{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T02:56:25Z","timestamp":1769655385599,"version":"3.49.0"},"reference-count":100,"publisher":"Walter de Gruyter GmbH","issue":"1","funder":[{"name":"Nanchang City High-level Scientifc and Technological Innovation Talents \u201cDouble Hundred Plan\u201d","award":["No. [2022]321"],"award-info":[{"award-number":["No. [2022]321"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Benef. Microbes"],"published-print":{"date-parts":[[2025,4,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Constipation is a widespread gastrointestinal disorder that significantly impacts individuals\u2019 health and quality of life. Although various treatment options are available, many patients experience unsatisfactory results, creating a demand for alternative therapeutic strategies. This study explores the efficacy of Bifid Triple Viable Capsules, containing Bifidobacterium longum, Lactobacillus acidophilus, and Enterococcus faecium, in alleviating loperamide-induced constipation in a rat model. Rats were administered high or low doses of Bifid after induction of constipation with loperamide. Our findings demonstrate that high-dose Bifid treatment significantly improves body weight and intestinal propulsion rate in constipated rats. Histopathological analysis reveals that Bifid restores colon tissue integrity, reducing inflammation and maintaining the intestinal epithelial barrier. Using 16S rRNA sequencing, we identified an increase in the gut microbial diversity and composition, with higher levels of beneficial\n                    <jats:italic>norank_f_norank_o_Coriobacteriales<\/jats:italic>\n                    and\n                    <jats:italic>Anaerofustis<\/jats:italic>\n                    bacteria. Transcriptomic analysis of colon tissues showed that high-dose Bifid treatment modulates gene expression involved in immune system regulation and epithelial barrier integrity. Differentially expressed genes (DEGs) were enriched in pathways related to the immune response and integral component of membrane, particularly those associated with the intestinal immune network and bile acid metabolism. These results suggest that Bifid alleviates constipation by balancing the gut microbiota, regulating the gut innate immune response, and maintaining the intestinal epithelial barrier. Our study provides a foundational basis for further research and therapeutic applications of probiotics in treating gastrointestinal diseases.\n                  <\/jats:p>","DOI":"10.1163\/18762891-bja00076","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:55:52Z","timestamp":1745974552000},"page":"61-74","source":"Crossref","is-referenced-by-count":1,"title":["Bifid Triple Viable Capsules alleviate constipation by modulating gut microbiota and maintaining the integrity of the intestinal epithelial barrier"],"prefix":"10.1163","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5473-6469","authenticated-orcid":true,"given":"D.","family":"Sun","sequence":"first","affiliation":[{"name":"State Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine, Nanchang, China"},{"name":"Research and Development Department, Jiangzhong Pharmaceutical Co., Ltd., Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine, Nanchang, China"},{"name":"Research and Development Department, Jiangzhong Pharmaceutical Co., Ltd., Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Zhan","sequence":"additional","affiliation":[{"name":"State Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine, Nanchang, China"},{"name":"Research and Development Department, Jiangzhong Pharmaceutical Co., Ltd., Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Cheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine, Nanchang, China"},{"name":"Research and Development Department, Jiangzhong Pharmaceutical Co., Ltd., Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine, Nanchang, China"},{"name":"Research and Development Department, Jiangzhong Pharmaceutical Co., Ltd., Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine, Nanchang, China"},{"name":"Research and Development Department, Jiangzhong Pharmaceutical Co., Ltd., Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine, Nanchang, China"},{"name":"Jiangxi University of Chinese Medicine, Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Xiong","sequence":"additional","affiliation":[{"name":"State Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine, Nanchang, China"},{"name":"Research and Development Department, Jiangzhong Pharmaceutical Co., Ltd., Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine, Nanchang, China"},{"name":"Research and Development Department, Jiangzhong Pharmaceutical Co., Ltd., Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"R000001","series-title":"Scandinavian Journal of Gastroenterology","first-page":"1483","article-title":"Altered bile acid metabolism in patients with constipation-predominant irritable bowel syndrome and functional constipation","volume":"43","author":"Abrahamsson, H.","unstructured":"Abrahamsson, H., \u00d6stlund-Lindqvist, A.-M., Nilsson, R., Simre\u0301n, M. and Gillberg, P.-G., 2009. Altered bile acid metabolism in patients with constipation-predominant irritable bowel syndrome and functional constipation. Scandinavian Journal of Gastroenterology 43: 1483-1488. https:\/\/doi.org\/10.1080\/00365520802321212"},{"key":"R000002","series-title":"Beneficial Microbes","first-page":"617","article-title":"The effect of a probiotic blend on gastrointestinal symptoms in constipated patients: a double blind, randomised, placebo controlled 2-week trial","volume":"10","author":"Airaksinen, K.","unstructured":"Airaksinen, K., Yeung, N., Lyra, A., Lahtinen, S.J., Huttunen, T., Shanahan, F. and Ouwehand, A.C., 2019. The effect of a probiotic blend on gastrointestinal symptoms in constipated patients: a double blind, randomised, placebo controlled 2-week trial. Beneficial Microbes 10: 617-628. https:\/\/doi.org\/10.3920\/bm2018.0163"},{"key":"R000003","series-title":"Expert Review of Gastroenterology & Hepatology","first-page":"39","article-title":"An approach to the diagnosis and management of Rome IV functional disorders of chronic constipation","volume":"14","author":"Aziz, I.","unstructured":"Aziz, I., Whitehead, W.E., Palsson, O.S., T\u00f6rnblom, H. and Simre\u0301n, M., 2020. An approach to the diagnosis and management of Rome IV functional disorders of chronic constipation. Expert Review of Gastroenterology & Hepatology 14: 39-46. https:\/\/doi.org\/10.1080\/17474124.2020.1708718"},{"key":"R000004","series-title":"Molecules","article-title":"The anti-inflammatory activities of fermented curcuma that contains butyrate mitigate DSS-induced colitis in mice","volume":"27","author":"Bayazid, A.B.","unstructured":"Bayazid, A.B., Jeong, S.A., Park, C.W., Kim, D.H. and Lim, B.O., 2022. The anti-inflammatory activities of fermented curcuma that contains butyrate mitigate DSS-induced colitis in mice. Molecules 27. https:\/\/doi.org\/10.3390\/molecules27154745"},{"key":"R000005","series-title":"Gastroenterology","first-page":"1232","article-title":"Mechanisms, evaluation, and management of chronic constipation","volume":"158","author":"Bharucha, A.E.","unstructured":"Bharucha, A.E. and Lacy, B.E., 2020. Mechanisms, evaluation, and management of chronic constipation. Gastroenterology 158: 1232-1249. e1233. https:\/\/doi.org\/10.1053\/j.gastro.2019.12.034"},{"key":"R000006","series-title":"Gastroenterology","first-page":"218","article-title":"American gastroenterological association technical review on constipation","volume":"144","author":"Bharucha, A.E.","unstructured":"Bharucha, A.E., Pemberton, J.H. and Locke, G.R., 2013. American gastroenterological association technical review on constipation. Gastroenterology 144: 218-238. https:\/\/doi.org\/10.1053\/j.gastro.2012.10.028"},{"key":"R000007","series-title":"Scientific Reports","article-title":"Dysbiosis contributes to chronic constipation development via regulation of serotonin transporter in the intestine","volume":"7","author":"Cao, H.","unstructured":"Cao, H., Liu, X., An, Y., Zhou, G., Liu, Y., Xu, M., Dong, W., Wang, S., Yan, F., Jiang, K. and Wang, B., 2017. Dysbiosis contributes to chronic constipation development via regulation of serotonin transporter in the intestine. Scientific Reports 7. https:\/\/doi.org\/10.1038\/s41598-017-10835-8"},{"key":"R000008","series-title":"Expert Review of Gastroenterology & Hepatology","first-page":"951","article-title":"Elobixibat for the treatment of constipation","volume":"12","author":"Chedid, V.","unstructured":"Chedid, V., Vijayvargiya, P. and Camilleri, M., 2018. Elobixibat for the treatment of constipation. Expert Review of Gastroenterology & Hepatology 12: 951-960. https:\/\/doi.org\/10.1080\/17474124.2018.1522248"},{"key":"R000009","series-title":"Current Gastroenterology Reports","article-title":"Symptom overlap and comorbidity of irritable bowel syndrome with other conditions","volume":"7","author":"Christine, L.","unstructured":"Christine, L. and Frissora, a.K.L.K., 2005. Symptom overlap and comorbidity of irritable bowel syndrome with other conditions. Current Gastroenterology Reports 7."},{"key":"R000010","series-title":"World Journal of Gastroenterology","first-page":"1564","article-title":"Intestinal epithelial barrier and neuromuscular compartment in health and disease","volume":"26","author":"D\u2019Antongiovanni, V.","unstructured":"D\u2019Antongiovanni, V., Pellegrini, C., Fornai, M., Colucci, R., Blandizzi, C., Antonioli, L. and Bernardini, N., 2020. Intestinal epithelial barrier and neuromuscular compartment in health and disease. World Journal of Gastroenterology 26: 1564-1597. https:\/\/doi.org\/10.3748\/wjg.v26.i14.1564"},{"key":"R000011","series-title":"Advances in Nutrition","first-page":"484","article-title":"Mechanisms of action of probiotics and the gastrointestinal microbiota on gut motility and constipation","volume":"8","author":"Dimidi, E.","unstructured":"Dimidi, E., Christodoulides, S., Scott, S.M. and Whelan, K., 2017. Mechanisms of action of probiotics and the gastrointestinal microbiota on gut motility and constipation. Advances in Nutrition 8: 484-494. https:\/\/doi.org\/10.3945\/an.116.014407"},{"key":"R000012","series-title":"Trends in Molecular Medicine","first-page":"702","article-title":"Bile acid-activated receptors, intestinal microbiota, and the treatment of metabolic disorders","volume":"21","author":"Fiorucci, S.","unstructured":"Fiorucci, S. and Distrutti, E., 2015. Bile acid-activated receptors, intestinal microbiota, and the treatment of metabolic disorders. Trends in Molecular Medicine 21: 702-714. https:\/\/doi.org\/10.1016\/j.molmed.2015.09.001"},{"key":"R000013","series-title":"Frontiers in Pharmacology","article-title":"Underlying beneficial effects of rhubarb on constipation-induced inflammation, disorder of gut microbiome and metabolism","volume":"13","author":"Gao, H.","unstructured":"Gao, H., He, C., Hua, R., Liang, C., Wang, B., Du, Y., Xin, S., Guo, Y., Gao, L., Zhang, L., Shang, H. and Xu, J., 2022. Underlying beneficial effects of rhubarb on constipation-induced inflammation, disorder of gut microbiome and metabolism. Frontiers in Pharmacology 13. https:\/\/doi.org\/10.3389\/fphar.2022.1048134"},{"key":"R000014","series-title":"Future Microbiology","article-title":"The composition of intestinal microbiota and its association with functional constipation of the elderly patients","author":"Guo, M.","unstructured":"Guo, M., Yao, J., Yang, F., Liu, W., Bai, H., Ma, J., Ma, X., Zhang, J., Fang, Y., Miao, Y., Sun, J., Zhang, J. and Zhao, H., 2020. The composition of intestinal microbiota and its association with functional constipation of the elderly patients. Future Microbiology."},{"key":"R000015","series-title":"Aging Cell","article-title":"Elevated miR-124-3p in the aging colon disrupts mucus barrier and increases susceptibility to colitis by targeting T-synthase","volume":"19","author":"Huang, L.","unstructured":"Huang, L., Sun, T.y., Hu, L.j., Hu, S.l., Sun, H.m., Zhao, F.q., Wu, B., Yang, S., Ji, F.q. and Zhou, D.s., 2020. Elevated miR-124-3p in the aging colon disrupts mucus barrier and increases susceptibility to colitis by targeting T-synthase. Aging Cell 19. https:\/\/doi.org\/10.1111\/acel.13252"},{"key":"R000016","series-title":"European Journal of Clinical Microbiology & Infectious Diseases","first-page":"555","article-title":"Analysis of fecal microbiota in patients with functional constipation undergoing treatment with synbiotics","volume":"37","author":"Huang, L.S.","unstructured":"Huang, L.S., Kong, C., Gao, R.Y., Yan, X., Yu, H.J., Wen, B., Zhu, Q., Shen, T.Y., Sun, Z.L. and Qin, H.L., 2018. Analysis of fecal microbiota in patients with functional constipation undergoing treatment with synbiotics. European Journal of Clinical Microbiology & Infectious Diseases 37: 555-563. https:\/\/doi.org\/10.1007\/s10096-017-3149-7"},{"key":"R000017","series-title":"American Journal of Physiology: Gastrointestinal and Liver Physiology","article-title":"Influence of microbial species on small intestinal myoelectric activity and transit in germ-free rats","author":"Husebye, E.","unstructured":"Husebye, E., Hellstr\u00f6m, P.M., Sundler, F., Chen, J. and Midtvedt, T., 2001. Influence of microbial species on small intestinal myoelectric activity and transit in germ-free rats. American Journal of Physiology: Gastrointestinal and Liver Physiology."},{"key":"R000018","series-title":"Nature Reviews Immunology","first-page":"639","article-title":"Immunological aspects of intestinal mucus and mucins","volume":"16","author":"Johansson, M.E.V.","unstructured":"Johansson, M.E.V. and Hansson, G.C., 2016. Immunological aspects of intestinal mucus and mucins. Nature Reviews Immunology 16: 639-649. https:\/\/doi.org\/10.1038\/nri.2016.88"},{"key":"R000019","series-title":"Science Advances","article-title":"Inhibition of microbial deconjugation of micellar bile acids protects against intestinal permeability and liver injury","volume":"8","author":"Li, D.K.","unstructured":"Li, D.K., Chaudhari, S.N., Lee, Y., Sojoodi, M., Adhikari, A.A., Zukerberg, L., Shroff, S., Barrett, S.C., Tanabe, K., Chung, R.T. and Devlin, S., 2022. Inhibition of microbial deconjugation of micellar bile acids protects against intestinal permeability and liver injury. Science Advances 8."},{"key":"R000020","series-title":"Frontiers in Cellular and Infection Microbiology","article-title":"Gut microbiota composition changes in constipated women of reproductive age","volume":"10","author":"Li, H.","unstructured":"Li, H., Chen, J., Ren, X., Yang, C., Liu, S., Bai, X., Shan, S. and Dong, X., 2021. Gut microbiota composition changes in constipated women of reproductive age. Frontiers in Cellular and Infection Microbiology 10. https:\/\/doi.org\/10.3389\/fcimb.2020.557515"},{"key":"R000021","series-title":"Food Sciences and Nutrition","first-page":"3297","article-title":"The potential of quercetin to protect against loperamide-induced constipation in rats","volume":"9","author":"Liu, W.","unstructured":"Liu, W. and Zhi, A., 2021. The potential of quercetin to protect against loperamide-induced constipation in rats. Food Sciences and Nutrition 9: 3297-3307. https:\/\/doi.org\/10.1002\/fsn3.2296"},{"key":"R000022","series-title":"The Lancet Gastroenterology & Hepatology","first-page":"831","article-title":"Efficacy of drugs in chronic idiopathic constipation: a systematic review and network meta-analysis","volume":"4","author":"Luthra, P.","unstructured":"Luthra, P., Camilleri, M., Burr, N.E., Quigley, E.M.M., Black, C.J. and Ford, A.C., 2019. Efficacy of drugs in chronic idiopathic constipation: a systematic review and network meta-analysis. The Lancet Gastroenterology & Hepatology 4: 831-844. https:\/\/doi.org\/10.1016\/s2468-1253(19)30246-8"},{"key":"R000023","series-title":"Nature Reviews Microbiology","first-page":"105","article-title":"The gut microbiota and its biogeography","volume":"22","author":"McCallum, G.","unstructured":"McCallum, G. and Tropini, C., 2023. The gut microbiota and its biogeography. Nature Reviews Microbiology 22: 105-118. https:\/\/doi.org\/10.1038\/s41579-023-00969-0"},{"key":"R000024","series-title":"Journal of Pain and Symptom Management","first-page":"737","article-title":"A review of the literature on gender and age differences in the prevalence and characteristics of constipation in North America","volume":"37","author":"McCrea, G.L.","unstructured":"McCrea, G.L., Miaskowski, C., Stotts, N.A., Macera, L. and Varma, M.G., 2009. A review of the literature on gender and age differences in the prevalence and characteristics of constipation in North America. Journal of Pain and Symptom Management 37: 737-745. https:\/\/doi.org\/10.1016\/j.jpainsymman.2008.04.016"},{"key":"R000025","series-title":"Frontiers in Medicine","article-title":"Gut microbiota and chronic constipation: a review and update","volume":"6","author":"Ohkusa, T.","unstructured":"Ohkusa, T., Koido, S., Nishikawa, Y. and Sato, N., 2019. Gut microbiota and chronic constipation: a review and update. Frontiers in Medicine 6. https:\/\/doi.org\/10.3389\/fmed.2019.00019"},{"key":"R000026","series-title":"Nature Reviews Gastroenterology & Hepatology","first-page":"447","article-title":"Gut-liver axis: barriers and functional circuits","volume":"20","author":"Pabst, O.","unstructured":"Pabst, O., Hornef, M.W., Schaap, F.G., Cerovic, V., Clavel, T. and Bruns, T., 2023. Gut-liver axis: barriers and functional circuits. Nature Reviews Gastroenterology & Hepatology 20: 447-461. https:\/\/doi.org\/10.1038\/s41575-023-00771-6"},{"key":"R000027","series-title":"International Journal of Environmental Research and Public Health","article-title":"Status of constipation and its association with sarcopenia in older adults: a population-based cohort study","volume":"18","author":"Park, H.","unstructured":"Park, H., Lim, J., Baek, J.Y., Lee, E., Jung, H.-W. and Jang, I.-Y., 2021. Status of constipation and its association with sarcopenia in older adults: a population-based cohort study. International Journal of Environmental Research and Public Health 18. https:\/\/doi.org\/10.3390\/ijerph182111083"},{"key":"R000028","series-title":"Cell Metabolism","first-page":"110","article-title":"Understanding the holobiont: how microbial metabolites affect human health and shape the immune system","volume":"26","author":"Postler, T.S.","unstructured":"Postler, T.S. and Ghosh, S., 2017. Understanding the holobiont: how microbial metabolites affect human health and shape the immune system. Cell Metabolism 26: 110-130. https:\/\/doi.org\/10.1016\/j.cmet.2017.05.008"},{"key":"R000029","series-title":"The American Journal of Gastroenterology","first-page":"894","article-title":"Association between constipation and colorectal cancer: systematic review and meta-analysis of observational studies","volume":"108","author":"Power, A.M.","unstructured":"Power, A.M., Talley, N.J. and Ford, A.C., 2013. Association between constipation and colorectal cancer: systematic review and meta-analysis of observational studies. The American Journal of Gastroenterology 108: 894-903. https:\/\/doi.org\/10.1038\/ajg.2013.52"},{"key":"R000030","series-title":"Gastroenterology","first-page":"300","article-title":"Constipation and the microbiome: lumen versus mucosa!","volume":"150","author":"Quigley, E.M.M.","unstructured":"Quigley, E.M.M. and Spiller, R.C., 2016. Constipation and the microbiome: lumen versus mucosa! Gastroenterology 150: 300-303. https:\/\/doi.org\/10.1053\/j.gastro.2015.12.023"},{"key":"R000031","series-title":"The American Journal of Gastroenterology","first-page":"876","article-title":"Chronic constipation, irritable bowel syndrome with constipation and constipation with pain\/discomfort: similarities and differences","volume":"109","author":"Rey, E.","unstructured":"Rey, E., Balboa, A. and Mearin, F., 2014. Chronic constipation, irritable bowel syndrome with constipation and constipation with pain\/discomfort: similarities and differences. The American Journal of Gastroenterology 109: 876-884. https:\/\/doi.org\/10.1038\/ajg.2014.18"},{"key":"R000032","series-title":"Drugs & Aging","article-title":"Constipation in the elderly managemt strategies","author":"Spinzi, G.","unstructured":"Spinzi, G., Amato, A., Imperiali, G., Lenoci, N., Mandelli, G., Paggi, S., Radaelli, F., Terreni, N. and Terruzzi, V., 2009. Constipation in the elderly managemt strategies. Drugs & Aging."},{"key":"R000033","series-title":"Scientific Reports","article-title":"Lacidophilin tablets alleviate constipation through regulation of intestinal microflora by promoting the colonisation of Akkermansia sps","volume":"14","author":"Sun, D.","unstructured":"Sun, D., Yu, J., Zhan, Y., Cheng, X., Zhang, J., Li, Y., Li, Q., Xiong, Y. and Liu, W., 2024. Lacidophilin tablets alleviate constipation through regulation of intestinal microflora by promoting the colonisation of Akkermansia sps. Scientific Reports 14. https:\/\/doi.org\/10.1038\/s41598-024-57732-5"},{"key":"R000034","series-title":"Frontiers in Microbiology","article-title":"Metaproteogenomics reveals taxonomic and functional changes between cecal and fecal microbiota in mouse","volume":"8","author":"Tanca, A.","unstructured":"Tanca, A., Manghina, V., Fraumene, C., Palomba, A., Abbondio, M., Deligios, M., Silverman, M. and Uzzau, S., 2017. Metaproteogenomics reveals taxonomic and functional changes between cecal and fecal microbiota in mouse. Frontiers in Microbiology 8. https:\/\/doi.org\/10.3389\/fmicb.2017.00391"},{"key":"R000035","series-title":"Therapeutic Advances in Gastroenterology","article-title":"Potential role of fecal microbiota in patients with constipation","volume":"13","author":"Tian, Y.","unstructured":"Tian, Y., Zuo, L., Guo, Q., Li, J., Hu, Z., Zhao, K., Li, C., Li, X., Zhou, J., Zhou, Y. and Li, X.-a., 2020. Potential role of fecal microbiota in patients with constipation. Therapeutic Advances in Gastroenterology 13. https:\/\/doi.org\/10.1177\/1756284820968423"},{"key":"R000036","series-title":"Cell Metabolism","first-page":"41","article-title":"Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism","volume":"24","author":"Wahlstr\u00f6m, A.","unstructured":"Wahlstr\u00f6m, A., Sayin, S.I., Marschall, H.-U. and B\u00e4ckhed, F., 2016. Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism. Cell Metabolism 24: 41-50. https:\/\/doi.org\/10.1016\/j.cmet.2016.05.005"},{"key":"R000037","series-title":"Cell Reports","first-page":"222","article-title":"Parabacteroides distasonis alleviates obesity and metabolic dysfunctions via production of succinate and secondary bile acids","volume":"26","author":"Wang, K.","unstructured":"Wang, K., Liao, M., Zhou, N., Bao, L., Ma, K., Zheng, Z., Wang, Y., Liu, C., Wang, W., Wang, J., Liu, S.J. and Liu, H., 2019. Parabacteroides distasonis alleviates obesity and metabolic dysfunctions via production of succinate and secondary bile acids. Cell Reports 26: 222-235. e225. https:\/\/doi.org\/10.1016\/j.celrep.2018.12.028"},{"key":"R000038","series-title":"Food & Function","first-page":"5037","article-title":"Bifidobacterium longum relieves constipation by regulating the intestinal barrier of mice","volume":"13","author":"Wang, L.","unstructured":"Wang, L., Chai, M., Wang, J., Yu, Q., Wang, G., Zhang, H., Zhao, J. and Chen, W., 2022a. Bifidobacterium longum relieves constipation by regulating the intestinal barrier of mice. Food & Function 13: 5037-5049. https:\/\/doi.org\/10.1039\/d1fo04151g"},{"key":"R000039","series-title":"Food & Function","first-page":"1628","article-title":"A randomised, double-blind, placebo-controlled trial ofBifidobacterium bifidumCCFM16 for manipulation of the gut microbiota and relief from chronic constipation","volume":"13","author":"Wang, L.","unstructured":"Wang, L., Wang, L., Tian, P., Wang, B., Cui, S., Zhao, J., Zhang, H., Qian, L., Wang, Q., Chen, W. and Wang, G., 2022b. A randomised, double-blind, placebo-controlled trial ofBifidobacterium bifidumCCFM16 for manipulation of the gut microbiota and relief from chronic constipation. Food & Function 13: 1628-1640. https:\/\/doi.org\/10.1039\/d1fo03896f"},{"key":"R000040","series-title":"Food & Function","first-page":"6015","article-title":"Lactococcus cremoris D2022 alleviates hyperuricemia and suppresses renal inflammation via potential gut-kidney axis","volume":"15","author":"Wang, Z.","unstructured":"Wang, Z., Huang, Y., Yang, T., Song, L., Xiao, Y., Chen, Y., Chen, M., Li, M. and Ren, Z., 2024. Lactococcus cremoris D2022 alleviates hyperuricemia and suppresses renal inflammation via potential gut-kidney axis. Food & Function 15: 6015-6027. https:\/\/doi.org\/10.1039\/d4fo00118d"},{"key":"R000041","series-title":"The American Journal of Gastroenterology","first-page":"2154","article-title":"Effects of A3309, an ileal bile acid transporter inhibitor, on colonic transit and symptoms in females with functional constipation","volume":"106","author":"Wong, B.S.","unstructured":"Wong, B.S., Camilleri, M., McKinzie, S., Burton, D., Graffner, H. and Zinsmeister, A.R., 2011. Effects of A3309, an ileal bile acid transporter inhibitor, on colonic transit and symptoms in females with functional constipation. The American Journal of Gastroenterology 106: 2154-2164. https:\/\/doi.org\/10.1038\/ajg.2011.285"},{"key":"R000042","series-title":"Microbiology Spectrum","article-title":"Probiotic consortia and their metabolites ameliorate the symptoms of inflammatory bowel diseases in a colitis mouse model","volume":"10","author":"Xu, L.","unstructured":"Xu, L., Liu, B., Huang, L., Li, Z., Cheng, Y., Tian, Y., Pan, G., Li, H., Xu, Y., Wu, W., Cui, Z. and Xiea, L., 2022. Probiotic consortia and their metabolites ameliorate the symptoms of inflammatory bowel diseases in a colitis mouse model. Microbiology Spectrum 10."},{"key":"R000043","series-title":"Food Research International","article-title":"Dietary synbiotic ameliorates constipation through the modulation of gut microbiota and its metabolic function","volume":"147","author":"Yang, Z.","unstructured":"Yang, Z., Ye, S., Xu, Z., Su, H., Tian, X., Han, B., Shen, B., Liao, Q., Xie, Z. and Hong, Y., 2021. Dietary synbiotic ameliorates constipation through the modulation of gut microbiota and its metabolic function. Food Research International 147. https:\/\/doi.org\/10.1016\/j.foodres.2021.110569"},{"key":"R000044","series-title":"Evidence-Based Complementary and Alternative Medicine","first-page":"1","article-title":"Maren pills improve constipation via regulating AQP3 and NF-\u03baB signalling pathway in slow transit constipation in vitro and in vivo","volume":"2020","author":"Zhan, Y.","unstructured":"Zhan, Y., Tang, X., Xu, H. and Tang, S., 2020. Maren pills improve constipation via regulating AQP3 and NF-\u03baB signalling pathway in slow transit constipation in vitro and in vivo. Evidence-Based Complementary and Alternative Medicine 2020: 1-12. https:\/\/doi.org\/10.1155\/2020\/9837384"},{"key":"R000045","series-title":"Frontiers in Pharmacology","article-title":"Effects of maren pills on the intestinal microflora and short-chain fatty acid profile in drug-induced slow transit constipation model rats","volume":"13","author":"Zhan, Y.","unstructured":"Zhan, Y., Wen, Y., Du, L.-j., Wang, X.-x., Tang, S.-y., Kong, P.-f., Huang, W.-g. and Tang, X.-g., 2022. Effects of maren pills on the intestinal microflora and short-chain fatty acid profile in drug-induced slow transit constipation model rats. Frontiers in Pharmacology 13. https:\/\/doi.org\/10.3389\/fphar.2022.804723"},{"key":"R000046","series-title":"Cell Metabolism","first-page":"943","article-title":"Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8(+) T cell immunity","volume":"35","author":"Zhang, Q.","unstructured":"Zhang, Q., Zhao, Q., Li, T., Lu, L., Wang, F., Zhang, H., Liu, Z., Ma, H., Zhu, Q., Wang, J., Zhang, X., Pei, Y., Liu, Q., Xu, Y., Qie, J., Luan, X., Hu, Z. and Liu, X., 2023. Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8(+) T cell immunity. Cell Metabolism 35: 943-960. e949. https:\/\/doi.org\/10.1016\/j.cmet.2023.04.015"},{"key":"R000047","series-title":"Gastroenterology Report","first-page":"392","article-title":"Role of gut microbiota in functional constipation","volume":"9","author":"Zhang, S.","unstructured":"Zhang, S., Wang, R., Li, D., Zhao, L. and Zhu, L., 2021. Role of gut microbiota in functional constipation. Gastroenterology Report 9: 392-401. https:\/\/doi.org\/10.1093\/gastro\/goab035"},{"key":"R000048","series-title":"Alimentary Pharmacology & Therapeutics","first-page":"1020","article-title":"Epidemiology of functional constipation and comparison with constipation-predominant irritable bowel syndrome: the Systematic Investigation of Gastrointestinal Diseases in China (SILC)","volume":"34","author":"Zhao, Y.F.","unstructured":"Zhao, Y.F., Ma, X.Q., Wang, R., Yan, X.Y., Li, Z.S., Zou, D.W. and He, J., 2011. Epidemiology of functional constipation and comparison with constipation-predominant irritable bowel syndrome: the Systematic Investigation of Gastrointestinal Diseases in China (SILC). Alimentary Pharmacology & Therapeutics 34: 1020-1029. https:\/\/doi.org\/10.1111\/j.1365-2036.2011.04809.x"},{"key":"R000049","series-title":"Food & Function","first-page":"7209","article-title":"Integrated gut microbiota and fecal metabolome analyses of the effect ofLycium barbarumpolysaccharide ond-galactose-induced premature ovarian insufficiency","volume":"14","author":"Zheng, H.","unstructured":"Zheng, H., Liang, X., Zhou, H., Zhou, T., Liu, X., Duan, J., Duan, J.-A. and Zhu, Y., 2023. Integrated gut microbiota and fecal metabolome analyses of the effect ofLycium barbarumpolysaccharide ond-galactose-induced premature ovarian insufficiency. Food & Function 14: 7209-7221. https:\/\/doi.org\/10.1039\/d3fo01659e"},{"key":"R000050","series-title":"Frontiers in Pharmacology","article-title":"Effects of Xiao Chengqi formula on slow transit constipation by assessing gut microbiota and metabolomics analysis in vitro and in vivo","volume":"13","author":"Zhou, Q.","unstructured":"Zhou, Q., Zhang, D., Zhang, H., Wan, X., Hu, B., Zou, Q., Su, D., Peng, H., Huang, D. and Ren, D., 2022. Effects of Xiao Chengqi formula on slow transit constipation by assessing gut microbiota and metabolomics analysis in vitro and in vivo. Frontiers in Pharmacology 13. https:\/\/doi.org\/10.3389\/fphar.2022.864598"},{"key":"R000001","series-title":"Scandinavian Journal of Gastroenterology","first-page":"1483","article-title":"Altered bile acid metabolism in patients with constipation-predominant irritable bowel syndrome and functional constipation","volume":"43","author":"Abrahamsson, H.","unstructured":"Abrahamsson, H., \u00d6stlund-Lindqvist, A.-M., Nilsson, R., Simre\u0301n, M. and Gillberg, P.-G., 2009. Altered bile acid metabolism in patients with constipation-predominant irritable bowel syndrome and functional constipation. Scandinavian Journal of Gastroenterology 43: 1483-1488. https:\/\/doi.org\/10.1080\/00365520802321212"},{"key":"R000002","series-title":"Beneficial Microbes","first-page":"617","article-title":"The effect of a probiotic blend on gastrointestinal symptoms in constipated patients: a double blind, randomised, placebo controlled 2-week trial","volume":"10","author":"Airaksinen, K.","unstructured":"Airaksinen, K., Yeung, N., Lyra, A., Lahtinen, S.J., Huttunen, T., Shanahan, F. and Ouwehand, A.C., 2019. The effect of a probiotic blend on gastrointestinal symptoms in constipated patients: a double blind, randomised, placebo controlled 2-week trial. Beneficial Microbes 10: 617-628. https:\/\/doi.org\/10.3920\/bm2018.0163"},{"key":"R000003","series-title":"Expert Review of Gastroenterology & Hepatology","first-page":"39","article-title":"An approach to the diagnosis and management of Rome IV functional disorders of chronic constipation","volume":"14","author":"Aziz, I.","unstructured":"Aziz, I., Whitehead, W.E., Palsson, O.S., T\u00f6rnblom, H. and Simre\u0301n, M., 2020. An approach to the diagnosis and management of Rome IV functional disorders of chronic constipation. Expert Review of Gastroenterology & Hepatology 14: 39-46. https:\/\/doi.org\/10.1080\/17474124.2020.1708718"},{"key":"R000004","series-title":"Molecules","article-title":"The anti-inflammatory activities of fermented curcuma that contains butyrate mitigate DSS-induced colitis in mice","volume":"27","author":"Bayazid, A.B.","unstructured":"Bayazid, A.B., Jeong, S.A., Park, C.W., Kim, D.H. and Lim, B.O., 2022. The anti-inflammatory activities of fermented curcuma that contains butyrate mitigate DSS-induced colitis in mice. Molecules 27. https:\/\/doi.org\/10.3390\/molecules27154745"},{"key":"R000005","series-title":"Gastroenterology","first-page":"1232","article-title":"Mechanisms, evaluation, and management of chronic constipation","volume":"158","author":"Bharucha, A.E.","unstructured":"Bharucha, A.E. and Lacy, B.E., 2020. Mechanisms, evaluation, and management of chronic constipation. Gastroenterology 158: 1232-1249. e1233. https:\/\/doi.org\/10.1053\/j.gastro.2019.12.034"},{"key":"R000006","series-title":"Gastroenterology","first-page":"218","article-title":"American gastroenterological association technical review on constipation","volume":"144","author":"Bharucha, A.E.","unstructured":"Bharucha, A.E., Pemberton, J.H. and Locke, G.R., 2013. American gastroenterological association technical review on constipation. Gastroenterology 144: 218-238. https:\/\/doi.org\/10.1053\/j.gastro.2012.10.028"},{"key":"R000007","series-title":"Scientific Reports","article-title":"Dysbiosis contributes to chronic constipation development via regulation of serotonin transporter in the intestine","volume":"7","author":"Cao, H.","unstructured":"Cao, H., Liu, X., An, Y., Zhou, G., Liu, Y., Xu, M., Dong, W., Wang, S., Yan, F., Jiang, K. and Wang, B., 2017. Dysbiosis contributes to chronic constipation development via regulation of serotonin transporter in the intestine. Scientific Reports 7. https:\/\/doi.org\/10.1038\/s41598-017-10835-8"},{"key":"R000008","series-title":"Expert Review of Gastroenterology & Hepatology","first-page":"951","article-title":"Elobixibat for the treatment of constipation","volume":"12","author":"Chedid, V.","unstructured":"Chedid, V., Vijayvargiya, P. and Camilleri, M., 2018. Elobixibat for the treatment of constipation. Expert Review of Gastroenterology & Hepatology 12: 951-960. https:\/\/doi.org\/10.1080\/17474124.2018.1522248"},{"key":"R000009","series-title":"Current Gastroenterology Reports","article-title":"Symptom overlap and comorbidity of irritable bowel syndrome with other conditions","volume":"7","author":"Christine, L.","unstructured":"Christine, L. and Frissora, a.K.L.K., 2005. Symptom overlap and comorbidity of irritable bowel syndrome with other conditions. Current Gastroenterology Reports 7."},{"key":"R000010","series-title":"World Journal of Gastroenterology","first-page":"1564","article-title":"Intestinal epithelial barrier and neuromuscular compartment in health and disease","volume":"26","author":"D\u2019Antongiovanni, V.","unstructured":"D\u2019Antongiovanni, V., Pellegrini, C., Fornai, M., Colucci, R., Blandizzi, C., Antonioli, L. and Bernardini, N., 2020. Intestinal epithelial barrier and neuromuscular compartment in health and disease. World Journal of Gastroenterology 26: 1564-1597. https:\/\/doi.org\/10.3748\/wjg.v26.i14.1564"},{"key":"R000011","series-title":"Advances in Nutrition","first-page":"484","article-title":"Mechanisms of action of probiotics and the gastrointestinal microbiota on gut motility and constipation","volume":"8","author":"Dimidi, E.","unstructured":"Dimidi, E., Christodoulides, S., Scott, S.M. and Whelan, K., 2017. Mechanisms of action of probiotics and the gastrointestinal microbiota on gut motility and constipation. Advances in Nutrition 8: 484-494. https:\/\/doi.org\/10.3945\/an.116.014407"},{"key":"R000012","series-title":"Trends in Molecular Medicine","first-page":"702","article-title":"Bile acid-activated receptors, intestinal microbiota, and the treatment of metabolic disorders","volume":"21","author":"Fiorucci, S.","unstructured":"Fiorucci, S. and Distrutti, E., 2015. Bile acid-activated receptors, intestinal microbiota, and the treatment of metabolic disorders. Trends in Molecular Medicine 21: 702-714. https:\/\/doi.org\/10.1016\/j.molmed.2015.09.001"},{"key":"R000013","series-title":"Frontiers in Pharmacology","article-title":"Underlying beneficial effects of rhubarb on constipation-induced inflammation, disorder of gut microbiome and metabolism","volume":"13","author":"Gao, H.","unstructured":"Gao, H., He, C., Hua, R., Liang, C., Wang, B., Du, Y., Xin, S., Guo, Y., Gao, L., Zhang, L., Shang, H. and Xu, J., 2022. Underlying beneficial effects of rhubarb on constipation-induced inflammation, disorder of gut microbiome and metabolism. Frontiers in Pharmacology 13. https:\/\/doi.org\/10.3389\/fphar.2022.1048134"},{"key":"R000014","series-title":"Future Microbiology","article-title":"The composition of intestinal microbiota and its association with functional constipation of the elderly patients","author":"Guo, M.","unstructured":"Guo, M., Yao, J., Yang, F., Liu, W., Bai, H., Ma, J., Ma, X., Zhang, J., Fang, Y., Miao, Y., Sun, J., Zhang, J. and Zhao, H., 2020. The composition of intestinal microbiota and its association with functional constipation of the elderly patients. Future Microbiology."},{"key":"R000015","series-title":"Aging Cell","article-title":"Elevated miR-124-3p in the aging colon disrupts mucus barrier and increases susceptibility to colitis by targeting T-synthase","volume":"19","author":"Huang, L.","unstructured":"Huang, L., Sun, T.y., Hu, L.j., Hu, S.l., Sun, H.m., Zhao, F.q., Wu, B., Yang, S., Ji, F.q. and Zhou, D.s., 2020. Elevated miR-124-3p in the aging colon disrupts mucus barrier and increases susceptibility to colitis by targeting T-synthase. Aging Cell 19. https:\/\/doi.org\/10.1111\/acel.13252"},{"key":"R000016","series-title":"European Journal of Clinical Microbiology & Infectious Diseases","first-page":"555","article-title":"Analysis of fecal microbiota in patients with functional constipation undergoing treatment with synbiotics","volume":"37","author":"Huang, L.S.","unstructured":"Huang, L.S., Kong, C., Gao, R.Y., Yan, X., Yu, H.J., Wen, B., Zhu, Q., Shen, T.Y., Sun, Z.L. and Qin, H.L., 2018. Analysis of fecal microbiota in patients with functional constipation undergoing treatment with synbiotics. European Journal of Clinical Microbiology & Infectious Diseases 37: 555-563. https:\/\/doi.org\/10.1007\/s10096-017-3149-7"},{"key":"R000017","series-title":"American Journal of Physiology: Gastrointestinal and Liver Physiology","article-title":"Influence of microbial species on small intestinal myoelectric activity and transit in germ-free rats","author":"Husebye, E.","unstructured":"Husebye, E., Hellstr\u00f6m, P.M., Sundler, F., Chen, J. and Midtvedt, T., 2001. Influence of microbial species on small intestinal myoelectric activity and transit in germ-free rats. American Journal of Physiology: Gastrointestinal and Liver Physiology."},{"key":"R000018","series-title":"Nature Reviews Immunology","first-page":"639","article-title":"Immunological aspects of intestinal mucus and mucins","volume":"16","author":"Johansson, M.E.V.","unstructured":"Johansson, M.E.V. and Hansson, G.C., 2016. Immunological aspects of intestinal mucus and mucins. Nature Reviews Immunology 16: 639-649. https:\/\/doi.org\/10.1038\/nri.2016.88"},{"key":"R000019","series-title":"Science Advances","article-title":"Inhibition of microbial deconjugation of micellar bile acids protects against intestinal permeability and liver injury","volume":"8","author":"Li, D.K.","unstructured":"Li, D.K., Chaudhari, S.N., Lee, Y., Sojoodi, M., Adhikari, A.A., Zukerberg, L., Shroff, S., Barrett, S.C., Tanabe, K., Chung, R.T. and Devlin, S., 2022. Inhibition of microbial deconjugation of micellar bile acids protects against intestinal permeability and liver injury. Science Advances 8."},{"key":"R000020","series-title":"Frontiers in Cellular and Infection Microbiology","article-title":"Gut microbiota composition changes in constipated women of reproductive age","volume":"10","author":"Li, H.","unstructured":"Li, H., Chen, J., Ren, X., Yang, C., Liu, S., Bai, X., Shan, S. and Dong, X., 2021. Gut microbiota composition changes in constipated women of reproductive age. Frontiers in Cellular and Infection Microbiology 10. https:\/\/doi.org\/10.3389\/fcimb.2020.557515"},{"key":"R000021","series-title":"Food Sciences and Nutrition","first-page":"3297","article-title":"The potential of quercetin to protect against loperamide-induced constipation in rats","volume":"9","author":"Liu, W.","unstructured":"Liu, W. and Zhi, A., 2021. The potential of quercetin to protect against loperamide-induced constipation in rats. Food Sciences and Nutrition 9: 3297-3307. https:\/\/doi.org\/10.1002\/fsn3.2296"},{"key":"R000022","series-title":"The Lancet Gastroenterology & Hepatology","first-page":"831","article-title":"Efficacy of drugs in chronic idiopathic constipation: a systematic review and network meta-analysis","volume":"4","author":"Luthra, P.","unstructured":"Luthra, P., Camilleri, M., Burr, N.E., Quigley, E.M.M., Black, C.J. and Ford, A.C., 2019. Efficacy of drugs in chronic idiopathic constipation: a systematic review and network meta-analysis. The Lancet Gastroenterology & Hepatology 4: 831-844. https:\/\/doi.org\/10.1016\/s2468-1253(19)30246-8"},{"key":"R000023","series-title":"Nature Reviews Microbiology","first-page":"105","article-title":"The gut microbiota and its biogeography","volume":"22","author":"McCallum, G.","unstructured":"McCallum, G. and Tropini, C., 2023. The gut microbiota and its biogeography. Nature Reviews Microbiology 22: 105-118. https:\/\/doi.org\/10.1038\/s41579-023-00969-0"},{"key":"R000024","series-title":"Journal of Pain and Symptom Management","first-page":"737","article-title":"A review of the literature on gender and age differences in the prevalence and characteristics of constipation in North America","volume":"37","author":"McCrea, G.L.","unstructured":"McCrea, G.L., Miaskowski, C., Stotts, N.A., Macera, L. and Varma, M.G., 2009. A review of the literature on gender and age differences in the prevalence and characteristics of constipation in North America. Journal of Pain and Symptom Management 37: 737-745. https:\/\/doi.org\/10.1016\/j.jpainsymman.2008.04.016"},{"key":"R000025","series-title":"Frontiers in Medicine","article-title":"Gut microbiota and chronic constipation: a review and update","volume":"6","author":"Ohkusa, T.","unstructured":"Ohkusa, T., Koido, S., Nishikawa, Y. and Sato, N., 2019. Gut microbiota and chronic constipation: a review and update. Frontiers in Medicine 6. https:\/\/doi.org\/10.3389\/fmed.2019.00019"},{"key":"R000026","series-title":"Nature Reviews Gastroenterology & Hepatology","first-page":"447","article-title":"Gut-liver axis: barriers and functional circuits","volume":"20","author":"Pabst, O.","unstructured":"Pabst, O., Hornef, M.W., Schaap, F.G., Cerovic, V., Clavel, T. and Bruns, T., 2023. Gut-liver axis: barriers and functional circuits. Nature Reviews Gastroenterology & Hepatology 20: 447-461. https:\/\/doi.org\/10.1038\/s41575-023-00771-6"},{"key":"R000027","series-title":"International Journal of Environmental Research and Public Health","article-title":"Status of constipation and its association with sarcopenia in older adults: a population-based cohort study","volume":"18","author":"Park, H.","unstructured":"Park, H., Lim, J., Baek, J.Y., Lee, E., Jung, H.-W. and Jang, I.-Y., 2021. Status of constipation and its association with sarcopenia in older adults: a population-based cohort study. International Journal of Environmental Research and Public Health 18. https:\/\/doi.org\/10.3390\/ijerph182111083"},{"key":"R000028","series-title":"Cell Metabolism","first-page":"110","article-title":"Understanding the holobiont: how microbial metabolites affect human health and shape the immune system","volume":"26","author":"Postler, T.S.","unstructured":"Postler, T.S. and Ghosh, S., 2017. Understanding the holobiont: how microbial metabolites affect human health and shape the immune system. Cell Metabolism 26: 110-130. https:\/\/doi.org\/10.1016\/j.cmet.2017.05.008"},{"key":"R000029","series-title":"The American Journal of Gastroenterology","first-page":"894","article-title":"Association between constipation and colorectal cancer: systematic review and meta-analysis of observational studies","volume":"108","author":"Power, A.M.","unstructured":"Power, A.M., Talley, N.J. and Ford, A.C., 2013. Association between constipation and colorectal cancer: systematic review and meta-analysis of observational studies. The American Journal of Gastroenterology 108: 894-903. https:\/\/doi.org\/10.1038\/ajg.2013.52"},{"key":"R000030","series-title":"Gastroenterology","first-page":"300","article-title":"Constipation and the microbiome: lumen versus mucosa!","volume":"150","author":"Quigley, E.M.M.","unstructured":"Quigley, E.M.M. and Spiller, R.C., 2016. Constipation and the microbiome: lumen versus mucosa! Gastroenterology 150: 300-303. https:\/\/doi.org\/10.1053\/j.gastro.2015.12.023"},{"key":"R000031","series-title":"The American Journal of Gastroenterology","first-page":"876","article-title":"Chronic constipation, irritable bowel syndrome with constipation and constipation with pain\/discomfort: similarities and differences","volume":"109","author":"Rey, E.","unstructured":"Rey, E., Balboa, A. and Mearin, F., 2014. Chronic constipation, irritable bowel syndrome with constipation and constipation with pain\/discomfort: similarities and differences. The American Journal of Gastroenterology 109: 876-884. https:\/\/doi.org\/10.1038\/ajg.2014.18"},{"key":"R000032","series-title":"Drugs & Aging","article-title":"Constipation in the elderly managemt strategies","author":"Spinzi, G.","unstructured":"Spinzi, G., Amato, A., Imperiali, G., Lenoci, N., Mandelli, G., Paggi, S., Radaelli, F., Terreni, N. and Terruzzi, V., 2009. Constipation in the elderly managemt strategies. Drugs & Aging."},{"key":"R000033","series-title":"Scientific Reports","article-title":"Lacidophilin tablets alleviate constipation through regulation of intestinal microflora by promoting the colonisation of Akkermansia sps","volume":"14","author":"Sun, D.","unstructured":"Sun, D., Yu, J., Zhan, Y., Cheng, X., Zhang, J., Li, Y., Li, Q., Xiong, Y. and Liu, W., 2024. Lacidophilin tablets alleviate constipation through regulation of intestinal microflora by promoting the colonisation of Akkermansia sps. Scientific Reports 14. https:\/\/doi.org\/10.1038\/s41598-024-57732-5"},{"key":"R000034","series-title":"Frontiers in Microbiology","article-title":"Metaproteogenomics reveals taxonomic and functional changes between cecal and fecal microbiota in mouse","volume":"8","author":"Tanca, A.","unstructured":"Tanca, A., Manghina, V., Fraumene, C., Palomba, A., Abbondio, M., Deligios, M., Silverman, M. and Uzzau, S., 2017. Metaproteogenomics reveals taxonomic and functional changes between cecal and fecal microbiota in mouse. Frontiers in Microbiology 8. https:\/\/doi.org\/10.3389\/fmicb.2017.00391"},{"key":"R000035","series-title":"Therapeutic Advances in Gastroenterology","article-title":"Potential role of fecal microbiota in patients with constipation","volume":"13","author":"Tian, Y.","unstructured":"Tian, Y., Zuo, L., Guo, Q., Li, J., Hu, Z., Zhao, K., Li, C., Li, X., Zhou, J., Zhou, Y. and Li, X.-a., 2020. Potential role of fecal microbiota in patients with constipation. Therapeutic Advances in Gastroenterology 13. https:\/\/doi.org\/10.1177\/1756284820968423"},{"key":"R000036","series-title":"Cell Metabolism","first-page":"41","article-title":"Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism","volume":"24","author":"Wahlstr\u00f6m, A.","unstructured":"Wahlstr\u00f6m, A., Sayin, S.I., Marschall, H.-U. and B\u00e4ckhed, F., 2016. Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism. Cell Metabolism 24: 41-50. https:\/\/doi.org\/10.1016\/j.cmet.2016.05.005"},{"key":"R000037","series-title":"Cell Reports","first-page":"222","article-title":"Parabacteroides distasonis alleviates obesity and metabolic dysfunctions via production of succinate and secondary bile acids","volume":"26","author":"Wang, K.","unstructured":"Wang, K., Liao, M., Zhou, N., Bao, L., Ma, K., Zheng, Z., Wang, Y., Liu, C., Wang, W., Wang, J., Liu, S.J. and Liu, H., 2019. Parabacteroides distasonis alleviates obesity and metabolic dysfunctions via production of succinate and secondary bile acids. Cell Reports 26: 222-235. e225. https:\/\/doi.org\/10.1016\/j.celrep.2018.12.028"},{"key":"R000038","series-title":"Food & Function","first-page":"5037","article-title":"Bifidobacterium longum relieves constipation by regulating the intestinal barrier of mice","volume":"13","author":"Wang, L.","unstructured":"Wang, L., Chai, M., Wang, J., Yu, Q., Wang, G., Zhang, H., Zhao, J. and Chen, W., 2022a. Bifidobacterium longum relieves constipation by regulating the intestinal barrier of mice. Food & Function 13: 5037-5049. https:\/\/doi.org\/10.1039\/d1fo04151g"},{"key":"R000039","series-title":"Food & Function","first-page":"1628","article-title":"A randomised, double-blind, placebo-controlled trial ofBifidobacterium bifidumCCFM16 for manipulation of the gut microbiota and relief from chronic constipation","volume":"13","author":"Wang, L.","unstructured":"Wang, L., Wang, L., Tian, P., Wang, B., Cui, S., Zhao, J., Zhang, H., Qian, L., Wang, Q., Chen, W. and Wang, G., 2022b. A randomised, double-blind, placebo-controlled trial ofBifidobacterium bifidumCCFM16 for manipulation of the gut microbiota and relief from chronic constipation. Food & Function 13: 1628-1640. https:\/\/doi.org\/10.1039\/d1fo03896f"},{"key":"R000040","series-title":"Food & Function","first-page":"6015","article-title":"Lactococcus cremoris D2022 alleviates hyperuricemia and suppresses renal inflammation via potential gut-kidney axis","volume":"15","author":"Wang, Z.","unstructured":"Wang, Z., Huang, Y., Yang, T., Song, L., Xiao, Y., Chen, Y., Chen, M., Li, M. and Ren, Z., 2024. Lactococcus cremoris D2022 alleviates hyperuricemia and suppresses renal inflammation via potential gut-kidney axis. Food & Function 15: 6015-6027. https:\/\/doi.org\/10.1039\/d4fo00118d"},{"key":"R000041","series-title":"The American Journal of Gastroenterology","first-page":"2154","article-title":"Effects of A3309, an ileal bile acid transporter inhibitor, on colonic transit and symptoms in females with functional constipation","volume":"106","author":"Wong, B.S.","unstructured":"Wong, B.S., Camilleri, M., McKinzie, S., Burton, D., Graffner, H. and Zinsmeister, A.R., 2011. Effects of A3309, an ileal bile acid transporter inhibitor, on colonic transit and symptoms in females with functional constipation. The American Journal of Gastroenterology 106: 2154-2164. https:\/\/doi.org\/10.1038\/ajg.2011.285"},{"key":"R000042","series-title":"Microbiology Spectrum","article-title":"Probiotic consortia and their metabolites ameliorate the symptoms of inflammatory bowel diseases in a colitis mouse model","volume":"10","author":"Xu, L.","unstructured":"Xu, L., Liu, B., Huang, L., Li, Z., Cheng, Y., Tian, Y., Pan, G., Li, H., Xu, Y., Wu, W., Cui, Z. and Xiea, L., 2022. Probiotic consortia and their metabolites ameliorate the symptoms of inflammatory bowel diseases in a colitis mouse model. Microbiology Spectrum 10."},{"key":"R000043","series-title":"Food Research International","article-title":"Dietary synbiotic ameliorates constipation through the modulation of gut microbiota and its metabolic function","volume":"147","author":"Yang, Z.","unstructured":"Yang, Z., Ye, S., Xu, Z., Su, H., Tian, X., Han, B., Shen, B., Liao, Q., Xie, Z. and Hong, Y., 2021. Dietary synbiotic ameliorates constipation through the modulation of gut microbiota and its metabolic function. Food Research International 147. https:\/\/doi.org\/10.1016\/j.foodres.2021.110569"},{"key":"R000044","series-title":"Evidence-Based Complementary and Alternative Medicine","first-page":"1","article-title":"Maren pills improve constipation via regulating AQP3 and NF-\u03baB signalling pathway in slow transit constipation in vitro and in vivo","volume":"2020","author":"Zhan, Y.","unstructured":"Zhan, Y., Tang, X., Xu, H. and Tang, S., 2020. Maren pills improve constipation via regulating AQP3 and NF-\u03baB signalling pathway in slow transit constipation in vitro and in vivo. Evidence-Based Complementary and Alternative Medicine 2020: 1-12. https:\/\/doi.org\/10.1155\/2020\/9837384"},{"key":"R000045","series-title":"Frontiers in Pharmacology","article-title":"Effects of maren pills on the intestinal microflora and short-chain fatty acid profile in drug-induced slow transit constipation model rats","volume":"13","author":"Zhan, Y.","unstructured":"Zhan, Y., Wen, Y., Du, L.-j., Wang, X.-x., Tang, S.-y., Kong, P.-f., Huang, W.-g. and Tang, X.-g., 2022. Effects of maren pills on the intestinal microflora and short-chain fatty acid profile in drug-induced slow transit constipation model rats. Frontiers in Pharmacology 13. https:\/\/doi.org\/10.3389\/fphar.2022.804723"},{"key":"R000046","series-title":"Cell Metabolism","first-page":"943","article-title":"Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8(+) T cell immunity","volume":"35","author":"Zhang, Q.","unstructured":"Zhang, Q., Zhao, Q., Li, T., Lu, L., Wang, F., Zhang, H., Liu, Z., Ma, H., Zhu, Q., Wang, J., Zhang, X., Pei, Y., Liu, Q., Xu, Y., Qie, J., Luan, X., Hu, Z. and Liu, X., 2023. Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8(+) T cell immunity. Cell Metabolism 35: 943-960. e949. https:\/\/doi.org\/10.1016\/j.cmet.2023.04.015"},{"key":"R000047","series-title":"Gastroenterology Report","first-page":"392","article-title":"Role of gut microbiota in functional constipation","volume":"9","author":"Zhang, S.","unstructured":"Zhang, S., Wang, R., Li, D., Zhao, L. and Zhu, L., 2021. Role of gut microbiota in functional constipation. Gastroenterology Report 9: 392-401. https:\/\/doi.org\/10.1093\/gastro\/goab035"},{"key":"R000048","series-title":"Alimentary Pharmacology & Therapeutics","first-page":"1020","article-title":"Epidemiology of functional constipation and comparison with constipation-predominant irritable bowel syndrome: the Systematic Investigation of Gastrointestinal Diseases in China (SILC)","volume":"34","author":"Zhao, Y.F.","unstructured":"Zhao, Y.F., Ma, X.Q., Wang, R., Yan, X.Y., Li, Z.S., Zou, D.W. and He, J., 2011. Epidemiology of functional constipation and comparison with constipation-predominant irritable bowel syndrome: the Systematic Investigation of Gastrointestinal Diseases in China (SILC). Alimentary Pharmacology & Therapeutics 34: 1020-1029. https:\/\/doi.org\/10.1111\/j.1365-2036.2011.04809.x"},{"key":"R000049","series-title":"Food & Function","first-page":"7209","article-title":"Integrated gut microbiota and fecal metabolome analyses of the effect ofLycium barbarumpolysaccharide ond-galactose-induced premature ovarian insufficiency","volume":"14","author":"Zheng, H.","unstructured":"Zheng, H., Liang, X., Zhou, H., Zhou, T., Liu, X., Duan, J., Duan, J.-A. and Zhu, Y., 2023. Integrated gut microbiota and fecal metabolome analyses of the effect ofLycium barbarumpolysaccharide ond-galactose-induced premature ovarian insufficiency. Food & Function 14: 7209-7221. https:\/\/doi.org\/10.1039\/d3fo01659e"},{"key":"R000050","series-title":"Frontiers in Pharmacology","article-title":"Effects of Xiao Chengqi formula on slow transit constipation by assessing gut microbiota and metabolomics analysis in vitro and in vivo","volume":"13","author":"Zhou, Q.","unstructured":"Zhou, Q., Zhang, D., Zhang, H., Wan, X., Hu, B., Zou, Q., Su, D., Peng, H., Huang, D. and Ren, D., 2022. Effects of Xiao Chengqi formula on slow transit constipation by assessing gut microbiota and metabolomics analysis in vitro and in vivo. Frontiers in Pharmacology 13. https:\/\/doi.org\/10.3389\/fphar.2022.864598"}],"container-title":["Beneficial Microbes"],"original-title":[],"link":[{"URL":"https:\/\/brill.com\/view\/journals\/bm\/17\/1\/article-p61_5.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/brill.com\/downloadpdf\/journals\/bm\/17\/1\/article-p61_5.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/brill.com\/downloadpdf\/journals\/bm\/17\/1\/article-p61_5.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T14:27:10Z","timestamp":1769610430000},"score":1,"resource":{"primary":{"URL":"https:\/\/brill.com\/view\/journals\/bm\/17\/1\/article-p61_5.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,29]]},"references-count":100,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1163\/18762891-bja00076","relation":{},"ISSN":["1876-2891"],"issn-type":[{"value":"1876-2891","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,29]]}}}