{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:08:19Z","timestamp":1781676499087,"version":"3.54.5"},"reference-count":126,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Kerry Shanghai"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Benef. Microbes"],"published-print":{"date-parts":[[2025,7,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Many healthy people complain of functional gastrointestinal (GI) tract symptoms that do not fit diagnostic criteria for established diseases. Disrupted intestinal microbiomes are associated with these functional conditions, thus the use of beneficial bacteria shown to restore the protective microbiome may be useful. Our aims were to determine if\n                    <jats:italic>Heyndrickxia<\/jats:italic>\n                    (\n                    <jats:italic>Bacillus<\/jats:italic>\n                    )\n                    <jats:italic>coagulans<\/jats:italic>\n                    GBI-30, 6086 (BC30) would improve GI functions in healthy adults living in China and to determine its effect on the GI microbiome. Healthy adults (\n                    <jats:inline-formula\/>\n                    , 18-65 years old) with functional GI complaints were enrolled in a prospective, double-blind trial and randomised (by random number table) to either BC30 (1\u00a0\u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    \/day) or placebo for four weeks. Outcomes were analysed by ANOVA or the Wilcoxon tests or with mixed regression models. Functional GI symptoms improved significantly in adults given BC30 compared to placebo: increase in number of stools\/week (\n                    <jats:inline-formula\/>\n                    ), improved fecal consistency (\n                    <jats:inline-formula\/>\n                    ) and fewer participants had constipation (\n                    <jats:inline-formula\/>\n                    ). Four weeks of BC30 increased intestinal\n                    <jats:italic>Bacteroides<\/jats:italic>\n                    levels and reduced\n                    <jats:italic>Clostridium<\/jats:italic>\n                    ,\n                    <jats:italic>Blautia<\/jats:italic>\n                    ,\n                    <jats:italic>Ruminococcus<\/jats:italic>\n                    levels but did not otherwise alter the general microbiome. BC30 significantly improved GI functions in healthy adults in China, with minor modifications of the fecal microbiome and was well-tolerated. The trial was registered at ClinicalTrials.gov (NCT06644001).\n                  <\/jats:p>","DOI":"10.1163\/18762891-bja00084","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T03:11:56Z","timestamp":1753413116000},"page":"29-46","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Heyndrickxia (Bacillus) coagulans GBI-30, 6086 (BC30) probiotic on gastrointestinal function in healthy adults: a randomised controlled trial"],"prefix":"10.1163","volume":"17","author":[{"given":"H.","family":"Gang","sequence":"first","affiliation":[{"name":"Beijing Institute of Geriatrics, https:\/\/dx.doi.org\/117555Beijing Hospital, National Center of Gerontology, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Wei","sequence":"additional","affiliation":[{"name":"Beijing Institute of Geriatrics, https:\/\/dx.doi.org\/117555Beijing Hospital, National Center of Gerontology, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9881-3453","authenticated-orcid":true,"given":"L.V.","family":"McFarland","sequence":"additional","affiliation":[{"name":"McFarland Consulting, Seattle, Washington 98115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9624-3200","authenticated-orcid":true,"given":"R.","family":"Zahra","sequence":"additional","affiliation":[{"name":"Kerry Canada Inc., 495 boulevard Armand-Frappier, Laval, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9299-2534","authenticated-orcid":true,"given":"M.E.","family":"Saez","sequence":"additional","affiliation":[{"name":"https:\/\/dx.doi.org\/16672Biosearch Life, a Kerry company, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6159-3597","authenticated-orcid":true,"given":"R.","family":"Blanco-Rojo","sequence":"additional","affiliation":[{"name":"https:\/\/dx.doi.org\/16672Biosearch Life, a Kerry company, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9134-3249","authenticated-orcid":true,"given":"M.","family":"Millette","sequence":"additional","affiliation":[{"name":"Kerry Canada Inc., 495 boulevard Armand-Frappier, Laval, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"R000001","series-title":"European Journal of Nutrition","first-page":"2111","article-title":"Is Bacillus coagulans supplementation plus low FODMAP diet superior to low FODMAP diet in irritable bowel syndrome management?","volume":"59","author":"Abhari, K.","unstructured":"Abhari, K., Saadati, S., Hosseini-Oskouiee, F., Yari, Z., Hosseini, H., Sohrab, G., Hejazi, E., Agah, S., Sadeghi, A. and Hekmatdoost, A., 2020. Is Bacillus coagulans supplementation plus low FODMAP diet superior to low FODMAP diet in irritable bowel syndrome management? European Journal of Nutrition 59: 2111-2117."},{"issue":"2","key":"R000002","series-title":"Applied Food Biotechnology","first-page":"91","article-title":"A review on Bacillus coagulans as a spore-forming probiotic","volume":"6","author":"Adibpour, N.","unstructured":"Adibpour, N., Hosseininezhad, M., Pahlevanlo, A. and Hussain, M.A., 2019. A review on Bacillus coagulans as a spore-forming probiotic. Applied Food Biotechnology 6(2): 91-100."},{"key":"R000003","series-title":"Lebensmittel-Wissenschaft + Technologie","article-title":"Identification and characterization of Bacillus coagulans strains for probiotic activity and safety","volume":"151","author":"Altun, G.K.","unstructured":"Altun, G.K. and Erginkaya, Z., 2021. Identification and characterization of Bacillus coagulans strains for probiotic activity and safety. 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Food Research International 125: 108567. https:\/\/doi.org\/10.1016\/j.foodres.2019.108567"},{"key":"R000005","series-title":"Clinical and Experimental Gastroenterology","first-page":"413","article-title":"Chronic idiopathic constipation in adults: a review on current guidelines and emerging treatment options","volume":"14","author":"Bassotti, G.","unstructured":"Bassotti, G., Usai Satta, P. and Bellini, M., 2021. Chronic idiopathic constipation in adults: a review on current guidelines and emerging treatment options. Clinical and Experimental Gastroenterology 14: 413-428. https:\/\/doi.org\/10.2147\/CEG.S256364"},{"key":"R000006","series-title":"Medical Journal of Australia","first-page":"86","article-title":"Chronic idiopathic constipation in adults: epidemiology, pathophysiology, diagnosis and clinical management","volume":"209","author":"Black, C.J.","unstructured":"Black, C.J. and Ford, A.C., 2018. 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Overview of probiotic strains of Weizmannia coagulans, previously known as Bacillus coagulans, as food supplements and their use in human health. Applied Microbiology 3: 935-947. https:\/\/doi.org\/10.3390\/applmicrobiol3030064"},{"key":"R000019","series-title":"Gut Pathogens","first-page":"1","article-title":"Bacillus coagulans GBI-30 (BC30) improves indices of Clostridium difficile-induced colitis in mice","volume":"3","author":"Fitzpatrick, L.R.","unstructured":"Fitzpatrick, L.R., Small, J.S., Greene, W.H., Karpa, K.D. and Keller, D., 2011. Bacillus coagulans GBI-30 (BC30) improves indices of Clostridium difficile-induced colitis in mice. Gut Pathogens 3: 1-9. https:\/\/doi.org\/10.1186\/1757-4749-3-16"},{"key":"R000020","series-title":"The Lancet","first-page":"1689","article-title":"Functional dyspepsia","volume":"396","author":"Ford, A.C.","unstructured":"Ford, A.C., Mahadeva, S., Carbone, M.F., Lacy, B.E. and Talley, N.J., 2020. Functional dyspepsia. 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