{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T03:40:04Z","timestamp":1754019604534,"version":"3.41.2"},"reference-count":36,"publisher":"Walter de Gruyter GmbH","issue":"4","funder":[{"name":"Medical Research Centre Program through the National Research Foundation of Korea","award":["NRF-2017R1A5A2014768"],"award-info":[{"award-number":["NRF-2017R1A5A2014768"]}]},{"DOI":"10.13039\/501100002597","name":"Kyung Hee University","doi-asserted-by":"crossref","award":["GS-1-JO-NON-20240385"],"award-info":[{"award-number":["GS-1-JO-NON-20240385"]}],"id":[{"id":"10.13039\/501100002597","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Basic Science Research Program through the National Research Foundation of Korea","award":["RS-2024-00412556"],"award-info":[{"award-number":["RS-2024-00412556"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Benef. Microbes"],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>Parkinson\u2019s disease (PD) is a complex progressive neurodegenerative disease characterized by both motor and nonmotor symptoms such as constipation and dyspepsia. Recently, growing evidence has suggested that a specific gut microbiome is associated with the pathophysiology of PD through the microbiota-gut-brain axis. We previously discovered that <jats:italic>Proteus mirabilis<\/jats:italic> induced motor impairment and brain dopaminergic neurodegeneration in normal mice. In this context, exploring beneficial microbe would be reasonable strategy to treat PD fundamentally. With that the current study aimed to evaluate whether <jats:italic>Lactobacillus taiwanensis<\/jats:italic> BCRC17755 (BCRC17755) could ameliorate PD pathologies induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and <jats:italic>P. mirabilis<\/jats:italic> in mice. To demonstrate this, we measured motor function by performing pole test and the rotarod test and conducted histological analysis to assess the changes of factors in both brain and the gut. As a result, BCRC17755 decreased faecal abundance of <jats:italic>P. mirabilis<\/jats:italic>, which was higher in both the MPTP and <jats:italic>P. mirabilis<\/jats:italic>-treated mice. Additionally, BCRC17755 improved the motor deficits and alleviated damage to nigrostriatal dopaminergic neurons observed in both MPTP and <jats:italic>P. mirabilis<\/jats:italic>-induced PD mice. Furthermore, BCRC17755 mitigated microglial hyperactivation triggered by MPTP and <jats:italic>P. mirabilis<\/jats:italic> in the substantia nigra pars compacta and striatum of mice. Similarly, the release of inflammatory cytokines, including interleukin-1 beta and tumor necrosis factor alpha, was suppressed following the administration of BCRC17755 in the colon. Taken together, all the results suggest that BCRC17755 is a beneficial microbe for the treatment of PD by inhibiting the <jats:italic>P. mirabilis<\/jats:italic> growth.<\/jats:p>","DOI":"10.1163\/18762891-bja00066","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T04:56:48Z","timestamp":1743483408000},"page":"413-423","source":"Crossref","is-referenced-by-count":0,"title":["Lactobacillus taiwanensis BCRC17755 alleviates motor dysfunction and dopaminergic neuronal loss in mouse models of Parkinson\u2019s disease"],"prefix":"10.1163","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8071-4558","authenticated-orcid":true,"given":"Y.","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Biomedical and Pharmaceutical Sciences, Graduate School, https:\/\/dx.doi.org\/26723Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5078-9527","authenticated-orcid":true,"given":"J.G.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Oriental Pharmaceutical Science and Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, https:\/\/dx.doi.org\/26723Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, South Korea"},{"name":"Current address: Mthera Pharma Co., 38 Magokjungang 8-ro, Gangseo-gu, Seoul 07793, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1090-1705","authenticated-orcid":true,"given":"E.","family":"Huh","sequence":"additional","affiliation":[{"name":"Department of Oriental Pharmaceutical Science and Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, https:\/\/dx.doi.org\/26723Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, South Korea"},{"name":"Current address: Department of Formulae Pharmacology, College of Korean Medicine, Gachon University, 1342 Seongnamdae-ro, Sujung-Gu, Seongnam 13120, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1532-613X","authenticated-orcid":true,"given":"H.","family":"Eo","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Pharmaceutical Sciences, Graduate School, https:\/\/dx.doi.org\/26723Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, South Korea"},{"name":"Current address: Department of Food and Nutrition, Chung-Ang University, Anseong, 17546, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.-J.","family":"Shin","sequence":"additional","affiliation":[{"name":"Neurobiota Research Center, College of Pharmacy, https:\/\/dx.doi.org\/26723Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.G.","family":"Park","sequence":"additional","affiliation":[{"name":"MetaCen Therapeutics Inc. R&D Center, 256 Changnyong-daero, Yeongtong-gu, Suwon 16229, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.-H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Neurobiota Research Center, College of Pharmacy, https:\/\/dx.doi.org\/26723Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8189-4066","authenticated-orcid":true,"given":"M.S.","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Pharmaceutical Sciences, Graduate School, https:\/\/dx.doi.org\/26723Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, South Korea"},{"name":"Department of Oriental Pharmaceutical Science and Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, https:\/\/dx.doi.org\/26723Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, South Korea"},{"name":"Neurobiota Research Center, College of Pharmacy, https:\/\/dx.doi.org\/26723Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"R000001","series-title":"Cellular and Molecular Neurobiology","first-page":"2815","article-title":"Gut microbial alteration in MPTP mouse model of Parkinson disease is administration regimen dependent","volume":"43","author":"Aktas, B.","unstructured":"Aktas, B., 2023. Gut microbial alteration in MPTP mouse model of Parkinson disease is administration regimen dependent. Cellular and Molecular Neurobiology 43: 2815-2829. https:\/\/doi.org\/10.1007\/s10571-023-01319-7"},{"key":"R000002","series-title":"Applied Microbiology and Biotechnology","first-page":"2939","article-title":"Bacteriocins of lactic acid bacteria: extending the family","volume":"100","author":"Alvarez-Sieiro, P.","unstructured":"Alvarez-Sieiro, P., Montalban-Lopez, M., Mu, D. and Kuipers, O.P., 2016. Bacteriocins of lactic acid bacteria: extending the family. 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Neurology 87: 1274-1280. https:\/\/doi.org\/10.1212\/WNL.0000000000003127"},{"key":"R000004","series-title":"Journal of Neurology","first-page":"III\/1","article-title":"Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson\u2019s disease (preclinical and clinical stages)","volume":"249","author":"Braak, H.","unstructured":"Braak, H., Del Tredici, K., Bratzke, H., Hamm-Clement, J., Sandmann-Keil, D. and R\u00fcb, U., 2002. Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson\u2019s disease (preclinical and clinical stages). 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Impact of probiotic supplements on microbiome diversity following antibiotic treatment of mice. Gut Microbes 7: 101-114. https:\/\/doi.org\/10.1080\/19490976.2016.1138197"},{"key":"R000013","series-title":"European Journal of Inflammation","article-title":"Gut microbiota and inflammation in Parkinson\u2019s disease: Pathogenetic and therapeutic insights","volume":"20","author":"Guo, T.","unstructured":"Guo, T. and Chen, L., 2022. Gut microbiota and inflammation in Parkinson\u2019s disease: Pathogenetic and therapeutic insights. 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Probiotics alleviate the progressive deterioration of motor functions in a mouse model of Parkinson\u2019s disease. Brain Science 10. https:\/\/doi.org\/10.3390\/brainsci10040206"},{"key":"R000018","series-title":"EBioMedicine","article-title":"P. mirabilis-derived pore-forming haemolysin, HpmA drives intestinal alpha-synuclein aggregation in a mouse model of neurodegeneration","volume":"98","author":"Huh, E.","unstructured":"Huh, E., Choi, J.G., Choi, Y., Ju, I.G., Kim, B., Shin, Y.J., An, J.M., Park, M.G., Yim, S.V., Chung, S.J., Seo, S.U., Kim, D., Kim, C.H., Kim, D.H. and Oh, M.S., 2023a. P. mirabilis-derived pore-forming haemolysin, HpmA drives intestinal alpha-synuclein aggregation in a mouse model of neurodegeneration. 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Antibiotic-induced microbiome depletion protects against MPTP-induced dopaminergic neurotoxicity in the brain. Aging (Albany NY) 11: 6915-6929. https:\/\/doi.org\/10.18632\/aging.102221"},{"key":"R000030","series-title":"Fronters in Aging Neuroscience","article-title":"Detection of microbial 16S rRNA gene in the blood of patients with Parkinson\u2019s disease","volume":"10","author":"Qian, Y.","unstructured":"Qian, Y., Yang, X., Xu, S., Wu, C., Qin, N., Chen, S.D. and Xiao, Q., 2018. Detection of microbial 16S rRNA gene in the blood of patients with Parkinson\u2019s disease. 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