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Microbes"],"published-print":{"date-parts":[[2024,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>Constipation during pregnancy can induce serious complications, including miscarriage and preterm labour, while the evidence of probiotics in improving constipation during pregnancy was little. In this study, 29 healthy pregnant women and 65 constipated pregnant women were enrolled to assess the effectiveness of probiotics on constipation during pregnancy. Our results showed that the probiotics were effective in improving the Constipation Severity Scale (CSS) and Bristol Stool Scale (BSS) scores, including increasing defecation frequency, decreasing defecation time, and improving fecal characteristics. 16S rRNA sequencing revealed that the probiotics effectively restored the diversity of intestinal microbiota. At the phylum level, <jats:italic>Firmicutes<\/jats:italic> (13.27% vs 57.20%) and <jats:italic>Actinobacteria<\/jats:italic> (3.77% vs 12.80%) were increased, while <jats:italic>Bacteroidetes<\/jats:italic> (77.82% vs 20.24%) was decreased. At the level of the genus, <jats:italic>Faecalibacterium<\/jats:italic> (2.03% vs 10.33%), <jats:italic>Bifidobacterium<\/jats:italic> (1.21% vs 8.56%), and <jats:italic>Phascolarctobacterium<\/jats:italic> (0.05% vs 2.88%), the beneficial bacteria were increased, while the <jats:italic>Bacteroides<\/jats:italic> (29.23% vs 12.28%) and <jats:italic>Prevotella<\/jats:italic> (24.32% vs 4.92%) were decreased. In conclusion, these results indicated that probiotics can effectively relieve the constipation symptoms by improving the diversity of intestinal microbiota, regulating the disturbance of microflorae, and restoring the balance of microflorae to exert a stronger moderating effect than diet and lifestyle modification. Our results provided clinical data and a theoretical basis for the exploitation of probiotics in treating constipation during pregnancy.<\/jats:p>\n<jats:p>Chinese Clinical Trial Registry: ChiCTR2100052069<\/jats:p>","DOI":"10.1163\/18762891-bja00020","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T12:50:05Z","timestamp":1722430205000},"page":"357-371","source":"Crossref","is-referenced-by-count":4,"title":["Probiotics combination effectively improves constipation in pregnancy by modifying the gut microbiota composition"],"prefix":"10.1163","volume":"15","author":[{"given":"X.","family":"He","sequence":"first","affiliation":[{"name":"National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Jiangxi Medical College, https:\/\/dx.doi.org\/529927Nanchang University, Nanchang 330031, China P.R."},{"name":"Ninth hospital in Nanchang, Nanchang 330006, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Chen","sequence":"additional","affiliation":[{"name":"Reproductive Hospital of Jiangxi University of Traditional Chinese Medicine, https:\/\/dx.doi.org\/529927Nanchang University, Nanchang 330006, China P.R."},{"name":"School of Pharmacy, Jiangxi Medical College, Nanchang 330006, China P.R."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Wang","sequence":"additional","affiliation":[{"name":"Ninth hospital in Nanchang, Nanchang 330006, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Chen","sequence":"additional","affiliation":[{"name":"Jiangxi Maternal and Child Health Hospital, Nanchang 330006, China P.R."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Xu","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Jiangxi Medical College, https:\/\/dx.doi.org\/529927Nanchang University, Nanchang 330031, China P.R."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Nanchang University, Nanchang 330031, China P.R."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Nanchang University, Nanchang 330031, China P.R."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Neurology, First Affiliated Hospital of Nanchang University, Nanchang 330006, China P.R."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Wei","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Jiangxi Medical College, https:\/\/dx.doi.org\/529927Nanchang University, Nanchang 330031, China P.R."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0506-8536","authenticated-orcid":true,"given":"T.","family":"Chen","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Jiangxi Medical College, https:\/\/dx.doi.org\/529927Nanchang University, Nanchang 330031, China P.R."},{"name":"School of Pharmacy, Jiangxi Medical College, Nanchang 330006, China P.R."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"R000001","series-title":"Diseases of the Colon and Rectum","first-page":"681","article-title":"A constipation scoring system to simplify evaluation and management of constipated patients","volume":"39","author":"Agachan, F.","unstructured":"Agachan, F., Chen, T., Pfeifer, J., Reissman, P. and Wexner, S.D., 1996. 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