{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T01:06:40Z","timestamp":1741309600462,"version":"3.38.0"},"reference-count":52,"publisher":"Walter de Gruyter GmbH","issue":"6","funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"crossref","award":["CBB-APQ-03613-17"],"award-info":[{"award-number":["CBB-APQ-03613-17"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["403193\/2022-2"],"award-info":[{"award-number":["403193\/2022-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Benef. Microbes"],"published-print":{"date-parts":[[2024,9,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>Chronic unpredictable mild stress (CUMS) is a widely accepted method for inducing depressive-like states in animal models. We decided to explore the effects of CUMS on the CantonS lineage of <jats:italic>Drosophila melanogaster<\/jats:italic>, which differs from the OregonR lineage in various ways. Additionally, we wanted to investigate the potential benefits of kefir in treating these chronically stressed flies, as previous research has shown promising results in using kefir components for depression treatment. To begin, we exposed male CantonS flies to a 10-day CUMS protocol and compared them to non-stressed flies. Within the stressed group, we had two subgroups: one treated with kefir (CUMS\u00a0+ Kefir group) and the other treated with sertraline (positive control). We then analysed various factors including serotonin levels, brain structure, markers of oxidative damage in lipids and proteins, and behavioural manifestations such as sociability, locomotor function, and anhedonic-like behaviour. Our results showed that flies exposed to CUMS experienced a decrease in serotonin levels without any signs of degeneration. They also exhibited reduced sociability, increased motor agitation, and decreased sucrose consumption, which are all indicative of stress-induced depressive-like behaviour. However, treatment with sertraline partially reversed these effects. Interestingly, treatment with kefir not only restored serotonin levels but also improved sociability and anhedonic-like behaviours. Additionally, flies in the CUMS\u00a0+ Kefir group had a longer lifespan compared to their untreated counterparts. These findings suggest that kefir has multiple advantageous effects on flies subjected to the 10-day CUMS protocol. In conclusion, our study demonstrates that the CantonS lineage of <jats:italic>D. melanogaster<\/jats:italic> displays depressive-like manifestations after exposure to CUMS. Furthermore, kefir emerges as a powerful nutritional tool capable of reversing these effects and promoting beneficial outcomes in chronically stressed flies.<\/jats:p>","DOI":"10.1163\/18762891-bja00037","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T05:24:13Z","timestamp":1726032253000},"page":"689-704","source":"Crossref","is-referenced-by-count":0,"title":["Kefir recovered depressive-like behaviour in CantonS lineage of Drosophila melanogaster exposed to chronic unpredictable mild stress protocol"],"prefix":"10.1163","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7532-4673","authenticated-orcid":true,"given":"T.G.C.","family":"Oliveira","sequence":"first","affiliation":[{"name":"Institute of Biomedical Sciences, https:\/\/dx.doi.org\/28119Federal University of Uberlandia (UFU), CP 592, CEP 38400-902, Uberla\u0302ndia, Minas Gerais, Brazil"},{"name":"Cellular and Structural Biology Program, Institute of Biology, https:\/\/dx.doi.org\/28132State University of Campinas, UNICAMP, Sa\u0303o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9330-9503","authenticated-orcid":true,"given":"S.M.","family":"Malta","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, https:\/\/dx.doi.org\/28119Federal University of Uberlandia, UFU, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6259-2927","authenticated-orcid":true,"given":"E.O.","family":"Marson","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, https:\/\/dx.doi.org\/28119Federal University of Uberlandia, UFU, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2412-7199","authenticated-orcid":true,"given":"A.G.","family":"Trovo\u0301","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, https:\/\/dx.doi.org\/28119Federal University of Uberlandia, UFU, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3616-6611","authenticated-orcid":true,"given":"A.B.","family":"Justino","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, https:\/\/dx.doi.org\/28119Federal University of Uberlandia, UFU, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9086-2944","authenticated-orcid":true,"given":"V.P.","family":"Bittar","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, https:\/\/dx.doi.org\/28119Federal University of Uberlandia, UFU, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6937-1411","authenticated-orcid":true,"given":"F.S.","family":"Espindola","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, https:\/\/dx.doi.org\/28119Federal University of Uberlandia, UFU, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8518-1688","authenticated-orcid":true,"given":"T.C.","family":"Tomiosso","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, https:\/\/dx.doi.org\/28119Federal University of Uberlandia (UFU), CP 592, CEP 38400-902, Uberla\u0302ndia, Minas Gerais, Brazil"},{"name":"Cellular and Structural Biology Program, Institute of Biology, https:\/\/dx.doi.org\/28132State University of Campinas, UNICAMP, Sa\u0303o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8369-9069","authenticated-orcid":true,"given":"C.","family":"Ueira-Vieira","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, https:\/\/dx.doi.org\/28119Federal University of Uberlandia, UFU, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5930-3821","authenticated-orcid":true,"given":"R.G.","family":"Zanon","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, https:\/\/dx.doi.org\/28119Federal University of Uberlandia (UFU), CP 592, CEP 38400-902, Uberla\u0302ndia, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"R000001","series-title":"International Clinical Psychopharmacology","first-page":"197","article-title":"Double-blind study of the efficacy and safety of sertraline versus fluoxetine in major depression","volume":"8","author":"Aguglia, E.","unstructured":"Aguglia, E., Casacchia, M., Cassano, G.B., Faravelli, C., Ferrari, G., Giordano, P., Pancheri, P., Ravizza, L., Trambuchi, M. and Bolino, F., 1993. 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