{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:35:56Z","timestamp":1792089356796,"version":"4.4.0"},"reference-count":44,"publisher":"Walter de Gruyter GmbH","issue":"1","funder":[{"name":"National Key R & Program of China","award":["2022YFC2010101"],"award-info":[{"award-number":["2022YFC2010101"]}]},{"name":"R&D Program of Zhejiang","award":["2022C03138"],"award-info":[{"award-number":["2022C03138"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Benef. Microbes"],"published-print":{"date-parts":[[2024,10,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>Chronic constipation is a multi-symptomatic, multifactorial, and heterogeneous gastrointestinal disorder. Current pharmacological treatments for chronic constipation are limited and might negatively impact the patients\u2019 quality of life. Although probiotics have been shown to improve constipation symptoms, their specific regulatory mechanisms remain unclear. This study sought to explore how probiotic complexes may affect chronic constipation by improving patients\u2019 defecation habits. Furthermore, microbial profiles and non-targeted metabolites were assessed to explore the metabolic pathways involved in the improvement of constipation by probiotics. Patients with chronic constipation were treated using a single-blind, randomised, placebo-controlled trial design. The experimental group was administered <jats:italic>Lactobacillus<\/jats:italic> powder prepared from 15 probiotic products, and maltodextrin was used as a placebo. Samples were collected twice daily for 4 weeks, and faecal samples were analysed using 16S rRNA sequencing and untargeted metabolic histology. Probiotic treatment changed the makeup of the gut microbiota, enhanced the quantity of <jats:italic>Bifidobacterium<\/jats:italic> and <jats:italic>Lactobacillus<\/jats:italic>, and markedly reduced clinical symptoms. The 16S rRNA analysis revealed that the abundance of <jats:italic>Bifidobacterium<\/jats:italic> and <jats:italic>Prevotella<\/jats:italic> increased while that of <jats:italic>Thickettsia<\/jats:italic> declined. Moreover, there was a decrease in the abundance of <jats:italic>Faecalibacterium<\/jats:italic> and <jats:italic>Roseburia<\/jats:italic>. Non-targeted metabolomics analysis identified several differential metabolites, including succinic acid, fumaric acid, cholesterol, xanthurenic acid, 3-alpha,7-alpha-trihydroxy-5beta-cholestan-26-oic, and N-methyltryptamine. KEGG analysis showed that these metabolites were mainly associated with metabolic pathways such as primary bile acid biosynthesis, tryptophan metabolism, alanine, aspartate and glutamate metabolism, phenylalanine metabolism, cholesterol metabolism, and propanoate metabolism. In this study, gut microbiome and non-targeted metabolome analyses were performed on collected faecal samples to compare characteristic microorganisms and differential metabolites to provide new insights and references for probiotic intervention in constipation.<\/jats:p>\n<jats:p>Trial registered at chictr.org.cn under number: ChiCTR2200056274<\/jats:p>","DOI":"10.1163\/18762891-bja00039","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T05:51:18Z","timestamp":1728539478000},"page":"35-49","source":"Crossref","is-referenced-by-count":7,"title":["Effects of complex probiotics on intestinal function and its regulatory mechanism in patients with constipation"],"prefix":"10.1163","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7610-449X","authenticated-orcid":true,"given":"X.","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Institute of Food Science, https:\/\/dx.doi.org\/74561Zhejiang Academy of Agricultural Sciences, 298 Desheng Middle Road, Hangzhou 310021, China P.R."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Jia","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Institute of Food Science, https:\/\/dx.doi.org\/74561Zhejiang Academy of Agricultural Sciences, 298 Desheng Middle Road, Hangzhou 310021, China P.R."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Institute of Food Science, https:\/\/dx.doi.org\/74561Zhejiang Academy of Agricultural Sciences, 298 Desheng Middle Road, Hangzhou 310021, China P.R."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Institute of Food Science, https:\/\/dx.doi.org\/74561Zhejiang Academy of Agricultural Sciences, 298 Desheng Middle Road, Hangzhou 310021, China P.R."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Li","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Hangzhou Normal University, 126 Wenzhou Road, Hangzhou 310015, China P.R."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Hangzhou Normal University, 126 Wenzhou Road, Hangzhou 310015, China P.R."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Dong","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Hangzhou Normal University, 126 Wenzhou Road, Hangzhou 310015, China P.R."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Ze","sequence":"additional","affiliation":[{"name":"BYHEALTH Institute of Nutrition & Health, 3-3 Techway Golden Valley, Science City, Whampoa District, Guangzhou 510663, China P.R."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"An","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Hospital of Shanxi University of Chinese Medicine, 75-1 Jinzi Road, Taiyuan 030024, China P.R."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4662-7207","authenticated-orcid":true,"given":"J.","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Institute of Food Science, https:\/\/dx.doi.org\/74561Zhejiang Academy of Agricultural Sciences, 298 Desheng Middle Road, Hangzhou 310021, China P.R."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"R000001","series-title":"Journal of Clinical Medicine","article-title":"The Firmicutes\/Bacteroidetes Ratio as a Risk Factor of Breast Cancer","volume":"12","author":"An, J.","unstructured":"An, J., Kwon, H. and Kim, Y.J., 2023. The Firmicutes\/Bacteroidetes Ratio as a Risk Factor of Breast Cancer. Journal of Clinical Medicine 12: 2216. https:\/\/doi.org\/10.3390\/jcm12062216"},{"key":"R000002","series-title":"Science","first-page":"337","article-title":"Induction of colonic regulatory T cells by indigenous Clostridium species","volume":"331","author":"Atarashi, K.","unstructured":"Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., Taniguchi, T., Takeda, K., Hori, S., Ivanov, I.I., Umesaki, Y., Itoh, K. and Honda, K., 2011. Induction of colonic regulatory T cells by indigenous Clostridium species. Science 331: 337-341. https:\/\/doi.org\/10.1126\/science.1198469"},{"key":"R000003","series-title":"Turkish Journal of Gastroenterology","first-page":"368","article-title":"Bifidobacteria was decreased in adult patients with irritable bowel syndrome based on PCR and bacterial culture: a systematic review and meta-analysis","volume":"33","author":"Bu, Z.","unstructured":"Bu, Z., Ye, X., Huang, B., Liu, R. and Peng, L., 2022. Bifidobacteria was decreased in adult patients with irritable bowel syndrome based on PCR and bacterial culture: a systematic review and meta-analysis. Turkish Journal of Gastroenterology 33: 368-376. https:\/\/doi.org\/10.5152\/tjg.2022.21543"},{"key":"R000004","series-title":"Scientific Reports","article-title":"Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls","volume":"6","author":"Chen, J.","unstructured":"Chen, J., Chia, N., Kalari, K.R., Yao, J.Z., Novotna, M., Paz Soldan, M.M., Luckey, D.H., Marietta, E.V., Jeraldo, P.R., Chen, X., Weinshenker, B.G., Rodriguez, M., Kantarci, O.H., Nelson, H., Murray, J.A. and Mangalam, A.K., 2016. Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls. Scientific Reports 6: 28484. https:\/\/doi.org\/10.1038\/srep28484"},{"key":"R000005","series-title":"Journal of Pharmaceutical and Biomedical Analysis","article-title":"An integrated metabolomics strategy to reveal dose-effect relationship and therapeutic mechanisms of different efficacy of rhubarb in constipation rats","volume":"177","author":"Chen, J.Q.","unstructured":"Chen, J.Q., Chen, Y.Y., Tao, H.J., Pu, Z.J., Shi, X.Q., Zhang, J., Tan, Y.J., Yue, S.J., Zhou, G.S., Shang, E.X., Tang, Y.P. and Duan, J.A., 2020. An integrated metabolomics strategy to reveal dose-effect relationship and therapeutic mechanisms of different efficacy of rhubarb in constipation rats. Journal of Pharmaceutical and Biomedical Analysis 177: 112837. https:\/\/doi.org\/10.1016\/j.jpba.2019.112837"},{"key":"R000006","series-title":"Cell Metabolism","first-page":"151","article-title":"Microbiota-produced succinate improves glucose homeostasis via intestinal gluconeogenesis","volume":"24","author":"De Vadder, F.","unstructured":"De Vadder, F., Kovatcheva-Datchary, P., Zitoun, C., Duchampt, A., Backhed, F. and Mithieux, G., 2016. Microbiota-produced succinate improves glucose homeostasis via intestinal gluconeogenesis. Cell Metabolism 24: 151-157. https:\/\/doi.org\/10.1016\/j.cmet.2016.06.013"},{"key":"R000007","series-title":"Gut","first-page":"1020","article-title":"Gut microbiome and health: mechanistic insights","volume":"71","author":"De Vos, W.M.","unstructured":"De Vos, W.M., Tilg, H., Van Hul, M. and Cani, P.D., 2022. Gut microbiome and health: mechanistic insights. Gut 71: 1020-1032. https:\/\/doi.org\/10.1136\/gutjnl-2021-326789"},{"key":"R000008","series-title":"European Journal of Gastroenterology and Hepatology","first-page":"1260","article-title":"Constipation-related direct medical costs in 16887 patients newly diagnosed with chronic constipation","volume":"26","author":"Dik, V.K.","unstructured":"Dik, V.K., Siersema, P.D., Joseph, A., Hodgkins, P., Smeets, H.M. and van Oijen, M.G., 2014. Constipation-related direct medical costs in 16887 patients newly diagnosed with chronic constipation. European Journal of Gastroenterology and Hepatology 26: 1260-1266. https:\/\/doi.org\/10.1097\/MEG.0000000000000167"},{"key":"R000009","series-title":"Advances in Nutrition","first-page":"484","article-title":"Mechanisms of action of probiotics and the gastrointestinal microbiota on gut motility and constipation","volume":"8","author":"Dimidi, E.","unstructured":"Dimidi, E., Christodoulides, S., Scott, S.M. and Whelan, K., 2017. Mechanisms of action of probiotics and the gastrointestinal microbiota on gut motility and constipation. Advances in Nutrition 8: 484-494. https:\/\/doi.org\/10.3945\/an.116.014407"},{"key":"R000010","series-title":"Frontiers in Cellular and Infection Microbiology","article-title":"Imbalance in the gut microbiota of children with autism spectrum disorders","volume":"11","author":"Ding, H.","unstructured":"Ding, H., Yi, X., Zhang, X., Wang, H., Liu, H. and Mou, W.W., 2021. Imbalance in the gut microbiota of children with autism spectrum disorders. Frontiers in Cellular and Infection Microbiology 11: 572752. https:\/\/doi.org\/10.3389\/fcimb.2021.572752"},{"key":"R000011","series-title":"Gastroenterology","first-page":"1257","article-title":"Rome IV \u2013 Functional GI disorders: disorders of gut-brain interaction","volume":"150","author":"Drossman, D.A.","unstructured":"Drossman, D.A. and Hasler, W.L., 2016. Rome IV \u2013 Functional GI disorders: disorders of gut-brain interaction. Gastroenterology 150: 1257-1261. https:\/\/doi.org\/10.1053\/j.gastro.2016.03.035"},{"key":"R000012","series-title":"Pediatric Research","first-page":"1120","article-title":"Bifidobacterium longum subsp infantis CECT7210-supplemented formula reduces diarrhea in healthy infants: a randomized controlled trial","volume":"83","author":"Escribano, J.","unstructured":"Escribano, J., Ferre, N., Gispert-Llaurado, M., Luque, V., Rubio-Torrents, C., Zaragoza-Jordana, M., Polanco, I., Codoner, F.M., Chenoll, E., Morera, M., Moreno-Munoz, J.A., Rivero, M. and Closa-Monasterolo, R., 2018. Bifidobacterium longum subsp infantis CECT7210-supplemented formula reduces diarrhea in healthy infants: a randomized controlled trial. Pediatric Research 83: 1120-1128. https:\/\/doi.org\/10.1038\/pr.2018.34"},{"key":"R000013","series-title":"Frontiers in Cellular and Infection Microbiology","article-title":"Abnormal bile acid metabolism is an important feature of gut microbiota and fecal metabolites in patients with slow transit constipation","volume":"12","author":"Fan, Y.","unstructured":"Fan, Y., Xu, C., Xie, L., Wang, Y., Zhu, S., An, J., Li, Y., Tian, Z., Yan, Y., Yu, S., Liu, H., Jia, B., Wang, Y., Wang, L., Yang, L. and Bian, Y., 2022. Abnormal bile acid metabolism is an important feature of gut microbiota and fecal metabolites in patients with slow transit constipation. Frontiers in Cellular and Infection Microbiology 12: 956528. https:\/\/doi.org\/10.3389\/fcimb.2022.956528"},{"key":"R000014","series-title":"Reviews in Endocrine and Metabolic Disorders","first-page":"439","article-title":"Gut microbiota-derived succinate: Friend or foe in human metabolic diseases?","volume":"20","author":"Fernandez-Veledo, S.","unstructured":"Fernandez-Veledo, S. and Vendrell, J., 2019. Gut microbiota-derived succinate: Friend or foe in human metabolic diseases? Reviews in Endocrine and Metabolic Disorders 20: 439-447. https:\/\/doi.org\/10.1007\/s11154-019-09513-z"},{"key":"R000015","series-title":"Medicine","article-title":"Chronic constipation: A review of literature","volume":"97","author":"Forootan, M.","unstructured":"Forootan, M., Bagheri, N. and Darvishi, M., 2018. Chronic constipation: A review of literature. Medicine 97: e10631. https:\/\/doi.org\/10.1097\/MD.0000000000010631"},{"key":"R000016","series-title":"Cell Reports","article-title":"A transepithelial pathway delivers succinate to macrophages, thus perpetuating their pro-inflammatory metabolic state","volume":"36","author":"Fremder, M.","unstructured":"Fremder, M., Kim, S.W., Khamaysi, A., Shimshilashvili, L., Eini-Rider, H., Park, I.S., Hadad, U., Cheon, J.H. and Ohana, E., 2021. A transepithelial pathway delivers succinate to macrophages, thus perpetuating their pro-inflammatory metabolic state. Cell Reports 36: 109521. https:\/\/doi.org\/10.1016\/j.celrep.2021.109521"},{"key":"R000017","series-title":"Journal of Lipid Research","first-page":"489","article-title":"Metabolism of 5 beta-cholestane-3 alpha, 7 alpha, 12 alpha, 26-tetrol and 5 beta-cholestane-3 alpha, 7 alpha, 12 alpha, 25-tetrol into cholic acid in normal human subjects","volume":"20","author":"Hanson, R.F.","unstructured":"Hanson, R.F., Staples, A.B. and Williams, G.C., 1979. Metabolism of 5 beta-cholestane-3 alpha, 7 alpha, 12 alpha, 26-tetrol and 5 beta-cholestane-3 alpha, 7 alpha, 12 alpha, 25-tetrol into cholic acid in normal human subjects. Journal of Lipid Research 20: 489-493."},{"key":"R000018","series-title":"Brain Structure and Function","first-page":"1663","article-title":"Astrocytic and neuronal localization of kynurenine aminotransferase-2 in the adult mouse brain","volume":"222","author":"Heredi, J.","unstructured":"Heredi, J., Berko, A.M., Jankovics, F., Iwamori, T., Iwamori, N., Ono, E., Horvath, S., Kis, Z., Toldi, J., Vecsei, L. and Gellert, L., 2017. Astrocytic and neuronal localization of kynurenine aminotransferase-2 in the adult mouse brain. Brain Structure and Function 222: 1663-1672. https:\/\/doi.org\/10.1007\/s00429-016-1299-5"},{"key":"R000019","series-title":"British Medical Journal","first-page":"999","article-title":"Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome","volume":"336","author":"Kaptchuk, T.J.","unstructured":"Kaptchuk, T.J., Kelley, J.M., Conboy, L.A., Davis, R.B., Kerr, C.E., Jacobson, E.E., Kirsch, I., Schyner, R.N., Nam, B.H., Nguyen, L.T., Park, M., Rivers, A.L., McManus, C., Kokkotou, E., Drossman, D.A., Goldman, P. and Lembo, A.J., 2008. Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome. British Medical Journal 336: 999-1003. https:\/\/doi.org\/10.1136\/bmj.39524.439618.25"},{"key":"R000020","series-title":"Nature Reviews Microbiology","first-page":"77","article-title":"Gut microbial metabolites as multi-kingdom intermediates","volume":"19","author":"Krautkramer, K.A.","unstructured":"Krautkramer, K.A., Fan, J. and Backhed, F., 2021. Gut microbial metabolites as multi-kingdom intermediates. Nature Reviews Microbiology 19: 77-94. https:\/\/doi.org\/10.1038\/s41579-020-0438-4"},{"key":"R000021","series-title":"Steroids","first-page":"421","article-title":"Synthesis of diastereomers of 3 alpha,7 alpha,12 alpha, 24-tetrahydroxy- and 3 alpha,7 alpha,24-trihydroxy-5 beta-cholestan-26-oic acids and their structures","volume":"61","author":"Kurosawa, T.","unstructured":"Kurosawa, T., Sato, M., Nakano, H. and Tohma, M., 1996. Synthesis of diastereomers of 3 alpha,7 alpha,12 alpha, 24-tetrahydroxy- and 3 alpha,7 alpha,24-trihydroxy-5 beta-cholestan-26-oic acids and their structures. Steroids 61: 421-428. https:\/\/doi.org\/10.1016\/0039-128x(96)00062-1"},{"key":"R000022","series-title":"Medical Science Monitor","article-title":"Alteration of serum metabolites in women of reproductive age with chronic constipation","volume":"28","author":"Liu, S.","unstructured":"Liu, S., Yang, C., Li, H., Bai, X., Hu, T., Xue, X., An, J., Zhang, Y. and Dong, X., 2022. Alteration of serum metabolites in women of reproductive age with chronic constipation. Medical Science Monitor 28: e934117. https:\/\/doi.org\/10.12659\/MSM.934117"},{"key":"R000023","series-title":"Journal of Gastroenterology and Hepatology","first-page":"116","article-title":"Placebo effect in patients with irritable bowel syndrome","volume":"26","author":"Lu, C.L.","unstructured":"Lu, C.L. and Chang, F.Y., 2011. Placebo effect in patients with irritable bowel syndrome. Journal of Gastroenterology and Hepatology 263: 116-118. https:\/\/doi.org\/10.1111\/j.1440-1746.2011.06651.x"},{"key":"R000024","series-title":"Proceedings of the Nutrition Society","first-page":"37","article-title":"SCFA: mechanisms and functional importance in the gut","volume":"80","author":"Martin-Gallausiaux, C.","unstructured":"Martin-Gallausiaux, C., Marinelli, L., Blottiere, H.M., Larraufie, P. and Lapaque, N., 2021. SCFA: mechanisms and functional importance in the gut. Proceedings of the Nutrition Society 80: 37-49. https:\/\/doi.org\/10.1017\/S0029665120006916"},{"key":"R000025","series-title":"Gender Medicine","first-page":"259","article-title":"Gender differences in self-reported constipation characteristics, symptoms, and bowel and dietary habits among patients attending a specialty clinic for constipation","volume":"6","author":"McCrea, G.L.","unstructured":"McCrea, G.L., Miaskowski, C., Stotts, N.A., Macera, L., Paul, S.M. and Varma, M.G., 2009. Gender differences in self-reported constipation characteristics, symptoms, and bowel and dietary habits among patients attending a specialty clinic for constipation. Gender Medicine 6: 259-271. https:\/\/doi.org\/10.1016\/j.genm.2009.04.007"},{"key":"R000026","series-title":"Annals of Gastroenterological Surgery","first-page":"629","article-title":"Effects of probiotic-containing products on stool frequency and intestinal transit in constipated adults: systematic review and meta-analysis of randomized controlled trials","volume":"30","author":"Miller, L.E.","unstructured":"Miller, L.E., Ouwehand, A.C. and Ibarra, A., 2017. Effects of probiotic-containing products on stool frequency and intestinal transit in constipated adults: systematic review and meta-analysis of randomized controlled trials. Annals of Gastroenterological Surgery 30: 629-639. https:\/\/doi.org\/10.20524\/aog.2017.0192"},{"key":"R000027","series-title":"Journal of Gastroenterology and Hepatology","first-page":"883","article-title":"Impact of elobixibat on serum and fecal bile acid levels and constipation symptoms in patients with chronic constipation","volume":"37","author":"Nakajima, A.","unstructured":"Nakajima, A., Ishizaki, S., Matsuda, K., Kurosu, S., Taniguchi, S., Gillberg, P.G., Mattsson, J.P., Hasunuma, T. and Camilleri, M., 2022. Impact of elobixibat on serum and fecal bile acid levels and constipation symptoms in patients with chronic constipation. Journal of Gastroenterology and Hepatology 37: 883-890. https:\/\/doi.org\/10.1111\/jgh.15800"},{"key":"R000028","series-title":"American Journal of Gastroenterology","first-page":"1838","article-title":"Placebo response in chronic idiopathic constipation: a systematic review and meta-analysis","volume":"114","author":"Nee, J.","unstructured":"Nee, J., Sugarman, M.A., Ballou, S., Katon, J., Rangan, V., Singh, P., Zubiago, J., Kaptchuk, T.J. and Lembo, A., 2019. Placebo response in chronic idiopathic constipation: a systematic review and meta-analysis. American Journal of Gastroenterology 114: 1838-1846. https:\/\/doi.org\/10.14309\/ajg.0000000000000399"},{"key":"R000029","series-title":"Clinical Gastroenterology and Hepatology","first-page":"208","article-title":"Psychological treatments in functional gastrointestinal disorders: a primer for the gastroenterologist","volume":"11","author":"Palsson, O.S.","unstructured":"Palsson, O.S. and Whitehead, W.E., 2013. Psychological treatments in functional gastrointestinal disorders: a primer for the gastroenterologist. Clinical Gastroenterology and Hepatology 11: 208-216; quiz e222-203. https:\/\/doi.org\/10.1016\/j.cgh.2012.10.031"},{"key":"R000030","series-title":"Physiological Reviews","first-page":"859","article-title":"Gut microbiota in health and disease","volume":"90","author":"Sekirov, I.","unstructured":"Sekirov, I., Russell, S.L., Antunes, L.C. and Finlay, B.B., 2010. Gut microbiota in health and disease. Physiological Reviews 90: 859-904. https:\/\/doi.org\/10.1152\/physrev.00045.2009"},{"key":"R000031","series-title":"Microbial Cell Factories","article-title":"Bacterial synthesis of N-hydroxycinnamoyl phenethylamines and tyramines","volume":"14","author":"Sim, G.Y.","unstructured":"Sim, G.Y., Yang, S.M., Kim, B.G. and Ahn, J.H., 2015. Bacterial synthesis of N-hydroxycinnamoyl phenethylamines and tyramines. Microbial Cell Factories 14: 162. https:\/\/doi.org\/10.1186\/s12934-015-0353-y"},{"key":"R000032","series-title":"Science","first-page":"569","article-title":"The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis","volume":"341","author":"Smith, P.M.","unstructured":"Smith, P.M., Howitt, M.R., Panikov, N., Michaud, M., Gallini, C.A., Bohlooly, Y.M., Glickman, J.N. and Garrett, W.S., 2013. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 341: 569-573. https:\/\/doi.org\/10.1126\/science.1241165"},{"key":"R000033","series-title":"Zhongguo Zhong Yao Za Zhi","first-page":"532","article-title":"Metabonomics study of Shouhui Tongbian Capsules in slow transit constipation based on UPLC-ESI-QE-Orbitrap-MS","volume":"46","author":"Sun, C.H.","unstructured":"Sun, C.H., Li, X.Z., Xiao, H., Zhang, L., Zhao, Y., Yao, J.C. and Zhang, G.M., 2021. [Metabonomics study of Shouhui Tongbian Capsules in slow transit constipation based on UPLC-ESI-QE-Orbitrap-MS]. Zhongguo Zhong Yao Za Zhi 46: 532-538. https:\/\/doi.org\/10.19540\/j.cnki.cjcmm.20201116.401"},{"key":"R000034","series-title":"International Journal of Molecular Sciences","article-title":"A role for xanthurenic acid in the control of brain dopaminergic activity","volume":"22","author":"Taleb, O.","unstructured":"Taleb, O., Maammar, M., Klein, C., Maitre, M. and Mensah-Nyagan, A.G., 2021. A role for xanthurenic acid in the control of brain dopaminergic activity. International Journal of Molecular Sciences 22: 6974. https:\/\/doi.org\/10.3390\/ijms22136974"},{"key":"R000035","series-title":"Nature","first-page":"238","article-title":"Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha","volume":"496","author":"Tannahill, G.M.","unstructured":"Tannahill, G.M., Curtis, A.M., Adamik, J., Palsson-McDermott, E.M., McGettrick, A.F., Goel, G., Frezza, C., Bernard, N.J., Kelly, B., Foley, N.H., Zheng, L., Gardet, A., Tong, Z., Jany, S.S., Corr, S.C., Haneklaus, M., Caffrey, B.E., Pierce, K., Walmsley, S., Beasley, F.C., Cummins, E., Nizet, V., Whyte, M., Taylor, C.T., Lin, H., Masters, S.L., Gottlieb, E., Kelly, V.P., Clish, C., Auron, P.E., Xavier, R.J. and O\u2019Neill, L.A., 2013. Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha. Nature 496: 238-242. https:\/\/doi.org\/10.1038\/nature11986"},{"key":"R000036","series-title":"Research in Veterinary Science","first-page":"287","article-title":"The effect of organic acids on the control of porcine post-weaning diarrhoea","volume":"70","author":"Tsiloyiannis, V.K.","unstructured":"Tsiloyiannis, V.K., Kyriakis, S.C., Vlemmas, J. and Sarris, K., 2001. The effect of organic acids on the control of porcine post-weaning diarrhoea. Research in Veterinary Science 70: 287-293. https:\/\/doi.org\/10.1053\/rvsc.2001.0476"},{"key":"R000037","series-title":"Nature Reviews Gastroenterology and Hepatology","first-page":"21","article-title":"Management of functional constipation in children and adults","volume":"17","author":"Vriesman, M.H.","unstructured":"Vriesman, M.H., Koppen, I.J.N., Camilleri, M., Di Lorenzo, C. and Benninga, M.A., 2020. Management of functional constipation in children and adults. Nature Reviews Gastroenterology and Hepatology 17: 21-39. https:\/\/doi.org\/10.1038\/s41575-019-0222-y"},{"key":"R000038","series-title":"Clinical Nutrition","first-page":"3189","article-title":"Overweight and underweight status are linked to specific gut microbiota and intestinal tricarboxylic acid cycle intermediates","volume":"39","author":"Wan, Y.","unstructured":"Wan, Y., Yuan, J., Li, J., Li, H., Yin, K., Wang, F. and Li, D., 2020. Overweight and underweight status are linked to specific gut microbiota and intestinal tricarboxylic acid cycle intermediates. Clinical Nutrition 39: 3189-3198. https:\/\/doi.org\/10.1016\/j.clnu.2020.02.014"},{"key":"R000039","series-title":"Cell Reports","first-page":"222","article-title":"Parabacteroides distasonis alleviates obesity and metabolic dysfunctions via production of succinate and secondary bile acids","volume":"26","author":"Wang, K.","unstructured":"Wang, K., Liao, M., Zhou, N., Bao, L., Ma, K., Zheng, Z., Wang, Y., Liu, C., Wang, W., Wang, J., Liu, S.J. and Liu, H., 2019. Parabacteroides distasonis alleviates obesity and metabolic dysfunctions via production of succinate and secondary bile acids. Cell Reports 26: 222-235, e225. https:\/\/doi.org\/10.1016\/j.celrep.2018.12.028"},{"key":"R000040","series-title":"International Journal of Colorectal Disease","article-title":"The role of psychological factors in functional gastrointestinal disorders: a systematic review and meta-analysis","volume":"38","author":"Yan, L.","unstructured":"Yan, L., Zhang, X., Li, Y., Liu, C., Yang, H. and Yang, C., 2023. The role of psychological factors in functional gastrointestinal disorders: a systematic review and meta-analysis. International Journal of Colorectal Disease 38: 65. https:\/\/doi.org\/10.1007\/s00384-023-04333-9"},{"key":"R000041","series-title":"BMC Microbiology","article-title":"Prevalence of blastocystis and its association with Firmicutes\/Bacteroidetes ratio in clinically healthy and metabolically ill subjects","volume":"21","author":"Yanez, C.M.","unstructured":"Yanez, C.M., Hernandez, A.M., Sandoval, A.M., Dominguez, M.A.M., Muniz, S.A.Z. and Gomez, J.O.G., 2021. Prevalence of blastocystis and its association with Firmicutes\/Bacteroidetes ratio in clinically healthy and metabolically ill subjects. BMC Microbiology 21: 339. https:\/\/doi.org\/10.1186\/s12866-021-02402-z"},{"key":"R000042","series-title":"Frontiers in Microbiology","article-title":"Integrated metagenomics and targeted-metabolomics analysis of the effects of phenylalanine on loperamide-induced constipation in rats","volume":"13","author":"Yang, C.","unstructured":"Yang, C., Bai, X., Hu, T., Xue, X., Su, X., Zhang, X., Wu, T., Zhang, M., Shen, X. and Dong, X., 2022a. Integrated metagenomics and targeted-metabolomics analysis of the effects of phenylalanine on loperamide-induced constipation in rats. Frontiers in Microbiology 13: 1018008. https:\/\/doi.org\/10.3389\/fmicb.2022.1018008"},{"key":"R000043","series-title":"Applied Microbiology and Biotechnology","first-page":"6899","article-title":"Gut microbiota: a new avenue to reveal pathological mechanisms of constipation","volume":"106","author":"Yang, L.","unstructured":"Yang, L., Wang, Y., Zhang, Y., Li, W., Jiang, S., Qian, D. and Duan, J., 2022b. Gut microbiota: a new avenue to reveal pathological mechanisms of constipation. Applied Microbiology and Biotechnology 106: 6899-6913. https:\/\/doi.org\/10.1007\/s00253-022-12197-2"},{"key":"R000044","series-title":"Clinical Nutrition","first-page":"2960","article-title":"Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults","volume":"39","author":"Zhang, C.","unstructured":"Zhang, C., Jiang, J., Tian, F., Zhao, J., Zhang, H., Zhai, Q. and Chen, W., 2020. Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults. Clinical Nutrition 39: 2960-2969. https:\/\/doi.org\/10.1016\/j.clnu.2020.01.005"}],"container-title":["Beneficial Microbes"],"original-title":[],"link":[{"URL":"https:\/\/brill.com\/view\/journals\/bm\/16\/1\/article-p35_2.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/brill.com\/downloadpdf\/journals\/bm\/16\/1\/article-p35_2.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/brill.com\/downloadpdf\/journals\/bm\/16\/1\/article-p35_2.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T06:01:30Z","timestamp":1737007290000},"score":1,"resource":{"primary":{"URL":"https:\/\/brill.com\/view\/journals\/bm\/16\/1\/article-p35_2.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,1]]},"references-count":44,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1163\/18762891-bja00039","relation":{},"ISSN":["1876-2891"],"issn-type":[{"value":"1876-2891","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,1]]}}}