{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T15:06:32Z","timestamp":1783436792851,"version":"3.54.6"},"reference-count":69,"publisher":"Walter de Gruyter GmbH","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Benef. Microbes"],"published-print":{"date-parts":[[2025,7,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>A mounting body of evidence suggests that probiotics may mitigate constipation through their favourable modulation of gut microbiota and its metabolic byproducts. The precise mechanisms underlying this effect remain to be fully elucidated. This randomised, double-blind, placebo-controlled study investigates the clinical efficacy of <jats:italic>Bifidobacterium longum<\/jats:italic> (<jats:italic>B. longum<\/jats:italic>) CCFM1112 in treating chronic constipation. Fifty-six volunteers diagnosed with chronic constipation according to the Rome IV criteria were randomly assigned to either the <jats:italic>B. longum<\/jats:italic> CCFM1112 group or a placebo group for a 4-week intervention. Key outcomes measured included weekly spontaneous bowel movements (SBM), stool consistency (Bristol Stool Form Scale [BSFS]), Patient Assessment of Constipation-Symptoms (PAC-SYM) questionnaire, and Quality of Life (PAC-QOL) questionnaire. In addition, gut microbiota was detected using metagenomic sequencing, and non targeted metabolomics was used to detect fecal and serum metabolites. Results demonstrated that <jats:italic>B. longum<\/jats:italic> CCFM1112 significantly reduced PAC-QOL scores and improved BSFS in patients with chronic constipation. Correlation analyses revealed that <jats:italic>B. longum<\/jats:italic> CCFM1112 significantly increased the abundance of the genera <jats:italic>Blautia<\/jats:italic>, <jats:italic>Anaerobutyricum<\/jats:italic>, and <jats:italic>Streptococcus<\/jats:italic>. Furthermore, the abundance of species, including <jats:italic>Blautia massiliensis<\/jats:italic>, <jats:italic>Blautia sp. SC05B48<\/jats:italic>, <jats:italic>Anaerobutyricum hallii<\/jats:italic>, and <jats:italic>Streptococcus salivarius<\/jats:italic>, was also significantly elevated. Furthermore, it elevated fecal levels of linoleic acid, gamma-aminobutyric acid (GABA), and arachidonic acid, while increasing L-glutamic acid and decreasing adenosine in serum. Our research findings provide evidence that the intake of <jats:italic>B. longum<\/jats:italic> CCFM1112 can alleviate constipation. <\/jats:p>\n<jats:p>\n<jats:fig position=\"float\" orientation=\"portrait\" id=\"IMG000001\">\n <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"18762891_bja00085_i0001.jpg\" position=\"float\" orientation=\"portrait\"\/> \n<\/jats:fig>\n<\/jats:p>","DOI":"10.1163\/18762891-bja00085","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T05:41:15Z","timestamp":1753249275000},"page":"1-17","source":"Crossref","is-referenced-by-count":2,"title":["The impact of Bifidobacterium longum CCFM1112 on chronic constipation: a randomised, double-blind, placebo-controlled study"],"prefix":"10.1163","author":[{"given":"W.","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, https:\/\/dx.doi.org\/66374Jiangnan University, Wuxi, Jiangsu, 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, https:\/\/dx.doi.org\/66374Jiangnan University, Wuxi, Jiangsu, China"},{"name":"School of Food Science and Technology, https:\/\/dx.doi.org\/66374Jiangnan University, Wuxi, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, https:\/\/dx.doi.org\/66374Jiangnan University, Wuxi, Jiangsu, China"},{"name":"School of Food Science and Technology, https:\/\/dx.doi.org\/66374Jiangnan University, Wuxi, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, https:\/\/dx.doi.org\/66374Jiangnan University, Wuxi, Jiangsu, China"},{"name":"School of Food Science and Technology, https:\/\/dx.doi.org\/66374Jiangnan University, Wuxi, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, https:\/\/dx.doi.org\/66374Jiangnan University, Wuxi, Jiangsu, China"},{"name":"School of Food Science and Technology, https:\/\/dx.doi.org\/66374Jiangnan University, Wuxi, Jiangsu, China"},{"name":"(Yangzhou) Institute of Food Biotechnology, https:\/\/dx.doi.org\/66374Jiangnan University, Yangzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, https:\/\/dx.doi.org\/66374Jiangnan University, Wuxi, Jiangsu, China"},{"name":"School of Food Science and Technology, https:\/\/dx.doi.org\/66374Jiangnan University, Wuxi, Jiangsu, China"},{"name":"(Yangzhou) Institute of Food Biotechnology, https:\/\/dx.doi.org\/66374Jiangnan University, Yangzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, https:\/\/dx.doi.org\/66374Jiangnan University, Wuxi, Jiangsu, China"},{"name":"School of Food Science and Technology, https:\/\/dx.doi.org\/66374Jiangnan University, Wuxi, Jiangsu, China"},{"name":"National Engineering Research Center for Functional Food, https:\/\/dx.doi.org\/66374Jiangnan University, Wuxi, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, https:\/\/dx.doi.org\/66374Jiangnan University, Wuxi, Jiangsu, China"},{"name":"School of Food Science and Technology, https:\/\/dx.doi.org\/66374Jiangnan University, Wuxi, Jiangsu, China"},{"name":"(Yangzhou) Institute of Food Biotechnology, https:\/\/dx.doi.org\/66374Jiangnan University, Yangzhou, Jiangsu, China"},{"name":"International Joint Research Laboratory for Maternal-Infant Microbiota and Health, https:\/\/dx.doi.org\/66374Jiangnan University, Wuxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"issue":"6","key":"R000001","series-title":"Beneficial Microbes","first-page":"617","article-title":"The effect of a probiotic blend on gastrointestinal symptoms in constipated patients: a double blind, randomised, placebo controlled 2-week trial","volume":"10","author":"Airaksinen, K.","unstructured":"Airaksinen, K., Yeung, N., Lyra, A., Lahtinen, S.J., Huttunen, T., Shanahan, F. and Ouwehand, A.C., 2019. The effect of a probiotic blend on gastrointestinal symptoms in constipated patients: a double blind, randomised, placebo controlled 2-week trial. Beneficial Microbes 10(6): 617-627. http:\/\/doi.org\/10.3920\/BM2018.0163"},{"issue":"3","key":"R000002","series-title":"Pharmacology & Therapeutics","first-page":"233","article-title":"Regulation of enteric functions by adenosine: pathophysiological and pharmacological implications","volume":"120","author":"Antonioli, L.","unstructured":"Antonioli, L., Fornai, M., Colucci, R., Ghisu, N., Tuccori, M., Del Tacca, M. and Blandizzi, C., 2008. Regulation of enteric functions by adenosine: pathophysiological and pharmacological implications. 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Frontiers in Microbiology 10. http:\/\/doi.org\/10.3389\/fmicb.2019.01477"},{"key":"R000004","series-title":"Pharmacological Research","first-page":"11","article-title":"GABA and GABA receptors in the gastrointestinal tract: from motility to inflammation","volume":"93","author":"Auteri, M.","unstructured":"Auteri, M., Zizzo, M.G. and Serio, R., 2015. GABA and GABA receptors in the gastrointestinal tract: from motility to inflammation. Pharmacological Research 93: 11-21. http:\/\/doi.org\/10.1016\/j.phrs.2014.12.001"},{"issue":"6","key":"R000005","series-title":"Nutrition Research","first-page":"427","article-title":"Butyrylated starch increases large bowel butyrate levels and lowers colonic smooth muscle contractility in rats","volume":"30","author":"Bajka, B.H.","unstructured":"Bajka, B.H., Clarke, J.M., Topping, D.L., Cobiac, L., Abeywardena, M.Y. and Patten, G.S., 2010. Butyrylated starch increases large bowel butyrate levels and lowers colonic smooth muscle contractility in rats. 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Systematic review: impact of constipation on quality of life in adults and children. Alimentary Pharmacology & Therapeutics 31(9): 938-949. http:\/\/doi.org\/10.1111\/j.1365-2036.2010.04273.x"},{"issue":"2","key":"R000008","series-title":"mSystems","article-title":"Depletion of Blautia species in the microbiota of obese children relates to intestinal inflammation and metabolic phenotype worsening","volume":"5","author":"Benitez-Paez, A.","unstructured":"Benitez-Paez, A., Gomez Del Pugar, E.M., Lopez-Almela, I., Moya-Perez, A., Codoner-Franch, P. and Sanz, Y., 2020. 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