin are involved in the regulation of paracellular permeability, J. Cell Biochem. 78, 85\u201396.","journal-title":"J. Cell Biochem."},{"key":"77442389_CR2","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1242\/jcs.112.12.1879","volume":"112","author":"S. D. Bamforth","year":"1999","unstructured":"Bamforth, S. D., Kniesel, U., Wolburg, H., et al. (1999). A dominant mutant of occludin disrupts tight junction structure and function, J. Cell Sci. 112, 1879\u20131888.","journal-title":"J. Cell Sci."},{"key":"77442389_CR3","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.1128\/MCB.18.7.3647","volume":"18","author":"E. Batsche","year":"1998","unstructured":"Batsche, E., Muchardt, C., Behrens, J., et al. (1998). RB and c-Myc activate expression of the E-cadherin gene in epithelial cells through interaction with transcription factor AP-2, Mol. Cell Biol. 18, 3647\u20133658.","journal-title":"Mol. Cell Biol."},{"key":"77442389_CR4","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1146\/annurev.physiol.60.1.161","volume":"60","author":"M. Cereijido","year":"1998","unstructured":"Cereijido, M., Valdes, J., Shoshani, L., et al. (1998). Role of tight junctions in establishing and maintaining cell polarity, Annu. Rev. Physiol. 60, 161\u2013177.","journal-title":"Annu. Rev. Physiol."},{"key":"77442389_CR5","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1681\/ASN.V1061337","volume":"10","author":"A. S. Fanning","year":"1999","unstructured":"Fanning, A. S., Mitic, L. L. and Anderson, J. M. (1999). Transmembrane proteins in the tight junction barrier, J. Am. Soc. Nephrol. 10, 1337\u20131345.","journal-title":"J. Am. Soc. Nephrol."},{"key":"77442389_CR6","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/nrc1454","volume":"4","author":"E. W. Gerner","year":"2004","unstructured":"Gerner, E. W. and Meyskens, F. L. (2004). Polyamines and cancer: old molecules, new understanding, Nature Rev. 4, 781\u2013792.","journal-title":"Nature Rev."},{"key":"77442389_CR7","doi-asserted-by":"crossref","first-page":"C722","DOI":"10.1152\/ajpcell.00054.2002","volume":"283","author":"X. Guo","year":"2002","unstructured":"Guo, X., Rao, J. N., Liu, L., et al. (2002). Polyamines regulate beta-catenin tyrosine phosphorylation via Ca2+ during intestinal epithelial cell migration, Am. J. Physiol. 283, C722\u2013C734.","journal-title":"Am. J. Physiol."},{"key":"77442389_CR8","doi-asserted-by":"crossref","first-page":"C1174","DOI":"10.1152\/ajpcell.00015.2003","volume":"285","author":"X. Guo","year":"2003","unstructured":"Guo, X., Rao, J. N., Liu, L., et al. (2003). Regulation of adherens junctions and epithelial paracellular permeability: a novel function for polyamines, Am. J. Physiol. 285, C1174\u2013C1187.","journal-title":"Am. J. Physiol."},{"key":"77442389_CR9","first-page":"A35","volume":"126","author":"X. Guo","year":"2004","unstructured":"Guo, X., Liu, L., Rao, J. N., Zou, T., et al. (2004a). Polyamines induce expression of the E-cadherin gene via c-Myc and enhance epithelial barrier function, Gastroenterology 126, A35.","journal-title":"Gastroenterology"},{"key":"77442389_CR10","first-page":"A710","volume":"18","author":"X. Guo","year":"2004","unstructured":"Guo, X., Rao, J. N., Liu, L., et al. (2004b). Involvement of cellular polyamines regulation of occludin expression and intestinal epithelial barrier function, FASEB J. 18, A710.","journal-title":"FASEB J."},{"key":"77442389_CR11","first-page":"G992","volume":"280","author":"L. Li","year":"2001","unstructured":"Li, L., Rao, J. N., Bass B. L., et al. (2001a). NF-\u03baB activation and susceptibility to apoptosis following polyamine depletion in intestinal epithelial cells, Am. J. Physiol. 280, G992\u2013G1004.","journal-title":"Am. J. Physiol."},{"key":"77442389_CR12","doi-asserted-by":"crossref","first-page":"C941","DOI":"10.1152\/ajpcell.2001.281.3.C941","volume":"281","author":"L. Li","year":"2001","unstructured":"Li, L., Rao, J. N., Guo, X., Liu, L., et al. (2001b). Polyamine depletion stabilizes p53 resulting in inhibition of normal intestinal epithelial cell proliferation, Am. J. Physiol. 281, C941\u2013C953.","journal-title":"Am. J. Physiol."},{"key":"77442389_CR13","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1053\/gast.2002.35386","volume":"123","author":"L. Li","year":"2002","unstructured":"Li, L., Liu, L., Rao, J. N., et al. (2002). JunD stabilization results in inhibition of normal intestinal epithelial cell growth through p21 after polyamine depletion, Gastroenterology 123, 764\u2013779.","journal-title":"Gastroenterology"},{"key":"77442389_CR14","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1242\/jcs.113.13.2363","volume":"113","author":"Y. Liu","year":"2000","unstructured":"Liu, Y., Nusrat, A., Schnell, F. J., et al. (2000). Human junction adhesion molecule regulates tight junction resealing in epithelia, J. Cell Sci. 113, 2363\u20132374.","journal-title":"J. Cell Sci."},{"key":"77442389_CR15","doi-asserted-by":"crossref","first-page":"C89","DOI":"10.1152\/ajpcell.00326.2004","volume":"288","author":"L. Liu","year":"2005","unstructured":"Liu, L., Li, L., Rao, N. J., Zou, T. T., et al. (2005). Polyamine-modulated expression of c-Myc plays a critical role in stimulation of normal intestinal epithelial cell proliferation, Am. J. Physiol. 288, C89\u2013C99.","journal-title":"Am. J. Physiol."},{"key":"77442389_CR16","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1126\/science.6774420","volume":"210","author":"G. D. Luk","year":"1980","unstructured":"Luk, G. D., Marton, L. J. and Baylin S. B. (1980). Ornithine decarboxylase is important in intestinal mucosal maturation and recovery from injury in rats, Science 210, 195\u2013198.","journal-title":"Science"},{"key":"77442389_CR17","first-page":"G795","volume":"260","author":"S. A. McCormack","year":"1991","unstructured":"McCormack, S. A. and Johnson, L. R. (1991). Role of polyamines in gastrointestinal mucosal growth, Am. J. Physiol. 260, G795\u2013G806.","journal-title":"Am. J. Physiol."},{"key":"77442389_CR18","doi-asserted-by":"crossref","first-page":"C1020","DOI":"10.1152\/ajpcell.1997.273.3.C1020","volume":"273","author":"A. R. Patel","year":"1997","unstructured":"Patel, A. R. and Wang, J. Y. (1997). Polyamines modulate transcription but not posttranscription of c-myc and c-jun in IEC-6 cells, Am. J. Physiol. 273, C1020\u2013C1029.","journal-title":"Am. J. Physiol."},{"key":"77442389_CR19","doi-asserted-by":"crossref","first-page":"G1149","DOI":"10.1152\/ajpcell.1999.277.6.C1149","volume":"277","author":"J. N. Rao","year":"1999","unstructured":"Rao, J. N., Li, J., Li, L., et al. (1999). Differentiated intestinal epithelial cells exhibit increased migration through polyamines and myosin II, Am. J. Physiol. 277, G1149\u2013G1158.","journal-title":"Am. J. Physiol."},{"key":"77442389_CR20","doi-asserted-by":"crossref","first-page":"C993","DOI":"10.1152\/ajpcell.2001.280.4.C993","volume":"280","author":"J. N. Rao","year":"2001","unstructured":"Rao, J. N., Li, L, Golovina, V. A., et al. (2001). Ca2+-RhoA signaling pathway required for polyamine-dependent intestinal epithelial cell migration, Am. J. Physiol. 280, C993\u2013C1007.","journal-title":"Am. J. Physiol."},{"key":"77442389_CR21","doi-asserted-by":"crossref","first-page":"C885","DOI":"10.1152\/ajpcell.00361.2001","volume":"282","author":"J. N. Rao","year":"2002","unstructured":"Rao, J. N., Platoshyn, O., Li, L., et al. (2002a). Activation of K+ channels and increased migration of differentiated intestinal epithelial cells after wounding, Am. J. Physiol. 282, C885\u2013C898.","journal-title":"Am. J. Physiol."},{"key":"77442389_CR22","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1042\/bj20011804","volume":"368","author":"R. K. Rao","year":"2002","unstructured":"Rao, R. K., Basuroy, S., Rao, V. U., et al. (2002b). Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-beta-catenin complexes from the cytoskeleton by oxidative stress, Biochem. J. 368, 471\u2013481.","journal-title":"Biochem. J."},{"key":"77442389_CR23","doi-asserted-by":"crossref","first-page":"C480","DOI":"10.1152\/ajpcell.2000.278.3.C480","volume":"278","author":"R. M. Ray","year":"2000","unstructured":"Ray, R. M., Viar, M. J., Yuan, Q., et al. (2000). Polyamine depletion delays apoptosis of rat intestinal epithelial cells, Am. J. Physiol. 278, C480\u2013C489.","journal-title":"Am. J. Physiol."},{"key":"77442389_CR24","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00232-001-0182-2","volume":"188","author":"B. Rothen-Rutishauser","year":"2002","unstructured":"Rothen-Rutishauser, B., Riesen, F. K., Braun, A., et al. (2002). Dynamics of tight and adherens junctions under EGTA treatment, J. Membr. Biol. 188, 151\u2013162.","journal-title":"J. Membr. Biol."},{"key":"77442389_CR25","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1083\/jcb.137.6.1393","volume":"137","author":"A. Sakakibara","year":"1997","unstructured":"Sakakibara, A., Furuse, M., Saitou, M., et al. (1997). Possible involvement of phosphorylation of occludin in tight junction formation, J. Cell Biol. 137, 1393\u20131401.","journal-title":"J. Cell Biol."},{"key":"77442389_CR26","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1146\/annurev.bi.53.070184.003533","volume":"53","author":"C. W. Tabor","year":"1984","unstructured":"Tabor, C. W. and Tabor, H. (1984). Polyamines, Annu. Rev. Biochem. 53, 749\u2013790.","journal-title":"Annu. Rev. Biochem."},{"key":"77442389_CR27","first-page":"G584","volume":"259","author":"J. Y. Wang","year":"1990","unstructured":"Wang, J. Y. and Johnson, L. R. (1990). Luminal polyamines stimulate repair of gastric mucosal stress ulcers, Am. J. Physiol. 259, G584\u2013G592.","journal-title":"Am. J. Physiol."},{"key":"77442389_CR28","first-page":"G331","volume":"265","author":"J. Y. Wang","year":"1993","unstructured":"Wang, J. Y., McCormack, S. A., Viar, M. J., et al. (1993). Decreased expression of protooncogenes c-fos, c-myc, and c-jun following polyamine depletion in IEC-6 cells, Am. J. Physiol. 265, G331\u2013G338.","journal-title":"Am. J. Physiol."},{"key":"77442389_CR29","doi-asserted-by":"crossref","first-page":"C303","DOI":"10.1152\/ajpcell.2000.278.2.C303","volume":"278","author":"J. Y. Wang","year":"2000","unstructured":"Wang, J. Y., Wang, J., Golovina, V. A., et al. (2000). Role of K+ channel expression in polyamine-dependent intestinal epithelial cell migration, Am. J. Physiol. 278, C303\u2013C314.","journal-title":"Am. J. Physiol."},{"key":"77442389_CR30","first-page":"G1279","volume":"276","author":"A. Youakim","year":"1999","unstructured":"Youakim, A. and Ahdieh, M. (1999). Interferon-gamma decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin, Am. J. Physiol. 276, G1279\u2013G1288.","journal-title":"Am. J. Physiol."},{"key":"77442389_CR31","doi-asserted-by":"crossref","first-page":"22539","DOI":"10.1074\/jbc.M314337200","volume":"279","author":"H. F. Zhang","year":"2004","unstructured":"Zhang, H. F., Rao, J. N., Guo, X., et al. (2004). Akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletion, J. Biol. Chem. 279, 22539\u201322547.","journal-title":"J. Biol. Chem."}],"container-title":["InflammoPharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.springerlink.com\/index\/pdf\/10.1163\/156856005774423890","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T12:59:36Z","timestamp":1626613176000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1163\/156856005774423890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":31,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["77442389"],"URL":"https:\/\/doi.org\/10.1163\/156856005774423890","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8]]}}}