{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:09:24Z","timestamp":1791724164630,"version":"4.3.4"},"reference-count":49,"publisher":"Walter de Gruyter GmbH","issue":"5","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Benef. Microbes"],"published-print":{"date-parts":[[2023,10,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A randomised, placebo-controlled, double-blind, parallel clinical study was performed to examine the effects of a probiotic- amylase (PRO) blend on gastrointestinal (GI) symptoms. Sixty men and women (44.4 \u00b1 8.9 yr; 82.0 \u00b1 18.4\u00a0kg; 170.3 \u00b1 11.5\u00a0cm; 28.1 \u00b1 4.6\u00a0kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ) were randomised into PRO (n = 29) or placebo (PLA: n = 31) groups. Participants exhibited mild to moderate GI symptoms and severity [via Gastrointestinal Symptom Rating Scale (GSRS)] to be eligible for participation. Participants were tested before (Baseline) and after (POST) 6 weeks of supplementation on various gastrointestinal indices, the GSRS (to assess GI symptoms, frequency, and severity), an anxiety questionnaire (GAD-7), and an overall well-being questionnaire (SF-36). Two (PRO vs PLA) \u00d7 2 (Baseline vs POST) mixed factorial ANOVAs were completed to assess group, time, and (group \u00d7 time) interaction effects. Fifty-two subjects who completed the entire study were analysed (PRO: n = 25, PLA: n = 27). There were statistically significant (\n                    <jats:inline-formula\/>\n                    ) interactions for bloating, GSRS score, and abdominal discomfort but time effects for flatulence, constipation, stool regularity, and GAD-7 total score. PRO significantly reduced GSRS score (\u223c60 vs 25%, d = 0.72), bloating (\u223c49% vs 25%, d = \u22120.63) and abdominal discomfort (59% vs 32%, d = \u22120.66) to a greater degree than PLA. PRO significantly reduced subjective feelings of irritability, pain, and overall health interference. Oral supplementation of the probiotic-amylase blend was very well tolerated. Our study showed that the probiotic-amylase blend reduced the GSRS score and other GI symptoms to a greater degree than PLA.\n                  <\/jats:p>\n                  <jats:p>Clinical trial registration: clinicaltrials.gov #NCT05614726<\/jats:p>","DOI":"10.1163\/18762891-20230043","type":"journal-article","created":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T04:51:17Z","timestamp":1697863877000},"page":"459-476","source":"Crossref","is-referenced-by-count":6,"title":["A probiotic amylase blend reduces gastrointestinal symptoms in a randomised clinical study"],"prefix":"10.1163","volume":"14","author":[{"given":"M.B.","family":"La Monica","sequence":"first","affiliation":[{"name":"The Center for Applied Health Sciences, 6570 Seville Dr., Canfield, OH 44406, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Raub","sequence":"additional","affiliation":[{"name":"The Center for Applied Health Sciences, 6570 Seville Dr., Canfield, OH 44406, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.L.","family":"Lopez","sequence":"additional","affiliation":[{"name":"The Center for Applied Health Sciences, 6570 Seville Dr., Canfield, OH 44406, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.N.","family":"Ziegenfuss","sequence":"additional","affiliation":[{"name":"The Center for Applied Health Sciences, 6570 Seville Dr., Canfield, OH 44406, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"R000001","series-title":"Journal of Personalized Medicine","article-title":"Altered gut microbiota in irritable bowel syndrome and its association with food components","volume":"11","author":"Barandouzi, Z.A.","unstructured":"Barandouzi, Z.A., Lee, J., Maas, K., Starkweather, A.R. and Cong, X.S., 2021. 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