{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:31:02Z","timestamp":1790285462278,"version":"4.1.0"},"reference-count":72,"publisher":"Walter de Gruyter GmbH","issue":"6","funder":[{"name":"USM-Probionic Grant","award":["304\/PTEKIND\/6501096"],"award-info":[{"award-number":["304\/PTEKIND\/6501096"]}]},{"name":"USM-Industry Research Matching Grant","award":["1001\/PTEKIND\/8070037"],"award-info":[{"award-number":["1001\/PTEKIND\/8070037"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Benef. Microbes"],"published-print":{"date-parts":[[2025,5,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The Human Papillomavirus (HPV) is one of the main causes of cervical cancer in women, while there are currently no treatment nor intervention to reduce the concentration of cervical HPV. We thus aimed to investigate the effects of a probiotic\n                    <jats:italic>Lactiplantibacillus plantarum<\/jats:italic>\n                    Probio87 (orally administered at 9 log CFU\/day) or placebo for 12-weeks, on reducing the abundance of vaginal HPV in HPV-positive women. A parallel, randomised, double-blind and placebo-controlled study was performed where women were randomised to either the probiotic (n\u00a0= 44, mean age 41.70\u00a0\u00b1 1.06 years) or placebo (n\u00a0= 45, mean age 41.13\u00a0\u00b1 1.20 years). After 12 weeks, the probiotic group showed reduced vaginal HPV abundance (\n                    <jats:inline-formula\/>\n                    ) and Nugent scores (\n                    <jats:inline-formula\/>\n                    ) as compared to the placebo. VAS and VuAS questionnaires showed that the probiotic group had improved vulvar dryness (\n                    <jats:inline-formula\/>\n                    ), soreness (\n                    <jats:inline-formula\/>\n                    ), social interactions, daily activities (\n                    <jats:inline-formula\/>\n                    ), and sexual activity (\n                    <jats:inline-formula\/>\n                    ) compared to the placebo group. Blood gene expressions showed that the placebo group had higher upregulation of pro-inflammatory cytokines (IL-1\u03b2,\n                    <jats:inline-formula\/>\n                    ; IFN-\u03b3,\n                    <jats:inline-formula\/>\n                    ) and T-cell markers (CD44,\n                    <jats:inline-formula\/>\n                    ; CXCR5,\n                    <jats:inline-formula\/>\n                    ; CD4,\n                    <jats:inline-formula\/>\n                    ) compared to the placebo group, indicating increased inflammation. Neurotrophic factors BDNF and CREB were upregulated in the placebo group (\n                    <jats:inline-formula\/>\n                    ), with higher IDO (\n                    <jats:inline-formula\/>\n                    ) and TDO (\n                    <jats:inline-formula\/>\n                    ) expressions compared to the probiotic group, suggesting increased kynurenine pathway activity and stress. Overall, probiotic supplementation appeared to reduce the abundance of vaginal HPV, possibly by lowering inflammation and enhancing immunity while mitigating the negative impacts of HPV infection on quality of life in HPV-positive women.\n                  <\/jats:p>\n                  <jats:p>Clinical trial registration: ClinicalTrials.gov (NCT05316064).<\/jats:p>","DOI":"10.1163\/18762891-bja00079","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T01:33:42Z","timestamp":1747100022000},"page":"667-684","source":"Crossref","is-referenced-by-count":6,"title":["Probiotic reduces vaginal HPV abundance, improves immunity and quality of life in HPV-positive women: a randomised, placebo-controlled and double-blind study"],"prefix":"10.1163","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0841-6152","authenticated-orcid":true,"given":"P.","family":"Xu","sequence":"first","affiliation":[{"name":"School of Industrial Technology, 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Penang, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2265-2005","authenticated-orcid":true,"given":"D.","family":"Rajendran","sequence":"additional","affiliation":[{"name":"Institute for Research in Molecular Medicine, https:\/\/dx.doi.org\/26689Universiti Sains Malaysia, 11800 Penang, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7027-6657","authenticated-orcid":true,"given":"J.J.","family":"Tan","sequence":"additional","affiliation":[{"name":"Advanced Medical and Dental Institute, https:\/\/dx.doi.org\/26689Universiti Sains Malaysia, Penang 13200, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5868-6717","authenticated-orcid":true,"given":"F.F.","family":"Roslan","sequence":"additional","affiliation":[{"name":"Advanced Medical and Dental Institute, https:\/\/dx.doi.org\/26689Universiti Sains Malaysia, Penang 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Orphanet Journal of Rare Diseases 12: 122. https:\/\/doi.org\/10.1186\/s13023-017-0664-7"},{"key":"R000003","series-title":"BMC Women\u2019s Health","article-title":"Probiotic effects on sexual function in women with polycystic ovary syndrome: a double blinded randomized controlled trial","volume":"22","author":"Azizi-Kutenaee, M.","unstructured":"Azizi-Kutenaee, M., Heidari, S., Taghavi, S.-A. and Bazarganipour, F., 2022. Probiotic effects on sexual function in women with polycystic ovary syndrome: a double blinded randomized controlled trial. BMC Women\u2019s Health 22: 373. https:\/\/doi.org\/10.1186\/s12905-022-01955-z"},{"key":"R000004","series-title":"Immunity","first-page":"104","article-title":"CD44 regulates survival and memory development in Th1 cells","volume":"32","author":"Baaten, B.J.G.","unstructured":"Baaten, B.J.G., Li, C.-R., Deiro, M.F., Lin, M.M., Linton, P.J. and Bradley, L.M., 2010. CD44 regulates survival and memory development in Th1 cells. 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Asian Pacific Journal of Cancer Prevention 11: 1645-1651."},{"key":"R000013","series-title":"Beneficial Microbes","first-page":"355","article-title":"Lactobacillus plantarum DR7 alleviates stress and anxiety in adults: a randomised, double-blind, placebo-controlled study","volume":"10","author":"Chong, H.X.","unstructured":"Chong, H.X., Yusoff, N.A.A., Hor, Y.-Y., Lew, L.-C., Jaafar, M.H., Choi, S.-B., Yusoff, M.S.B., Wahid, N., Abdullah, M.F.I.L., Zakaria, N., Ong, K.-L., Park, Y.-H. and Liong, M.-T., 2019a. Lactobacillus plantarum DR7 alleviates stress and anxiety in adults: a randomised, double-blind, placebo-controlled study. 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Oncology Letters 9: 1015-1026. https:\/\/doi.org\/10.3892\/ol.2015.2884"},{"key":"R000022","series-title":"Microorganisms","article-title":"Evaluation of different activity of lactobacillus spp. against two proteus mirabilis isolated clinical strains in different anatomical sites in vitro: an explorative study to improve the therapeutic approach","volume":"11","author":"Fusco, A.","unstructured":"Fusco, A., Savio, V., Chiaromonte, A., Alfano, A., D\u2019Ambrosio, S., Cimini, D. and Donnarumma, G., 2023. Evaluation of different activity of lactobacillus spp. against two proteus mirabilis isolated clinical strains in different anatomical sites in vitro: an explorative study to improve the therapeutic approach. 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