{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:44:05Z","timestamp":1784036645978,"version":"3.55.0"},"reference-count":90,"publisher":"Walter de Gruyter GmbH","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Benef. Microbes"],"published-print":{"date-parts":[[2026,4,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Fermented milk containing\n                    <jats:italic>Lacticaseibacillus paracasei<\/jats:italic>\n                    strain Shirota (LcS) has been shown to improve stool consistency in various countries; however, its effect on hard or lumpy stools (HLS) in the Vietnamese population remains unclear. We investigated the effects of LcS-fermented milk on constipated Vietnamese adults with a high prevalence of HLS. In a single-centre, open-label trial, 51 participants with HLS were randomised to receive one bottle per day of fermented milk containing \u22656.5\u00a0\u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    cfu of LcS for 4 weeks (probiotic group) or no intervention (control group), followed by a 2-week washout. The primary endpoint was the proportion of participants with HLS (Bristol Stool Form Scale score of 1 or 2) in \u226525% of bowel movements over 4 weeks. Secondary endpoints included total stool frequency, HLS frequency, ideal stool form, and defecation-related symptoms \u2013 all recorded in daily diaries. The Chinese Constipation Questionnaire (CCQ) and gut microbiota composition (16S rRNA sequencing) were assessed every 2 weeks. During the intervention, the probiotic group had a significantly lower proportion of participants with HLS in \u226525% of bowel movements compared to controls (odds ratio: 0.00; 95% confidence interval: 0.00-0.16;\n                    <jats:inline-formula\/>\n                    ). The probiotic group also showed increased total stool frequency (\n                    <jats:inline-formula\/>\n                    ), reduced HLS frequency (\n                    <jats:inline-formula\/>\n                    ), and fewer participants with CCQ scores \u22655 indicating constipation (\n                    <jats:inline-formula\/>\n                    ) at 4 weeks. Gut microbiota beta-diversity differed between groups after 2 weeks (\n                    <jats:inline-formula\/>\n                    ), with reductions in\n                    <jats:italic>Peptococcaceae<\/jats:italic>\n                    ,\n                    <jats:italic>Clostridium_methylpentosum_group<\/jats:italic>\n                    , and\n                    <jats:italic>Clostridia<\/jats:italic>\n                    (unclassified at the order level), followed by increases in\n                    <jats:italic>Lachnospiraceae_UCG-004<\/jats:italic>\n                    at 4 weeks and\n                    <jats:italic>Lachnospiraceae_ND3007_group<\/jats:italic>\n                    post-follow-up (\n                    <jats:inline-formula\/>\n                    ), suggesting microbial changes linked to constipation improvement. No serious adverse events related to the intervention were observed. These findings support daily LcS-fermented milk as a dietary strategy in Vietnam to manage constipation via gut microbiota modulation.\n                  <\/jats:p>\n                  <jats:p>The study was registered at ClinicalTrials.gov (ID: NCT05982743).<\/jats:p>","DOI":"10.1163\/18762891-bja00116","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T03:00:58Z","timestamp":1776222058000},"page":"1-14","source":"Crossref","is-referenced-by-count":2,"title":["Effects of fermented milk containing Lacticaseibacillus paracasei strain Shirota on constipation and gut microbiota: A randomised pilot study in\u00a0Vietnam"],"prefix":"10.1163","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7061-0515","authenticated-orcid":true,"given":"V.","family":"Hoang\u00a0Van","sequence":"first","affiliation":[{"name":"Institute of Microbiology and Biotechnology, Vietnam National University, Hanoi, No.\u00a0144 Xuan Thuy street, Cau Giay district, Hanoi city, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9757-3367","authenticated-orcid":true,"given":"T.","family":"Dong\u00a0Van","sequence":"additional","affiliation":[{"name":"Bach Mai Hospital, No. 78 Giai Phong street, Dong Da district, Hanoi city, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6230-4365","authenticated-orcid":true,"given":"N.","family":"Nguyen\u00a0Bao","sequence":"additional","affiliation":[{"name":"Bach Mai Hospital, No. 78 Giai Phong street, Dong Da district, Hanoi city, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7086-4087","authenticated-orcid":true,"given":"U.","family":"Nguyen\u00a0Quynh","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Biotechnology, Vietnam National University, Hanoi, No.\u00a0144 Xuan Thuy street, Cau Giay district, Hanoi city, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3114-5012","authenticated-orcid":true,"given":"C.","family":"Nguyen\u00a0Thi\u00a0Linh","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Biotechnology, Vietnam National University, Hanoi, No.\u00a0144 Xuan Thuy street, Cau Giay district, Hanoi city, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3182-2993","authenticated-orcid":true,"given":"C.","family":"Dao\u00a0Xuan","sequence":"additional","affiliation":[{"name":"Bach Mai Hospital, No. 78 Giai Phong street, Dong Da district, Hanoi city, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3124-2040","authenticated-orcid":true,"given":"T.","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Yakult Central Institute, 5-11 Izumi, Kunitachi-shi, Tokyo 186-8650, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"R000001","series-title":"Alimentary Pharmacology & Therapeutics","first-page":"938","article-title":"Systematic review: impact of constipation on quality of life in adults and children","volume":"31","author":"Belsey, J.","unstructured":"Belsey, J., Greenfield, S., Candy, D. and Geraint, M., 2010. Systematic review: impact of constipation on quality of life in adults and children. Alimentary Pharmacology & Therapeutics 31: 938-949. https:\/\/doi.org\/10.1111\/j.1365-2036.2010.04273.x"},{"key":"R000002","series-title":"Journal of Pediatric Gastroenterology & Nutrition","first-page":"273","article-title":"The Paris Consensus on Childhood Constipation Terminology (PACCT) group","volume":"40","author":"Benninga, M.","unstructured":"Benninga, M., Candy, D.C., Catto-Smith, A.G., Clayden, G., Loening-Baucke, V., Di Lorenzo, C., Nurko, S. and Staiano, A., 2005. The Paris Consensus on Childhood Constipation Terminology (PACCT) group. Journal of Pediatric Gastroenterology & Nutrition 40: 273-275. https:\/\/doi.org\/10.1097\/01.mpg.0000158071.24327.88"},{"key":"R000003","series-title":"Nature Biotechnology","first-page":"852","article-title":"Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2","volume":"37","author":"Bolyen, E.","unstructured":"Bolyen, E., Rideout, J.R., Dillon, M.R., Bokulich, N.A., Abnet, C.C., Al-Ghalith, G.A., Alexander, H., Alm, E.J., Arumugam, M., Asnicar, F., Bai, Y., Bisanz, J.E., Bittinger, K., Brejnrod, A., Brislawn, C.J., Brown, C.T., Callahan, B.J., Caraballo-Rodr\u0131\u0301guez, A.M., Chase, J., Cope, E.K., Da Silva, R., Diener, C., Dorrestein, P.C., Douglas, G.M., Durall, D.M., Duvallet, C., Edwardson, C.F., Ernst, M., Estaki, M., Fouquier, J., Gauglitz, J.M., Gibbons, S.M., Gibson, D.L., Gonzalez, A., Gorlick, K., Guo, J., Hillmann, B., Holmes, S., Holste, H., Huttenhower, C., Huttley, G.A., Janssen, S., Jarmusch, A.K., Jiang, L., Kaehler, B.D., Kang, K.B., Keefe, C.R., Keim, P., Kelley, S.T., Knights, D., Koester, I., Kosciolek, T., Kreps, J., Langille, M.G.I., Lee, J., Ley, R., Liu, Y., Loftfield, E., Lozupone, C., Maher, M., Marotz, C., Martin, B.D., McDonald, D., McIver, L.J., Melnik, A.V., Metcalf, J.L., Morgan, S.C., Morton, J.T., Naimey, A.T., Navas-Molina, J.A., Nothias, L.F., Orchanian, S.B., Pearson, T., Peoples, S.L., Petras, D., Preuss, M.L., Pruesse, E., Rasmussen, L.B., Rivers, A., Robeson, M.S., Rosenthal, P., Segata, N., Shaffer, M., Shiffer, A., Sinha, R., Song, S.J., Spear, J.R., Swafford, A.D., Thompson, L.R., Torres, P.J., Trinh, P., Tripathi, A., Turnbaugh, P.J., Ul-Hasan, S., van\u00a0der Hooft, J.J.J., Vargas, F., Va\u0301zquez-Baeza, Y., Vogtmann, E., von Hippel, M., Walters, W., Wan, Y., Wang, M., Warren, J., Weber, K.C., Williamson, C.H.D., Willis, A.D., Xu, Z.Z., Zaneveld, J.R., Zhang, Y., Zhu, Q., Knight, R. and Caporaso, J.G., 2019. 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Alimentary Pharmacology & Therapeutics 22: 483-488. https:\/\/doi.org\/10.1111\/j.1365-2036.2005.02621.x"},{"key":"R000005","series-title":"Journal of Neurogastroenterology & Motility","first-page":"148","article-title":"Differential effects of Lactobacillus casei Strain Shirota on patients with constipation regarding stool consistency in China","volume":"25","author":"Chen, S.","unstructured":"Chen, S., Ou, Y., Zhao, L., Li, Y., Qiao, Z., Hao, Y. and Ren, F., 2019. Differential effects of Lactobacillus casei Strain Shirota on patients with constipation regarding stool consistency in China. 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Nature Communications 7: 11939. https:\/\/doi.org\/10.1038\/ncomms11939"},{"key":"R000025","series-title":"Bioscience & Microflora","first-page":"39","article-title":"The effects of a probiotic milk product containing Lactobacillus casei Strain Shirota on the defecation frequency and the intestinal microflora of sub-optimal health state volunteers: a randomized placebo controlled cross-over study","volume":"25","author":"Matsumoto, K.","unstructured":"Matsumoto, K., Takada, T., Shimizu, K., Kado, Y., Kawakami, K., Makino, I., Yamaoka, Y., Hirano, K., Nishimura, A., Kajimoto, O. and Nomoto, K., 2006. The effects of a probiotic milk product containing Lactobacillus casei Strain Shirota on the defecation frequency and the intestinal microflora of sub-optimal health state volunteers: a randomized placebo controlled cross-over study. 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