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Microbes"],"published-print":{"date-parts":[[2025,7,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>This study investigated the effects of <jats:italic>Dysosmobacter welbionis<\/jats:italic> J115<jats:sup>T<\/jats:sup> on stress- and anxiety-related behaviours, inflammation, and neurobiological markers under different dietary conditions in female mice. Daily oral gavage with <jats:italic>D. welbionis<\/jats:italic> J115<jats:sup>T<\/jats:sup> for six weeks did not significantly impact body weight or fat mass, regardless of dietary treatment. Notably, high-fat diet (HFD)-fed female mice displayed increased body weight and adipose tissue accumulation compared to control diet (CTD) counterparts; however, this was not significantly altered by <jats:italic>D. welbionis<\/jats:italic> J115<jats:sup>T<\/jats:sup> administration. Behavioural testing revealed that HFD-fed female mice exhibited a mild stress\/anxiety-like phenotype, especially in the elevated plus maze (EPM) and forced swim test (FST), which was attenuated by <jats:italic>D. welbionis<\/jats:italic> J115<jats:sup>T<\/jats:sup> treatment. These mice showed increased exploratory behaviour in the light-dark test (LDT), reduced time spent in closed arms of the EPM, and longer cumulative time in a highly active state in the FST. Plasma corticosterone levels, elevated post-behavioural testing in all female groups, increased less in HFD-fed <jats:italic>D. welbionis<\/jats:italic>-treated mice, suggesting a blunted stress response. These findings highlight sex-specific behavioural and molecular responses to dietary and probiotic interventions and suggest that <jats:italic>D. welbionis<\/jats:italic> J115<jats:sup>T<\/jats:sup> may modulate stress-related behaviours in female mice via the gut-brain axis.<\/jats:p>","DOI":"10.1163\/18762891-bja00091","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T03:28:27Z","timestamp":1754450907000},"page":"1-12","source":"Crossref","is-referenced-by-count":1,"title":["Dysosmobacter welbionis J115T reduces stress-like phenotype in high-fat diet-induced obese female mice"],"prefix":"10.1163","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3084-0599","authenticated-orcid":true,"given":"G.C.","family":"Wong","sequence":"first","affiliation":[{"name":"Louvain Drug Research Institute (LDRI), Metabolism and Nutrition Research Group (MNUT), https:\/\/dx.doi.org\/83415UCLouvain, Universite\u0301 catholique de Louvain, 1200 Brussels, Belgium"},{"name":"Walloon Excellence in Life Sciences and BIOtechnology (WELBIO), WELBIO department, WEL Research Institute, Wavre, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2115-6082","authenticated-orcid":true,"given":"N.M.","family":"Delzenne","sequence":"additional","affiliation":[{"name":"Louvain Drug Research Institute (LDRI), Metabolism and Nutrition Research Group (MNUT), https:\/\/dx.doi.org\/83415UCLouvain, Universite\u0301 catholique de Louvain, 1200 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5503-107X","authenticated-orcid":true,"given":"M.","family":"Van\u00a0Hul","sequence":"additional","affiliation":[{"name":"Louvain Drug Research Institute (LDRI), Metabolism and Nutrition Research Group (MNUT), https:\/\/dx.doi.org\/83415UCLouvain, Universite\u0301 catholique de Louvain, 1200 Brussels, Belgium"},{"name":"Walloon Excellence in Life Sciences and BIOtechnology (WELBIO), WELBIO department, WEL Research Institute, Wavre, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2040-2448","authenticated-orcid":true,"given":"P.D.","family":"Cani","sequence":"additional","affiliation":[{"name":"Louvain Drug Research Institute (LDRI), Metabolism and Nutrition Research Group (MNUT), https:\/\/dx.doi.org\/83415UCLouvain, Universite\u0301 catholique de Louvain, 1200 Brussels, Belgium"},{"name":"Walloon Excellence in Life Sciences and BIOtechnology (WELBIO), WELBIO department, WEL Research Institute, Wavre, Belgium"},{"name":"Institute of Experimental and Clinical Research (IREC), https:\/\/dx.doi.org\/83415UCLouvain, Universite\u0301 catholique de Louvain, 1200 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"R000001","series-title":"European Neuropsychopharmacology","first-page":"1321","article-title":"Nutritional psychiatry: towards improving mental health by what you eat","volume":"29","author":"Adan, R.A.H.","unstructured":"Adan, R.A.H., van\u00a0der Beek, E.M., Buitelaar, J.K., Cryan, J.F., Hebebrand, J., Higgs, S., Schellekens, H. and Dickson, S.L., 2019. 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