{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:53:56Z","timestamp":1791431636234,"version":"4.3.3"},"reference-count":36,"publisher":"Walter de Gruyter GmbH","issue":"5","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Benef. Microbes"],"published-print":{"date-parts":[[2026,2,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The viability and persistence of orally administered microbes in the human gut are essential to their biological function. We previously described the development of two synbiotic medical foods, SBD111 and SBD121, each comprising four food-derived microbial strains and prebiotic fibres for the dietary management of postmenopausal bone loss and rheumatoid arthritis, respectively. Here, we report a randomised, open-label clinical study examining gut persistence of SBD111 and SBD121 microbes by testing faecal samples from healthy adults following administration for seven days. Thirty-eight participants, aged 18-64 years with a body mass index (BMI) of 18.5-35\u00a0kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    , were randomised to receive one of the two synbiotic medical foods daily for one week, followed by a four-week monitoring period. Employing quantitative PCR (qPCR), shotgun metagenomics, and culture-based assays, we evaluated the presence and viability of the microbial strains comprising each synbiotic medical food during and after administration. SBD111 and SBD121 were well-tolerated with minimal adverse events reported. Strains were detected in over 80% of participants during the administration period, with strain abundance peaking in the first week. Persistence in the follow-up period varied by strain and detection method. The microbial strains were detected by qPCR and metagenomic sequencing for a median of seven days and three days during the follow-up period, respectively. However,\n                    <jats:italic>Bacillus amyloliquefaciens<\/jats:italic>\n                    was consistently detected for seven days by both methods. Culture-based assays confirmed the presence of viable strains from both synbiotic medical foods in stool samples up to one-week post-consumption. Faecal metagenome diversity and metabolic functional potential remained stable throughout the administration and follow-up periods. Collectively, these results establish that SBD111 and SBD121 deliver viable microbes that transiently persist in the gut, reinforcing their promise for safe and targeted dietary interventions and highlighting the value of multi-platform detection strategies for comprehensive microbial persistence assessment.\n                  <\/jats:p>\n                  <jats:p>This trial, funded by S\u014dlarea bi\u014d, is registered at ClinicalTrials.gov (NCT06614166).<\/jats:p>","DOI":"10.1163\/18762891-bja00109","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T11:26:33Z","timestamp":1772105193000},"page":"477-489","source":"Crossref","is-referenced-by-count":1,"title":["Targeted detection of microbes in synbiotic medical foods SBD111 and SBD121 to evaluate gut persistence: a randomised, open label trial"],"prefix":"10.1163","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2835-2652","authenticated-orcid":true,"given":"K.J.","family":"Miller","sequence":"first","affiliation":[{"name":"S\u014dlaria bi\u014d, 100 Beaver Street, Waltham, MA 02453, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1428-5033","authenticated-orcid":true,"given":"I.M.","family":"Wolff","sequence":"additional","affiliation":[{"name":"S\u014dlaria bi\u014d, 100 Beaver Street, Waltham, MA 02453, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7639-5967","authenticated-orcid":true,"given":"L.A.","family":"Montes de Oca Valeriano","sequence":"additional","affiliation":[{"name":"S\u014dlaria bi\u014d, 100 Beaver Street, Waltham, MA 02453, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8033-8962","authenticated-orcid":true,"given":"M.J.","family":"Soto-Giron","sequence":"additional","affiliation":[{"name":"S\u014dlaria bi\u014d, 100 Beaver Street, Waltham, MA 02453, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5488-5770","authenticated-orcid":true,"given":"S.","family":"Jangi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Tufts Medical Center, Boston, MA 02111, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.M.","family":"Schott","sequence":"additional","affiliation":[{"name":"S\u014dlaria bi\u014d, 100 Beaver Street, Waltham, MA 02453, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4893-8244","authenticated-orcid":true,"given":"M.R.","family":"Charbonneau","sequence":"additional","affiliation":[{"name":"S\u014dlaria bi\u014d, 100 Beaver Street, Waltham, MA 02453, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1536-2941","authenticated-orcid":true,"given":"A.E.","family":"Ballok","sequence":"additional","affiliation":[{"name":"S\u014dlaria bi\u014d, 100 Beaver Street, Waltham, MA 02453, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8033-2149","authenticated-orcid":true,"given":"G.V.","family":"Toledo","sequence":"additional","affiliation":[{"name":"S\u014dlaria bi\u014d, 100 Beaver Street, Waltham, MA 02453, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"issue":"10","key":"R000001","series-title":"Nature Microbiology","first-page":"1309","article-title":"Precise quantification of bacterial strains after faecal microbiota transplantation delineates long-term engraftment and explains outcomes","volume":"6","author":"Aggarwala, V.","unstructured":"Aggarwala, V., Mogno, I., Li, Z., Yang, C., Britton, G.J., Chen-Liaw, A., Mitcham, J., Bongers, G., Gevers, D., Clemente, J.C., Colombel, J.-F., Grinspan, A. and Faith, J., 2021. 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Letters in Applied Microbiology 24(5): 361-364. https:\/\/doi.org\/10.1046\/J.1472-765X.1997.00140.X"},{"issue":"1","key":"R000003","series-title":"Applied and Environmental Microbiology","first-page":"351","article-title":"Persistence of colonisation of human colonic mucosa by a probiotic strain, Lactobacillus rhamnosus GG, after oral consumption","volume":"65","author":"Alander, M.","unstructured":"Alander, M., Satokari, R., Korpela, R., Saxelin, M., Vilpponen-Salmela, T., Mattila-Sandholm, T. and Von Wright, A., 1999. Persistence of colonisation of human colonic mucosa by a probiotic strain, Lactobacillus rhamnosus GG, after oral consumption. Applied and Environmental Microbiology 65(1): 351-354."},{"key":"R000004","series-title":"ELife","article-title":"Integrating taxonomic, functional and strain-level profiling of diverse microbial communities with bioBakery 3","volume":"10","author":"Beghini, F.","unstructured":"Beghini, F., McIver, L.J., Blanco-M\u0131\u0301guez, A., Dubois, L., Asnicar, F., Maharjan, S., Mailyan, A., Manghi, P., Scholz, M., Thomas, A.M., Valles-Colomer, M., Weingart, G., Zhang, Y., Zolfo, M., Huttenhower, C., Franzosa, E.A. and Segata, N., 2021. Integrating taxonomic, functional and strain-level profiling of diverse microbial communities with bioBakery 3. ELife 10: 65088. https:\/\/doi.org\/10.7554\/eLife.65088"},{"issue":"11","key":"R000005","series-title":"Nature Biotechnology","first-page":"1633","article-title":"Extending and improving metagenomic taxonomic profiling with uncharacterised species using MetaPhlAn 4","volume":"41","author":"Blanco-M\u0131\u0301guez, A.","unstructured":"Blanco-M\u0131\u0301guez, A., Beghini, F., Cumbo, F., McIver, L.J., Thompson, K.N., Zolfo, M., Manghi, P., Dubois, L., Huang, K.D., Thomas, A.M., Nickols, W.A., Piccinno, G., Piperni, E., Punc\u030cocha\u0301r\u030c, M., Valles-Colomer, M., Tett, A., Giordano, F., Davies, R., Wolf, J. and Segata, N., 2023. Extending and improving metagenomic taxonomic profiling with uncharacterised species using MetaPhlAn 4. Nature Biotechnology 41(11): 1633-1644. https:\/\/doi.org\/10.1038\/s41587-023-01688-w"},{"issue":"15","key":"R000006","series-title":"Bioinformatics","first-page":"2114","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger, A.M.","unstructured":"Bolger, A.M., Lohse, M. and Usadel, B., 2014. Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics 30(15): 2114-2120. https:\/\/doi.org\/10.1093\/bioinformatics\/btu170"},{"issue":"19","key":"R000007","series-title":"Applied and Environmental Microbiology","first-page":"6198","article-title":"Survival of Lactobacillus reuteri DSM 17938 and Lactobacillus rhamnosus GG in the human gastrointestinal tract with daily consumption of a low-fat probiotic spread","volume":"75","author":"Dommels, Y.E.M.","unstructured":"Dommels, Y.E.M., Kemperman, R.A., Zebregs, Y.E.M.P., Draaisma, R.B., Jol, A., Wolvers, D.A.W., Vaughan, E.E. and Albers, R., 2009. Survival of Lactobacillus reuteri DSM 17938 and Lactobacillus rhamnosus GG in the human gastrointestinal tract with daily consumption of a low-fat probiotic spread. Applied and Environmental Microbiology 75(19): 6198-6204. https:\/\/doi.org\/10.1128\/AEM.01054-09"},{"key":"R000008","series-title":"Food and Chemical Toxicology","article-title":"Food safety assessment and 28-day toxicity study of the synbiotic medical food consortium SBD121","volume":"191","author":"Easson, D.D.","unstructured":"Easson, D.D., Murphy, V.A., Ballok, A.E., Soto-Giron, M.J., Miller, K.J., Charbonneau, M.R., Schott, E.M., Greene, T., Rodricks, J. and Toledo, G.V., 2024. Food safety assessment and 28-day toxicity study of the synbiotic medical food consortium SBD121. Food and Chemical Toxicology 191: 114839. https:\/\/doi.org\/10.1016\/j.fct.2024.114839"},{"key":"R000009","series-title":"Food and Chemical Toxicology","article-title":"Food safety assessment and toxicity study of the synbiotic consortium SBD111","volume":"168","author":"Easson, D.D.","unstructured":"Easson, D.D., Murphy, V.A., Ballok, A.E., Soto-Giron, M.J., Schott, E.M., Rodricks, J. and Toledo, G.V., 2022. Food safety assessment and toxicity study of the synbiotic consortium SBD111. Food and Chemical Toxicology 168: 113329. https:\/\/doi.org\/10.1016\/j.fct.2022.113329"},{"issue":"3","key":"R000010","series-title":"Letters in Applied Microbiology","first-page":"154","article-title":"Attachment of Lactobacillus casei strain GG to human colon carcinoma cell line Caco-2: comparison with other dairy strains","volume":"13","author":"Elo, S.","unstructured":"Elo, S., Saxelin, M. and Salminen, S., 1991. Attachment of Lactobacillus casei strain GG to human colon carcinoma cell line Caco-2: comparison with other dairy strains. Letters in Applied Microbiology 13(3): 154-156. https:\/\/doi.org\/10.1111\/J.1472-765X.1991.TB00595.X"},{"issue":"1","key":"R000011","series-title":"Beneficial Microbes","first-page":"19","article-title":"Evaluation of Bacillus subtilis R0179 on gastrointestinal viability and general wellness: A randomised, double-blind, placebo-controlled trial in healthy adults","volume":"6","author":"Hanifi, A.","unstructured":"Hanifi, A., Culpepper, T., Mai, V., Anand, A., Ford, A.L., Ukhanova, M., Christman, M., Tompkins, T.A. and Dahl, W.J., 2015. Evaluation of Bacillus subtilis R0179 on gastrointestinal viability and general wellness: A randomised, double-blind, placebo-controlled trial in healthy adults. Beneficial Microbes 6(1): 19-27. https:\/\/doi.org\/10.3920\/BM2014.0031"},{"issue":"8","key":"R000012","series-title":"Nature Reviews Gastroenterology and Hepatology","first-page":"506","article-title":"The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic","volume":"11","author":"Hill, C.","unstructured":"Hill, C., Guarner, F., Reid, G., Gibson, G.R., Merenstein, D.J., Pot, B., Morelli, L., Canani, R.B., Flint, H.J., Salminen, S., Calder, P.C. and Sanders, M.E., 2014. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nature Reviews Gastroenterology and Hepatology 11(8): 506-514. https:\/\/doi.org\/10.1038\/nrgastro.2014.66."},{"issue":"4","key":"R000013","series-title":"Journal of Pharmaceutical Investigation","first-page":"377","article-title":"Probiotic delivery systems: a brief overview","volume":"46","author":"Kim, J.","unstructured":"Kim, J., Muhammad, N., Jhun, B.H. and Yoo, J.-W., 2016. Probiotic delivery systems: a brief overview. Journal of Pharmaceutical Investigation 46(4): 377-386. https:\/\/doi.org\/10.1007\/s40005-016-0259-7"},{"issue":"13","key":"R000014","series-title":"Journal of Statistical Software","first-page":"1","article-title":"lmerTest Package: tests in linear mixed effects models","volume":"82","author":"Kuznetsova, A.","unstructured":"Kuznetsova, A., Brockhoff, P.B. and Christensen, R.H.B., 2017. lmerTest Package: tests in linear mixed effects models. Journal of Statistical Software 82(13): 1-26. https:\/\/doi.org\/10.18637\/jss.v082.i13"},{"issue":"4","key":"R000015","series-title":"Nature Methods","first-page":"357","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead, B.","unstructured":"Langmead, B. and Salzberg, S.L., 2012. Fast gapped-read alignment with Bowtie 2. Nature Methods 9(4): 357-359. https:\/\/doi.org\/10.1038\/nmeth.1923"},{"issue":"11","key":"R000016","series-title":"European Journal of Clinical Nutrition","first-page":"1284","article-title":"Dose-response study of probiotic bacteria Bifidobacterium animalis subsp lactis BB-12 and Lactobacillus paracasei subsp paracasei CRL-341 in healthy young adults","volume":"60","author":"Larsen, C.N.","unstructured":"Larsen, C.N., Nielsen, S., K\u00e6stel, P., Brockmann, E., Bennedsen, M., Christensen, H.R., Eskesen, D.C., Jacobsen, B.L. and Michaelsen, K., 2006. Dose-response study of probiotic bacteria Bifidobacterium animalis subsp lactis BB-12 and Lactobacillus paracasei subsp paracasei CRL-341 in healthy young adults. European Journal of Clinical Nutrition 60(11): 1284-1293. https:\/\/doi.org\/10.1038\/sj.ejcn.1602450"},{"issue":"4","key":"R000017","series-title":"American Journal of Physiology-Endocrinology and Metabolism","first-page":"E344","article-title":"Development of a synbiotic that protects against ovariectomy-induced trabecular bone loss","volume":"322","author":"Lawenius, L.","unstructured":"Lawenius, L., Gustafsson, K.L., Wu, J., Nilsson, K.H., Move\u0301rare-Skrtic, S., Schott, E.M., Soto-Giro\u0301n, M.J., Toledo, G.V., Sj\u00f6gren, K. and Ohlsson, C., 2022. Development of a synbiotic that protects against ovariectomy-induced trabecular bone loss. American Journal of Physiology-Endocrinology and Metabolism 322(4): E344-E354. https:\/\/doi.org\/10.1152\/ajpendo.00366.2021"},{"key":"R000018","author":"Li, H.","unstructured":"Li, H., 2013. Aligning sequence reads, clone sequences and assembly contigs with BWA-MEM. ArXiv https:\/\/doi.org\/10.48550\/arXiv.1303.3997"},{"issue":"16","key":"R000019","series-title":"Bioinformatics","first-page":"2078","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"Li, H.","unstructured":"Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G. and Durbin, R., 2009. The sequence alignment\/map format and SAMtools. Bioinformatics 25(16): 2078-2079. https:\/\/doi.org\/10.1093\/bioinformatics\/btp352"},{"issue":"4","key":"R000020","series-title":"Applied Microbiology and Biotechnology","first-page":"1419","article-title":"Novel encapsulation improves recovery of probiotic strains in faecal samples of human volunteers","volume":"101","author":"Mai, V.","unstructured":"Mai, V., Waugh, S., Byrd, D., Simpson, D. and Ukhanova, M., 2017. Novel encapsulation improves recovery of probiotic strains in faecal samples of human volunteers. 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Cell Host and Microbe 20(4): 515-526. https:\/\/doi.org\/10.1016\/j.chom.2016.09.001"},{"issue":"8","key":"R000022","series-title":"Journal of Dairy Science","first-page":"3572","article-title":"In vitro assessment of the gastrointestinal transit tolerance of taxonomic reference strains from human origin and probiotic product isolates of Bifidobacterium","volume":"90","author":"Masco, L.","unstructured":"Masco, L., Crockaert, C., Van Hoorde, K., Swings, J. and Huys, G., 2007. In vitro assessment of the gastrointestinal transit tolerance of taxonomic reference strains from human origin and probiotic product isolates of Bifidobacterium. 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Applied and Environmental Microbiology 75(7): 1961-1969. https:\/\/doi.org\/10.1128\/AEM.01843-08"},{"issue":"6","key":"R000024","series-title":"Dairy Science and Technology","first-page":"695","article-title":"Characterization of probiotic properties of Lactobacillus strains","volume":"88","author":"Millette, M.","unstructured":"Millette, M., Luquet, F.M., Ruiz, M.T. and Lacroix, M., 2008. Characterization of probiotic properties of Lactobacillus strains. Dairy Science and Technology 88(6): 695-705. https:\/\/doi.org\/10.1051\/dst:2008018"},{"issue":"4","key":"R000025","series-title":"Beneficial Microbes","first-page":"321","article-title":"A critical evaluation of the factors affecting the survival and persistence of beneficial bacteria in healthy adults","volume":"12","author":"Morelli, L.","unstructured":"Morelli, L. and Pellegrino, P., 2021. A critical evaluation of the factors affecting the survival and persistence of beneficial bacteria in healthy adults. Beneficial Microbes 12(4): 321-331. https:\/\/doi.org\/10.3920\/BM2021.0017"},{"issue":"12","key":"R000026","series-title":"Journal of Food Science and Technology","first-page":"7577","article-title":"Probiotics, prebiotics and synbiotics \u2013 a review","volume":"52","author":"Pandey, K.R.","unstructured":"Pandey, K.R., Naik, S.R. and Vakil, B.V., 2015. Probiotics, prebiotics and synbiotics \u2013 a review. Journal of Food Science and Technology 52(12): 7577-7587. https:\/\/doi.org\/10.1007\/s13197-015-1921-1"},{"key":"R000027","series-title":"LWT","first-page":"191","article-title":"The effect of prebiotics on the viability of encapsulated probiotic bacteria","volume":"73","author":"Peredo, A.G.","unstructured":"Peredo, A.G., Beristain, C.I., Pascual, L.A., Azuara, E. and Jimenez, M., 2016. The effect of prebiotics on the viability of encapsulated probiotic bacteria. LWT 73: 191-196. https:\/\/doi.org\/10.1016\/j.lwt.2016.06.021"},{"issue":"3","key":"R000028","series-title":"MSystems","article-title":"Nonpareil 3: Fast estimation of metagenomic coverage and sequence diversity","volume":"3","author":"Rodriguez, R.L.M.","unstructured":"Rodriguez, R.L.M., Gunturu, S., Tiedje, J.M., Cole, J.R. and Konstantinidis, K.T., 2018. Nonpareil 3: Fast estimation of metagenomic coverage and sequence diversity. MSystems 3(3). https:\/\/doi.org\/10.1128\/mSystems.00039-18"},{"issue":"1","key":"R000029","series-title":"Journal of Microbiology and Experimentation","first-page":"1","article-title":"Randomised clinical trial to test the safety and tolerability of SBD111, an optimized synbiotic medical food combination designed for the dietary management of the metabolic processes underlying osteopenia and osteoporosis","volume":"11","author":"Sahni, S.","unstructured":"Sahni, S., Schott, E.M., Carroll, D., Soto-Giron, M.J., Corbett, S., Toledo, G.V. and Kiel, P.D., 2023. Randomised clinical trial to test the safety and tolerability of SBD111, an optimized synbiotic medical food combination designed for the dietary management of the metabolic processes underlying osteopenia and osteoporosis. Journal of Microbiology and Experimentation 11(1): 1-11. https:\/\/doi.org\/10.15406\/jmen.2023.11.00379"},{"issue":"1","key":"R000030","series-title":"LWT","first-page":"419","article-title":"Co-encapsulation of probiotics with prebiotics on alginate matrix and its effect on viability in simulated gastric environment","volume":"57","author":"Sathyabama, S.","unstructured":"Sathyabama, S., Ranjith Kumar, M., Bruntha Devi, P., Vijayabharathi, R. and Brindha Priyadharisini, V., 2014. Co-encapsulation of probiotics with prebiotics on alginate matrix and its effect on viability in simulated gastric environment. LWT 57(1): 419-425. https:\/\/doi.org\/10.1016\/j.lwt.2013.12.024"},{"issue":"2","key":"R000031","series-title":"International Journal of Food Microbiology","first-page":"293","article-title":"Persistence of probiotic strains in the gastrointestinal tract when administered as capsules, yoghurt, or cheese","volume":"144","author":"Saxelin, M.","unstructured":"Saxelin, M., Lassig, A., Karjalainen, H., Tynkkynen, S., Surakka, A., Vapaatalo, H., J\u00e4rvenp\u00e4\u00e4, S., Korpela, R., Mutanen, M. and Hatakka, K., 2010. Persistence of probiotic strains in the gastrointestinal tract when administered as capsules, yoghurt, or cheese. International Journal of Food Microbiology 144(2): 293-300. https:\/\/doi.org\/10.1016\/j.ijfoodmicro.2010.10.009"},{"issue":"10","key":"R000032","series-title":"Osteoporosis International","first-page":"2019","article-title":"A randomised, double-blind, placebo-controlled clinical study to evaluate the efficacy of the synbiotic medical food, SBD111, for the clinical dietary management of bone loss in menopausal women","volume":"36","author":"Schott, E.M.","unstructured":"Schott, E.M., Charbonneau, M., Kiel, D.P., Bukata, S., Zuscik, M.J., Rosen, C., Ballok, A., Toledo, G.V., Steels, E., Huntress, H., Rao, A., Travison, T.G., Soto-Giron, M.J., Wolff, I., Easson, D.D., Engelke, K. and Vitetta, L., 2025. A randomised, double-blind, placebo-controlled clinical study to evaluate the efficacy of the synbiotic medical food, SBD111, for the clinical dietary management of bone loss in menopausal women. Osteoporosis International 36(10): 2019-2030. https:\/\/doi.org\/10.1007\/s00198-025-07650-7"},{"issue":"6","key":"R000033","series-title":"Foods","article-title":"Probiotic and potentially probiotic yeasts \u2013 characteristics and food application","volume":"10","author":"Staniszewski, A.","unstructured":"Staniszewski, A. and Kordowska-Wiater, M., 2021. Probiotic and potentially probiotic yeasts \u2013 characteristics and food application. Foods 10(6): 1306. https:\/\/doi.org\/10.3390\/foods10061306"},{"issue":"2","key":"R000034","series-title":"Journal of Neurogastroenterology and Motility","first-page":"218","article-title":"Total transit time and probiotic persistence in healthy adults: a pilot study","volume":"29","author":"Tremblay, A.","unstructured":"Tremblay, A., Auger, J., Alyousif, Z., Caballero Calero, S.E., Mathieu, O., Rivero-Mendoza, D., Elmaoui, A., Dahl, W.J. and Tompkins, T.A., 2023. Total transit time and probiotic persistence in healthy adults: a pilot study. Journal of Neurogastroenterology and Motility 29(2): 218-228. https:\/\/doi.org\/10.5056\/jnm22031"},{"issue":"9","key":"R000035","series-title":"Foods","article-title":"Role of lactic acid bacteria in food preservation and safety","volume":"11","author":"Zapas\u0301nik, A.","unstructured":"Zapas\u0301nik, A., Soko\u0142owska, B. and Bry\u0142a, M., 2022. Role of lactic acid bacteria in food preservation and safety. Foods 11(9). https:\/\/doi.org\/10.3390\/foods11091283"},{"issue":"6","key":"R000036","series-title":"Cell","first-page":"1388","article-title":"Personalized gut mucosal colonisation resistance to empiric probiotics is associated with unique host and microbiome features","volume":"174","author":"Zmora, N.","unstructured":"Zmora, N., Zilberman-Schapira, G., Suez, J., Mor, U., Dori-Bachash, M., Bashiardes, S., Kotler, E., Zur, M., Regev-Lehavi, D., Brik, R.B.Z., Federici, S., Cohen, Y., Linevsky, R., Rothschild, D., Moor, A.E., Ben-Moshe, S., Harmelin, A., Itzkovitz, S., Maharshak, N., Shibolet, O., Shapiro, H., Pevsner-Fischer, M., Sharon, I., Halpern, Z., Segal, E. and Elinav, E., 2018. Personalized gut mucosal colonisation resistance to empiric probiotics is associated with unique host and microbiome features. 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