{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:12:56Z","timestamp":1793725976717,"version":"4.6.1"},"reference-count":210,"publisher":"Walter de Gruyter GmbH","issue":"6","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Benef. Microbes"],"published-print":{"date-parts":[[2023,11,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Bifidobacterium adolescentis<\/jats:italic>\n                    is one of the most abundant bifidobacterial species in the human large intestine, and is prevalent in 60-80% of healthy human adults with cell densities ranging from 10\n                    <jats:sup>9<\/jats:sup>\n                    -10\n                    <jats:sup>10<\/jats:sup>\n                    cells\/g of faeces. Lower abundance is found in children and in elderly individuals. The species is evolutionary adapted to fermenting plant-derived glycans and is equipped with an extensive sugar transporter and degradation enzymes repertoire. Consequently, the species is strongly affected by dietary carbohydrates and is able to utilize a wide range of prebiotic molecules.\n                    <jats:italic>B. adolescentis<\/jats:italic>\n                    is specialized in metabolizing resistant starch and is considered a primary starch degrader enabling growth of other beneficial bacteria by cross-feeding. The major metabolic output is acetate and lactate in a ratio of 3:2. Several health-beneficial properties have been demonstrated in certain strains of\n                    <jats:italic>B. adolescentis in vitro<\/jats:italic>\n                    and in rodent models, including enhancement of the intestinal barrier function, anti-inflammatory and immune-regulatory effects, and the production of neurotransmitters (GABA), and vitamins. Although causalities have not been established, reduced abundance of\n                    <jats:italic>B. adolescentis<\/jats:italic>\n                    as part of a dysbiotic colonic microbiota in human observational studies has been associated with inflammatory bowel diseases, irritable bowel syndrome, coeliac disease, cystic fibrosis,\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    infection, type 1 and 2 diabetes, metabolic syndrome, nonalcoholic steatohepatitis, and certain allergies. It is therefore reasonable to conceive\n                    <jats:italic>B. adolescentis<\/jats:italic>\n                    as a health-associated, or even health-promoting bacterial species in humans.\n                  <\/jats:p>","DOI":"10.1163\/18762891-20230030","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T22:17:59Z","timestamp":1700864279000},"page":"525-551","source":"Crossref","is-referenced-by-count":47,"title":["Bifidobacterium adolescentis \u2013 a beneficial microbe"],"prefix":"10.1163","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3799-7767","authenticated-orcid":true,"given":"T.","family":"Leser","sequence":"first","affiliation":[{"name":"Human Health, Scientific Affairs, Future Lab., Chr. 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