{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T04:24:33Z","timestamp":1793939073742,"version":"4.8.0"},"reference-count":42,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Benef. Microbes"],"published-print":{"date-parts":[[2026,5,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Topical probiotic formulations containing live bacteria are being explored as treatments for skin disorders such as atopic dermatitis and acne vulgaris. Certain bacterial strains with antimicrobial and\/or anti-inflammatory properties show promise as bacterial therapeutics that could improve these conditions and serve as alternatives to antibiotics, which are increasingly compromised by rising antimicrobial resistance. However, little is known about the engraftment efficacy of such bacterial strains or their impact on the native skin microbiome. In this study, we applied two different coagulase-negative staphylococcal strains, one with antimicrobial activity (\n                    <jats:italic>Staphylococcus epidermidis<\/jats:italic>\n                    2C-5) and one lacking any activity (\n                    <jats:italic>Staphylococcus hominis<\/jats:italic>\n                    H2-S92), on human back skin of 14 healthy volunteers. Engraftment was assessed using strain-specific PCR and three amplicon-based sequencing approaches at 7 and 30 days after application. Microbial profiles shifted modestly, showing a relative increase in staphylococci and a decrease in\n                    <jats:italic>Cutibacterium<\/jats:italic>\n                    spp.\n                    <jats:italic>S. epidermidis<\/jats:italic>\n                    2C-5 drastically increased from 0.8% pre-application to 46.9% and 12.1% at days 7 and 30, respectively.\n                    <jats:italic>S. hominis<\/jats:italic>\n                    H2-S92 showed a relative rise from 1.4% to 35.8% at day 7, declining to 2.4% by day 30. Interestingly,\n                    <jats:italic>Staphylococcus capitis<\/jats:italic>\n                    relative abundance decreased by 50-60% at the application sites. These findings indicate that both strains can temporarily engraft and competitively displace native staphylococci.\n                    <jats:italic>S. epidermidis<\/jats:italic>\n                    2C-5 appeared to colonize more effectively, possibly due to its bacteriocin production. Neither strain affected the phylotype composition of\n                    <jats:italic>Cutibacterium acnes<\/jats:italic>\n                    , suggesting lack of reach to sebaceous follicles,\n                    <jats:italic>C. acnes<\/jats:italic>\n                    \u2019 primary niche. This study supports the potential of staphylococcal probiotics for modulating the skin microbiome. While they may be effective for conditions involving staphylococcal dysbiosis, such as atopic dermatitis, they appear less suited for treating disorders like acne vulgaris, which are associated with\n                    <jats:italic>C. acnes<\/jats:italic>\n                    imbalance.\n                  <\/jats:p>","DOI":"10.1163\/18762891-bja00119","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:06:07Z","timestamp":1778641567000},"page":"569-582","source":"Crossref","is-referenced-by-count":0,"title":["Engraftment of staphylococcal strains on human skin can competitively displace native staphylococci"],"prefix":"10.1163","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1918-6974","authenticated-orcid":true,"given":"C.","family":"Feidenhansl","sequence":"first","affiliation":[{"name":"Department of Biomedicine, Faculty of Health, https:\/\/dx.doi.org\/1006Aarhus University, Wilhelm Meyers Alle\u0301 4, 8000 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Schweinshaut","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Faculty of Health, https:\/\/dx.doi.org\/1006Aarhus University, Wilhelm Meyers Alle\u0301 4, 8000 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9921-2075","authenticated-orcid":true,"given":"E.","family":"Rruci","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Faculty of Health, https:\/\/dx.doi.org\/1006Aarhus University, Wilhelm Meyers Alle\u0301 4, 8000 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.-T.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2473-6202","authenticated-orcid":true,"given":"A.","family":"Poehlein","sequence":"additional","affiliation":[{"name":"Department of Genomic and Applied Microbiology, Institute of Microbiology and Genetics, University of G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7433-0190","authenticated-orcid":true,"given":"H.","family":"Br\u00fcggemann","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Faculty of Health, https:\/\/dx.doi.org\/1006Aarhus University, Wilhelm Meyers Alle\u0301 4, 8000 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"R000001","series-title":"Communications Biology","article-title":"Interference and co-existence of staphylococci and Cutibacterium acnes within the healthy human skin microbiome","volume":"5","author":"Ahle, C.M.","unstructured":"Ahle, C.M., St\u00f8dkilde, K., Poehlein, A., B\u00f6meke, M., Streit, W.R., Wenck, H., Reuter, J.H., H\u00fcpeden, J. and Br\u00fcggemann, H., 2022. 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