{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:53:56Z","timestamp":1791431636197,"version":"4.3.3"},"reference-count":42,"publisher":"Walter de Gruyter GmbH","issue":"5","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Benef. Microbes"],"published-print":{"date-parts":[[2026,2,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Irritable bowel syndrome (IBS) is a chronic functional disorder characterised by abdominal pain and altered bowel habits. The most prevalent subtype is diarrhoea-predominant IBS (IBS-D). The combination of\n                    <jats:italic>Bacillus subtilis<\/jats:italic>\n                    HU58 and\n                    <jats:italic>Heyndrickxia faecalis<\/jats:italic>\n                    (formerly\n                    <jats:italic>Bacillus coagulans<\/jats:italic>\n                    ) SC208 has previously exerted positive effects in people with antibiotic-associated diarrhoea and infective diarrhoea. The present multicentre study conducted in India aimed to evaluate the effectiveness and safety of the dual-strain probiotic in adults (18-65 years) with IBS-D. In this randomised, double-blind, placebo-controlled pilot study, 61 participants were recruited and assessed for changes in abdominal pain intensity (Numeric Rating Scale, NRS) and stool consistency (Bristol Stool Form Scale, BSFS) over a 4-week intervention period, with secondary outcomes including responder rates for IBS Global Assessment of Improvement (IBS-GAI) and perceived stress (Perceived Stress Scale, PSS). The probiotic group showed significantly higher overall responder rates for both abdominal pain and stool consistency (\n                    <jats:inline-formula\/>\n                    ) compared to the placebo group. Significant improvements were observed in abdominal pain (\n                    <jats:inline-formula\/>\n                    ) and stool consistency (\n                    <jats:inline-formula\/>\n                    ) scores in the probiotic versus placebo group from baseline to end of intervention. IBS-GAI responder rates were significantly higher among the probiotic versus placebo group (\n                    <jats:inline-formula\/>\n                    ) whilst perceived stress scores did not differ significantly between groups. In conclusion, supplementation with\n                    <jats:italic>B. subtilis<\/jats:italic>\n                    HU58 and\n                    <jats:italic>H. faecalis<\/jats:italic>\n                    SC208 for 4 weeks was safe and effective in improving stool consistency and abdominal pain in individuals with IBS-D, supporting its potential for symptom management in IBS-D.\n                  <\/jats:p>\n                  <jats:p>\n                    The trial is registered at\n                    <jats:uri>https:\/\/ctri.nic.in\/Clinicaltrials<\/jats:uri>\n                    (CTRI\/2022\/07\/044154).\n                  <\/jats:p>","DOI":"10.1163\/18762891-bja00113","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T11:25:37Z","timestamp":1772105137000},"page":"491-502","source":"Crossref","is-referenced-by-count":0,"title":["Effects of a Bacillus subtilis HU58 and Heyndrickxia faecalis SC208 spore-forming probiotic formula on gastrointestinal health: results of a\u00a0randomised, double-blind, placebo-controlled pilot study"],"prefix":"10.1163","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2585-1613","authenticated-orcid":true,"given":"K.","family":"Sorensen","sequence":"first","affiliation":[{"name":"Clinical Development, https:\/\/dx.doi.org\/1451Novozymes A\/S, Krogsh\u00f8jvej 36, 2880 Bagsvaerd, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Khanna","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Dr. Sanjeev Khanna Clinic, E2, Vishal Apartments, Behind Vishal Hall, M.V. Road, Andheri East, Mumbai-400 069, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4824-3215","authenticated-orcid":true,"given":"A.","family":"Porwal","sequence":"additional","affiliation":[{"name":"Department of Proctology, Healing Hands Clinic, Fourth Floor, Millenium Star Extension, Adjacent to Ruby Hall, Dhole Patil Road, Pune-411001, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2048-398X","authenticated-orcid":true,"given":"B.L.","family":"Dharmendra","sequence":"additional","affiliation":[{"name":"Department of Surgical Gastroenterology, Mysore Medical College & Research Institute and Associated Hospitals, K.R. Hospital, Irwin Road, Mysore-570001, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0839-5003","authenticated-orcid":true,"given":"P.","family":"Soni","sequence":"additional","affiliation":[{"name":"Department of Medicine, Second Floor, PCMC\u2019s Post Graduate Institute, YCM Hospital, Sant Tukaram Nagar, Pimpri, Pune-411018, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9012-7483","authenticated-orcid":true,"given":"D.","family":"Siddavaram","sequence":"additional","affiliation":[{"name":"Clinical Research Department, Saideep Healthcare & Research Pvt. Ltd., Seventh Floor, Viraj Estate, Behind Yashwant Colony, Near DSP Chowk, Ahilyanagar [formerly Ahmednagar]-414003, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5166-2250","authenticated-orcid":true,"given":"C.","family":"Holz","sequence":"additional","affiliation":[{"name":"Clinical Development, Novozymes Berlin GmbH, Kronenstra\u00dfe 63, 10117 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7723-4110","authenticated-orcid":true,"given":"S.","family":"Jadhav","sequence":"additional","affiliation":[{"name":"Clinical Development, Synergia Life Sciences Pvt. Ltd, Gut No.\/S. No. 65, H. No. 2 Paiki, Village-Gatesh Budruk, Saja Kone, Wada, Thane, Wada, 421303, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"issue":"5","key":"R000001","series-title":"Applied and Environmental Microbiology","first-page":"2344","article-title":"Bacillus probiotics: spore germination in the gastrointestinal tract","volume":"68","author":"Casula, G.","unstructured":"Casula, G. and Cutting, S.M., 2002. Bacillus probiotics: spore germination in the gastrointestinal tract. Applied and Environmental Microbiology 68(5): 2344-2352. https:\/\/doi.org\/10.1128\/aem.68.5.2344-2352.2002"},{"issue":"28","key":"R000002","series-title":"Critical Reviews in Food Science and Nutrition","first-page":"7929","article-title":"Short-chain fatty acids-producing probiotics: A novel source of psychobiotics","volume":"62","author":"Cheng, Y.","unstructured":"Cheng, Y., Liu, J. and Ling, Z., 2022. Short-chain fatty acids-producing probiotics: A novel source of psychobiotics. Critical Reviews in Food Science and Nutrition 62(28): 7929-7959. https:\/\/doi.org\/10.1080\/10408398.2021.1920884"},{"issue":"4","key":"R000003","series-title":"Journal of Health and Social Behavior","first-page":"385","article-title":"A global measure of perceived stress","volume":"24","author":"Cohen, S.","unstructured":"Cohen, S., Kamarck, T. and Mermelstein, R., 1983. A global measure of perceived stress. Journal of Health and Social Behavior 24(4): 385-396. https:\/\/doi.org\/10.2307\/2136404"},{"issue":"2","key":"R000004","series-title":"Food Microbiology","first-page":"214","article-title":"Bacillus probiotics","volume":"28","author":"Cutting, S.M.","unstructured":"Cutting, S.M., 2011. Bacillus probiotics. Food Microbiology 28(2): 214-220. https:\/\/doi.org\/10.1016\/j.fm.2010.03.007"},{"key":"R000005","series-title":"Frontiers in Public Health","article-title":"Gastrointestinal problem among Indian adults: Evidence from longitudinal aging study in India 2017-18","volume":"10","author":"Dawoodi, S.","unstructured":"Dawoodi, S., Dawoodi, I. and Dixit, P., 2022. Gastrointestinal problem among Indian adults: Evidence from longitudinal aging study in India 2017-18. Frontiers in Public Health 10: 911354. https:\/\/doi.org\/10.3389\/fpubh.2022.911354"},{"key":"R000006","series-title":"Clinical Nutrition ESPEN","first-page":"13","article-title":"Sporulated Bacillus as alternative treatment for diarrhea of hospitalized adult patients under enteral nutrition: A pilot randomized controlled study","volume":"22","author":"De Castro Soares, G.G.","unstructured":"De Castro Soares, G.G., Marinho, C.H., Pitol, R., Andretta, C., Oliveira, E., Martins, C. and Riella, M.C., 2017. Sporulated Bacillus as alternative treatment for diarrhea of hospitalized adult patients under enteral nutrition: A pilot randomized controlled study. Clinical Nutrition ESPEN 22: 13-18. https:\/\/doi.org\/10.1016\/j.clnesp.2017.08.006"},{"key":"R000007","series-title":"Pediatric Infectious Disease Journal","first-page":"86","article-title":"The efficacy and safety of a Bacillus probiotic combination for the treatment of acute diarrhea in children: a double-blind, randomized, placebo-controlled multicentric study","volume":"4","author":"Dhongade, A.J.","unstructured":"Dhongade, A.J., Kulkarni, S., Jadhav, S., Nargundkar, N., Deshmukh, D. and Mehta, A., 2022. The efficacy and safety of a Bacillus probiotic combination for the treatment of acute diarrhea in children: a double-blind, randomized, placebo-controlled multicentric study. Pediatric Infectious Disease Journal 4: 86-91. https:\/\/doi.org\/10.5005\/jp-journals-10081-1370"},{"issue":"10","key":"R000008","series-title":"Methods and Findings in Experimental and Clinical Pharmacology","first-page":"655","article-title":"Effects of a proprietary Bacillus coagulans preparation on symptoms of diarrhea-predominant irritable bowel syndrome","volume":"31","author":"Dolin, B.J.","unstructured":"Dolin, B.J., 2009. Effects of a proprietary Bacillus coagulans preparation on symptoms of diarrhea-predominant irritable bowel syndrome. Methods and Findings in Experimental and Clinical Pharmacology 31(10): 655-659. https:\/\/doi.org\/10.1358\/mf.2009.31.10.1441078"},{"issue":"9","key":"R000009","series-title":"The Indian Practitioner","first-page":"15","article-title":"The effect of probiotic Bacillus subtilis HU58 on immune function in healthy human","volume":"70","author":"Dound, Y.A.","unstructured":"Dound, Y.A., Jadhav, S.S., Devale, M., Bayne, T., Krishnan, K. and Mehta, D.S., 2017. The effect of probiotic Bacillus subtilis HU58 on immune function in healthy human. The Indian Practitioner 70(9): 15-20."},{"issue":"6","key":"R000010","series-title":"Gastroenterology","first-page":"1262","article-title":"Functional gastrointestinal disorders: history, pathophysiology, clinical features, and Rome IV","volume":"150","author":"Drossman, D.A.","unstructured":"Drossman, D.A., 2016. Functional gastrointestinal disorders: history, pathophysiology, clinical features, and Rome IV. Gastroenterology 150(6): 1262-1279.e2. https:\/\/doi.org\/10.1053\/j.gastro.2016.02.032"},{"issue":"3","key":"R000011","series-title":"Journal of Neurogastroenterology and Motility","first-page":"325","article-title":"The placebo response in functional bowel disorders: perspectives and putative mechanisms","volume":"17","author":"Enck, P.","unstructured":"Enck, P. and Klosterhalfen, S., 2005. The placebo response in functional bowel disorders: perspectives and putative mechanisms. Journal of Neurogastroenterology and Motility 17(3): 325-331. https:\/\/doi.org\/10.1111\/j.1365-2982.2005.00676.x"},{"issue":"3","key":"R000012","series-title":"Nature Reviews Drug Discovery","first-page":"191","article-title":"The placebo response in medicine: minimize, maximize or personalize?","volume":"12","author":"Enck, P.","unstructured":"Enck, P., Bingel, U., Schedlowski, M. and Rief, W., 2013. The placebo response in medicine: minimize, maximize or personalize? Nature Reviews Drug Discovery 12(3): 191-204. https:\/\/doi.org\/10.1038\/nrd3923"},{"key":"R000013","unstructured":"Food Safety and Standards Authority of India (FSSAI), 2022. Direction under Section 16(5) of the Food Safety and Standards Act, 2006 regarding operationalization of FSS (Health Supplements, Nutraceuticals, Food for Special Dietary Use, Food for Special Medical Purpose and Prebiotic and Probiotic Food) Regulations, 2022 [FSS (Nutra) Regulations, 2022]. New Delhi: FSSAI, 29 March 2022."},{"issue":"9","key":"R000014","series-title":"Nutrients","first-page":"2211","article-title":"Short-chain fatty-acid-producing bacteria: key components of the human gut microbiota","volume":"15","author":"Fusco, W.","unstructured":"Fusco, W., Lorenzo, M.B., Cintoni, M., Porcari, S., Rinninella, E., Kaitsas, F., Lener, E., Mele, M.C., Gasbarrini, A., Collado, M.C., Cammarota, G. and Ianiro, G., 2023. Short-chain fatty-acid-producing bacteria: key components of the human gut microbiota. Nutrients 15(9): 2211 https:\/\/doi.org\/10.3390\/nu15092211"},{"key":"R000015","series-title":"World Gastroenterology Organisation Global Guidelines \u2013 Probiotics and prebiotics","author":"Guarner, F.","unstructured":"Guarner, F., Sanders, M., Szajewska, H., Cohen, H., Eliakim, R., Herrera, C., Karakan, T., Merenstein, D., Piscoya, A., Ramakrishna, B. and Salminen, S., 2023. World Gastroenterology Organisation Global Guidelines \u2013 Probiotics and prebiotics. World Gastroenterology Organisation. Available at: https:\/\/www.worldgastroenterology.org\/UserFiles\/file\/guidelines\/probiotics-and-prebiotics-english-2023.pdf"},{"issue":"4","key":"R000016","series-title":"FEMS Microbiology Reviews","first-page":"813","article-title":"The use of bacterial spore formers as probiotics","volume":"29","author":"Hong, H.A.","unstructured":"Hong, H.A., Duc le, H. and Cutting, S.M., 2005. The use of bacterial spore formers as probiotics. FEMS Microbiology Reviews 29(4): 813-835. https:\/\/doi.org\/10.1016\/j.femsre.2004.12.001"},{"issue":"2","key":"R000017","series-title":"Research in Microbiology","first-page":"134","article-title":"Bacillus subtilis isolated from the human gastrointestinal tract","volume":"160","author":"Hong, H.A.","unstructured":"Hong, H.A., Khaneja, R., Tam, N.M., Cazzato, A., Tan, S., Urdaci, M., Brisson, A., Gasbarrini, A., Barnes, I. and Cutting, S.M., 2009a. Bacillus subtilis isolated from the human gastrointestinal tract. Research in Microbiology 160(2): 134-143. https:\/\/doi.org\/10.1016\/j.resmic.2008.11.002"},{"issue":"6","key":"R000018","series-title":"Research in Microbiology","first-page":"375","article-title":"Defining the natural habitat of Bacillus spore-formers","volume":"160","author":"Hong, H.A.","unstructured":"Hong, H.A., To, E., Fakhry, S., Baccigalupi, L., Ricca, E. and Cutting, S.M., 2009b. Defining the natural habitat of Bacillus spore-formers. Research in Microbiology 160(6): 375-379. https:\/\/doi.org\/10.1016\/j.resmic.2009.06.006"},{"issue":"4","key":"R000019","series-title":"Stress and Health","first-page":"694","article-title":"Systematic review with meta-analysis: Stress-management interventions for patients with irritable bowel syndrome","volume":"39","author":"Horn, A.","unstructured":"Horn, A., Stangl, S., Parisi, S., Bauer, N., Roll, J., L\u00f6ffler, C., Ga\u0301gyor, I., Haas, K., Heuschmann, P.U., Langhorst, J. and Keil, T., 2023. Systematic review with meta-analysis: Stress-management interventions for patients with irritable bowel syndrome. Stress and Health 39(4): 694-707. https:\/\/doi.org\/10.1002\/smi.3226"},{"issue":"9","key":"R000020","series-title":"Scandinavian Journal of Gastroenterology","first-page":"920","article-title":"Stool form scale as a useful guide to intestinal transit time","volume":"32","author":"Lewis, S.J.","unstructured":"Lewis, S.J. and Heaton, K.W., 1997. Stool form scale as a useful guide to intestinal transit time. Scandinavian Journal of Gastroenterology 32(9): 920-924. https:\/\/doi.org\/10.3109\/00365529709011203."},{"key":"R000021","series-title":"Nutrition Journal","first-page":"21","article-title":"Bacillus coagulans MTCC 5856 supplementation in the management of diarrhea predominant Irritable Bowel Syndrome: a double blind randomized placebo controlled pilot clinical study","volume":"15","author":"Majeed, M.","unstructured":"Majeed, M., Nagabhushanam, K., Natarajan, S., Sivakumar, A., Ali, F., Pande, A., Majeed, S. and Karri, S.K., 2016. Bacillus coagulans MTCC 5856 supplementation in the management of diarrhea predominant Irritable Bowel Syndrome: a double blind randomized placebo controlled pilot clinical study. Nutrition Journal 15: 21. https:\/\/doi.org\/10.1186\/s12937-016-0140-6"},{"issue":"7","key":"R000022","series-title":"Microorganisms","first-page":"1028","article-title":"Bacillus subtilis HU58 and Bacillus coagulans SC208 Probiotics reduced the effects of antibiotic-induced gut microbiome\u00a0dysbiosis in an M-SHIME((R)) model","volume":"8","author":"Marzorati, M.","unstructured":"Marzorati, M., Abbeele, P.V.D., Bubeck, S.S., Bayne, T., Krishnan, K., Young, A., Mehta, D. and DeSouza, A., 2020. Bacillus subtilis HU58 and Bacillus coagulans SC208 Probiotics reduced the effects of antibiotic-induced gut microbiome\u00a0dysbiosis in an M-SHIME((R)) model. Microorganisms 8(7): 1028. https:\/\/doi.org\/10.3390\/microorganisms8071028"},{"key":"R000023","series-title":"Pain: Clinical Manual for Nursing Practice","author":"McCaffery, M.","unstructured":"McCaffery, M. and Beebe, A., 1989. Pain: Clinical Manual for Nursing Practice. C.V. Mosby Company, St. Louis, USA."},{"issue":"4","key":"R000024","series-title":"Biomedical Journal of Scientific & Technical Research","first-page":"22679","article-title":"An open labeled, placebo controlled trial to evaluate the role of probiotics \u2013 Bacillus subtilis HU58 and Bacillus coagulans SC208 on antibiotic associated diarrhea in humans","volume":"29","author":"Mehta, D.S.","unstructured":"Mehta, D.S., de Souza, A., Jadhav, S. and Devale, M., 2020a. An open labeled, placebo controlled trial to evaluate the role of probiotics \u2013 Bacillus subtilis HU58 and Bacillus coagulans SC208 on antibiotic associated diarrhea in humans. Biomedical Journal of Scientific & Technical Research 29(4): 22679-22684. https:\/\/doi.org\/10.26717\/BJSTR.2020.29.004839"},{"issue":"4","key":"R000025","series-title":"Indian Practitioner","first-page":"22","article-title":"A study of probiotic Bacillus subtilis HU58 for the management of antibiotic-associated diarrhoea in adults","volume":"73","author":"Mehta, D.S.","unstructured":"Mehta, D.S., de Souza, A., Jadhav, S. and Devale, M., 2020b. A study of probiotic Bacillus subtilis HU58 for the management of antibiotic-associated diarrhoea in adults. Indian Practitioner 73(4): 22-28."},{"issue":"2","key":"R000026","series-title":"Microorganisms","first-page":"411","article-title":"Probiotics\u2019 effects in the treatment of anxiety and depression: a comprehensive review of 2014-2023 clinical trials","volume":"12","author":"Merkouris, E.","unstructured":"Merkouris, E., Mavroudi, T., Miliotas, D., Tsiptsios, D., Serdari, A., Christidi, F., Doskas, T.K., Mueller, C. and Tsamakis, K., 2024. Probiotics\u2019 effects in the treatment of anxiety and depression: a comprehensive review of 2014-2023 clinical trials. Microorganisms 12(2): 411. https:\/\/doi.org\/10.3390\/microorganisms12020411"},{"issue":"7","key":"R000027","series-title":"International Journal of Systematic and Evolutionary Microbiology","first-page":"5961","article-title":"Genome-based reclassification of Bacillus acidicola, Bacillus pervagus and the genera Heyndrickxia, Margalitia and Weizmannia","volume":"73","author":"Narsing Rao, M.P.","unstructured":"Narsing Rao, M.P., Banerjee, A., Liu, G.-H. and Thamchaipenet, A., 2023. Genome-based reclassification of Bacillus acidicola, Bacillus pervagus and the genera Heyndrickxia, Margalitia and Weizmannia. International Journal of Systematic and Evolutionary Microbiology 73(7): 5961. https:\/\/doi.org\/10.1099\/ijsem.0.005961"},{"issue":"6","key":"R000028","series-title":"Nutrients","first-page":"1351","article-title":"Effect of probiotic supplementation on gut microbiota in patients with major depressive disorders: a systematic review","volume":"15","author":"Ng, Q.X.","unstructured":"Ng, Q.X., Lim, Y.L., Yaow, C.Y.L., Ng, W.K., Thumboo, J. and Liew, T.M., 2023. Effect of probiotic supplementation on gut microbiota in patients with major depressive disorders: a systematic review. Nutrients 15(6): 1351. https:\/\/doi.org\/10.3390\/nu15061351"},{"issue":"10","key":"R000029","series-title":"The Lancet Gastroenterology & Hepatology","first-page":"908","article-title":"Global prevalence of irritable bowel syndrome according to Rome III or IV criteria: a systematic review and meta-analysis","volume":"5","author":"Oka, P.","unstructured":"Oka, P., Parr, H., Barberio, B., Black, C.J., Savarino, E.V. and Ford, A.C., 2020. Global prevalence of irritable bowel syndrome according to Rome III or IV criteria: a systematic review and meta-analysis. 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American Journal of Gastroenterology 104(4): 912-919. https:\/\/doi.org\/10.1038\/ajg.2009.13"},{"issue":"2","key":"R000031","series-title":"Beneficial Microbes","first-page":"127","article-title":"Evaluation of Bacillus subtilis strains as probiotics and their potential as a food ingredient","volume":"3","author":"Permpoonpattana, P.","unstructured":"Permpoonpattana, P., Hong, H.A., Khaneja, R. and Cutting, S.M., 2012. Evaluation of Bacillus subtilis strains as probiotics and their potential as a food ingredient. Beneficial Microbes 3(2): 127-135. https:\/\/doi.org\/10.3920\/Bm2012.0002"},{"issue":"6","key":"R000032","series-title":"mSystems","article-title":"Alterations in gut microbiome composition and function in irritable bowel syndrome and increased probiotic abundance with daily supplementation","volume":"6","author":"Phan, J.","unstructured":"Phan, J., Nair, D., Jain, S., Montagne, T., Flores, D.V., Nguyen, A., Dietsche, S., Gombar, S. and Cotter, P., 2021. Alterations in gut microbiome composition and function in irritable bowel syndrome and increased probiotic abundance with daily supplementation. mSystems 6(6): e0121521. https:\/\/doi.org\/10.1128\/mSystems.01215-21"},{"key":"R000033","series-title":"Frontiers in Endocrinology","first-page":"25","article-title":"The role of short-chain fatty acids from gut microbiota in gut-brain communication","volume":"11","author":"Silva, Y.P.","unstructured":"Silva, Y.P., Bernardi, A. and Frozza, R.L., 2020. The role of short-chain fatty acids from gut microbiota in gut-brain communication. Frontiers in Endocrinology 11: 25. https:\/\/doi.org\/10.3389\/fendo.2020.00025"},{"issue":"26","key":"R000034","series-title":"World Journal of Gastroenterology","first-page":"8103","article-title":"Patients with irritable bowel syndrome-diarrhea have lower disease-specific quality of life than irritable bowel syndrome-constipation","volume":"21","author":"Singh, P.","unstructured":"Singh, P., Staller, K., Barshop, K., Dai, E., Newman, J., Yoon, S., Castel, S. and Kuo, B., 2015. Patients with irritable bowel syndrome-diarrhea have lower disease-specific quality of life than irritable bowel syndrome-constipation. World Journal of Gastroenterology 21(26): 8103-8109. https:\/\/doi.org\/10.3748\/wjg.v21.i26.8103"},{"issue":"1","key":"R000035","series-title":"Gastroenterology","first-page":"99","article-title":"Worldwide prevalence and burden of functional gastrointestinal disorders, results of Rome foundation global study","volume":"160","author":"Sperber, A.D.","unstructured":"Sperber, A.D., Bangdiwala, S.I., Drossman, D.A., Ghoshal, U.C., Simren, M., Tack, J., Whitehead, W.E., Dumitrascu, D.L., Fang, X., Fukudo, S., Kellow, J., Okeke, E., Quigley, E.M.M., Schmulson, M., Whorwell, P., Archampong, T., Adibi, P., Andresen, V., Benninga, M.A., Bonaz, B., Bor, S., Fernandez, L.B., Choi, S.C., Corazziari, E.S., Francisconi, C., Hani, A., Lazebnik, L., Lee, Y.Y., Mulak, A., Rahman, M.M., Santos, J., Setshedi, M., Syam, A.F., Vanner, S., Wong, R.K., Lopez-Colombo, A., Costa, V., Dickman, R., Kanazawa, M., Keshteli, A.H., Khatun, R., Maleki, I., Poitras, P., Pratap, N., Stefanyuk, O., Thomson, S., Zeevenhooven, J. and Palsson, O.S., 2021. 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