{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:24:13Z","timestamp":1790879053471,"version":"4.1.0"},"reference-count":26,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Benef. Microbes"],"published-print":{"date-parts":[[2024,9,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>Treatment with probiotics can help manage chronic constipation by softening the stools and possibly acting synergistically with front-line treatments. We assessed the efficacy of <jats:italic>Bifidobacterium animalis<\/jats:italic> subsp. <jats:italic>lactis<\/jats:italic> BLa80 in maltodextrin as a food supplement in regulating the intestinal habit of subjects with chronic constipation with type 1 or 2 stools on the Bristol scale index and\/or less than three stools per week. A multicentre, randomised, double-blind, placebo-controlled clinical trial was carried out in subjects aged 18 and over with chronic constipation. The study enrolled forty-six subjects who were randomised one-to-one to receive the potential probiotic in maltodextrin (n\u00a0= 23) or a placebo (n\u00a0= 23). Investigators assessed changes in intestinal habits by analysing the mean number of weekly stools and the stool types according to the Bristol Scale. Patients reported constipation symptoms with PAC-SYM (patient assessment of constipation\u00a0\u2013 symptoms), and the impact on quality of life with PAC-QoL (patient assessment of constipation\u00a0\u2013 quality of life) and GI-QLI (gastrointestinal quality of life index). Patients on the intervention group showed a greater tendency to normalise the type of stools than those in the placebo group. This difference towards regular stool types (type 3 and 4) was statistically significant at weeks 8 and 12 relative to week 4 (<jats:italic>P<\/jats:italic>-values\u00a0= 0.006 and 0.027, respectively). The proportion of constipated patients in the experimental group dropped over time, while the rate slightly increased in the placebo group in a statistically significant manner at week 12 relative to week 4 (<jats:inline-formula\/>). Overall, the present study shows oral intake of <jats:italic>B. animalis<\/jats:italic> subsp. <jats:italic>lactis<\/jats:italic> BLa80 in maltodextrin for 12 weeks improves intestinal habits in subjects with chronic constipation. Our study provides evidence to the efficacy and safety use of this formulation as an effective tool for improving stool consistency in constipated patients.<\/jats:p>\n<jats:p>The trial was registered at ClinicalTrials.gov: NCT05980988.<\/jats:p>","DOI":"10.1163\/18762891-bja00038","type":"journal-article","created":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T07:46:54Z","timestamp":1725695214000},"page":"679-688","source":"Crossref","is-referenced-by-count":12,"title":["Bifidobacterium animalis subsp. lactis BLa80 regulates the intestinal habit in adults with chronic constipation: a multicentre, randomised, double-blind, placebo-controlled study"],"prefix":"10.1163","volume":"15","author":[{"given":"E.","family":"Salo","sequence":"first","affiliation":[{"name":"Complife Group, Parc Cient\u0131\u0301fic de Barcelona (Edifici Clu\u0301ster), Avinguda Doctor Maran\u0303o\u0301n, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7524-4590","authenticated-orcid":true,"given":"D.","family":"Roche","sequence":"additional","affiliation":[{"name":"Universitat Internacional de Catalunya, Faculty of Economics and Social Sciences, 08017 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.B.","family":"Gomez-Martinez","sequence":"additional","affiliation":[{"name":"Equip d\u2019Atencio\u0301 Prima\u0300ria (EAP) Corbera de Llobregat\/La Palma de Cervello\u0301, Servei d\u2019Atencio\u0301 Prima\u0300ria (SAP) Baix Llobregat Centre, Direccio\u0301 d\u2019Atencio\u0301 Prima\u0300ria (DAP) Metropolitana Sud. Institut Catala\u0300 de la Salut (ICS), Departament de Salut, Generalitat de Catalunya, Catalonia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Cruz-Domenech","sequence":"additional","affiliation":[{"name":"CAP Roger (EAP Badal), Servei d\u2019Atencio\u0301 Prima\u0300ria (SAP) Esquerra, Direccio\u0301 d\u2019Atencio\u0301 Prima\u0300ria (DAP) Barcelona Ciutat, Institut Catala\u0300 de la Salut (ICS), Departament de Salut, Generalitat de Catalunya, Catalonia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.G.","family":"Garcia-Mora","sequence":"additional","affiliation":[{"name":"CAP Can Bou, Consorci de Castelldefels Agents de Salut (CASAP), Castelldefels, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Gabernet-Castello","sequence":"additional","affiliation":[{"name":"Complife Group, Parc Cient\u0131\u0301fic de Barcelona (Edifici Clu\u0301ster), Avinguda Doctor Maran\u0303o\u0301n, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3626-1494","authenticated-orcid":true,"given":"N.","family":"Freixenet","sequence":"additional","affiliation":[{"name":"Equip d\u2019Atencio\u0301 Prima\u0300ria (EAP) Corbera de Llobregat\/La Palma de Cervello\u0301, Servei d\u2019Atencio\u0301 Prima\u0300ria (SAP) Baix Llobregat Centre, Direccio\u0301 d\u2019Atencio\u0301 Prima\u0300ria (DAP) Metropolitana Sud. Institut Catala\u0300 de la Salut (ICS), Departament de Salut, Generalitat de Catalunya, Catalonia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"R000001","series-title":"Expert Review of Gastroenterology and Hepatology","first-page":"39","article-title":"An approach to the diagnosis and management of Rome IV functional disorders of chronic constipation","volume":"14","author":"Aziz, I.","unstructured":"Aziz, I., Whitehead, W.E., Palsson, O.S., T\u00f6rnblom, H. and Simre\u0301n, M., 2020. An approach to the diagnosis and management of Rome IV functional disorders of chronic constipation. 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