{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:02:42Z","timestamp":1784034162508,"version":"3.55.0"},"reference-count":63,"publisher":"Walter de Gruyter GmbH","issue":"3","funder":[{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 32172213, 31972052, 32021005"],"award-info":[{"award-number":["No. 32172213, 31972052, 32021005"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Key Research and Development Program of China","award":["2019YFF0217601"],"award-info":[{"award-number":["2019YFF0217601"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["JUSRP121001, JUSRP22006, JUSRP51501"],"award-info":[{"award-number":["JUSRP121001, JUSRP22006, JUSRP51501"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Benef. Microbes"],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>Probiotics exert beneficial effects by regulating the intestinal microbiota, metabolism, immune function and other ways of their host. Patients with constipation, a common gastrointestinal disorder, experience disturbances in their intestinal microbiota. In the present study, we investigated the effectiveness of two microbial ecological agents (postbiotic extract PE0401 and a combination of postbiotic extract PE0401 and <jats:italic>Lacticaseibacillus paracasei<\/jats:italic> CCFM 2711) in regulating the makeup of the intestinal microbiota and alleviating loperamide hydrochloride-induced constipation in mice. We also preliminarily explored the mechanism underlying their effects. Both microbial ecological agents increased the abundance of the beneficial bacteria <jats:italic>Lactobacilli<\/jats:italic> and <jats:italic>Bifidobacterium<\/jats:italic> after administration and were able to relieve constipation. However, the degree of improvement in constipation symptoms varied depending on the makeup of the supplement. The postbiotic extract PE0401 increased peristalsis time and improved faecal properties throughout the intestinal tract of the host. PE0401 relieved constipation, possibly by modulating the levels of the constipation-related gastrointestinal regulatory transmitters mouse motilin, mouse vasoactive intestinal peptide, and 5-hydoxytryptamine in the intestinal tract of the host and by increasing the levels of the short-chain fatty acids (SCFAs) acetic acid, propionic acid, and isovaleric acid. It also increased the relative abundance of <jats:italic>Lactobacillus<\/jats:italic> and <jats:italic>Bifidobacterium<\/jats:italic> and reduced that of <jats:italic>Faecalibaculum<\/jats:italic>, <jats:italic>Mucispirillum<\/jats:italic>, <jats:italic>Staphylococcus<\/jats:italic>, and <jats:italic>Lachnoclostridium<\/jats:italic>, which are among the beneficial microbiota in the host intestine. Furthermore, PE0401 decreased the levels of constipation-induced host inflammatory factors. Therefore, the two microbial ecological agents can regulate the intestinal microbiota of constipation mice, and PE0401 has a stronger ability to relieve constipation.<\/jats:p>","DOI":"10.1163\/18762891-bja00011","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T09:18:30Z","timestamp":1714468710000},"page":"311-329","source":"Crossref","is-referenced-by-count":5,"title":["Different microbial ecological agents change the composition of intestinal microbiota and the levels of SCFAs in mice to alleviate loperamide-induced constipation"],"prefix":"10.1163","volume":"15","author":[{"given":"C.","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Food Science and Resources, https:\/\/dx.doi.org\/66374Jiangnan University, Wuxi 214122, P.R. China"},{"name":"School of Food Science and Technology, https:\/\/dx.doi.org\/66374Jiangnan University, Wuxi 214122, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Resources, https:\/\/dx.doi.org\/66374Jiangnan University, Wuxi 214122, P.R. China"},{"name":"School of Food Science and Technology, https:\/\/dx.doi.org\/66374Jiangnan University, Wuxi 214122, P.R. China"},{"name":"(Yangzhou) Institute of Food Biotechnology, https:\/\/dx.doi.org\/66374Jiangnan University, Yangzhou 225004, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Resources, https:\/\/dx.doi.org\/66374Jiangnan University, Wuxi 214122, P.R. China"},{"name":"School of Food Science and Technology, https:\/\/dx.doi.org\/66374Jiangnan University, Wuxi 214122, P.R. China"},{"name":"(Yangzhou) Institute of Food Biotechnology, https:\/\/dx.doi.org\/66374Jiangnan University, Yangzhou 225004, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Resources, https:\/\/dx.doi.org\/66374Jiangnan University, Wuxi 214122, P.R. China"},{"name":"School of Food Science and Technology, https:\/\/dx.doi.org\/66374Jiangnan University, Wuxi 214122, P.R. China"},{"name":"(Yangzhou) Institute of Food Biotechnology, https:\/\/dx.doi.org\/66374Jiangnan University, Yangzhou 225004, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Guo","sequence":"additional","affiliation":[{"name":"JinQiao Biotechnology Co., Ltd., Huai\u2019an 223010, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Liu","sequence":"additional","affiliation":[{"name":"JinQiao Biotechnology Co., Ltd., Huai\u2019an 223010, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Resources, https:\/\/dx.doi.org\/66374Jiangnan University, Wuxi 214122, P.R. China"},{"name":"School of Food Science and Technology, https:\/\/dx.doi.org\/66374Jiangnan University, Wuxi 214122, P.R. China"},{"name":"(Yangzhou) Institute of Food Biotechnology, https:\/\/dx.doi.org\/66374Jiangnan University, Yangzhou 225004, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Resources, https:\/\/dx.doi.org\/66374Jiangnan University, Wuxi 214122, P.R. China"},{"name":"School of Food Science and Technology, https:\/\/dx.doi.org\/66374Jiangnan University, Wuxi 214122, P.R. China"},{"name":"National Engineering Research Center for Functional Food, https:\/\/dx.doi.org\/66374Jiangnan University, Wuxi 214122, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"R000001","series-title":"Frontiers in Microbiology","article-title":"Independent and interactive effects of habitually ingesting fermented milk products containing Lactobacillus casei strain Shirota and of engaging in moderate habitual daily physical activity on the intestinal health of older people","volume":"10","author":"Aoyagi, Y.","unstructured":"Aoyagi, Y., Amamoto, R., Park, S., Honda, Y., Shimamoto, K., Kushiro, A., Tsuji, H., Matsumoto, H., Shimizu, K., Miyazaki, K., Matsubara, S. and Shepherd, R.J., 2019. Independent and interactive effects of habitually ingesting fermented milk products containing Lactobacillus casei strain Shirota and of engaging in moderate habitual daily physical activity on the intestinal health of older people. Frontiers in Microbiology 10: 1447. https:\/\/doi.org\/10.3389\/fmicb.2019.01477"},{"key":"R000002","series-title":"Nutrition","article-title":"A multiple-strain probiotic product provides a better enzymatic antioxidant response in individuals with constipation in a double-blind randomized controlled trial","volume":"89","author":"Araujo, A.d.M.","unstructured":"Araujo, A.d.M., Botelho, P.B., Ribeiro, D.J.S., Magalhaes, K.G., Nakano, E.Y. and Arruda, S.F., 2021. A multiple-strain probiotic product provides a better enzymatic antioxidant response in individuals with constipation in a double-blind randomized controlled trial. Nutrition 89: 111225. https:\/\/doi.org\/10.1016\/j.nut.2021.111225"},{"key":"R000003","series-title":"Frontiers in Nutrition","article-title":"Probiotics, prebiotics, and synbiotics in chronic constipation: Outstanding aspects to be considered for the current evidence","volume":"9","author":"Araujo, M.M.","unstructured":"Araujo, M.M. and Botelho, P.B., 2022. Probiotics, prebiotics, and synbiotics in chronic constipation: Outstanding aspects to be considered for the current evidence. Frontiers in Nutrition 9: 935830. https:\/\/doi.org\/10.3389\/fnut.2022.935830"},{"key":"R000004","series-title":"Current Opinion in Food Science","first-page":"1","article-title":"Paraprobiotics and postbiotics: concepts and potential applications in dairy products","volume":"32","author":"Barros, C.P.","unstructured":"Barros, C.P., Guimaraes, J.T., Esmerino, E.A., Duarte, M.C.K.H., Silva, M.C., Silva, R., Ferreira, B.M., Sant\u2019Ana, A.S., Freitas, M.Q. and Cruz, A.G., 2020. Paraprobiotics and postbiotics: concepts and potential applications in dairy products. Current Opinion in Food Science 32: 1-8. https:\/\/doi.org\/10.1016\/j.cofs.2019.12.003"},{"key":"R000005","series-title":"Food Function","first-page":"6058","article-title":"Different Bifidobacterium bifidum strains change the intestinal flora composition of mice via different mechanisms to alleviate loperamide-induced constipation","volume":"12","author":"Chai, M.","unstructured":"Chai, M., Wang, L., Li, X., Zhao, J., Zhang, H., Wang, G. and Chen, W., 2021. Different Bifidobacterium bifidum strains change the intestinal flora composition of mice via different mechanisms to alleviate loperamide-induced constipation. Food Function 12: 6058-6069."},{"key":"R000006","series-title":"Gastroenterology","first-page":"179","article-title":"Interactions between commensal bacteria and enteric neurons, via FPR1 induction of ROS, increase gastrointestinal motility in mice","volume":"157","author":"Chandrasekharan, B.","unstructured":"Chandrasekharan, B., Saeedi, B.J., Alam, A., Houser, M., Srinivasan, S., Tansey, M., Jones, R., Nusrat, A. and Neish, A.S., 2019. Interactions between commensal bacteria and enteric neurons, via FPR1 induction of ROS, increase gastrointestinal motility in mice. Gastroenterology 157: 179-192. https:\/\/doi.org\/10.1053\/j.gastro.2019.03.045"},{"key":"R000007","series-title":"Clinical Nutrition","first-page":"2960","article-title":"Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults","volume":"39","author":"Chengcheng, Z.","unstructured":"Chengcheng, Z., Jinchi, J., Fengwei, T., Jianxin, Z., Hao, Z., Qixiao, Z. and Wei, C., 2020. Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults. Clinical Nutrition 39: 2960-2969. https:\/\/doi.org\/10.1016\/j.clnu.2020.01.005"},{"key":"R000008","series-title":"Food and Function","first-page":"3476","article-title":"Identification of the key characteristics of Bifidobacterium longum strains for the alleviation of ulcerative colitis","volume":"12","author":"Chengcheng, Z.","unstructured":"Chengcheng, Z., Yan, Z., Jinchi, J., Leilei, Y., Fengwei, T., Jianxin, Z., Hao, Z., Wei, C. and Qixiao, Z., 2021. Identification of the key characteristics of Bifidobacterium longum strains for the alleviation of ulcerative colitis. Food and Function 12: 3476-3492. https:\/\/doi.org\/10.1039\/d1fo00017a"},{"key":"R000009","series-title":"American Journal of Physiology-Gastrointestinal and Liver Physiology","first-page":"G1415","article-title":"Short-chain fatty acids modify colonic motility through nerves and polypeptide YY release in the rat","volume":"275","author":"Cherbut, C.","unstructured":"Cherbut, C., Ferrier, L., Roze, C., Anini, Y., Blottiere, H., Lecannu, G. and Galimiche, J.P., 1998. Short-chain fatty acids modify colonic motility through nerves and polypeptide YY release in the rat. American Journal of Physiology-Gastrointestinal and Liver Physiology 275: G1415-G1422. https:\/\/doi.org\/10.1152\/ajpgi.1998.275.6.G1415"},{"key":"R000010","series-title":"Iranian Journal of Kidney Diseases","article-title":"Urinary tract infection and enuresis in children with chronic functional constipation","volume":"7","author":"Dehghani, S.M.","unstructured":"Dehghani, S.M., Basiratnia, M., Matin, M., Hamidpour, L., Haghighat, M. and Imanieh, M.H., 2013. Urinary tract infection and enuresis in children with chronic functional constipation. Iranian Journal of Kidney Diseases 7: 363."},{"key":"R000011","series-title":"American Journal of Clinical Nutrition","first-page":"1075","article-title":"The effect of probiotics on functional constipation in adults: a systematic review and meta-analysis of randomized controlled trials","volume":"100","author":"Dimidi, E.","unstructured":"Dimidi, E., Christodoulides, S., Fragkos, K.C., Scott, S.M. and Whelan, K., 2014. The effect of probiotics on functional constipation in adults: a systematic review and meta-analysis of randomized controlled trials. American Journal of Clinical Nutrition 100: 1075-1084. https:\/\/doi.org\/10.3945\/ajcn.114.089151"},{"key":"R000012","series-title":"BMC Gastroenterology","article-title":"Epidemiology of constipation in Europe and Oceania: a systematic review","volume":"8","author":"Eleni, M.","unstructured":"Eleni, M., Alexiou, V.G., George, P. and Falagas, M.E., 2008. Epidemiology of constipation in Europe and Oceania: a systematic review. BMC Gastroenterology 8: 5."},{"key":"R000013","series-title":"Science","first-page":"2184","article-title":"Receptor for motilin identified in the human gastrointestinal system","volume":"284","author":"Feighner, S.D.","unstructured":"Feighner, S.D., Tan, C.P., McKee, K.K., Palyha, O.C., Hreniuk, D.L., Pong, S.S., Austin, C.P., Figueroa, D., MacNeil, D., Cascieri, M.A., Nargund, R., Bakshi, R., Abramovitz, M., Stocco, R., Kargman, S., O\u2019Neill, G., Van\u00a0der Ploeg, L.H.T., Evans, J., Patchett, A.A., Smith, R.G. and Howard, A.D., 1999. Receptor for motilin identified in the human gastrointestinal system. Science 284: 2184-2188. https:\/\/doi.org\/10.1126\/science.284.5423.2184"},{"key":"R000014","series-title":"American Journal of Physiology \u2013 Regulatory Integrative and Comparative Physiology","first-page":"R1269","article-title":"Short-chain fatty acids stimulate colonic transit via intraluminal 5-HT release in rats","volume":"284","author":"Fukumoto, S.","unstructured":"Fukumoto, S., Tatewaki, M., Yamada, T., Fujimiya, M., Mantyh, C., Voss, M., Eubanks, S., Harris, M., Pappas, T.N. and Takahashi, T., 2003. Short-chain fatty acids stimulate colonic transit via intraluminal 5-HT release in rats. American Journal of Physiology \u2013 Regulatory Integrative and Comparative Physiology 284: R1269-R1276. https:\/\/doi.org\/10.1152\/ajpregu.00442.2002"},{"key":"R000015","series-title":"Indian Journal of Gastroenterology","first-page":"1","article-title":"Chronic constipation in Rome IV era: the Indian perspective","volume":"36","author":"Ghoshal, U.C.","unstructured":"Ghoshal, U.C., 2017. Chronic constipation in Rome IV era: the Indian perspective. Indian Journal of Gastroenterology 36: 1-11."},{"key":"R000016","series-title":"Journal of Clinical Gastroenterology","first-page":"S185","article-title":"Effect of acute mucosal exposure to Lactobacillus rhamnosus GG on human colonic smooth muscle cells","volume":"42","author":"Guarino, M.P.L.","unstructured":"Guarino, M.P.L., Altomare, A., Stasi, E., Marignani, M., Severi, C., Alloni, R., Dicuonzo, G., Morelli, L., Coppola, R. and Cicala, M., 2008. Effect of acute mucosal exposure to Lactobacillus rhamnosus GG on human colonic smooth muscle cells. Journal of Clinical Gastroenterology 42: S185-S190. https:\/\/doi.org\/10.1097\/MCG.0b013e31817e1cac"},{"key":"R000017","series-title":"Alimentary Pharmacology Therapeutics","first-page":"83","article-title":"Risk of developing colorectal cancer and benign colorectal neoplasm in patients with chronic constipation","volume":"40","author":"Gue\u0301rin, A.","unstructured":"Gue\u0301rin, A., Mody, R., Fok, B., Lasch, K.L., Zhou, Z., Wu, E.Q., Zhou, W. and Talley, N.J., 2014. Risk of developing colorectal cancer and benign colorectal neoplasm in patients with chronic constipation. Alimentary Pharmacology Therapeutics 40: 83-92."},{"key":"R000018","series-title":"Journal of Dairy Science","first-page":"1518","article-title":"Genotype-phenotype association analysis revealed different utilization ability of 2\u2032-fucosyllactose in Bifidobacterium genus","volume":"104","author":"He, Z.","unstructured":"He, Z., Yang, B., Liu, X., Ross, R.P., Stanton, C., Zhao, J., Zhang, H. and Chen, W., 2021. Genotype-phenotype association analysis revealed different utilization ability of 2\u2032-fucosyllactose in Bifidobacterium genus. Journal of Dairy Science 104: 1518-1523. https:\/\/doi.org\/10.3168\/jds.2020-19013"},{"key":"R000019","series-title":"Cell Host and Microbe","first-page":"681","article-title":"Mucispirillum schaedleri antagonizes Salmonella virulence to protect mice against colitis","volume":"25","author":"Herp, S.","unstructured":"Herp, S., Brugiroux, S., Garzetti, D., Ring, D., Jochum, L.M., Beutler, M., Eberl, C., Hussain, S., Walter, S., Gerlach, R.G., Ruscheweyh, H.J., Huson, D., Selling, M.E., Slack, E., Hanson, B., Loy, A., Baines, J.F., Bausch, P., Basic, M., Bleich, A., Berry, D. and Stecher, B., 2019. Mucispirillum schaedleri antagonizes Salmonella virulence to protect mice against colitis. Cell Host and Microbe 25: 681-694. https:\/\/doi.org\/10.1016\/j.chom.2019.03.004"},{"key":"R000020","series-title":"Journal of Nutrition","first-page":"534","article-title":"Constipation is relieved more by rye bread than wheat bread or laxatives without increased adverse gastrointestinal effects","volume":"140","author":"Holma, R.","unstructured":"Holma, R., Hongisto, S.-M., Saxelin, M. and Korpela, R., 2010. Constipation is relieved more by rye bread than wheat bread or laxatives without increased adverse gastrointestinal effects. Journal of Nutrition 140: 534-541. https:\/\/doi.org\/10.3945\/jn.109.118570"},{"key":"R000021","series-title":"International Journal of Molecular Sciences","article-title":"Flavonoids in Amomum tsaoko Crevost et Lemarie ameliorate loperamide-induced constipation in mice by regulating gut microbiota and related metabolites","volume":"24","author":"Hu, Y.","unstructured":"Hu, Y., Gao, X., Zhao, Y., Liu, S., Luo, K., Fu, X., Li, J., Sheng, J., Tian, Y. and Fan, Y., 2023. Flavonoids in Amomum tsaoko Crevost et Lemarie ameliorate loperamide-induced constipation in mice by regulating gut microbiota and related metabolites. International Journal of Molecular Sciences 24: 7191. https:\/\/doi.org\/10.3390\/ijms24087191"},{"key":"R000022","series-title":"Food Function","first-page":"5607","article-title":"Pediococcus pentosaceus B49 from human colostrum ameliorates constipation in mice","volume":"11","author":"Huang, J.","unstructured":"Huang, J., Li, S., Wang, Q., Guan, X., Qian, L., Li, J., Zheng, Y. and Lin, B., 2020. Pediococcus pentosaceus B49 from human colostrum ameliorates constipation in mice. Food Function 11: 5607-5620."},{"key":"R000023","series-title":"Journal of Dairy Science","first-page":"11025","article-title":"Fermented milk containing Lactobacillus casei Zhang and Bifidobacterium animalis ssp. lactis V9 alleviated constipation symptoms through regulation of intestinal microbiota, inflammation, and metabolic","volume":"103","author":"Jicheng, W.","unstructured":"Jicheng, W., Xiaoye, B., Chuantao, P., Zhongjie, Y., Bohai, L., Wenyi, Z., Zhihong, S. and Heping, Z., 2020. Fermented milk containing Lactobacillus casei Zhang and Bifidobacterium animalis ssp. lactis V9 alleviated constipation symptoms through regulation of intestinal microbiota, inflammation, and metabolic. Journal of Dairy Science 103: 11025-11038."},{"key":"R000024","series-title":"Neurogastroenterology and Motility","first-page":"883","article-title":"Substance P and vasoactive intestinal peptide are reduced in right transverse colon in pediatric slow-transit constipation","volume":"22","author":"King, S.K.","unstructured":"King, S.K., Sutcliffe, J.R., Ong, S.Y., Lee, M., Koh, T.L., Wong, S.Q., Farmer, P.J., Peck, C.J., Stanton, M.P., Keck, J., Cook, D.J., Chow, C.W., Hutson, J.M. and Southwell, B.R., 2010. Substance P and vasoactive intestinal peptide are reduced in right transverse colon in pediatric slow-transit constipation. Neurogastroenterology and Motility 22: 883-E234. https:\/\/doi.org\/10.1111\/j.1365-2982.2010.01524.x"},{"key":"R000025","series-title":"Journal of Epidemiology","first-page":"242","article-title":"Bowel movement frequency, laxative use, and mortality from coronary heart disease and stroke among japanese men and women: the Japan Collaborative Cohort (JACC) study","volume":"26","author":"Kubota, Y.","unstructured":"Kubota, Y., Iso, H., Tamakoshi, A. and Jacc Study, G., 2016. Bowel movement frequency, laxative use, and mortality from coronary heart disease and stroke among japanese men and women: the Japan Collaborative Cohort (JACC) study. Journal of Epidemiology 26: 242-248. https:\/\/doi.org\/10.2188\/jea.JE20150123"},{"key":"R000026","series-title":"European Journal of Clinical Nutrition","first-page":"1284","article-title":"Dose-response study of probiotic bacteria Bifidobacterium animalis subsp lactis BB-12 and Lactobacillus paracasei subsp paracasei CRL-341 in healthy young adults","volume":"60","author":"Larsen, C.N.","unstructured":"Larsen, C.N., Nielsen, S., Kaestel, P., Brockmann, E., Bennedsen, M., Christensen, H.R., Eskesen, D.C., Jacobsen, B.L. and Michaelsen, K.F., 2006. Dose-response study of probiotic bacteria Bifidobacterium animalis subsp lactis BB-12 and Lactobacillus paracasei subsp paracasei CRL-341 in healthy young adults. European Journal of Clinical Nutrition 60: 1284-1293. https:\/\/doi.org\/10.1038\/sj.ejcn.1602450"},{"key":"R000027","series-title":"Nutrients","article-title":"Combination of Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis shows a stronger anti-inflammatory effect than individual strains in HT-29 cells","volume":"11","author":"Li, S.C.","unstructured":"Li, S.C., Hsu, W.F., Chang, J.S. and Shih, C.K.J.N., 2019. Combination of Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis shows a stronger anti-inflammatory effect than individual strains in HT-29 cells. Nutrients 11: 969. https:\/\/doi.org\/10.3390\/nu11050969"},{"key":"R000028","series-title":"Journal of Pure and Applied Microbiology","first-page":"1771","article-title":"The function of mixed postbiotic PE0401 in improving intestinal health via elevating anti-inflammation, anti-oxidation, epithelial tight junction gene expression and promoting beneficial bacteria growth","volume":"16","author":"Lin, W.","unstructured":"Lin, W., Kuo, Y., Chen, C., Hsu, Y., Huang, Y., Hsu, C., Lin, J., Lin, C., Lin, C., Yi, T., Chu, Y. and Ho, H., 2022a. The function of mixed postbiotic PE0401 in improving intestinal health via elevating anti-inflammation, anti-oxidation, epithelial tight junction gene expression and promoting beneficial bacteria growth. Journal of Pure and Applied Microbiology 16: 1771-1782. https:\/\/doi.org\/10.22207\/JPAM.16.3.19"},{"key":"R000029","series-title":"Journal of Pure and Applied Microbiology","first-page":"1771","article-title":"The function of mixed postbiotic PE0401 in improving intestinal health via elevating anti-inflammation, anti-oxidation, epithelial tight junction gene expression and promoting beneficial bacteria growth","volume":"16","author":"Lin, W.-Y.","unstructured":"Lin, W.-Y., Kuo, Y.-W., Chen, C.-W., Hsu, Y.-C., Huang, Y.-F., Hsu, C.-H., Lin, J.-H., Lin, C.-H., Lin, C.-C., Yi, T.-H., Chu, Y.-W. and Ho, H.-H., 2022b. The function of mixed postbiotic PE0401 in improving intestinal health via elevating anti-inflammation, anti-oxidation, epithelial tight junction gene expression and promoting beneficial bacteria growth. Journal of Pure and Applied Microbiology 16: 1771-1782. https:\/\/doi.org\/10.22207\/jpam.16.3.19"},{"key":"R000030","series-title":"Msystems","article-title":"Lifestyle and horizontal gene transfer-mediated evolution of Mucispirillum schaedleri, a core member of the murine gut microbiota","volume":"2","author":"Loy, A.","unstructured":"Loy, A., Pfann, C., Steinberger, M., Hanson, B., Herp, S., Brugiroux, S., Gomes Neto, J.C., Boekschoten, M.V., Schwab, C., Urich, T., Ramer-Tait, A.E., Rattei, T., Stecher, B. and Berry, D., 2017. Lifestyle and horizontal gene transfer-mediated evolution of Mucispirillum schaedleri, a core member of the murine gut microbiota. Msystems 2: 00171-16. https:\/\/doi.org\/10.1128\/mSystems.00171-16"},{"key":"R000031","series-title":"Gastroenterology","first-page":"88","article-title":"Epidemiologic burden and treatment of chronic symptomatic functional bowel disorders in the United States: a nationwide analysis","volume":"160","author":"Ma, C.","unstructured":"Ma, C., Congly, S.E., Novak, K.L., Belletrutti, P.J., Raman, M., Woo, M., Andrews, C.N. and Nasser, Y., 2021. Epidemiologic burden and treatment of chronic symptomatic functional bowel disorders in the United States: a nationwide analysis. Gastroenterology 160: 88-98. https:\/\/doi.org\/10.1053\/j.gastro.2020.09.041"},{"key":"R000032","series-title":"PLoS ONE","article-title":"Improvement of loperamide-induced slow transit constipation by Bifidobacterium bifidum G9-1 is mediated by the correction of butyrate production and neurotransmitter profile due to improvement in dysbiosis","volume":"16","author":"Makizaki, Y.","unstructured":"Makizaki, Y., Uemoto, T., Yokota, H., Yamamoto, M., Tanaka, Y. and Ohno, H., 2021. Improvement of loperamide-induced slow transit constipation by Bifidobacterium bifidum G9-1 is mediated by the correction of butyrate production and neurotransmitter profile due to improvement in dysbiosis. PLoS ONE 16: e0248584."},{"key":"R000033","series-title":"Nutrients","article-title":"The effect of probiotics on the production of short-chain fatty acids by human intestinal microbiome","volume":"12","author":"Markowiak-Kopec, P.","unstructured":"Markowiak-Kopec, P. and Slizewska, K., 2020. The effect of probiotics on the production of short-chain fatty acids by human intestinal microbiome. Nutrients 12: 1107. https:\/\/doi.org\/10.3390\/nu12041107"},{"key":"R000034","series-title":"Medicine","article-title":"Chronic constipation: A review of literature","volume":"97","author":"Mojgan, F.","unstructured":"Mojgan, F., Nazila, B. and Mohamma, D., 2018. Chronic constipation: A review of literature. Medicine 97: e10631."},{"key":"R000035","series-title":"British Journal of Anaesthesia","first-page":"815","article-title":"Constipation and its implications in the critically ill patient","volume":"91","author":"Mostafa, S.M.","unstructured":"Mostafa, S.M., Bhandari, S., Ritchie, G., Gratton, N. and Wenstone, R., 2003. Constipation and its implications in the critically ill patient. British Journal of Anaesthesia 91: 815-819."},{"key":"R000036","series-title":"Bioscience Biotechnology and Biochemistry","first-page":"1233","article-title":"Effect of dietary fiber on morphine-induced constipation in rats","volume":"66","author":"Niwa, T.","unstructured":"Niwa, T., Nakao, M., Hoshi, S., Yamada, K., Inagaki, K., Nishida, M. and Nabeshima, T., 2002. Effect of dietary fiber on morphine-induced constipation in rats. Bioscience Biotechnology and Biochemistry 66: 1233-1240."},{"key":"R000037","series-title":"Frontiers in Medicine","article-title":"Gut microbiota and chronic constipation: a review and update","volume":"6","author":"Ohkusa, T.","unstructured":"Ohkusa, T., Koido, S., Nishikawa, Y. and Sato, N., 2019. Gut microbiota and chronic constipation: a review and update. Frontiers in Medicine 6: 19. https:\/\/doi.org\/10.3389\/fmed.2019.00019"},{"key":"R000038","series-title":"Food and Fermentation Industries","first-page":"62","article-title":"Preparation of the acid-resistant freeze-dried Lactobacillus casei CCFM711","volume":"46","author":"Ouyang, B.","unstructured":"Ouyang, B., Cui, S., Mao, B., Tang, X., Ma, F., Zhao, J., Zhang, H. and Chen, W., 2020. Preparation of the acid-resistant freeze-dried Lactobacillus casei CCFM711. Food and Fermentation Industries 46: 62-68."},{"key":"R000039","series-title":"Applied Sciences","article-title":"Preventive effects of Lactobacillus plantarum YS4 on constipation induced by activated carbon in Mice","volume":"8","author":"Qian, Y.","unstructured":"Qian, Y., Song, J.-L., Yi, R., Li, G., Sun, P., Zhao, X. and Huo, G., 2018. Preventive effects of Lactobacillus plantarum YS4 on constipation induced by activated carbon in Mice. Applied Sciences 8: 363. https:\/\/doi.org\/10.3390\/app8030363"},{"key":"R000040","series-title":"Nature Reviews Gastroenterology and Hepatology","first-page":"295","article-title":"Diagnosis and management of chronic constipation in adults","volume":"13","author":"Rao, S.S.C.","unstructured":"Rao, S.S.C., Rattanakovit, K. and Patcharatrakul, T., 2016. Diagnosis and management of chronic constipation in adults. Nature Reviews Gastroenterology and Hepatology 13: 295-305. https:\/\/doi.org\/10.1038\/nrgastro.2016.53"},{"key":"R000041","series-title":"Expert Opinion on Pharmacotherapy","first-page":"547","article-title":"Management of constipation in Parkinson\u2019s disease","volume":"16","author":"Rossi, M.","unstructured":"Rossi, M., Merello, M. and Perez-Lloret, S., 2015. Management of constipation in Parkinson\u2019s disease. Expert Opinion on Pharmacotherapy 16: 547-557."},{"key":"R000042","series-title":"Revista de Gastroenterologia de Mexico","first-page":"13","article-title":"Quality of life in patients with different constipation subtypes based on the Rome III criteria","volume":"80","author":"Ruiz-Lopez, M.C.","unstructured":"Ruiz-Lopez, M.C. and Coss-Adame, E., 2015. Quality of life in patients with different constipation subtypes based on the Rome III criteria. Revista de Gastroenterologia de Mexico 80: 13-20. https:\/\/doi.org\/10.1016\/j.rgmx.2015.01.003"},{"key":"R000043","series-title":"Nature Reviews Gastroenterology and Hepatology","first-page":"649","article-title":"The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics","volume":"18","author":"Salminen, S.","unstructured":"Salminen, S., Collado, M.C., Endo, A., Hill, C., Lebeer, S., Quigley, E.M.M., Sanders, M.E., Shamir, R., Swann, J.R., Szajewska, H. and Vinderola, G., 2021. The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics. Nature Reviews Gastroenterology and Hepatology 18: 649-667. https:\/\/doi.org\/10.1038\/s41575-021-00440-6"},{"key":"R000044","series-title":"Food and Function","first-page":"310","article-title":"Ligilactobacillus acidipiscis YJ5 modulates the gut microbiota and produces beneficial metabolites to relieve constipation by enhancing the mucosal barrier","volume":"15","author":"Shen, F.","unstructured":"Shen, F., Wang, Q., Ullah, S., Pan, Y., Zhao, M., Wang, J., Chen, M., Feng, F. and Zhong, H., 2024. Ligilactobacillus acidipiscis YJ5 modulates the gut microbiota and produces beneficial metabolites to relieve constipation by enhancing the mucosal barrier. Food and Function 15: 310-325. https:\/\/doi.org\/10.1039\/d3fo03259k"},{"key":"R000045","series-title":"Frontiers in Cellular Neuroscience","article-title":"Constitutively active 5-HT receptors: an explanation of how 5-HT antagonists inhibit gut motility in species where 5-HT is not an enteric neurotransmitter?","volume":"9","author":"Spencer, N.J.","unstructured":"Spencer, N.J., 2015. Constitutively active 5-HT receptors: an explanation of how 5-HT antagonists inhibit gut motility in species where 5-HT is not an enteric neurotransmitter? Frontiers in Cellular Neuroscience 9: 487. https:\/\/doi.org\/10.3389\/fncel.2015.00487"},{"key":"R000046","series-title":"Cytokine","first-page":"1","article-title":"Lactobacillus paracasei modulates LPS-induced inflammatory cytokine release by monocyte-macrophages via the up-regulation of negative regulators of NF-kappaB signaling in a TLR2-dependent manner","volume":"92","author":"Sun, K.-Y.","unstructured":"Sun, K.-Y., Xu, D.-H., Xie, C., Plummer, S., Tang, J., Yang, X.F. and Ji, X.H., 2017. Lactobacillus paracasei modulates LPS-induced inflammatory cytokine release by monocyte-macrophages via the up-regulation of negative regulators of NF-kappaB signaling in a TLR2-dependent manner. Cytokine 92: 1-11. https:\/\/doi.org\/10.1016\/j.cyto.2017.01.003"},{"key":"R000047","series-title":"Journal of Korean Gerontological Nursing","first-page":"65","article-title":"Effects of stress due to constipation and nutritional status on degree of constipation among community-dwelling elders","volume":"22","author":"Sun, S.M.","unstructured":"Sun, S.M. and Young, Y.N., 2020. Effects of stress due to constipation and nutritional status on degree of constipation among community-dwelling elders. Journal of Korean Gerontological Nursing 22: 65-74. https:\/\/doi.org\/10.17079\/jkgn.2020.22.1.65"},{"key":"R000048","series-title":"Evidence-based Complementary and Alternative Medicine","article-title":"Curative effect and mechanism of guiren runchang granules on morphine-induced slow transit constipation in mice","volume":"2020","author":"Sun, Y.","unstructured":"Sun, Y., Yan, C., Jin, S., Shi, C. and Li, G., 2020. Curative effect and mechanism of guiren runchang granules on morphine-induced slow transit constipation in mice. Evidence-based Complementary and Alternative Medicine 2020: 5493192."},{"key":"R000049","series-title":"Clinical Nutrition","first-page":"2759","article-title":"Probiotics and synbiotics in chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials","volume":"41","author":"Van\u00a0der Schoot, A.","unstructured":"Van\u00a0der Schoot, A., Helander, C., Whelan, K. and Dimidi, E., 2022. Probiotics and synbiotics in chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials. Clinical Nutrition 41: 2759-2777. https:\/\/doi.org\/10.1016\/j.clnu.2022.10.015"},{"key":"R000050","series-title":"Frontiers in Cellular and Infection Microbiology","article-title":"Lactobacillus rhamnosus strains relieve loperamide-induced constipation via different pathways independent of short-chain fatty acids","volume":"10","author":"Wang, G.","unstructured":"Wang, G., Yang, S., Sun, S., Si, Q., Wang, L., Zhang, Q., Wu, G., Zhao, J., Zhang, H. and Chen, W., 2020a. Lactobacillus rhamnosus strains relieve loperamide-induced constipation via different pathways independent of short-chain fatty acids. Frontiers in Cellular and Infection Microbiology 10: 435. https:\/\/doi.org\/10.3389\/fcimb.2020.00423"},{"key":"R000051","series-title":"Journal of Dairy Science","first-page":"11025","article-title":"Fermented milk containing Lactobacillus casei Zhang and Bifidobacterium animalis ssp. lactis V9 alleviated constipation symptoms through regulation of intestinal microbiota, inflammation, and metabolic pathways","volume":"103","author":"Wang, J.","unstructured":"Wang, J., Bai, X., Peng, C., Yu, Z., Li, B., Zhang, W., Sun, Z. and Zhang, H., 2020b. Fermented milk containing Lactobacillus casei Zhang and Bifidobacterium animalis ssp. lactis V9 alleviated constipation symptoms through regulation of intestinal microbiota, inflammation, and metabolic pathways. Journal of Dairy Science 103: 11025-11038. https:\/\/doi.org\/10.3168\/jds.2020-18639"},{"key":"R000052","series-title":"Frontiers in Microbiology","article-title":"Adhesive Bifidobacterium induced changes in cecal microbiome alleviated constipation in mice","volume":"10","author":"Wang, L.","unstructured":"Wang, L., Chen, C., Cui, S., Lee, Y.-k., Wang, G., Zhao, J., Zhang, H. and Chen, W., 2019. Adhesive Bifidobacterium induced changes in cecal microbiome alleviated constipation in mice. Frontiers in Microbiology 10: 1721. https:\/\/doi.org\/10.3389\/fmicb.2019.01721"},{"key":"R000053","series-title":"Food Function","first-page":"3587","article-title":"Bifidobacteria exert species-specific effects on constipation in BALB\/c mice","volume":"8","author":"Wang, L.","unstructured":"Wang, L., Hu, L., Xu, Q., Jiang, T., Fang, S., Wang, G., Zhao, J., Zhang, H. and Chen, W., 2017. Bifidobacteria exert species-specific effects on constipation in BALB\/c mice. Food Function 8: 3587-3600."},{"key":"R000054","series-title":"Foods","article-title":"Lactobacillus paracasei relieves constipation by acting on the acetic acid-5-HT-intestinal motility pathway","volume":"12","author":"Wang, L.","unstructured":"Wang, L., Yang, S., Mei, C., Tang, N., Wang, J., Yu, Q., Wang, G., Wu, G., Zhao, J. and Chen, W., 2023. Lactobacillus paracasei relieves constipation by acting on the acetic acid-5-HT-intestinal motility pathway. Foods 12: 4176. https:\/\/doi.org\/10.3390\/foods12224176"},{"key":"R000055","series-title":"Food and Fermentation Industries","first-page":"1","article-title":"Lactobacillus paracasei LPC-F relieved constipation by promoting the proliferation of interstitial cells of Cajal","volume":"48","author":"Wang, L.","unstructured":"Wang, L., Yang, S., Wang, J., Wang, G., Zhang, H., Zhao, J. and Chen, W., 2022. Lactobacillus paracasei LPC-F relieved constipation by promoting the proliferation of interstitial cells of Cajal. Food and Fermentation Industries 48: 1-9."},{"key":"R000056","series-title":"Journal of the Science of Food and Agriculture","first-page":"692","article-title":"Alleviation of loperamide-induced constipation with sticky rice fermented huangjiu by the regulation of serum neurotransmitters and gut microbiota","volume":"103","author":"Xinjing, F.","unstructured":"Xinjing, F., Ying, S., Zhilei, Z., Zhongwei, J., Weibiao, Z., Shuguang, C. and Jian, M., 2023. Alleviation of loperamide-induced constipation with sticky rice fermented huangjiu by the regulation of serum neurotransmitters and gut microbiota. Journal of the Science of Food and Agriculture 103: 692-704. https:\/\/doi.org\/10.1002\/jsfa.12181"},{"key":"R000057","series-title":"Journal of the Science of Food and Agriculture","first-page":"4778","article-title":"Defatted hempseed meal altered the metabolic profile of fermented yogurt and enhanced the ability to alleviate constipation in rats","volume":"103","author":"Xu, J.","unstructured":"Xu, J., Xu, X., Hua, D., Yuan, Z., Bai, M., Song, H., Yang, L., Li, J., Zhu, D. and Liu, H., 2023. Defatted hempseed meal altered the metabolic profile of fermented yogurt and enhanced the ability to alleviate constipation in rats. Journal of the Science of Food and Agriculture 103: 4778-4791. https:\/\/doi.org\/10.1002\/jsfa.12575"},{"key":"R000058","series-title":"Clinical Nutrition","first-page":"1315","article-title":"Mining Lactobacillus and Bifidobacterium for organisms with long-term gut colonization potential","volume":"39","author":"Yue, X.","unstructured":"Yue, X., Jianxin, Z., Hao, Z., Qixiao, Z. and Wei, C., 2020. Mining Lactobacillus and Bifidobacterium for organisms with long-term gut colonization potential. Clinical Nutrition 39: 1315-1323. https:\/\/doi.org\/10.1016\/j.clnu.2019.05.014"},{"key":"R000059","series-title":"Gastroenterology Report","first-page":"392","article-title":"Role of gut microbiota in functional constipation","volume":"9","author":"Zhang, S.","unstructured":"Zhang, S., Wang, R., Li, D., Zhao, L. and Zhu, L., 2021. Role of gut microbiota in functional constipation. Gastroenterology Report 9: 392-401. https:\/\/doi.org\/10.1093\/gastro\/goab035"},{"key":"R000060","series-title":"Journal of Functional Foods","first-page":"266","article-title":"Fiber-rich foods affected gut bacterial community and short-chain fatty acids production in pig model","volume":"57","author":"Zhao, J.","unstructured":"Zhao, J., Bai, Y., Tao, S., Zhang, G., Wang, J., Liu, L. and Zhang, S., 2019. Fiber-rich foods affected gut bacterial community and short-chain fatty acids production in pig model. Journal of Functional Foods 57: 266-274. https:\/\/doi.org\/10.1016\/j.jff.2019.04.009"},{"key":"R000061","series-title":"Frontiers in Microbiology","article-title":"Alleviating effects of gut micro-ecologically regulatory treatments on mice with constipation","volume":"13","author":"Zhao, Y.","unstructured":"Zhao, Y., Liu, Q., Hou, Y. and Zhao, Y., 2022. Alleviating effects of gut micro-ecologically regulatory treatments on mice with constipation. Frontiers in Microbiology 13. https:\/\/doi.org\/10.3389\/fmicb.2022.956438"},{"key":"R000062","series-title":"Physiological Genomics","first-page":"679","article-title":"Structural changes in the gut microbiome of constipated patients","volume":"46","author":"Zhu, L.","unstructured":"Zhu, L., Liu, W., Alkhouri, R., Baker, R.D., Bard, J.E., Quigley, E.M. and Baker, S.S., 2014. Structural changes in the gut microbiome of constipated patients. Physiological Genomics 46: 679-686. https:\/\/doi.org\/10.1152\/physiolgenomics.00082.2014"},{"key":"R000063","series-title":"Molecular Nutrition and Food Research","article-title":"Abundance of probiotics and butyrate-production microbiome manages constipation via short-chain fatty acids production and hormones secretion","volume":"63","author":"Zhuang, M.","unstructured":"Zhuang, M., Shang, W., Ma, Q., Strappe, P. and Zhou, Z., 2019. Abundance of probiotics and butyrate-production microbiome manages constipation via short-chain fatty acids production and hormones secretion. Molecular Nutrition and Food Research 63: 1801187. https:\/\/doi.org\/10.1002\/mnfr.201801187"}],"container-title":["Beneficial Microbes"],"original-title":[],"link":[{"URL":"https:\/\/brill.com\/view\/journals\/bm\/15\/3\/article-p311_6.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/brill.com\/downloadpdf\/journals\/bm\/15\/3\/article-p311_6.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/brill.com\/downloadpdf\/journals\/bm\/15\/3\/article-p311_6.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T04:57:38Z","timestamp":1740027458000},"score":1,"resource":{"primary":{"URL":"https:\/\/brill.com\/view\/journals\/bm\/15\/3\/article-p311_6.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,1]]},"references-count":63,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1163\/18762891-bja00011","relation":{},"ISSN":["1876-2891"],"issn-type":[{"value":"1876-2891","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,1]]}}}