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Microbes"],"published-print":{"date-parts":[[2025,2,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:italic>Faecalibacterium<\/jats:italic> is an essential probiotic in the human gut; changes in its abundance are associated with various disease states in many studies. However, the causal nature of such associations remains obscure. Therefore, we aimed to thoroughly investigate the causal relationships between <jats:italic>Faecalibacterium<\/jats:italic> and its related diseases. A\u00a0two-sample bi-directional Mendelian randomisation analysis was conducted using publicly available genome-wide association studies summary statistics for <jats:italic>Faecalibacterium<\/jats:italic> and its related diseases. We found that <jats:italic>Faecalibacterium<\/jats:italic> was negatively correlated with the risk of ankylosing spondylitis (odds ratio [OR]\u00a0= 0.526, 95% confidence interval [CI]:0.304-0.908, <jats:inline-formula\/>), atopic dermatitis (OR\u00a0= 0.484, 95%CI: 0.261-0.898, <jats:inline-formula\/>) and heart failure (OR\u00a0= 0.657, 95%CI: 0.467-0.924, <jats:inline-formula\/>), while <jats:italic>Faecalibacterium<\/jats:italic> was positively associated with autism spectrum disorder risk (OR\u00a0= 2.529, 95%CI: 1.012-6.319, <jats:inline-formula\/>). The results of reverse Mendelian randomisation analysis showed that acute sinusitis (OR\u00a0= 0.902, 95%CI: 0.839-0.970, <jats:inline-formula\/>) and Alzheimer\u2019s disease (OR\u00a0= 0.976, 95%CI: 0.958-0.993, <jats:inline-formula\/>) was causally associated with lower <jats:italic>Faecalibacterium<\/jats:italic> abundance, respectively, while cirrhosis (OR\u00a0= 1.154, 95%CI: 1.028-1.295, <jats:inline-formula\/>) and multiple myeloma (OR\u00a0= 2.619\u00a0\u00d7 10<jats:sup>12<\/jats:sup>, 95%CI: 2.492-2.754\u00a0\u00d7 10<jats:sup>24<\/jats:sup>, <jats:inline-formula\/>) was causally associated with higher <jats:italic>Faecalibacterium<\/jats:italic> abundance. Our findings firstly showed that changes in <jats:italic>Faecalibacterium<\/jats:italic> abundance may contribute to the risk of ankylosing spondylitis, atopic dermatitis, heart failure and autism spectrum disorders, and potentially as a result of acute sinusitis, Alzheimer\u2019s disease, cirrhosis and multiple myeloma.<\/jats:p>","DOI":"10.1163\/18762891-bja00058","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T04:39:51Z","timestamp":1740026391000},"page":"363-376","source":"Crossref","is-referenced-by-count":3,"title":["Causal relationship between Faecalibacterium abundance and risk of Faecalibacterium-related diseases: a two-sample bi-directional Mendelian randomisation study"],"prefix":"10.1163","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0825-9485","authenticated-orcid":true,"given":"S.","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology, Xiangya Hospital, https:\/\/dx.doi.org\/159374Central South University, 87 Xiangya Road, Changsha, 410008 Hunan, China P.R."},{"name":"Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha, 410008 Hunan, China P.R."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1426-4063","authenticated-orcid":true,"given":"Y.","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Xiangya Hospital, https:\/\/dx.doi.org\/159374Central South University, 87 Xiangya Road, Changsha, 410008 Hunan, China P.R."},{"name":"Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha, 410008 Hunan, China P.R."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Xiangya Hospital, https:\/\/dx.doi.org\/159374Central South University, 87 Xiangya Road, Changsha, 410008 Hunan, China P.R."},{"name":"Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha, 410008 Hunan, China P.R."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Xiangya Hospital, https:\/\/dx.doi.org\/159374Central South University, 87 Xiangya Road, Changsha, 410008 Hunan, China P.R."},{"name":"Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha, 410008 Hunan, China P.R."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Xiangya Hospital, https:\/\/dx.doi.org\/159374Central South University, 87 Xiangya Road, Changsha, 410008 Hunan, China P.R."},{"name":"Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha, 410008 Hunan, China P.R."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Xiangya Hospital, https:\/\/dx.doi.org\/159374Central South University, 87 Xiangya Road, Changsha, 410008 Hunan, China P.R."},{"name":"Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha, 410008 Hunan, China P.R."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Xiangya Hospital, https:\/\/dx.doi.org\/159374Central South University, 87 Xiangya Road, Changsha, 410008 Hunan, China P.R."},{"name":"Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha, 410008 Hunan, China P.R."},{"name":"National Clinical Research Centeor Geratric Disorders, Xiangya Hospital, https:\/\/dx.doi.org\/159374Central South University, Changsha, 410008 Hunan China\u00a0P.R."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Xiangya Hospital, https:\/\/dx.doi.org\/159374Central South University, 87 Xiangya Road, Changsha, 410008 Hunan, China P.R."},{"name":"Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha, 410008 Hunan, China P.R."},{"name":"National Clinical Research Centeor Geratric Disorders, Xiangya Hospital, https:\/\/dx.doi.org\/159374Central South University, Changsha, 410008 Hunan China\u00a0P.R."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Xiangya Hospital, https:\/\/dx.doi.org\/159374Central South University, 87 Xiangya Road, Changsha, 410008 Hunan, China P.R."},{"name":"Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha, 410008 Hunan, China P.R."},{"name":"National Clinical Research Centeor Geratric Disorders, Xiangya Hospital, https:\/\/dx.doi.org\/159374Central South University, Changsha, 410008 Hunan China\u00a0P.R."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6704-8477","authenticated-orcid":true,"given":"H.","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Second Xiangya Hospital, https:\/\/dx.doi.org\/159374Central South University, Changsha 410011 Hunan, China P.R."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7167-8332","authenticated-orcid":true,"given":"X.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Xiangya Hospital, https:\/\/dx.doi.org\/159374Central South University, 87 Xiangya Road, Changsha, 410008 Hunan, China P.R."},{"name":"Institute of Clinical Pharmacology, Central South University; 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