{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:20:03Z","timestamp":1790266803231,"version":"4.1.0"},"reference-count":28,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Benef. Microbes"],"published-print":{"date-parts":[[2023,11,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The development of probiotics has now included the areas along the gut-vaginal axis. We thus aimed to investigate the effects of lactobacilli probiotic to modulate and restore vaginal and gut microbiota of pregnant women with vaginal candidiasis (VC). A\u00a0randomised, double-blind and placebo-controlled study was performed in 78 pregnant women with VC. Patients were randomised to either the probiotic (SynForU-HerCare) or placebo which were administered at baseline and continued for 8-weeks (two capsules\/day of 9.5 log cfu\/capsule). Microbiota profiles were assessed at time points of weeks-0, 4 and 8 for high vaginal swab and faecal samples. Shannon diversity index showed that after 8-weeks amid VC, a shift in microbial community compositional changes occurred in the high vaginal region at both genus (\n                    <jats:inline-formula\/>\n                    ) and species (\n                    <jats:inline-formula\/>\n                    ) levels, where the administration of probiotic prevented such a shift. These changes were mainly attributed to a decreased in abundance of\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    (\n                    <jats:inline-formula\/>\n                    ) accompanied by increased abundance of\n                    <jats:italic>Prevotella<\/jats:italic>\n                    (\n                    <jats:inline-formula\/>\n                    ) and\n                    <jats:italic>Atopobium<\/jats:italic>\n                    (\n                    <jats:inline-formula\/>\n                    ) in the placebo group while the probiotic group remained unchanged over time. The administration of probiotics also prevented a reduced abundance of faecal phylum\n                    <jats:italic>Firmicutes<\/jats:italic>\n                    after 8-weeks as seen in the placebo group (\n                    <jats:inline-formula\/>\n                    ), which also showed reduction at subsequent taxonomic levels of class, family, genera and species. VC has not only altered the microbiota of vagina regions but also gut microbiota profiles, causing lessening of gut microbiota that are crucial for gut nutrient availability, protection and immunity. The administration of lactobacilli probiotics has prevented such a shift, leading to better modulated gut and vaginal microenvironment amid VC.\n                  <\/jats:p>\n                  <jats:p>The study was registered at ClinicalTrials.gov: identifier number NCT03940612<\/jats:p>","DOI":"10.1163\/18762891-20220103","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T09:34:25Z","timestamp":1700645665000},"page":"421-431","source":"Crossref","is-referenced-by-count":20,"title":["Lactobacillus probiotics restore vaginal and gut microbiota of pregnant women with vaginal candidiasis"],"prefix":"10.1163","volume":"14","author":[{"given":"X.-Y.","family":"Ang","sequence":"first","affiliation":[{"name":"School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.S.","family":"Roslan","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Universiti Sains Malaysia, 16150 Kelantan, Malaysia"},{"name":"Hospital Universiti Sains Malaysia (HUSM), Health Campus, 16150 Kelantan, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Kota Bharu Health Clinic, Ministry of Health Malaysia, 15200 Kelantan, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.Mo.","family":"Yusof","sequence":"additional","affiliation":[{"name":"Kubang Kerian Health Clinic, Ministry of Health Malaysia, 16150 Kelantan, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Abdullah","sequence":"additional","affiliation":[{"name":"Pengkalan Chepa Health Clinic, Ministry of Health Malaysia, 16100 Kelantan, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.N.","family":"Nik Ab Rahman","sequence":"additional","affiliation":[{"name":"Wakaf Che Yeh Health Clinic, Ministry of Health Malaysia, 15100 Kelantan, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-J.","family":"Woon","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.S.-J.","family":"Teh","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.D.","family":"Todorov","sequence":"additional","affiliation":[{"name":"ProBacLab, Department of Food Science and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, 05508-090, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Liu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100864, China P.R."},{"name":"CAS-TWAS Centre of Excellence for Biotechnology, Beijing 100101, China P.R."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4471-8271","authenticated-orcid":true,"given":"M.-T.","family":"Liong","sequence":"additional","affiliation":[{"name":"School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia"},{"name":"Renewable Biomass Transformation Cluster, School of Industrial Technology, Universiti Sains Malaysia, Penang 11800, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"R000001","series-title":"Journal of Applied Microbiology","first-page":"3168","article-title":"Lactobacilli reduce recurrences of vaginal candidiasis in pregnant women: a randomized, double-blind, placebo-controlled study","volume":"132","author":"Ang, X.Y.","unstructured":"Ang, X.Y., Chung, F.Y.L., Lee, B.K., Azhar, S.N.A., Sany, S., Roslan, N.S., Ahmad, N., Yusof, S.M., Abdullah, N., Nik Ab Rahman, N.N., Abdul Wahid, N., Deris, Z.Z., Oon, C.E., Wan Adnan, W.F. and Liong, M.T., 2021. Lactobacilli reduce recurrences of vaginal candidiasis in pregnant women: a randomized, double-blind, placebo-controlled study. Journal of Applied Microbiology132: 3168-3180."},{"key":"R000002","series-title":"Microorganisms","article-title":"Probiotics reduce vaginal candidiasis in pregnant women via modulating abundance of Candida and Lactobacillus in vaginal and cervicovaginal regions","volume":"10","author":"Ang, X.Y.","unstructured":"Ang, X.Y., Mageswaran, U.M., Chung, Y.L.F., Lee, B.K., Azhar, S.N.A., Roslan, N.S., Saufian, I.F., Mustaffa, N.S., Kalam, E.M., Ibrahim, A.F., Abdul Wahid, N., Deris, Z.Z., Oon, C.E., Wan Adnan, W.F., Sany, S. and Liong, M.T., 2022. Probiotics reduce vaginal candidiasis in pregnant women via modulating abundance of Candida and Lactobacillus in vaginal and cervicovaginal regions. Microorganisms10: 285."},{"key":"R000003","series-title":"mSystems","article-title":"Depletion of Blautia species in the microbiota of obese children relates to intestinal inflammation and metabolic phenotype worsening","volume":"5","author":"Ben\u0131\u0301tez-Pa\u0301ez, A.","unstructured":"Ben\u0131\u0301tez-Pa\u0301ez, A., Go\u0301mez del\u00a0Pugar, E.M., Lo\u0301pez-Almela, I., Moya-Pe\u0301rez, A\u0301., Codon\u0303er-Franch, P. and Sanz, Y., 2020. Depletion of Blautia species in the microbiota of obese children relates to intestinal inflammation and metabolic phenotype worsening. mSystems5: e00857-19."},{"key":"R000004","series-title":"Journal of Clinical Investigation","first-page":"4019","article-title":"Gut microbiome communication with bone marrow regulates susceptibility to amebiasis","volume":"130","author":"Burgess, S.L.","unstructured":"Burgess, S.L., Leslie, J.L., Uddin, J., Oakland, D.N., Gilchrist, C., Moreau, G.B., Watanabe, K., Saleh, M., Simpson, M., Thompson, B.A., Auble, D.T., Turner, S.D., Giallourou, N., Swann, J., Pu, Z., Ma, J.Z., Haque, R. and Petri, W.A., 2020. Gut microbiome communication with bone marrow regulates susceptibility to amebiasis. Journal of Clinical Investigation130: 4019-4024."},{"key":"R000005","series-title":"Scientific Reports","article-title":"Diversity of vaginal microbiome and metabolome during genital infections","volume":"9","author":"Ceccarani, C.","unstructured":"Ceccarani, C., Foschi, C., Parolin, C., D\u2019Antuono, A., Gaspari, V., Consolandi, C., Laghi, L., Camboni, T., Vitali, B., Severgnini, M. and Marangoni, A., 2019. Diversity of vaginal microbiome and metabolome during genital infections. Scientific Reports9: 14095."},{"key":"R000006","series-title":"International Journal of Systematic and Evolutionary Microbiology","first-page":"1393","article-title":"Ruminococcus gauvreauii sp. nov., a glycopeptide-resistant species isolated from a human faecal specimen","volume":"58","author":"Domingo, M.C.","unstructured":"Domingo, M.C., Huletsky, A., Boissinot, M., Bernard, K.A., Picard, F.J. and Bergeron, M.G., 2008. Ruminococcus gauvreauii sp. nov., a glycopeptide-resistant species isolated from a human faecal specimen. International Journal of Systematic and Evolutionary Microbiology58: 1393-1397."},{"key":"R000007","unstructured":"Food and Agriculture Organization of the United Nations\/ World Health Organization (FAO\/WHO), 2006. Probiotics in food. Health and nutritional properties and guidelines for evaluation. FAO Food and Nutritional paper no. 85. FAO, Rome, Italy. Available at: http:\/\/tinyurl.com\/8bccc3r."},{"key":"R000008","series-title":"Journal of Applied Microbiology","first-page":"311","article-title":"Antimicrobial properties of Pediococcus acidilactici and Pediococcus pentosaceus isolated from silage","volume":"132","author":"Fugaban, J.I.","unstructured":"Fugaban, J.I., Vazquez Bucheli, J.E., Park, Y.J., Suh, D.H., Jung, E.S., Franco, B.D., Ivanova, I.V., Holzapfel, W.H. and Todorov, S.D., 2022. Antimicrobial properties of Pediococcus acidilactici and Pediococcus pentosaceus isolated from silage. Journal of Applied Microbiology132: 311-330."},{"key":"R000009","series-title":"LWT Food Science and Technology","first-page":"563","article-title":"Evaluation of proteolytic and ACE-inhibitory activity of Lactobacillus acidophilus in soy whey growth medium via response surface methodology","volume":"43","author":"Fung, W.Y.","unstructured":"Fung, W.Y. and Liong, M.T., 2010. Evaluation of proteolytic and ACE-inhibitory activity of Lactobacillus acidophilus in soy whey growth medium via response surface methodology. LWT Food Science and Technology43: 563-567."},{"key":"R000010","series-title":"Gastroenterology Research and Practice","article-title":"Involvement of reduced microbial diversity in inflammatory bowel disease","volume":"2016","author":"Gong, D.","unstructured":"Gong, D., Gong, X., Wang, L., Yu, X. and Dong, Q., 2016. Involvement of reduced microbial diversity in inflammatory bowel disease. Gastroenterology Research and Practice2016: 6951091."},{"key":"R000011","series-title":"Heliyon","article-title":"Study of microbiome changes in patients with ulcerative colitis in the central European part of Russia","volume":"7","author":"Gryaznova, M.V.","unstructured":"Gryaznova, M.V., Solodskikh, S.A., Panevina, A.V., Syromyatnikov, M.Y., Dvoretskaya, Y.D., Sviridova, T.N., Popov, E.S. and Popov, V.N., 2021. Study of microbiome changes in patients with ulcerative colitis in the central European part of Russia. Heliyon7: e06432."},{"key":"R000012","series-title":"Pharmacological Research","article-title":"Lactobacillus sp. improved microbiota and metabolite profiles of aging rats","volume":"146","author":"Hor, Y.Y.","unstructured":"Hor, Y.Y., Lew, L.C., Jaafar, M.H., Lau, A.S., Ong, J.S., Kato, T., Nakanishi, Y., Azzam, G., Azlan, A., Ohno, H. and Liong, M.T., 2019. Lactobacillus sp. improved microbiota and metabolite profiles of aging rats. Pharmacological Research146: 104312."},{"key":"R000013","series-title":"Progress in brain research 252","first-page":"357","article-title":"The gut microbiome in Parkinson\u2019s disease: a culprit or a bystander?","author":"Keshavarzian, A.","unstructured":"Keshavarzian, A., Engen, P., Bonvegna, S. and Cilia, R., 2020. The gut microbiome in Parkinson\u2019s disease: a culprit or a bystander? In: Bj\u00f6rklund, A. and Cenci, M.A. (eds.) Progress in brain research 252. Elsevier, Amsterdam, the Netherlands, pp.\u00a0357-450."},{"key":"R000014","series-title":"Journal of Microbiology","first-page":"199","article-title":"The Ruminococci: key symbionts of the gut ecosystem","volume":"56","author":"La Reau, A.J.","unstructured":"La Reau, A.J. and Suen, G., 2018. The Ruminococci: key symbionts of the gut ecosystem. Journal of Microbiology56: 199-208."},{"key":"R000015","series-title":"Minerva Ginecologica","first-page":"303","article-title":"Association of pregnancy and Candida vaginal colonization in women with or without symptoms of vulvovaginitis","volume":"65","author":"Leli, C.","unstructured":"Leli, C., Mencacci, A., Meucci, M., Bietolini, C., Vitali, M., Farinelli, S., D\u2019 Alo\u0300, F., Bombaci, J.C., Perito, S. and Bistoni, F., 2013. Association of pregnancy and Candida vaginal colonization in women with or without symptoms of vulvovaginitis. Minerva Ginecologica65: 303-309."},{"key":"R000016","series-title":"International Journal of Molecular Sciences","article-title":"Lactobacillus plantarum DR7 modulated bowel movement and gut microbiota associated with dopamine and serotonin pathways in stressed adults","volume":"21","author":"Liu, G.","unstructured":"Liu, G., Chong, H.X., Chung, F.Y.L., Li, Y. and Liong, M.T., 2020. Lactobacillus plantarum DR7 modulated bowel movement and gut microbiota associated with dopamine and serotonin pathways in stressed adults. International Journal of Molecular Sciences21: 4608."},{"key":"R000017","series-title":"Journal of Biotechnology","first-page":"75","article-title":"Lactobacillus fermentum FTDC 8312 combats hypercholesterolemia via alteration of gut microbiota","volume":"262","author":"Lye, H.S.","unstructured":"Lye, H.S., Kato, T., Low, W.Y., Taylor, T.D., Prakash, T., Lew, L.C., Ohno, H. and Liong, M.T., 2017. Lactobacillus fermentum FTDC 8312 combats hypercholesterolemia via alteration of gut microbiota. Journal of Biotechnology262: 75-83."},{"key":"R000018","series-title":"Microbiota of the human body: implications in health and disease. Advances in experimental medicine and biology","first-page":"83","article-title":"Vaginal microbiota","author":"Mendling, W.","unstructured":"Mendling, W., 2016. Vaginal microbiota. In: Schwiertz, A. (ed.) Microbiota of the human body: implications in health and disease. Advances in experimental medicine and biology. Springer International Publishing, Cham, Switzerland, pp.\u00a083-93."},{"key":"R000019","series-title":"Microbiome and metabolome in diagnosis, therapy, and other strategic applications","first-page":"307","article-title":"The oral, genital and gut microbiome in HIV infection","author":"Pe\u0301rez-Matute, P.","unstructured":"Pe\u0301rez-Matute, P., I\u0301n\u0303iguez, M., Villanueva-Milla\u0301n, M. and Oteo, J.A., 2019. The oral, genital and gut microbiome in HIV infection. In: Faintuch, J. and Faintuch, S. (eds.) Microbiome and metabolome in diagnosis, therapy, and other strategic applications. Academic Press Publishing, Cambridge, MA, USA, pp.\u00a0307-323."},{"key":"R000020","series-title":"Frontiers in Cellular and Infection Microbiology","article-title":"Crosstalks between gut microbiota and Vibrio cholerae","volume":"10","author":"Qin, Z.","unstructured":"Qin, Z., Yang, X., Chen, G., Park, C. and Liu, Z., 2020. Crosstalks between gut microbiota and Vibrio cholerae. Frontiers in Cellular and Infection Microbiology10: 582554."},{"key":"R000021","series-title":"World Journal of Gastroenterology","first-page":"2124","article-title":"Diet and microbiota in inflammatory bowel disease: the gut in disharmony","volume":"23","author":"Rapozo, D.C.M.","unstructured":"Rapozo, D.C.M., Bernardazzi, C. and de Souza, H.S.P., 2017. Diet and microbiota in inflammatory bowel disease: the gut in disharmony. World Journal of Gastroenterology23: 2124-2140."},{"key":"R000022","series-title":"PLoS ONE","article-title":"Bacterial communities in women with bacterial vaginosis: high resolution phylogenetic analyses reveal relationships of microbiota to clinical criteria","volume":"7","author":"Srinivasan, S.","unstructured":"Srinivasan, S., Hoffman, N.G., Morgan, M.T., Matsen, F.A., Fiedler, T.L., Hall, R.W., Ross, F.J., McCoy, C.O., Bumgarner, R., Marrazzo, J.M. and Fredricks, D.N., 2012. Bacterial communities in women with bacterial vaginosis: high resolution phylogenetic analyses reveal relationships of microbiota to clinical criteria. PLoS ONE7: e37818."},{"key":"R000023","series-title":"Beneficial Microbes","first-page":"79","article-title":"Lactobacillus probiotics improved the gut microbiota profile of a Drosophila melanogaster Alzheimer\u2019s disease model and alleviated neurodegeneration in the eye","volume":"11","author":"Tan, F.H.P.","unstructured":"Tan, F.H.P., Liu, G., Lau, S.Y., Jaafar, M.H., Park, Y.H., Azzam, G., Li, Y. and Liong, M.T., 2020. Lactobacillus probiotics improved the gut microbiota profile of a Drosophila melanogaster Alzheimer\u2019s disease model and alleviated neurodegeneration in the eye. Beneficial Microbes11: 79-89."},{"key":"R000024","series-title":"Nutrients","article-title":"Probiotics in food systems: significance and emerging strategies towards improved viability and delivery of enhanced beneficial value","volume":"11","author":"Terpou, A.","unstructured":"Terpou, A., Papadaki, A., Lappa, I.K., Kachrimanidou, V., Bosnea, L.A. and Kopsahelis, N., 2019. Probiotics in food systems: significance and emerging strategies towards improved viability and delivery of enhanced beneficial value. Nutrients11: 1591."},{"key":"R000025","series-title":"Annals of Microbiology","first-page":"1079","article-title":"Probiotic properties of bifidobacteria and lactobacilli isolated from local dairy products","volume":"62","author":"Tham, C.S.C.","unstructured":"Tham, C.S.C., Peh, K.K., Bhat, R. and Liong, M.T., 2012. Probiotic properties of bifidobacteria and lactobacilli isolated from local dairy products. Annals of Microbiology62: 1079-1087."},{"key":"R000026","series-title":"PLoS ONE","article-title":"Coronary artery disease is associated with an altered gut microbiome composition","volume":"15","author":"Toya, T.","unstructured":"Toya, T., Corban, M.T., Marrietta, E., Horwath, I.E., Lerman, L.O., Murray, J.A. and Lerman, A., 2020. Coronary artery disease is associated with an altered gut microbiome composition. PLoS ONE15: e0227147."},{"key":"R000027","series-title":"Natural Microbiology","first-page":"623","article-title":"The neuroactive potential of the human gut microbiota in quality of life and depression","volume":"4","author":"Valles-Colomer, M.","unstructured":"Valles-Colomer, M., Falony, G., Darzi, Y., Tigchelaar, E.F., Wang, J., Tito, R.Y., Schiweck, C., Kurilshikov, A., Joossens, M., Wijmenga, C., Claes, S., Van Oudenhove, L., Zhernakova, A., Vieira-Silva, S. and Raes, J., 2019. The neuroactive potential of the human gut microbiota in quality of life and depression. Natural Microbiology4: 623-632."},{"key":"R000028","series-title":"Gut Microbes","first-page":"4","article-title":"The role of gut microbiota in immune homeostasis and autoimmunity","volume":"3","author":"Wu, H.J.","unstructured":"Wu, H.J. and Wu, E., 2012. The role of gut microbiota in immune homeostasis and autoimmunity. Gut Microbes3: 4-14."}],"container-title":["Beneficial Microbes"],"original-title":[],"link":[{"URL":"https:\/\/brill.com\/view\/journals\/bm\/14\/5\/article-p421_1.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/brill.com\/downloadpdf\/journals\/bm\/14\/5\/article-p421_1.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/brill.com\/downloadpdf\/journals\/bm\/14\/5\/article-p421_1.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T03:58:40Z","timestamp":1709179120000},"score":1,"resource":{"primary":{"URL":"https:\/\/brill.com\/view\/journals\/bm\/14\/5\/article-p421_1.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,23]]},"references-count":28,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.1163\/18762891-20220103","relation":{},"ISSN":["1876-2883","1876-2891"],"issn-type":[{"value":"1876-2883","type":"print"},{"value":"1876-2891","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,23]]}}}