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Microbes"],"published-print":{"date-parts":[[2024,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>This study investigated the effect of <jats:italic>Lacticaseibacillus rhamnosus<\/jats:italic> LRa05 on alcoholic fatty liver disease (ALD) and its mechanism for liver protection. Mice were randomly divided into three groups: a control (CLT) group, an ALD group, and a LRa05 intervention group. The ALD mouse model was established by Lieber-DeCarli chronic alcohol feeding. Tissues staining, enzyme-linked immunosorbent assay (ELISA) was performed to detect changes in histopathology and inflammatory cytokines, respectively. Moreover, intestinal permeability was evaluated by the level of dextran-fluorescein isothiocyanate (Dx-FITC) in serum and tight junction protein in the colon. Changes in the composition of the gut microbiota were assessed by 16S rRNA sequencing. Alcohol consumption induced liver damage in mice with significantly increased levels of triglycerides (TG), aspartate aminotransferase (AST), alanine transaminase (ALT), and inflammatory cytokines. Moreover, alcohol further induced the increase of intestinal permeability and disruption of gut microbiota in mice, with an increase in the relative abundance of potentially pathogenic bacteria <jats:italic>Enterococcus<\/jats:italic>, <jats:italic>Parabacteroides<\/jats:italic>, and <jats:italic>Alistipes<\/jats:italic>. LRa05 intervention significantly attenuated alcohol-induced liver injury by reducing the contents of TG, ALT, and AST, and suppressing the inflammatory responses. Meanwhile, by stimulating the expression of ZO-1, Occludin, and Claudin in the colon tissue, LRa05 additionally strengthened the intestine barrier function. Furthermore, gut microbiota analysis suggested that LRa05 partially ameliorated gut microbiota disorders in ALD mice and up-regulated the abundance of <jats:italic>Desulfovibrio<\/jats:italic> and <jats:italic>Akkermansia<\/jats:italic>, which were negatively correlated with the indicators of ALD progression. The reconstructive effects of LRa05 on the gut microbiota might be related to the efficacy of LRa05 in improving gut permeability and further protecting against ALD.<\/jats:p>","DOI":"10.1163\/18762891-bja00022","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T13:25:07Z","timestamp":1722432307000},"page":"481-493","source":"Crossref","is-referenced-by-count":6,"title":["Lacticaseibacillus rhamnosus LRa05 alleviated liver injury in mice with alcoholic fatty liver disease by improving intestinal permeability and balancing gut microbiota"],"prefix":"10.1163","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1007-9469","authenticated-orcid":true,"given":"J.","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Research and Development, Wecare Probiotics Co., Ltd., 999 Guangming Road, Suzhou, Jiangsu, China P.R."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, https:\/\/dx.doi.org\/47901Henan University of Technology, Zhengzhou, China P.R."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Human Resources, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China P.R."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Integrated Traditional Chinese and Western Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China P.R."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4685-8312","authenticated-orcid":true,"given":"Z.","family":"Gai","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Wecare Probiotics Co., Ltd., 999 Guangming Road, Suzhou, Jiangsu, China P.R."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9035-7876","authenticated-orcid":true,"given":"Y.","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Wecare Probiotics Co., Ltd., 999 Guangming Road, Suzhou, Jiangsu, China P.R."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6139-2552","authenticated-orcid":true,"given":"F.","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, https:\/\/dx.doi.org\/47901Henan University of Technology, Zhengzhou, China P.R."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"R000001","series-title":"Cellular and Molecular Life Sciences","first-page":"473","article-title":"An insight into gut microbiota and its functionalities","volume":"76","author":"Adak, A.","unstructured":"Adak, A. and Khan, M.R., 2019. An insight into gut microbiota and its functionalities. Cellular and Molecular Life Sciences 76: 473-493. https:\/\/doi.org\/10.1007\/s00018-018-2943-4"},{"key":"R000002","series-title":"Archives of Toxicology","first-page":"1337","article-title":"Cytokines in alcoholic liver disease","volume":"86","author":"An, L.","unstructured":"An, L., Wang, X. and Cederbaum, A.I., 2012. Cytokines in alcoholic liver disease. Archives of Toxicology 86: 1337-1348. https:\/\/doi.org\/10.1007\/s00204-012-0814-6"},{"key":"R000003","series-title":"Toxicologic Pathology","first-page":"567","article-title":"Hepatocyte proliferation is the possible mechanism for the transient decrease in liver injury during steatosis stage of alcoholic liver disease","volume":"32","author":"Apte, U.M.","unstructured":"Apte, U.M., McRee, R. and Ramaiah, S.K., 2004. Hepatocyte proliferation is the possible mechanism for the transient decrease in liver injury during steatosis stage of alcoholic liver disease. Toxicologic Pathology 32: 567-576. https:\/\/doi.org\/10.1080\/01926230490508812"},{"key":"R000004","series-title":"Clinics in Liver Disease","first-page":"667","article-title":"Alcohol metabolism","volume":"16","author":"Cederbaum, A.I.","unstructured":"Cederbaum, A.I., 2012. Alcohol metabolism. Clinics in Liver Disease 16: 667-685. https:\/\/doi.org\/10.1016\/j.cld.2012.08.002"},{"key":"R000005","series-title":"BMC Complementary Medicine and Therapies","article-title":"Probiotics and their beneficial effects on alcohol-induced liver injury in a rat model: the role of fecal microbiota","volume":"22","author":"Chayanupatkul, M.","unstructured":"Chayanupatkul, M., Somanawat, K., Chuaypen, N., Klaikeaw, N., Wanpiyarat, N., Siriviriyakul, P., Tumwasorn, S. and Werawatganon, D., 2022. Probiotics and their beneficial effects on alcohol-induced liver injury in a rat model: the role of fecal microbiota. BMC Complementary Medicine and Therapies 22: 168. https:\/\/doi.org\/10.1186\/s12906-022-03643-9"},{"key":"R000006","series-title":"Cell Bioscience","article-title":"Modulating phenylalanine metabolism by L. acidophilus alleviates alcohol-related liver disease through enhancing intestinal barrier function","volume":"13","author":"Chen, L.","unstructured":"Chen, L., Yang, P., Hu, L., Yang, L., Chu, H. and Hou, X., 2023. Modulating phenylalanine metabolism by L. acidophilus alleviates alcohol-related liver disease through enhancing intestinal barrier function. Cell Bioscience 13: 24. https:\/\/doi.org\/10.1186\/s13578-023-00974-z"},{"key":"R000007","series-title":"Hepatology","first-page":"883","article-title":"Dysbiosis-induced intestinal inflammation activates tumor necrosis factor receptor I and mediates alcoholic liver disease in mice","volume":"61","author":"Chen, P.","unstructured":"Chen, P., St\u00e4rkel, P., Turner, J.R., Ho, S.B. and Schnabl, B., 2015. 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Toxicology Letters 241: 103-110. https:\/\/doi.org\/10.1016\/j.toxlet.2015.11.019"},{"key":"R000009","series-title":"Food Research International","article-title":"Lactobacillus plantarum ZY08 relieves chronic alcohol-induced hepatic steatosis and liver injury in mice via restoring intestinal flora homeostasis","volume":"157","author":"Ding, Q.","unstructured":"Ding, Q., Cao, F., Lai, S., Zhuge, H., Chang, K., Valencak, T.G., Liu, J., Li, S. and Ren, D., 2022. Lactobacillus plantarum ZY08 relieves chronic alcohol-induced hepatic steatosis and liver injury in mice via restoring intestinal flora homeostasis. Food Research International 157: 111259. https:\/\/doi.org\/10.1016\/j.foodres.2022.111259"},{"key":"R000010","series-title":"AMB Express","article-title":"Bifidobacterium BLa80 mitigates colitis by altering gut microbiota and alleviating inflammation","volume":"12","author":"Dong, Y.","unstructured":"Dong, Y., Liao, W., Tang, J., Fei, T., Gai, Z. and Han, M., 2022. 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Frontiers in Pharmacology 13: 797499. https:\/\/doi.org\/10.3389\/fphar.2022.797499"},{"key":"R000013","series-title":"American Journal of Physiology\u00a0\u2013 Gastrointestinal and Liver Physiology","first-page":"G1356","article-title":"Acetaldehyde disrupts tight junctions in Caco-2 cell monolayers by a protein phosphatase 2A-dependent mechanism","volume":"303","author":"Dunagan, M.","unstructured":"Dunagan, M., Chaudhry, K., Samak, G. and Rao, R.K., 2012. Acetaldehyde disrupts tight junctions in Caco-2 cell monolayers by a protein phosphatase 2A-dependent mechanism. 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Journal of Agricultural and Food Chemistry 70: 4631-4643. https:\/\/doi.org\/10.1021\/acs.jafc.1c07884"},{"key":"R000037","series-title":"Infection and Immunity","first-page":"2762","article-title":"Enterococcus faecalis gelatinase mediates intestinal permeability via protease-activated receptor 2","volume":"83","author":"Maharshak, N.","unstructured":"Maharshak, N., Huh, E.Y., Paiboonrungruang, C., Shanahan, M., Thurlow, L., Herzog, J., Djukic, Z., Orlando, R., Pawlinski, R., Ellermann, M., Borst, L., Patel, S., Dotan, I., Sartor, R.B. and Carroll, I.M., 2015. Enterococcus faecalis gelatinase mediates intestinal permeability via protease-activated receptor 2. Infection and Immunity 83: 2762-2770. https:\/\/doi.org\/10.1128\/iai.00425-15"},{"key":"R000038","series-title":"American Journal of Physiology\u00a0\u2013 Gastrointestinal and Liver Physiology","first-page":"G497","article-title":"Recent advances in alcoholic liver disease\u00a0\u2013 IV. 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