{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T14:27:46Z","timestamp":1778077666871,"version":"3.51.4"},"reference-count":110,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"crossref","award":["232300420207"],"award-info":[{"award-number":["232300420207"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Benef. Microbes"],"published-print":{"date-parts":[[2025,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Aim: this study explored the impact of BLa80 (\n                    <jats:italic>Bifidobacterium animalis<\/jats:italic>\n                    subsp.\n                    <jats:italic>lactis<\/jats:italic>\n                    ) and LRa05 (\n                    <jats:italic>Lacticaseibacillus rhamnosus<\/jats:italic>\n                    ) on the gut microbiota composition and metabolic indicators of volunteers with alcohol-consuming habits. Methods: in this randomised, placebo-controlled trial, we assessed the impacts of a probiotic complex containing BLa80 and LRa05 (BLC) on the gut microbiota, short-chain fatty acids (SCFAs), alanine transaminase (ALT), aspartate aminotransferase (AST) and uric acid levels in healthy participants. A total of 112 subjects were randomly assigned to receive either a placebo (maltodextrin) or the intervention (maltodextrin\u00a0+ BLC at 20 billion colony-forming units\/day) for eight weeks. Gut microbiota alterations were monitored via 16S rRNA gene sequencing, while fecal SCFAs were quantified via gas chromatography-mass spectrometry (GC-MS). Key metabolic indicators, including ALT, AST, and uric acid, were also measured. Results: BLC intervention maintained the gut microbiota composition in participants with alcohol consumption habits, notably increasing the abundance of beneficial genera such as\n                    <jats:italic>Blautia<\/jats:italic>\n                    ,\n                    <jats:italic>Faecalibacterium<\/jats:italic>\n                    , and\n                    <jats:italic>Subdoligranulum<\/jats:italic>\n                    . Significant alterations were observed in the levels of acetic acid, valeric acid, and total SCFAs, suggesting a favourable influence on gut health and metabolic function. Furthermore, BLC showed potential for improving serum uric acid levels. Conclusion: supplementation with BLC appears to beneficially modulate the composition of the gut microbiota, aiding in the management of alcohol-related gastrointestinal disturbances and dependency. These findings highlight BLC\u2019s potential as a therapeutic adjunct for alcohol-induced gut dysbiosis, offering a non-pharmacological strategy to mitigate metabolic risks and improve gut barrier integrity in individuals with chronic alcohol consumption. This intervention may significantly contribute to gut health improvement.\n                  <\/jats:p>","DOI":"10.1163\/18762891-bja00083","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T23:08:26Z","timestamp":1750201706000},"page":"11-27","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Bifidobacterium animalis subsp. lactis BLa80 and Lacticaseibacillus rhamnosus LRa05 supplementation on the gut microbiota and metabolic health of alcohol-consuming individuals: a randomised, double-blind, placebo-controlled trial"],"prefix":"10.1163","volume":"17","author":[{"given":"Y.","family":"Liu","sequence":"first","affiliation":[{"name":"College of Food Science and Technology, https:\/\/dx.doi.org\/47901Henan University of Technology, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Human Resources, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Integrated Traditional Chinese and Western Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, https:\/\/dx.doi.org\/47901Henan University of Technology, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, https:\/\/dx.doi.org\/47901Henan University of Technology, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6139-2552","authenticated-orcid":true,"given":"F.","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, https:\/\/dx.doi.org\/47901Henan University of Technology, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, https:\/\/dx.doi.org\/47901Henan University of Technology, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"R000001","series-title":"Alimentary Pharmacology & Therapeutics","first-page":"357","article-title":"Validation of the gastrointestinal symptom score for the assessment of symptoms in patients with functional dyspepsia","volume":"22","author":"Adam, B.","unstructured":"Adam, B., Liebregts, T., Saadat-Gilani, K., Vinson, B. and Holtmannn, G., 2005. 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